Selective in Medical News

Gene therapy eliminates brain tumors through selective recruitment of immune cells

LOS ANGELES (January 13, 2009) Scientists seeking to harness the power of the immune system to eradicate brain tumors face two major hurdles: recruiting key immune cells called dendritic cells into areas of the brain where they are not naturally found and helping them recognize tumor cells as tar...

UltraShape(R) Commences Pivotal Study for First Non-Invasive Fat Reduction and Body Contouring Device Using Non-Thermal Selective Focused Ultrasound

YOQNEAM, Israel and SAN RAMON, California, June 12 /PRNewswire/ -- - Study Will Evaluate Safety and Effectiveness of Contour Plus(TM) Device UltraShape(R), a global leader in non-invasive fat reduction and body contouring, today announced the commencement of its pivotal IDE (Investigationa...

Moving beyond tamoxifen: Drug discovery and the future of selective hormone receptor modulators

How did a failed contraceptive become the first targeted therapy for the treatment of breast cancer" The transformation of tamoxifen, from cast-off to lifesaver, laid the foundation for a new class of therapeutics selective estrogen receptor modulators that could treat or prevent a variety of hu...

Pharmacopeia Acquires Selective Androgen Receptor Modulator ('SARM') Program from Bristol-Myers Squibb

PRINCETON, N.J., Oct. 15 /PRNewswire-FirstCall/ -- Pharmacopeia (Nasdaq: PCOP ), an innovator in the discovery and development of novel small molecule therapeutics, today announced that it has licensed from Bristol-Myers Squibb (NYSE: BMY ) a selective androgen receptor modulator (SARM) prog...

Novel 3-D cell culture model shows selective tumour uptake of nanoparticles

A nanoparticle drug delivery system designed for brain tumour therapy has shown promising tumour cell selectivity in a novel cell culture model devised by scientists at The University of Nottingham. The project, conducted jointly by the Schools of Pharmacy, Biomedical Sciences and Human Developmen...

Lung Cancer Alliance Calls American Cancer Society's Claim of Progress Selective

WASHINGTON, May 29 /PRNewswire-USNewswire/ -- Lung Cancer Alliance (LCA) said that the American Cancer Society's claim of "progress in cancer fight" earlier this week was based on "selective culling of statistics and ignores the dismal truth that we have made very little progress on the most letha...

WBC Selective About Sugar

Neutrophil is selective of its reaction to a particular variety of sugar present on the surface of pathogenic fungi . According to Biology textbooks neutrophils are regarded as mindless killers. White blood cells (WBC) form an integral part of blood. They are the policeman guarding our inter...

Govt to Pass Amendment to Curb Sex Selective Abortions: Ramadoss

Health and Family Welfare Minister Anbumani Ramadoss Wednesday assured representatives of the civil society and NGOs that the government is willing //to bring amendments in the legislation concerned to prevent sex selective abortions. "The government is willing to bring further amendments in ...

New Study Questions Cannibalism As A Worldwide Selective Force

A team of scientists reports that 'mad cow'-like diseases have not been a major force in human history, nor have been cannibalistic rituals that are known to be associated with disease transmission.// In a new study published by the journal Genome Research, Prof. Jaume Bertranpetit at the Univ...

EntreMed Reports Second Quarter 2009 Financial Results

...tological cancers. About EntreMed EntreMed, Inc. is a clinical-stage pharmaceutical company committed to developing primarily ENMD-2076, a selective angiogenic kinase inhibitor, for the treatment of cancer. ENMD-2076 is currently in Phase 1 studies in advanced cancers, multiple myeloma, and leukem...

ICBS to focus on pharmaceutical and environmental markets

...ies have entered a multi billion dollar market place in recession proof industries. ICBS will continue to acquire undervalued opportunities in these selective high-growth industries to create value for our shareholders and target partners by combining expertise in both the product and capital markets. Taking...

Zogenix and Astellas Enter Exclusive Co-Promotion Agreement in the US for Newly Approved Sumavel(TM) DosePro(TM)

... used within 24 hours of other ergotamine-containing or ergot-type medications or other 5-HT1( )agonists and is not generally recommended for use with selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors SNRIs or MAO inhibitors. Sumavel DosePro should be used during ...

Long-term health and social outcomes for neuroblastoma survivors

...this population probably has fewer late-arising complications than might be expected for either of the latter two groups. "The introduction of more selective and less toxic molecularly-targeted drugs holds the promise of substantially altering the acute and long-term toxic effects of cancer therapy," the ed...

Nanoparticle-delivered 'Suicide' Genes Slowed Ovarian Tumor Growth

... cancer cells, as scientists were able to deliver diphtheria toxin genes, using a nanoparticle, to the actual tumor site (peritoneum) with a basis for selective activity in the cancer cells (how the toxin genes were regulated once inside the cells). "A real plus of a cancer therapy like this is not j...

JNCI news brief: Antibody linked to chemotherapy drug inhibits ovarian cancer in lab

...gs typically affect both tumor and normal tissues, which can result in side effects. The immunoconjugate tested by the in this study allows for highly selective delivery of chemotherapy. "In summary," the authors write, "the findings herein provide a novel EphA2-targeted immunoconjugate with potent antitumor a...

American Association for Homecare Sets the Record Straight About Recent Home Medical Equipment Issues in the News

... REALITY: The "competitive" bidding program in Medicare sounds good, but as designed, the program eliminates most of the providers through selective contracting (even if providers agree to lower bid prices), and thereby reduces access to care, patient choice, and quality of care. The initial roun...

Carboxytherapy and Mesotherapy Unproven, Warns The Physicians Coalition for Injectable Safety

...nds and, until there exists credible evidence, consumers are advised not to have these injections." The Coalition urges consumers to be very selective about cosmetic treatments, and the individuals who provide them. "Only accept treatment prescribed by a qualified physician and administered unde...

QuatRx Announces Further Positive Phase 3 Results For Ophena(TM) (Ospemifene Tablets) in Postmenopausal Vaginal Atrophy

...tes in clinical development and a preclinical program. Fispemifene is a new selective estrogen receptor antagonist that is in Phase 2 studies as an oral treatment for the symptoms of secondary hypogonadism in men. Sobetirome, a novel, selective thyroid receptor beta agonist, is in Phase 1 as a potential treatment for d...

Quark Pharmaceuticals Announces Data Indicating Potential Utility of QPI-1007 for Treatment of Glaucoma

... field changes and vision loss are caused by the death of retinal ganglion cells. While existing therapeutics are capable of reducing IOP, none act as selective neuroprotective agents. We are encouraged by the QPI-1007 data, which suggest a neuroprotective effect on retinal ganglion cells in experimental glauc...

Research Scientist Reports On Time-Tested Solution To Current Medical Crisis

...ater he formed several research companies around his patents in the field of energy conversion and the development of synthetic membranes with natural selective characteristics. His interest in energy conversion led him to study and uncover ancient views of the energy exchanges within the human body about whic...

New strategy in tumor treatment

... might be used and tumors not susceptible to low doses could be attacked successfully at higher doses, without harm to host tissues." To assess the selective killing of tumor cells when they were present in excess of normal cells, the researchers designed co-culture experiments in vitro and animal studies a...

World's First Deep Brain Stimulation Device Approved for Treatment of Psychiatric Condition in Europe

...CD, as defined by a Y-BOCS score over 30, and who have tried at least three selective serotonin reuptake inhibitors (SSRIs) without treatment success, may be con...-compulsive disorder (OCD) in adult patients who have failed at least three selective serotonin reuptake inhibitors (SSRIs). About Reclaim DBS Therapy ...

Caltech chemists say antibody surrogates are just a 'click' away

...and then we modify the end of THAT with an alkyne, and add it back to the library, to produce a three-segment peptide, which is long enough to be both selective for and specific to the target protein," Heath says. "What Heath has shown now is that in several iterations, a high-affinity ligand for a protein...

Pluronic L-81 is a potential anti-diabetic drug?

...e. Similar to the action of insulin, L-81 exerted its effect on the MTP promoter. Their study L-81 is a promising candidate in the development of a selective insulin-mimetic molecule and an anti-diabetic agent. ...

Do bilingual persons have distinct language areas in the brain?

...t damage to the patient's Hebrew skills were significantly more severe than the damage to his Arabic skills. According to Dr. Ibrahim, even if this selective impairment of the patient's linguistic capabilities does not constitute sufficient evidence to develop a structural model to represent languages in th...

Ready for relapse: Molecule helps breast cancer cells to survive in the bone marrow

...er-related enzyme called Src was associated with late-onset bone metastasis. Interestingly, this link was independent of breast cancer subtype and was selective and specific for cell survival in the bone marrow. The researchers went on to identify Src-regulated signaling molecules that were expressed in th...

Montana Meth Project Statement Regarding Billings Gazette Story

...(6) The assessment of usage and other behavioral trends requires a complete view of all the data available, not selective data. The Montana Meth Project reviews a broad range of trend data to provide an accurate assessment of the changes, in all areas, since the launch o...

Research Reveals Clues to Breast Cancer's Spread

...und that a cancer-related enzyme called Src was associated with late-onset bone metastasis. This link was independent of breast cancer subtype and was selective and specific for breast cancer cell survival in bone marrow. Massague and colleagues then identified Src-regulated signaling molecules that were ex...

Sundia MediTech Appoints Dr. Chen Chen as Senior VP of Chemistry

...red NBI-31772, the first small molecule inhibitor for the insulin-like growth factor-I/IGF-binding protein. In addition, Dr. Chen identified the first selective antagonist of the melanocortin-5 receptor, and discovered numerous agonists and antagonists for the melanocortin-4 receptor for eating disorders. ...

Johnson & Johnson and Elan Corporation plc Announce Definitive Agreement for Alzheimer's Immunotherapy Program and Equity Investment

...an's outstanding ordinary shares. The AIP Program represents Elan's interest in a collaboration with Wyeth to research, develop and commercialize selective products for the treatment and/or prevention of neurodegenerative conditions, including Alzheimer's disease. Johnson & Johnson, through its...

Amira Pharmaceuticals Announces Initial Positive Phase 1 Clinical Data for AM211, a Novel Product Candidate for the Treatment of Respiratory Diseases

...al positive data from a Phase 1 clinical study of AM211, the company's oral selective antagonist of the DP2 (also known as CRTH2) receptor. The interim resu...as compared to exposures observed in safety species. While there are no DP2 selective antagonists approved for therapeutic use, there is a strong scientific rati...

Maybe Men Aren't So Picky After All

... Women can be just as selective when choosing mates, study finds MONDAY, June 29 (HealthDay News) -- Women and men are equally selective when picking a mate, according to a U.S. study that challenges the belief t...

Dermatologic and Ophthalmic Drugs Advisory Committee Unanimously Recommends Bepreve(TM) for the Treatment of Ocular Itching Associated with Allergic Conjunctivitis

...ser Fee Action Date of September 12, 2009. About Bepreve (bepotastine besilate ophthalmic solution) 1.5% Bepreve is a non-sedating, highly selective antagonist of the histamine (H1) receptor. It has a stabilizing effect on mast cells, and it suppresses the migration of eosinophils into inflamed ti...

Positive CHMP Opinion for JAVLOR(R) in Metastatic Treatment of Bladder Cancer After Failure of a Prior Platinum-Containing Regimen

...ity of Vinca scaffold in superacidic media. Such strategy, finalized in collaboration with experts at the University of Poitiers (France), enabled the selective introduction of two fluorine atoms in a part of that structure previously inaccessible by classic chemistry, thereby leading to the first bi-fluorinat...

Video: New Biological Therapy Ilaris(R) Approved in US to Treat Children and Adults with CAPS, a Serious Life-Long Auto-Inflammatory Disease

...riodic syndrome (CAPS) - Ilaris is the first approved treatment for children as young as four and is given only every eight weeks - Highly selective in targeting and blocking interleukin-1 beta (IL-1 beta), which is overproduced in CAPS patients causing inflammation - Studies under way in oth...

Bonus Payout Trends and Continuing Cost Controls Reflect Challenging Business Climate, Says Aon Consulting's Radford

...o pay bonuses at lower levels compared to the previous fiscal year, or do not expect to pay any bonuses at all. Many companies are instead considering selective awards, such as project team bonuses or special incentives, to top performers to recognize and reward superior efforts and outcomes that rise above th...

Neuromed Announces that Merck & Co., Inc. Terminates Research Collaboration and License Agreement for Compounds Targeting N-Type Calcium Channels

...itted to further research and development in this field." N-type calcium channel blockers represent a potentially novel class of analgesics that are selective for calcium channels involved in pain signal transmission. Calcium channels control the entry of calcium into the neuron. When a pain signal is transm...

Sleeping Helps Preserve Important Memories

... Brain uses selective process to store most relevant information, study shows THURSDAY, June 11 (HealthDay News) -- Sleep is good for your memory, but the slee...

InteKrin Therapeutics Announces INT131 Phase 2a Results at the 2009 American Diabetes Association Annual Meeting

... "These data are supportive of INT131 acting as a selective modulator of PPARgamma in T2DM patients," remarked...1 into the clinic is an exciting validation of the selective PPAR modulator design of the molecule," added Dr L... a next-generation, non-TZD insulin sensitizer and selective modulator of PPARgamma (SPPARM). INT131 belongs t...

Aethlon Medical Releases Shareholder Letter to Discuss the Treatment of Hepatitis-C Virus (HCV)

...tream. In HCV care, the Hemopurifier(R) inhibits viral replication through selective adsorption of circulating HCV and augments the immune response by removing ...he requirement for two cartridges and multiple pumps with DFPP. The selective ability of the Hemopurifier(R) to capture targeted viruses and immunosuppre...