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SLE in Medical News

Several genes that regulate the disease SLE have been identified

Swedish researchers, in collaboration with foreign colleagues, have identified a number of new genes that can be tied to the disease SLE, including a gene that hopefully might be used to treat the disease in the future by regulating the production of antibodies. These unique findings are being pu...

Usage Of Oral Contraceptives Need Not Be Feared By SLE Patients

In a research co headed by Jill Buyon, M.D., of New York’s Hospital for Joint Diseases said that oral contraceptives can be given to women with inactive or stable Systemic// Lupus Erythematosus (SLE) and they would not show symptoms of increased risk of flares of the disease. This research was ...

Infertility is Seen in Men With SLE

The prognosis for systemic lupus erythematosus (SLE), an autoimmune disease that mainly affects women in their reproductive years , has improved recently, prompting a shift toward improving quality of life. For men with SLE, concerns have been raised about their future fertility. However, n...

Immune responses to flu vaccine are diminished in lupus patients

...sed patients, it is recommended that patients with sle get annual flu shots, which are safe and do not in...as the first to examine cell-mediated responses in sle patients prior to and following influenza vaccinat...e Netherlands, the study involved 54 patients with sle and 54 healthy controls who received subunit flu v...

Almost 1 quarter of Spanish women take antidepressants

...iazepine use increases with age. However, they did not find the same with antidepressant use. "We think that greater training is needed in identifying sle and family dysfunction, and recording these in patients' records in order to help psychologists, psychiatrists and primary healthcare specialists", Pr...

Human Genome Sciences Announces Second-Quarter 2009 Financial Results and Key Developments

...esented at the Congress of the European League against Rheumatism (EULAR). The data showed that BENLYSTA was associated with sustained improvement in sle disease activity and patient response rates, decreased frequency of disease flares and was generally well tolerated through four years on treatment in...

Anxiety and depression lower quality of life in majority of systemic lupus erythematosus patients

...(52 of 56) of the patients who were diagnosed with sle had an element of confirmed neuropsychiatric (NP) ... Several other conditions that may occur alongside sle were also shown to influence aspects of QoL (as me...Italy, who conducted the study, said: "People with sle experience a range of both psychological and physi...

Novel DNA vaccine leads to kidney damage prevention in systemic lupus erythematosus models

...eague Against Rheumatism in Copenhagen, Denmark. sle is a complex, chronic autoimmune disease that caus...idney failure, often a significant complication of sle associated with the more severe forms of the disea...ignaling molecules involved in the immune process. sle was induced in the mice and the levels of antibodi...

Decrease in sense of smell seen in lupus patients

...us system in a condition known as neuropsychiatric sle (NPSLE). Research in mice has shown that NPSLE-lik...plored. A new study assessed olfactory function in sle patients and found that there is a decrease in the...ter in Tel-Hashomer, Israel, the study involved 50 sle patients and 50 age and sex-matched controls. Rese...

Oral contraceptives associated with increased risk of lupus

...matched with up to 10 controls among women without sle at the time of the case's diagnosis. The result...and possibly a dose-response effect of estrogen on sle onset," according to the authors. They note that e...ce seen in SLE. Previous studies on the risk of sle following use of oral contraceptives have had conf...

'Multi-target' immune therapy improves outcomes of severe lupus nephritis

...ditionally treated with a single immunosuppressant drug, but the efficacy is very poor," says Dr. Li. "We considered that, since the impact of severe sle on the kidney involves various parts of the immune system, it is necessary to treat the different immune targets with a combination of immunosuppressa...

Specific location of the TRAF1/C5 gene associated with multiple autoimmune diseases

...genotyping of 735 type 1 diabetes patients and 746 sle patients from Spain and The Netherlands identified...ith type 1 diabetes (odds ratio 1.14, p=0.027) and sle (odds ratio 1.16, p=0.016). In order to test the r...joint analysis of all type 1 diabetes (n=834)) and sle patients (n=1018) patients yielded a common odds r...

Ovarian function and fertility preserved in women with severe systemic lupus erythematosus

... chemotherapeutic agent, is a standard therapy for sle but may also be associated with ovarian failure in...ens, said: "Although the prognosis for people with sle has considerably improved over the years, a patien...ery important consideration in treating women with sle of child-bearing age, who are already burdened by ...

Lupus more severe in patients with Southern European ancestry

...tack the body's own cells, tissues or organs). sle is a complex autoimmune disease characterised by c...ls of the patient's body, including immune cells. sle has the potential to affect a variety of areas of ...elationship between specific European ancestry and sle severity has not been studied. Professor Lindse...

Autoantibodies and neuropsychiatric events in lupus

...pending on the study, between 37 and 95 percent of sle patients experience signs and symptoms of neuropsy...when managing nervous system disease in individual sle patients, as well as a critical factor in selectin... P (anti-P) antibodies and psychosis attributed to sle and the other between lupus anticoagulant (LAC) an...

Mayo Clinic shows therapy effective for reducing lupus flares

... that an immunosuppressive drug used in organ transplant cases is effective in reducing flare-ups in patients with systemic lupus erythematosus (SLE). sle results in inflammation of connective tissues and can involve the skin, joints and kidneys. Its cause is unknown. The findings were announced today at...

New Round of Lupus Research Institute Awards Brings Promise of More Breakthroughs

...etts General Hospital Identification of genes that mediate the response to sle immune complexes Vicki Kelley, PhD Brigham and Women's Hospital Colony ...nsylvania Expression and function of T cell-specific microRNAs in a murine sle model Tracy McGaha, PhD Temple University Marginal Zone Macrophages in ...

Identification of gene

...ate formation. These findings provide new insights into understanding autoimmune disease and suggest new diagnostic tests for possible causes of human sle ". ...

High expression of interferon induces lupus disease

...the type I interferon pathway is more common among sle patients who are most affected. The activation of ...er disease patients, the study results showed that sle patients scored more for activation of the type I ...nterferon pathway than patients of other diseases. sle patients with high scores in this regard are also ...
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