Progression of SIV infection in monkeys raises

A sudden loss of T cells -- white blood cells crucial to the immune system -- is not the trigger for the onset of AIDS, according to a study published in the September 2007 issue of the Journal of Immunology by a team of researchers at Tulane National Primate Research Center. The study, Acute ...

The Deadly Evolution of SIV to HIV

According to a study it was found that a mutation led to the deadly change from benign SIV in apes and monkeys to a deadly infection called AIDS in humans. // Statistics show that the disease in man has killed more than 25 million people in 25 years. The researchers said that the virus appears to ...

Yerkes researchers propose ambitious new strategies for AIDS vaccine research

...ican monkey are critical for the AIDS vaccine effort and understanding why siv infection does not progress to HIV/AIDS. SIV-infected sooty mangabeys devel...ad that does not increase their risk for developing AIDS. Additionally, the siv virus is rarely transmitted from mothers to babies. Silvestri also notes...

Vaccine Shields Monkeys From Simian Form of HIV

... The researchers' efforts focused on preventing siv infection in nine macaque monkeys who were "immunized" against siv by inserting genes already known to express anti-S...began attacking the SIV. After being exposed to siv four weeks later, six of the nine monkeys appeared...

Nuvilex Advances Release of Citroxin(TM) Antiviral Surface Cleaner to Help Combat Swine Flu

...ted the use of Citroxin to treat viral subtypes of siv (H1N1). In Dr. Goyal's first experiment, his team...s of 1:10 and 1:100) to inhibit the replication of siv H1N1 in vitro. Compared to the controls, high conc...xin (1:10 dilution) were found to be virucidal for siv growing in MDCK (Madin-Darby canine kidney) cells....

New HIV Drug May Help Those Resistant to Therapy

...ans. After six days of treatment, only three of the macaques had detectable siv levels, and after 13 days, only very low siv levels could be found in two of the macaques. When the researchers gave ...

OHSU vaccine research targets HIV in the slower, early stage of infection

...duced an altered monkey form of cytomegalovirus (CMV) programmed to express siv proteins and trigger specialized effector memory T-cells to look for and attack siv in its early stages. In total, 12 rhesus macaque monkeys at the Oregon N...

Possible AIDS Treatment Shows Promise in Monkeys

...s in monkeys. Nine rhesus macaque monkeys infected with a virus known as siv underwent treatment and remain alive eight months later. The treatment appe...ars in the Dec. 10 online edition of Nature The monkeys, infected with siv for as long as 21 months, were able to beat back the virus. Levels of virus...

Cold Spring Harbor scientists reveal a protein's role in enabling AIDS virus to reproduce

...icine in New York City. Like versions of the virus that occur in humans, siv viral particles, or virions, are composed of a few fundamental parts. At t... its internal machineries in order to reproduce. HIV and its simian cousin siv are members of a viral subspecies called retroviruses that invert the usual...

JCI table of contents: May 22, 2008

...ed to HIV. These viruses are known collectively as siv and naturally infected monkeys do not develop AIDS... understanding why monkeys naturally infected with siv do not develop AIDS might teach researchers import...beys naturally infected with SIVsmm, the strain of siv that naturally infects sooty mangabeys, has now be...

New 'OPAL Therapy' presents simple, cost-effective method of treating HIV infection

...n Kent, propose a technique named OPAL therapyOverlapping Peptide-pulsed Autologous CeLlsa reinfusion of fresh blood cells incubating with overlapping siv peptides. The OPAL technique was successfully tested in animal trials for stimulation of immunity, control of virus levels, and prevention of AIDS. ...

SIV infection of natural hosts provides new insights into HIV disease complexity

... said Sodora. Sodoras paper provides evidence, using the sooty mangabey siv natural host, that virally induced CD4 T-cell depletion, by itself, is not ...n another natural host, the African green monkey, is also not predictive of siv virulence. These three papers published together indicate that CD4 T-ce...

Evolution of HIV from African Greek Monkeys

... years ago. Previously, scientists thought siv infected an ancestor of green monkeys before the lineage split, much longer ago. "Studying siv helps us learn more about HIV," said the paper's f...research also challenges the idea that one ancient siv was transmitted vertically, down through time, and...

Secret to AIDS Resistance Is in the Blood

...pecies that do not develop AIDS when infected with siv to the same tissues of those species that do develop AIDS as a result of siv or HIV infection. She analyzed the presence of CCR...due to the adaptation of AIDS-resistant monkeys to siv infection over millennia, while the others only re...

Monkey Virus Identical to HIV Endemic in Gorillas

... analysis of the samples showed the gorillas were infected with a strain of siv related to the O group. The infected gorillas lived nearly 400 kilometers (250 miles) apart so the scientists believe it is likely siv infection is endemic in the animals. Peeters, who reported the finding...

Chronic binge drinking can hasten HIV development

...on. For this reason, we adopted the rhesus macaque siv model of HIV disease in order to more effectively ...d rhesus macaques and HIV-infected humans. Because siv infection in rhesus macaques is so similar to what...icates alcohol abuse as a cofactor in accelerating siv disease progression and, by extrapolation, HIV dis...

HIV Vaccine for Monkeys Increases Survival Rates

...the studies also identified a measurable marker of siv vaccine effectiveness in monkeys -- something know...ably accelerate future efficacy trials.' The siv vaccine regimen used in the two studies was a simp...ederer and their colleagues sought to determine if siv vaccines confer such a survival advantage to monke...

Three-Dimensional Image Of AIDS Virus – BY FSU Researcher

...r to those from a CAT scan, but at the level of viruses and molecules rather than tissues and organs. They imaged HIV samples as well as a mutant siv (non-human primate) strain, genetically engineered for the study by collaborators at the National Cancer Institute to express about 74 spikes as oppos...