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Ras in Medical News

Yet Another Use For Cell Phone Cameras

Researchers say there might be another use for cell phones that come complete with cameras: diagnosing chronic leg ulcerations.// Swiss researchers who used the phone cameras to send pictures of wounds to specialists in remote locations say doctors felt fairly comfortable diagnosing the wounds from...

Addario Lung Cancer Medical Institute Announces Diagnostic Screening and Clinical Research Collaborations With Response Genetics, Inc.

... (Logo: http://www.newscom.com/cgi-bin/prnh/20090731/DC55399LOGO ) Specific molecular features of tumors, including EGFR mutations, ras mutations, ERCC1, RRM1 or TS overexpression, have been shown in multiple studies to have prognostic importance and/or be associated with benefit from ...

New Gene May Signal Aggressive Breast Cancer

... metastasis. According to the study, RCP overexpression also impacts the ras protein, which previous research has implicated in tumor growth. Researchers said RCP may promote breast cancer by activating the ras signaling pathway. Developing treatments that target RCP may represent a ne...

New drug candidate prolongs the lives of pancreatic cancer patients

...ast cancers as well as diabetes. Blocking the ras protein Salirasib works by inhibiting a protei...ancers. In cancer of the pancreas, mutant forms of ras are found in up to 90% of all tumors. Salirasib's ..., works to block the formation of cancer-promoting ras nanoclusters, thus blocking a cascade of biochemic...

Cell Protein Could Help Spur Malignancy

... be highly specific for cancer cells." Levy and his team made the discovery about the mitochondrial role of STAT3 by analyzing tumors caused by the ras oncogene, which has been determined to be involved in many human cancers. A report on the findings appears in the June 26 issue of Science . "F...

Are angiotensins involved in the hemodynamic changes of cirrhosis patients?

...terized by marked changes in the precursors of the ras cascade (renin and Ang 1 with repercussions on the 2 main ras components, Ang 2 and Ang-(1-7), in the splanchnic...circulation. Therefore, the circulating profile of ras components at different stages of liver cirrhosis ...

Quest Diagnostics Introduces First Comprehensive Laboratory Test To Analyze KRAS, NRAS, and BRAF Gene Mutations in Reflex Testing Service

...lable from a single test offering for identifying ras and BRAF gene mutations in patients with mCRC w...colon cancer samples that found that 11 percent of ras mutations would have been missed if only codons 12...ed (as recommended by ASCO's PCO), and recommended ras mutation testing include KRAS and NRAS encompassin...

Cancer cells need normal, nonmutated genes to survive

...ery way except for onethe presence or absence of a ras oncogene. ras mutations are prevalent in many deadly cancers, an...evels of a particular protein while cells with the ras mutation perished. Luo validated 50 of these hits ...

The vulnerable cancer cell

... "Efforts to develop drugs that inhibit oncogenic ras proteins have been largely unsuccessful, despite the fact that ras gene family members are mutated in about 30 percen...nted in Cell shows that STK33 is not a part of the ras signaling pathway, nor is it mutated in human canc...

American Cancer Society awards 143 research grants to investigators at 83 institutions nationwide

...s interest is in how growth factors initiate the process of cell movement. This work could supply a critical new understanding of why mutations called ras mutations are so common in so many different cancers. Preclinical and Translational Cancer Research Kimberly Stegmaier, M.D., Dana-Far...

Scripps Research cancer biology department awarded more than $8 million in new research grants

... ornithine decarboxylase (Odc). This enzyme plays key roles in cancer and is directly regulated by cancer-causing Myc oncoproteins and also by mutated ras oncogenes, which together are activated in more than 80 percent of all human tumors. This new study focuses on defining the various roles of Odc in re...

What is the suppressing effect of the PPAR-gamma ligands on stomach cancer cells?

...gly by troglitazone than by ciglitazone, and this effect was more evident in the SNU-668 than in the SNU-216 cells. SNU-668 cells demonstrated p53 and ras mutations, and it will be necessary in future studies to clarify the relationship between these results and the underlying mechanisms. This means that...

Cell biologists identify new tumor suppressor for lung cancer

...searchers did not understand the specific cellular events by which abnormal ras expression leads to transformation. UC researchers sought to define the... for the gene as a tumor suppressor. "PKC-zeta would normally slow down ras transformation and put the brakes on tumor development, but when PKC-zeta i...

Dormant cancer cells rely on cellular self-cannibalization to survive

...loping a blood supply, but the mechanism for this has not been well understood," Bast said. Bast and colleagues focused on ARHI, short for aplasia ras homolog member I, a gene found in normal cells, but that is underexpressed in 60-70 percent of ovarian cancers. When normal levels of ARHI were r...

Mutations common to cancer and developmental disorder examined in a novel disease model

... Costello Syndrome is one of several developmental disorders caused by mutations in a gene known as H-RAS. Additionally, mutations in H-RAS and the ras family of genes are common in most human cancers. Thus, scientists are trying to determine how genetic mutations that activate H-RAS can cause a cong...

Cellular senescence a double-edged sword

...iated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic ras and the p53 Tumor Suppressor." Co-authoring the paper with Campisi were ...ins. For example, normal cells that acquired a highly active version of the ras oncogene became senescent and secreted higher levels of SASP components. T...

Escape cancer, but age sooner? The dark side of the tumor suppressing process

... can cause DNA damage. The study also showed that normal cells that acquire a highly active, mutant version of a cancer-promoting protein known as ras secrete higher levels of the tissue-altering molecules, as do cells that lose functions of the tumor suppressor protein p53. The study therefore expla...

Surprise discovery made in cancer research

...pression, but we now realise that they can also influence other processes like cell migration". The classical mitogenic cascade (MAPK) is triggered by ras proteins, which are activated by mutations in nearly 20 % of all human tumours. In this signalling cascade, the RAS-protein is immediately followed by...

On Staying Alive's 10th Anniversary, Gym Class Heroes Singer Travis McCoy Named 2009 Foundation Ambassador

...V Staying Alive: Not to Me *** 1-hour short film -- focusing on HIV risk across the Caribbean Marks the long-form directorial debut of ras Kassa [acclaimed music video director -- Welcome to Jamrock, Beanie Man's Dude (remix), and Sean Paul's Never Gonna Be the Same] *** MTV Stayi...

Also in the Nov. 11 JNCI

...@umcutrecht.nl , + 31887556565 Downstream ras Signaling Protein May Be Lung Cancer Target Blocking expression of a protein involved in ras signaling, called seven-in-absentia homolog 2 (SIA... decreased the tumorigenicity of the cells. The ras signaling pathway drives cell proliferation and is...

Jefferson researchers show antibody to breast cancer-secreted protein blocks metastasis

...l role in the cancer cells' ability to migrate and invade, the prelude to metastasis. They focused on its effects on cancer-causing oncogenes, such as ras and Myc. In a series of experiments, the scientists, led by Dr. Pestell and first author Kongming Wu, Ph.D., assistant professor of Cancer Biology...

GRAS Proudly Announces Photometrica Version 2.0. Hailed as a Brilliant Solution for More Productive Astronomical Research by Those Engaged in Photometry Using the Global-Rent-a-scope Telescope Systems

... analysis and options available. Dr. Ed Wiley, research director of the ras Observatory, a robotic astronomical observatory, comments about the new ver...otometry variable star data to the AAVSO," said Robert Gagliano, M.D., ras Observatory member. Free, an exciting free offer. A carefully kept secr...

Gene mutation improves leukemia drug's effect

...a (AML) whose leukemic cells have mutations in the ras gene are more likely to be cured when treated afte...g cytarabine. It also suggests that testing for ras mutations might help doctors identify which AML pa...patients in the future will likely be screened for ras mutations, and those who have one may get high-dos...

Stem cell discovery sheds light on placenta development

...rocess of embryonic tissue differentiation." By activating a gene called ras in cells bathed in a very specific culture medium, scientists were able to ...c stem cells are more plastic than we had thought. By simply activating the ras gene, we changed the fate of embryonic stem cells to an entirely unexpected...

JCI online early table of contents: June 5, 2008

...by Jnos Peti-Peterdi and colleagues, at the University of Southern California, Los Angeles, have provided new insight into the mechanisms by which the ras might be activated in individuals with diabetes. Individuals with diabetes have increased levels of glucose in their blood and other bodily fluids....

Researchers find roadmap to next-generation cancer therapies

...ination of two of the most prevalent cancer genes, ras and p53, and were expressed differently in normal ...CRGs) had a similar effect. The significance of ras and p53, and by association the CRGs, is enormous. ras and p53 are implicated in about half of all cancer...

Cedars-Sinai Medical Center opens patient trial of virus that attacks brain cancer cells

...er cells have a defect in a signaling pathway (the ras pathway) that controls key cell functions. The reo...nfect and kill cancer cells that have an activated ras pathway, but the virus does not normally come into... that many types of cancer cells have an activated ras pathway, the company estimates that up to two thir...

Module map links embryonic stem cells and cancer stem cells

...ot other oncogenes, was sufficient to reactivate the ESC-like program in normal and cancer cells. In primary cells transformed by tumor-inducing genes ras and I"B", c-Myc increased the number of tumor-initiating cells that exhibited key properties associated with cancer stem cells and dramatically increa...

New finding may help explain development of preeclampsia

... in the blood during pregnancy, most women do not develop preeclampsia. This the first study to demonstrate that all three peptides involved in the ras are found in the chorionic villi of both normal and preeclamptic women. And, it was the first to show that levels of Ang II are higher in the chorioni...

UQ health and medical researchers recognized in awards

...n cancer and other human diseases such as muscular dystrophy. Professor Hancock is the Deputy Director (Research) of the IMB and a world authority on ras proteins, which are located on the underside of the cell membrane and play a role in triggering 30 percent of all human tumours. Professor Parton is ...

Cancer gene drives pivotal decision in early brain development

...lic adenosine monophosphate (cAMP) pathway and the ras pathway. This allows neurofibromin to regulate the.... "We found that neurofibromin regulation of the ras pathway is essential for the development of astroc...ntifying new or existing treatments that normalize ras pathway activity," Gutmann says. "To treat the lea...

American Cancer Society to Present Highest Honor to Matthew L. Myers, Douglas R. Lowy, and Mark Schiffman for Outstanding Contributions to Cancer Fight

...owy, deputy director for the Division of Basic Sciences at the National Cancer Institute, has also done pioneering research on murine retroviruses and ras oncogenes and continues to be a recognized leader in the discussion of global public health issues and the HPV vaccine. Mark Schiffman, M.D., M.P.H....

Pharsight Achieves $7.3 Million in Quarterly Revenue

... Lupin Pharmaceuticals, Seattle Genetics and NeurogesX -- Expanded the ras team with the addition of four scientific specialists. -- Continued to exp... and reporting. -- Achieved positive margin and strong revenue growth; ras revenue grew 30% sequentially compared with the fiscal first quarter of...

Phase I pharmacokinetic study of ECO-4601, a novel bifunctional targeting agent

...t within the pathway, specifically at the level of ras itself, Falardeau said. As a target for inhibition, ras presented researchers with a chance to affect the ... the pathway will compensate for its loss. Because ras sits at a crossroad of multiple signaling pathways...

Combination targets: some drugs may work best when they work together

...licated as creating computer models that accurately predict the weather, Dr. Korn said. The MEK protein is an enzyme involved in the well-studied ras pathway, which plays a central role in promoting cell growth and multiplication. When not functioning properly, this pathway has been implicated in a ...

Pharsight Expands Global Consulting Services Teams

...group's PK/PD analysis and reporting services. The ras team has also added a Quality Assurance Inspector ...w drug approval. Since its launch in May 2007, the ras unit has more than tripled its staff and has plans...s facilities in Montreal, Canada. In addition, the ras unit has accepted into its internship program a st...

Enzyme's second messenger contributes to cell overgrowth

..., and colleagues found that PLC- uniquely activates a second and distinctly different signaling cascade. This second signal catalyzes activation of a ras family of small G proteins associated with cell growth. In combination with the first set of signals, this can lead to cell proliferation and could...

Cytokine IL6 as a New Chemotherapeutic Target for Ras-driven Cancers

...l growth and proliferation. Over-expression of the ras oncogene, or of its growth-promoting pathway, is a... Unfortunately, though, attempts to target ras for inhibition in a clinical setting have proved unsuccessful. "We knew ras was really important for cancer, but time after ti...

Researchers Find New Target for Anti-cancer Drugs

...t is the hallmark of tumour formation. The ras gene, known as an oncogene when it is in this muta...lungs. To date, efforts at blocking or turning off ras have proven ineffective. Pancreatic cancer has been shown to have the strongest link to the ras oncogene, and it is also one of the hardest cancer...

Pediatric Cancer Stem Cell Identified

...r. Zon and colleagues have developed an animal model to identify and test therapeutic targets of human ERMS. The scientists artificially activated the ras pathways to induce ERMS in a strain of genetically engineered zebrafish. Some transgenic zebrafish developed visible tumors by 10 days of age. ...
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