Nexavar in Combination with Chemotherapy Shown to Extend Progression-Free Survival in Patients with Advanced Breast Cancer

...volved in both cell proliferation (growth) and angiogenesis (blood supply) - two important processes that enable cancer growth. These kinases included raf kinase, VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-B, KIT, FLT-3 and RET. Nexavar is also being evaluated by the companies, international study groups...

Sunesis Pharmaceuticals Receives Milestone Payment From Biogen Idec

...ogen Idec (Nasdaq: BIIB ) for the selection of a raf kinase inhibitor development candidate for the tre...ducting IND-enabling GLP preclinical work with the raf kinase development candidate. "While our inte...ed progress being made by Biogen Idec to advance a raf kinase inhibitor toward the clinic," said Daniel S...

Bladder Cancer No Longer a Death Sentence

...uency Ablation (RAF), a guided imagery surgery where a needle like probe transmits microwaves into tumors causing the destruction of tumor cells. The raf destroyed the tumors, but he was told they would come back - there is no mainstream cure for his cancer. Daniels then began researching alternati...

Bayer and Onyx Initiate Phase 3 Trial of Nexavar in Non-Small Cell Lung Cancer

...olved in both cell proliferation (growth) and angiogenesis (blood supply) - two important processes that enable cancer growth. These kinases included raf kinase, VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-B, KIT, FLT-3 and RET. Nexavar is also being evaluated by the companies, international study groups, g...

Phase 3 Trial Initiated to Evaluate Combination Therapy of Nexavar(R) and Tarceva(R) in Patients with Liver Cancer

...olved in both cell proliferation (growth) and angiogenesis (blood supply) - two important processes that enable cancer growth. These kinases included raf kinase, VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-B, KIT, FLT-3 and RET. Nexavar, which is co-developed by Bayer Healthcare Pharmaceuticals and Onyx Pharm...

Nexavar Approved in Japan for the Treatment of Advanced Liver Cancer

...volved in both cell proliferation (growth) and angiogenesis (blood supply) - two important processes that enable cancer growth. These kinases included raf kinase, VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-B, KIT, FLT-3 and RET. Preclinical models have also demonstrated that Raf/MEK/ERK has a role in HCC; therefor...

Oncogene inhibits tumor suppressor to promote cancer: Study links B-RAF and LKB1

...d malignant melanoma cells that often have a mutation called "V600E" in the raf protein B-RAF. The RAF-MEK-ERK pathway is well established as a key regulat...l growth, proliferation, differentiation and survival. Mutations in the raf kinase B-RAF have been found in many types of human cancer but, while oncog...

DSS Research Announces Senior Health Risk Assessment Tool

...eling and DSS has national norms available for users. DSS provides full risk stratification in comparison to norms for your population, comparisons to raf scores and other detailed analyses. Results can be delivered in hardcopy or interactive web reporting. Seniors with chronic conditions and various ris...

Sunesis Pharmaceuticals' SNS-595 Shows Clinical Activity in Patients With Relapsed or Refractory Acute Leukemias; Data Presented in Oral Session at 49th Annual Meeting of the American Society of Hematology

...a Phase 1 dose-escalating clinical trial in patients with advanced solid tumors. In addition, Sunesis is developing novel small molecule inhibitors of raf kinase and receptor tyrosine kinases in collaboration with Biogen Idec. About Sunesis Pharmaceuticals Sunesis is a clinical-stage biopharmaceutica...

The African Medical and Research Foundation (AMREF) Honors Merck & Co., Inc. with Global Corporate Philanthropy Award

...tain, Dr. Rees met his mentor Sir Archibald McIndoe, the surgeon renowned for having developed reconstructive surgical techniques to treat hundreds of raf fighter pilots whose planes went down in flames. Dr. Rees' training with Archie McIndoe literally changed his life - and began his lifelong commitment...

Anti-Cancer Drug Shows Early Promise in Pulmonary Hypertension

...signed to fight colon cancer, the drug, sorafenib (Nexavar?), proved much more effective against kidney cancer. Sorafenib inhibits an enzyme, known as raf kinase, which plays a role in tumor-cell growth. Researchers eventually realized it also hit other targets. After clinical trials in kidney cancer pat...

NHS needs changes like ‘Tesco' and ‘Toyot’

...were all carried out in the Toyota group of companies, which needs to be copied by NHS to make patient believe its work. Methods followed by the raf and Royal Navy were influenced by the Tesco. Thus showing a piece of work to detail how the system would weed out excess paperwork and processes...