Lethality of H1N1 Influenza Virus Increasing According to Latest Replikin Analysis of Virus Peptide Genomic Data
Boston Biotech Firm Reports First Rise in 76 Years of Replikin Count* of H1N1 Lethality Gene
Boston (PRWeb) June 11, 2009-- As the World Health Organization raised its pandemic alert to phase 6, the top of its six-point scale, a new analysis released yesterday (June 10)...
Brookhaven Lab and BioSET patent a synthetic peptide that enhances bone growth
UPTON, NY Brookhaven Science Associates, the company that operates and manages the U.S. Department of Energy's Brookhaven National Laboratory (BNL), and Biosurface Engineering Technologies, Inc. (BioSET), have been issued a U.S. patent on a synthetic peptide, called B2A.
"About 250,000 Americ...
Merck Serono and Apitope Announce Licensing Agreement on Novel Peptide Therapeutics for the Treatment of Multiple Sclerosis
- Merck Serono and Apitope to Collaborate on Development and Commercialization of ATX-MS-1467, Apitope's Peptide
Therapeutic for the Treatment of Multiple Sclerosis (MS)
GENEVA, Jan. 13 /PRNewswire/ -- Merck Serono, a division of Merck KGaA, Darmstadt, Germany, announced today the signature o...
New Experts Help New England Peptide Combat Global Acetonitrile Shortage; Company Integrating Cost-Effective Chemical Solvent Alternatives
New England Peptide, a Massachusetts-based designer and producer of custom peptides and polyclonal antibodies for drug and vaccine discovery organizations worldwide, is providing customers with alternative chemical solutions in the face of the global shortage of acetonitrile. Heading New England...
A New Way to Predict Outbreaks: Replikin Peptide Concentration in H5N1 Influenza Virus Genome as a Marker for Lethal Outbreaks
WHO and CDC have stated that the predictive accuracy of their annual formulations for human influenza vaccines is "suboptimal" - often correct less than 50% of the time, especially for seniors. Perhaps in part because we are not yet accurate in our predictions of upcoming influenza stra...
Bacterial peptide provides new insight into common tumor suppressor
Scientists have identified a new antitumor drug that might prove useful in developing treatments for a multiple human cancers. The research, published by Cell Press in the July 8 issue of the journal Cancer Cell , advances the understanding of one of the most frequently disrupted tumor suppressor...
Xenome Enters Into Joint Research Collaboration to Discover Novel Peptide Therapeutics with Amylin Pharmaceuticals
BRISBANE, Australia, Nov. 27 /PRNewswire/ -- Xenome Ltd., a leader in
developing unique peptides for therapeutic applications in a variety of
diseases, today announced the signing of a joint research collaboration
agreement with Amylin Pharmaceuticals, Inc. The partnership will focus on
New peptide communication factor enabling bacteria to 'talk to each other' discovered
Jerusalem Discovery by Hebrew University of Jerusalem researchers of a new communication factor that enables bacteria to talk to each other and causes their death could have significant consequences leading to development of a new class of antibiotic medications.
Bacteria are traditionally cons...
Novel role of protein in generating amyloid-beta peptide
A defining hallmark of Alzheimer's disease is the accumulation of the amyloid β protein (Aβ), otherwise known as "senile plaques," in the brain's cortex and hippocampus, where memory consolidation occurs. Researchers at the University of California, San Diego School of Medicine have ide...
Stress Protein Inactivation Cuts Alzheimer's Peptide in Mice
While previous studies have already revealed that stress boosts the production of a brain peptide
critical to Alzheimers disease, a new study on mice has now shown that blocking a different brain peptide
slows the stress-induced increases.
The study, reported online in the Proceedings of th...
Discovery of Elevated Amyloid Peptide levels could lead to Alzheimer’s Preventio
A faulty molecule, identified in the brain of patients suffering from mild cognitive impairment (MCI) could be responsible for the progression of MCI to Alzheimer’s disease (AD) dementia//, according to a recent study published in the journal of Neurobiology of Aging.
Researchers at Mount Sinai...
Biocon to colloborate for development of Oral peptide drugs for heart diseases.
The Indian Biotech Company, Biocon to colloborate with Nobex Corporation of United States to develop a new oral peptide
drug for cardiovascular diseases. The spokesperson of Biocon informed that the company has gone into global research collaboration // on Tuesday for development of peptide
New Insight To The Role Of Peptide Signals
New knowledge about the hormonal signals like peptide
signals reveals that they play// an important role in information processing in the brain along with the conventional neurotransmitters.
Investigations done by the scientists of University of Edinburgh report that hypothalamic neurons use t...
Cryo-Cell to Present Novel Adult Stem Cell Research During 2009 China Medical Biotech Forum
...y to make presentations on their latest progress. Presentations focus on topics such as vaccine separation, purification and application; antibody and peptide
drug research and clinical application; the latest developments of enzyme engineering and fermentation engineering; as well as regenerative medicine t...
Photos: Lumixyl(TM) Enters the Market to Improve the Appearance of Hyperpigmentation without Irritation and Side Effects
...Lumixyl(TM) a non-toxic, non-irritating, synthetic peptide
technology shown to significantly help improve the..., Lumixyl's ground-breaking technology is the only peptide
shown to measurably promote healthy skin function ...entrations, skin that was treated with the Lumixyl peptide
expressed a reduced production of melanin by as mu...
While Some New Agents Will Achieve Strong Sales, the Migraine Drug Market Will Decline $1.3 Billion by 2018 as Generic Erosion Takes Toll on Top-Selling Brands
...et during the next decade and will exert increasing pressure on new products. However, the emergence of Merck's first-in-class calcitonin gene-related peptide
receptor antagonist telcagepant as an alternative to triptan therapy will help counteract market losses -- according to the report, telcagepant will g...
Michael J. Fox Foundation Awards $3.8 Million To Drive Nine Industry Partnerships For Pre-Clinical Parkinson's Drug Development
...afer, PhD, Medtronic Neuromodulation, Minneapolis, Minnesota
Pre-clinical development of a Parkinson's disease therapy using a glucagon-like peptide
(GLP-1) receptor agonist
Kevin Tomaselli, PhD, Amylin Pharmaceuticals, Inc., San Diego, California
Tips from the journals of the American Society for Microbiology
...iciting antibodies that target a gastrin-releasing peptide
which is known to play a key role in cancer develo...cal and Vaccine Immunology .
(GRP) is an important human peptide
that regulates gastric acid secretion and motor fu...
A Phase III Alzheimer's Drug Increases Levels of Beta Amyloid in the Brain - But Still Provides Benefits
...e in tau tangles observed by her team is in accord with previous findings by Asuni's group, though Asuni immunized with a different phosphorylated tau peptide
and immunization protocol.
"We believe that these results point to the therapeutic potential of phosphorylated-tau-immunotherapy in Alzheimer...
Caltech chemists say antibody surrogates are just a 'click' away
...de group at one end. The alkyne group on the added peptide
can potentially chemically react with the azide group of the library's peptides, to create a new peptide
that is now two segments long.
However, the reaction can only occur when the second peptide
comes into close contact with the first on the sur...
Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells
...expressed in several solid tumors including pancreatic cancer. YSA, a small peptide
ligand that binds the EphA2R with high affinity, was inserted into the HI l...tes reduced adenoviral transduction at least 100-fold. Insertion of the YSA peptide
in the HI loop restored adenoviral transduction of EphA2R-expressing cells ...
Access Pharmaceuticals Announces Initiation of Two New Cobalamin(TM) Oral Insulin Drug Delivery Collaborations
...flexible to allow us to deliver a wide range of actives," commented David P. Nowotnik, Ph.D, Access' Senior Vice President of R&D. "In addition to peptide
delivery, we have received inquiries recently about the potential of this technology to deliver actives ranging from small molecules to siRNA to ...
Video: 'BeautyScoop(R) Is a Trip to Your Nutritionist and Dermatologist in One Single Packet.' Lauren Slayton, NYC Nutritionist & Owner of FoodTrainers
...hat are simple multivitamin preparations. BeautyScoop(R) is a beauty breakthrough that easily outperforms the competition with its patent-pending, peptide
and lipid formula and clinically proven results.
Doctor-developed, after nearly a decade of research and development, BeautyScoop (R) is a who...
Mayo Genomic Discovery: Protecting Kidney Function During Heart Failure
...ayo Clinic cardiology researchers have found a peptide
that helps preserve and improve kidney function du...fecting blood pressure. Earlier variations of this peptide
caused blood pressure to drop limiting the potenti...y and keep you out of the hospital."
This new peptide
(a unique link of amino acids) has been tested in ...
New approach for treating recurrent prostate cancer on the horizon
...dioactive substances attached to the radiopeptide. Prostate cancer cellsand many other types of cancer cellshave an overabundance of gastrin-releasing peptide
receptors, making the cancer a strong candidate for treatment with radiopeptides.
The study compared two different types of radiopeptides. One gro...
Over half of people with rheumatoid arthritis have periodontitis
... greater risk for the development of RA. Those with RA who had moderate to severe periodontitis also developed significantly higher Anti-Citrullinated peptide
Antibody (ACPA) levels than those with no-mild periodontitis.
The retrospective study identified 45 RA patients based on their hospital discharge di...
Are angiotensins involved in the hemodynamic changes of cirrhosis patients?
...ance between these 2 opposing peptides.
The relationship between Ang-(1-7) and Ang 2 may play a role in hemodynamic changes of human cirrhosis. The peptide
Ang-(1-7) probably predominates in the peripheral circulation in the initial stages of human cirrhosis and in the splanchnic circulation in the advanc...
CEL-SCI Expands Testing of Its Vaccine to Determine Efficacy Against More Virulent Strain of H1N1 Swine and Other Influenza Viruses
...peptides. The L.E.A.P.S. constructs containing the antigenic disease epitope linked to an Immune/T-cell binding ligand (I/TCBL) can be manufactured by peptide
synthesis or by covalently linking the two peptides. Depending upon the type of L.E.A.P.S. construct and I/TCBL used, CEL-SCI is able to direct the o...
Synthetech Announces Fiscal 2009 Results
...issues also impact our contract drug synthesis market where our traditional peptide
building block products are sold. Despite potential adverse effects on our... We develop and manufacture amino acid derivatives, specialty amino acids, peptide
fragments and proprietary custom chiral intermediates and specialty resins,...
Estrogen linked to lowered immunity in fish
...hormone, researchers also suspect that hepcidin may act as an antimicrobial peptide
in mammals, fish and frogs. Antimicrobial peptides are the first line of de... in two ways. "First," said Robertson, "hepcidin could be an antimicrobial peptide
that actually kills pathogens. Or it could be more complex. To live, a micr...
Study further expands understanding of leptin's role in brain neurocircuitry
...as one key area where leptin exerts its influence, and within the ARC, they have identified two types of leptin-responsive neurons, the Agouti-related peptide
(AgRP) neurons, which stimulate appetite and the pro-opiomelanocortin (POMC) neurons, which curb appetite.
"Still other studies had indicated that,...
Vaccine shows therapeutic promise against advanced melanoma
... currently medical director of the Goshen Center for Cancer Care, were involved in the vaccine's development and early basic and clinical studies. The peptide
vaccine, known as gp100:209-217 (200M), works by stimulating patients' T cells, known for controlling immune responses.
"This vaccine activates the...
Experts Optimistic About Melanoma Vaccine
...0 will die of the disease, according to the American Cancer Society.
The study, a phase 3 clinical trial involving 185 people, found that using the peptide
vaccine in combination with the immunotherapy drug Interleukin-2 improved response rates and progression-free survival, according to University of Tex...
Amylin Pharmaceuticals to Present Compelling Efficacy and Safety Data From Diabetes Programs at ADA 2009
...ate-sponsored symposia focused on the potential of peptide
therapy treatment approaches for type 2 diabetes, ...ATURED SYMPOSIA
"Effective Use of peptide
Therapies for Optimal Glucose and Weight Control i...p healthcare providers understand the potential of peptide
therapy treatment approaches for diabetes. The eve...
The future of personalized cancer treatment: An entirely new direction for RNAi delivery
...n difficult due to their size and negative electrical charge which prohibits them from readily entering cells.
A small section of protein called a peptide
transduction domain (PTD) has the ability to permeate cell membranes. Dowdy and colleagues saw the potential for PTDs as a delivery mechanism for get...
Palatin Technologies, Inc. Reports Fiscal Year 2009 Third Quarter Results; Teleconference and Webcast to be held on May 15, 2009
Palatin Technologies, Inc. is a biopharmaceutical company focused on discovering and developing targeted, receptor-specific small molecule and peptide
therapeutics. Palatin's strategy is to develop products and then form marketing collaborations with industry leaders in order to maximize their comme...
AdvanDx Receives FDA 510(k) Clearance for GBS PNA FISH(R) for Rapid Detection of Group B Strep from Lim Broths
...A (peptide nucleic acid) probes to target species specific ribosomal RNA (rRNA) in live bacteria and yeast. The unique properties of the non-charged, peptide
backbone of PNA probes enable the use of FISH assays in exceedingly complex sample matrixes, such as blood and blood cultures, and this in turn facili...
Nile Therapeutics Reports 2009 First Quarter Financial Results
...ther areas of unmet medical needs. Nile is initially focusing its efforts on developing its lead compound, CD-NP, a novel rationally designed chimeric peptide
in clinical studies for the treatment of heart failure, and CU-NP, a novel rationally designed natriuretic peptide. A key component of the company's s...
NPs-NPR-B/pGC-cGMP signal pathway is involved in diabetic gastroparesis
... The natriuretic peptide
(NP) receptor type B (NPR-B) gene was expressed in gastric smooth muscles of normal and diabetic rats and the expression was increased in diabetic rat...
Biomarkers May Help Measure Rate of Decline in Dementia
...s disease. Samples of cerebrospinal fluid taken from the patients were tested for several biomarkers associated with Alzheimer's, including alpha-beta peptide
1-42 (Aβ42), tau, and phosphorylated tau 181 (ptau 181).
The patients had at least one follow-up assessment an average of 3.5 years later and ...