Pathway in Medical News

Critical link in cell death pathway revealed

The role of a protein called XIAP in the regulation of cell death has been identified by Walter and Eliza Hall Institute researchers and has led them to recommend caution when drugs called IAP inhibitors are used to treat cancer patients with underlying liver conditions. A team led by Professor ...

Cell Pathway May Be Key to Lung Cancer's Spread

Researchers express hope that finding will lead to treatments,, FRIDAY, July 3 (HealthDay News) -- U.S. researchers say they've found a major cellular flaw that may drive the rapid spread of relapsed lung cancer. When caught early, lung cancer can often be treated. But most cases a...

Genetic pathway responsible for link between body clock disturbance and worsening arthritis

Copenhagen, Denmark, Wednesday 10 June 2009: The genes that regulate human circadian rhythm, or 'the body clock', are significantly disturbed in individuals with arthritis, according to the results of a new study presented today at EULAR 2009, the Annual Congress of the European League Against Rhe...

U-M researchers link pathway to breast cancer stem cells

ANN ARBOR, Mich. A gene well known to stop or suppress cancer plays a role in cancer stem cells, according to a new study from the University of Michigan Comprehensive Cancer Center. The researchers found that several pathways linked to the gene, called PTEN, also affected the growth of breast ca...

Research reveals molecular pathway behind invasive prostate cancers

CINCINNATIUniversity of Cincinnati (UC) cancer and cell biologists have identified a new molecular pathway key to the development of invasive prostate cancers. In a preclinical study led by Maria Diaz-Meco, PhD, the UC team found that simultaneous inactivation of two particular genesknown as...

Set out on the Pathway to Change with the Dermatology Nurses' Association

Dermatology Nurses to Convene in Boston, July 31-August 2 BOSTON, May 18 /PRNewswire/ -- Within health care, dermatology nursing professionals play a critical role in providing quality care to their patients. When the Dermatology Nurses' Association (DNA) hosts its Annual Summer Meeting in 2...

NPs-NPR-B/pGC-cGMP signal pathway is involved in diabetic gastroparesis

The natriuretic peptide (NP) receptor type B (NPR-B) gene was expressed in gastric smooth muscles of normal and diabetic rats and the expression was increased in diabetic rats. These results suggest that natriuretic peptide-dependent pGC-cGMP signal is up-regulated and it may contribute to diabeti...

GPhA Statement on Introduction of H.R. 1548, 'The Pathway for Biosimilars Act'

ARLINGTON, Va., March 17 /PRNewswire-USNewswire/ -- The Generic Pharmaceutical Association (GPhA) released the following statement today from GPhA President and CEO Kathleen Jaeger regarding the introduction of H.R. 1548, "The Pathway for Biosimilars Act." " The Pathway for Biosimilars Act i...

Cell pathway on overdrive prevents cancer response to dietary restriction

FINDINGS: Whitehead Institute researchers have pinpointed a cellular pathway that determines whether cancerous tumors are susceptible to dietary restriction during their development. When this pathway, known as PI3K is permanently turned "on" via mutation, tumors grow and proliferate independent o...

Blocking molecular pathway with whimsical name possible therapeutic target for pancreatic cancer

A possible new therapeutic target for pancreatic cancer, the most lethal form of human cancer, has been identified in the proteins whose DNA recipe comes from gene, "Seven-In-Absentia," according to researchers at the American Society for Cell Biology (ASCB) 48th Annual Meeting, Dec. 13-17, 2008 i...

UCLA scientists find cell pathway driving a deadly sub-type of breast cancer

An intra cellular pathway not previously linked to breast cancer is driving a sub-type of the disease that is highly lethal and disproportionately over-represented in African American women. The pathway regulates how cells identify and destroy proteins and represents a class of genes called pr...

Scientists ID Pathway That Makes Antipsychotic Drugs Work

Finding could aid drug manufacturers in development of new therapies TUESDAY, Aug. 26 (HealthDay News) -- New findings that antipsychotic drugs may not work as scientists have assumed could lead to changes in how the drugs are developed and prescribed, say Duke University Medical Cent...

Schizophrenia linked to dysfunction in molecular brain pathway activated by marijuana

PITTSBURGH, July 7 Alterations in a molecular brain pathway activated by marijuana may contribute to the cognitive symptoms of schizophrenia, according to a report in the July issue of Archives of General Psychiatry , one of the JAMA/Archives journals. Expression of the cannabinoid 1 receptor...

Pathway Medical Technologies Awarded New Patent for Pathway PV(TM) Atherectomy System for Improved Differential Cutting

KIRKLAND, Wash., June 25 /PRNewswire/ -- Pathway Medical Technologies, Inc., an innovator of endovascular treatments for peripheral arterial disease (PAD), announced it was recently granted another patent for its Pathway PV(TM) Atherectomy System. The issuance of this latest patent enhances th...

Penn researchers find key developmental pathway activates lung stem cells

PHILADELPHIA Researchers from the University of Pennsylvania School of Medicine found that the activation of a molecular pathway important in stem cell and developmental biology leads to an increase in lung stem cells. Harnessing this knowledge could help develop therapies for lung-tissue repair ...

Scientists ID Brain Pathway That Stops Seizures

Mouse study finds gene affects acids that regulate severity of convulsions SUNDAY, June 8 (HealthDay News) -- A brain pathway that stops seizures has been found by Iowa researchers. Applying modern genetics and molecular biology to clinical observations made more than 80 years ago...

Discovery of new signal pathway important to diabetes research

[PRESS RELEASE, 4 June 2008] Scientists at Karolinska Institutet in Sweden and Miami University have discovered that cells in the pancreas cooperate signal in a way hitherto unknown. The discovery can eventually be of significance to the treatment of diabetes. The aim of the project was to f...

Researchers ID Inflammation-Fighting Pathway in Fat Cells

But this protection breaks down when obesity sets in, study finds WEDNESDAY, June 4 (HealthDay News) -- A new molecular signaling pathway in fat cells that suppresses harmful inflammation has been identified by Harvard School of Public Health researchers. The pathway prevents the fat c...

Major 'missed' biochemical pathway emerges as important in virtually all cells

DURHAM, N.C. -- A new study by Duke University researchers provides more evidence that the nitric oxide (NO) system in the life of a cell plays a key role in disease, and the findings point to ways to improve treatment of illnesses such as heart disease and cancer. The nitric oxide system in ce...

Embryonic pathway delivers stem cell traits

CAMBRIDGE, Mass. (May 15, 2008) Studies of how cancer cells spread have led to a surprising discovery about the creation of cells with adult stem cell characteristics, offering potentially major implications for regenerative medicine and for cancer treatment. Some cancer cells acquire the abil...

Immune system pathway identified to fight allergens, asthma

PITTSBURGH, May 7 For the first time, researchers from the University of Pittsburgh School of Medicine have identified genetic components of dendritic cells that are key to asthma and allergy-related immune response malfunction. Targeting these elements could result in more effective drugs to tre...

New MedPAC Report: Abbreviated Biogenerics Pathway 'Urgently Needed'

PCMA: Competition Necessary to Drive Down Costs WASHINGTON, March 10 /PRNewswire-USNewswire/ -- A new Medicare Payment Advisory Committee (MedPAC) report that says "having an abbreviated biogenerics approval process is urgently needed because many of the most innovative and costly products...

3 newly discovered ERK pathway proteins related to CagA induced disease

Cytotoxin-associated gene A protein (CagA) from type I H.pylori has been proved by epidemiological and experimental studies to be closely associated with the H.pylori induced gastric diseases, especially gastric cancer. However, the precise role of CagA in cell function after H. pylori infection r...

U of M researchers discover a pathway to turn off immune system cells

University of Minnesota researchers have discovered a new way to turn genes off in human T cells, a type of white blood cell that helps the immune system fight infections. Turning off genes, through a process known as mRNA decay, is important for regulating the bodys immune response after fighti...

New pathway provides more clues about BRCA1 role in breast cancer

DURHAM, N.C. -- A breast cancer gene's newly discovered role in repairing damaged DNA may help explain why women who inherit a mutated copy of the gene are at increased risk for developing both breast and ovarian cancer. The discovery also could lead to more effective therapies for women with ...

Molecular pathway appears crucial in development of pulmonary fibrosis

A study led by Massachusetts General Hospital (MGH) researchers may have found a key mechanism underlying idiopathic pulmonary fibrosis (IPF), a usually fatal lung disease for which transplantation is the only successful treatment. The investigators found that a specific molecular pathway appears ...

A powerful literature and pathway mining system released to the public for free access

Genomatix Software GmbH of Munich, Germany and its US branch Genomatix Software, Inc. in Ann Arbor, MI (USA) announced today the release of LitInspector. LitInspector can be accessed without limits and free of charge by the scientific community world wide. All that is required is registration fo...

UC Davis researchers identify a cellular pathway that makes prostate cancer fatal

(SACRAMENTO, Calif.) Expanding evidence that tiny strands of RNA called microRNAs play big roles in the progress of some cancers, UC Davis researchers have identified one that helps jump start prostate cancer cell growth midway through the disease process, eventually causing it to become fatal....

UC Davis researchers discover novel pathway to increased inflammation in diabetes patients

(SACRAMENTO, Calif.) -- Researchers at UC Davis Health System have discovered a novel pathway that results in increased inflammation of blood vessels in patients with type 1 diabetes. Their findings suggest that, with good diabetes control, this inflammation may be reduced, possibly resulting in a...

Anticancer Drugs Targeting the ErbB (EGFr/HEr2) Pathway Alone Generated Global Sales of Nearly $5 Billion in the First Nine Months of 2007

Currently, Over 370 Agents are in Active Clinical Development, Addressing Over 190 Targets LAKE FOREST, Calif., Nov. 27 /PRNewswire/ -- Six ErbB (EGFr/HEr2)-pathway inhibitors, marketed for the treatment of several major solid tumor indications, generated global sales...

Quest Diagnostics Licenses Technology Underlying SensiTrop(TM) HIV Co-Receptor Tropism Test from Pathway Diagnostics

-First national diagnostic testing company to license proprietary technology- MADISON, N.J., Oct. 26 /PRNewswire-FirstCall/ -- Quest Diagnostics Incorporated (NYSE: DGX ), the nation's leading provider of diagnostic testing, information and services, announced ...

Second pathway behind HIV-associated immune system dysfunction identified

Researchers at the Partners AIDS Research Center at Massachusetts General Hospital (PARC-MGH) may have discovered a second molecular switch responsible for turning off the immune systems response against HIV. Last year members of the same team identified a molecule called PD-1 that suppresses the...

Fate Therapeutics to Present Data on Stimulation of Osteogenic Activity Using Small Molecule Modulators of Wnt Pathway

LA JOLLA, Calif., and BARCELONA, July 8 /PRNewswire/ -- Fate Therapeutics, Inc. announced today the presentation of data from its research on small molecule modulators of the Wnt pathway for osteo-regeneration at the 7th Annual Meeting of the International Society for Stem Cell Research (ISSCR...

Scientists identify gene in breast cancer pathway

May 12, 2009 (BRONX, NY) Scientists at Albert Einstein College of Medicine of Yeshiva University have discovered how a gene crucial in triggering the spread of breast cancer is turned on and off. The findings could help predict whether breast tumors will metastasize and also reveal potential dru...

Developing cancer treatments directed at critical developmental pathway

PHILADELPHIA - Researchers from the University of Pennsylvania School of Medicine and colleagues discovered that the Notch signaling pathway, which determines the development of many cell types, and is also implicated in some cancers, is not universally essential for the maintenance of stem cells....

NHS Choices Launches Heart Disease Pathway

LONDON, March 12 /PRNewswire/ -- NHS Choices ( http://www.nhs.uk ), the digital 'front door' to the NHS, launches a new guide aimed to help people understand the different stages of coronary heart disease (CHD) - from avoiding CHD right through to living with the condition. Based on NHS accr...

Brain Pathway for Depression Revealed

Researchers at the Stanford University School of Medicine have identified one unifying principle that could explain how a range of causes and treatments for depression converge. Scientists hunt for the cause of depression has implicated so many suspects and found so many treatments with different ...

Parkinsons Disease Protein Pathway Identified

The research by a team of Emory University scientists have found a novel signaling pathway in cells that is altered by genetic mutations recently identified in Parkinson disease development. These new findings show how the mutations affect cellular function and could provide a target for drug the...

Protein Pathway Involved in Parkinson Disease Development Identified

Boffins at Emory University have identified a protein pathway in cells that is altered by genetic mutations recently identified in Parkinson disease development . Parkinson disease is a degenerative disorder of the central nervous system resulting from the loss of neurons in the brain that pro...

Scientists Trace New Pathway That may Stem Antibiotic Resistance

Scientists at University of Alabama at Birmingham (UAB) have traced the differences and similarities between polymerase enzyme in bacteria RNA and that in human RNA , a significant development that may lead to improved antibiotics and less antibiotic resistance. The new findings have been r...