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Nitric in Medical News

Clinical Utility of Exhaled Nitric Oxide Highlighted By American Thoracic Society Panel

Panel also addresses limitations of current randomized trials MENLO PARK, Calif., June 2 /PRNewswire/ -- Apieron, Inc . highlighted recent clinical panel presentations underscoring the positive impact of measuring exhaled nitric oxide (eNO) for treating asthma in adults and children. The c...

NO help: Nitric oxide monitoring does not help most children with asthma

The level of nitric oxide (NO) in an asthmatic's exhaled breath can portend worsening asthma symptoms, and may even signify an imminent attack linked to underlying airway inflammation. This has made the monitoring of NO levels, particularly in children, of significant interest as a potential way t...

Monitoring exhaled nitric oxide does not help manage asthma

A new study shows that monitoring levels of exhaled nitric oxide in adolescents with asthma and adjusting treatment accordingly does not improve the course of their disease. The study was conducted by the Inner City Asthma Consortium (ICAC), which is funded by the National Institute of Allergy...

New study: pine bark extract boosts nitric oxide production

A study to be published in the October edition of Hypertension Research reveals Pycnogenol, (pic-noj-en-all), an antioxidant plant extract from the bark of the French maritime pine tree, helps individuals by enhancing healthy nitric oxide (NO) production which leads to an increase in blood flow an...

Early Nitric Oxide Treatment Can Help Low Birth Weight Preemies

Inhaled nitric oxide can significantly lower the risk of lung and brain damage in some very low birth weight premature infants// but children must be studied for several years to assess the long-term, protective benefits of the treatment on brain development. A clinical trial led by John Kins...

Inhaled nitric oxide therapy does not reduce death risk of infants

Premature infants with lung problem are often treated with inhaled nitric oxide// therapy. A recent study had brought out the fact that this therapy does not reduce the chances of death or further lung infections. Researchers for the study are of opinion that premature babies who weigh less th...

Benefits of Nitric Oxide in the Treatment of Premature Infants

Chronic lung disease is a primary long-term complication among premature infants suffering from respiratory distress syndrome.// These infants are at greater risk for pulmonary hypertension and impaired growth, and they also have a sharply increased risk of developing neurological problems. A ...

Beetroot Juice May Boost Stamina

...d his colleagues don't know the exact mechanism that causes nitrate in beetroot juice to increase stamina, but they suspect that nitrate may turn into nitric oxide in the body, leading to a reduction in oxygen uptake and making exercise less tiring. More information The U.S. National Heart, Lung, an...

Scientists Learn How Cancer Drugs Cause Hypertension

...d in a school news release. "Our studies in mice show that blocking VEGF causes hypertension because it disrupts an important biological system -- the nitric oxide pathway that regulates blood vessel health." The researchers used an antibody to block an important VEGF receptor called VEGFR2. After about ...

Apieron, Inc. Files Infringement Complaint Against Aerocrine AB, Aerocrine AG and Mr. Magnus Pelles

... Insight(TM) eNO System for measurement of exhaled nitric oxide, presented this complaint against Aerocrine ...et portable and stationary analyzers to detect the nitric oxide content in breath, which Apieron considers t...sthma. Its Insight(TM) eNO System measures exhaled nitric oxide (eNO) which is a well established indicator ...

Simple Steps Deliver Relief for Tennis Elbow

...arm that affects about 3 percent of the general population. "Compared to other treatments for tennis elbow, such as cortisone injections or topical nitric oxide, which require direct medical supervision and often [cause] side effects, this treatment is not only cost-effective, but dosage is not limited b...

Easy Strength Training Exercise May Help Treat Tennis Elbow, Study Shows

...tended 30 patients having already completed the study. "Compared to other treatments for tennis elbow such as cortisone injections or topical nitric oxide which require direct medical supervision and often side effects, this treatment is not only cost effective but dosage is not limited by the pati...

News briefs from the July issue of CHEST

...therapy had no effect on sputum, bronchoalveolar lavage (BAL), or mucosal inflammatory cell findings in adults or children. LABAs did decrease exhaled nitric oxide levels and BAL albumin levels in adults, suggesting a possible benefit. The study is published in the July issue of CHEST , the peer-reviewed j...

Novel light-sensitive compounds show promise for cancer therapy

...pond to specific wavelengths of light by releasing nitric oxide, which triggers cell death. "For cancer t...localized delivery of a very high concentration of nitric oxide. We've designed these molecules to do just t...ofessor of chemistry and biochemistry at UCSC. nitric oxide is a simple molecule with a wide range of bi...

After 10 Years A Stronger and More Enhanced Form of Viagra Now Available

...sitivity and orgasm). Adding L-Arginine greatly increases the levels of nitric Oxide (NO) in the corpus cavernosum and the clitoral-vaginal area, resultin...g and L-Arginine. -All the benefits of L-Arginine and its conversion to nitric Oxide (NO). -The strongest and most enhanced treatment of its kind. ...

Arete Therapeutics Presents Positive Clinical and Preclinical Data for AR9281

...xide Hydrolase, in Diet-Induced Obese Mice Does Not Depend on Active nitric Oxide Synthase" (Vincelette, J, Chen, D, Mehra, U, Cheng, Y, Gless, ...hat these effects are not inhibited by concurrent treatment with the nitric oxide synthase inhibitor L-NAME (NG-nitro-L-arginine methyl ester), ...

Obesity does not worsen asthma, but may reduce response to medications

...fect of increased weight. Among a subgroup of 183 people, lean patients taking inhaled corticosteroids alone showed a 55% greater reduction in exhaled nitric oxide, a measure of inflammation. Lean patients taking a combination inhaled steroid and long-acting beta agonist increased their FEV1 by 80 more mill...

Cordex Receives Special Protocol Assessment Approval from FDA for ATPace(TM)

...es based upon the emerging pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism... successful commercialization of technologies relating to the use of ATP or nitric oxide. Additional uncertainties and risks are described in Cordex's most re...

Apieron Secures Series D Commitments

...ccurate, safe and efficient measurement of exhaled nitric oxide, a well-documented marker for airway inflamm...thma. Its Insight(TM) eNO System measures exhaled nitric oxide (eNO) which is a well established indicator ...n's Insight eNO System can detect trace amounts of nitric oxide in a patient's breath. It is highly accurate...

Indiana U. research at the American College of Sports Medicine conference

...e test involves measuring exhaled breath levels of nitric oxide. The other involved measuring the pH level o...ch has shown that pre-exercise fraction of exhaled nitric oxide (FENO) levels, which is a marker of airway i...nge for six minutes. "Our study found that exhaled nitric oxide may be a useful tool in predicting EIB and t...

Apieron Strengthens Senior Leadership With Commercial, Financial Appointments

...2008. The system uses a proprietary biosensor technology to measure exhaled nitric oxide, a well established indicator of asthma severity and steroid responsi...evelop a simple-to-use, non-invasive monitor for the measurement of exhaled nitric oxide (eNO) for the management of asthma. The Apieron biosensor technology ...

Recent developments at Burnham Institute for Medical Research, May 2009

... connections to other nerve cells are lost and eventually the nerve cells die. The chemical reaction mediated by free radicals (in this case a form of nitric oxide or NO) is called S-nitrosylation. Dr. Stuart Lipton and Dr. Adam Godzik found that S-nitrosylation of Drp1 causes excessive mitochondrial fragme...

More evidence for the benefit of exercise in cardiovascular disease -- and even in heart failure

...obic capacity. Endothelial function was assessed by ultrasound measurement of arterial diameter, which is predominantly dependent on the release of nitric oxide from the endothelium and represents a well accepted predictor of outcome in heart failure. Results showed that in both young and older heart fai...

Genetic variants predict recurrence of bladder cancer, patient survival

...around 50 percent over four years. In this study of 596 patients at M. D. Anderson, 46 percent of those who had a common genotype of the inducible nitric oxide synthase (iNOS) gene experienced a recurrence after receiving maintenance BCG therapy. Only 22 percent of patients with the variant-containing g...

Cordex Pharma to Collaborate with BG Medicine in a Clinical Study of Heart Failure Biomarkers

...heart failure. The drug is designed to correct the nitric oxide and redox imbalance in the failing heart and...of excessive reactive oxygen radicals and restores nitric oxide to physiologic levels. The primary therapeut...g pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical role...

N30 Pharma Forms Scientific Advisory Board

...pment programs across cardiopulmonary medicine and nitric Oxide (NO) and redox biology. Dr. Joseph Loscalzo...potential clinical impact of modulating endogenous nitric Oxide bioavailability." About N30 Pharma N3...ne company focused on the modulation of endogenous nitric Oxide bioavailability using targeted novel small m...

Brain Cells Give New Clues to Alzheimer's

...e of Science , researchers at the U.S.-based Burnham Institute for Medical Research have shown that beta-amyloid protein "multimers" create excessive nitric oxide. This free radical then reacts with the protein Drp1, causing the fragmentation of mitochondria -- the cell's energy storehouses -- in the brain...

U-M researcher's idea jells into potential new disease-detection method

...researchers are devising a new method of detecting nitric oxide in exhaled breath. Because elevated concentrations of nitric oxide in breath are a telltale sign of many diseas...by particular cue ---in this case, the presence of nitric oxide and oxygen. Other research groups have achie...

Less of a stink in diabetes patients?

...Glasgow this week and published in Diabetic Medicine . H 2 S is produced naturally within our bodies, along with other chemical compounds such as nitric oxide, where it is believed to help regulate blood pressure. Research shows that a balance between these compounds relates to good health, whereas an ...

Breath or urine analysis may detect cancer, diabetes

... will analyze breath or urine samples for volatile markers inside the body that indicate disease. These volatile markers, such as alkanes, acetones or nitric oxide, give doctors clues about what is happening inside the body and can be used as a diagnostic tool. "Little traces of certain gas molecules...

Cordex Pharma Files ATPace Formulation Patent

...es based upon the emerging pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism ... successful commercialization of technologies relating to the use of ATP or nitric oxide. Additional uncertainties and risks are described in Cordex's most re...

Sigma-tau HealthScience Launches www.GlycoCarn.com

...mational website devoted to their revolutionary new L-Carnitine, GlycoCarn(R),USP (Glycine Propionyl-L-Carnitine or GPLC). GlycoCarn(R), "the ultimate nitric oxide and performance enhancing nutraceutical ingredient," has been gaining notice in the athletic, fitness and health world for many benefits continu...

New study shows how spikes in nitrite can have

... modulating its oxidation status and its protein machinery. Nitrite, an oxidation product of the ubiquitous short-lived cell signaling molecule, nitric oxide (NO), was until recently thought to be biologically inert at the relatively low levels found in the body. Traces of nitrite are present in our d...

Electroacupuncture protects acetylsalicylic acid-induced acute gastritis in rats

...Each rat was fasted for 18 to 24hours before experimentation, and lesion scores, gastric acidity, cyclooxygenase (COX)-1 and -2 mRNA levels, and total nitric oxide (NO) concentration were measured. They found that the lesion scores of the EA group were significantly lower than those of the NSAID-induced ...

Muscular dystrophy mystery solved; Mizzou scientist moves closer to MD solution

...e tissue. One of these "helper" molecular compounds is nNOS, which produces nitric oxide. This is important for muscles that are in use during high intensity ...vessels are constricted," Duan said. "nNOS is important because it produces nitric oxide that relaxes the blood vessels, helping to maintain the muscle with a...

Compounds Found to Protect Rabbits From Cerebral Palsy

... oxygen. "It is known that if you have too much nitric oxide in the brain, which can be produced during h...that block an enzyme in brain cells that produces nitric oxide. At normal levels, nitric oxide is a neurotransmitter, which is important fo...

Stunning finding: Compounds protect against cerebral palsy

...hibit an enzyme found in brain cells that produces nitric oxide, thus lowering nitric oxide levels. At normal levels, nitric oxide acts as a neurotransmitter and is important ...

Cordex Pharma Submits to the FDA an Amended Special Protocol Assessment for ATPace

...es based upon the emerging pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism ... successful commercialization of technologies relating to the use of ATP or nitric oxide. Additional uncertainties and risks are described in Cordex's most re...

Cordex Pharma Sets Fourth Quarter 2008 Program Update Call

...es based upon the emerging pharmacology of adenosine triphosphate (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism ... successful commercialization of technologies relating to the use of ATP or nitric oxide. Additional uncertainties and risks are described in Cordex's most re...

Smoking-Low Birth Weight Link Explained in Part

... smoking during pregnancy lowers production of an enzyme called endothelial nitric oxide synthase (eNOS), which regulates blood vessel dilation. Reduced produ...s restricted blood flow to the fetus. Reduced production of the vasodilator nitric oxide may lower the blood flow to the fetus," Andersen said in an American ...
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