Generation of a severe memory-deficit mutant mouse by exclusively eliminating the kinase activity of CaMKIIalpha
Ca2+/calmodulin-dependent protein kinase II alpha (CaMKII alpha) is an enzyme that adds phosphates to a variety of protein substrates to modify their functions. CaMKII alpha is enriched in the hippocampus, the memory center of the brain, and is believed to be an essential mediator of activity-dep...
Stem cell transplant in mouse embryo yields heart protection in adulthood
Rochester, Minn. May 14, 2009 - Stem cells play a role in heart muscle rejuvenation by attracting cells from the body that develop into heart muscle cells. They have been successfully used to halt or reverse cardiac injury following heart attack, but not to prevent injury before it occurs.
Common anesthetic induces Alzheimer's-associated changes in mouse brains
For the first time researchers have shown that a commonly used anesthetic can produce changes associated with Alzheimer's disease in the brains of living mammals, confirming previous laboratory studies. In their Annals of Neurology report, which has received early online release, a team of Mass...
Mutant Mouse Gene Offers Clues to Hearing Loss
Variant prevented ear hair cells from pumping out excess calcium, study finds
FRIDAY, Oct. 31 (HealthDay News) -- A mutation in mice that mimics progressive hearing loss in humans has been identified by European researchers.
They found that mice with a mutation in a gene called Obli...
Mature Mouse Cells Reprogrammed to Stem Cell-Like State
Work could lead to better understanding of autoimmune diseases, researchers say
THURSDAY, April 17 (HealthDay News) -- Without using an egg, researchers have been able to reprogram certain mature cells back to an embryonic-stem-cell-like state, a new report says.
A research team fro...
Boston College biologists build a better mouse model for cancer research
CHESTNUT HILL, MA (4/9/08) Researchers at Boston College have developed the first laboratory mouse
model that mimics cancers spread through the human body. Using their novel cell line, the team discovered one of the bodys primary defensive cells plays a role in cancers attack.
The development ...
Seal Shield Introduces New Silver Seal Washable, Antimicrobial Mouse at HiMSS Healthcare Symposium
aimed at reducing cross contaminations including Influenza and MRSA.
ORLANDO, Fla., Feb. 25 /PRNewswire/ -- Seal Shield LLC today introduced
the new SILVER SEAL(TM) Washable, Antimicrobial Mouse
at the HiMSS
Healthcare Symposium in Orlando, FL. Accordi...
Gene Tweak Reverses Aging in Mouse Skin Cells
It's a long way from this to a human 'fountain of youth,' however
THURSDAY, Nov. 29 (HealthDay News) -- Scientists say they've been able to temporarily return old skin cells to their youthful state by blocking the activity of a single gene.
"This gene gets more and more active with...
A longer-living, healthier mouse that could hold clues to human aging
A study by scientists at UCL (University College London) shows that mice lacking the insulin receptor substrate (IRS)-1 are more resistant to ageing than normal mice. The research adds to a growing body of work showing the importance of insulin signalling pathways as an ageing mechanism in mammals...
Effectiveness of mouse breeds that mimic Alzheimer's disease symptoms questioned
BETHESDA, Md. Scientists have shown that recently developed mouse
breeds that mimic the symptoms of Alzheimer's disease (AD) may not be as effective as previously assumed. Sascha Weggen, Professor of Molecular Neuropathology at Heinrich-Heine-University, Duesseldorf, Germany; lead author Eva Czir...
Astrocytes help separate man from mouse
A type of brain cell that was long overlooked by researchers embodies one of very few ways in which the human brain differs fundamentally from that of a mouse
or rat, according to researchers who published their findings as the cover story in the March 11 issue of the Journal of Neuroscience .
Cosmetic Surgery -'Goldilocks' Anesthesia Is Not Mickey Mouse
CORONA DEL MAR, Calif., Dec. 16 /PRNewswire/ -- While all cosmetic surgery
can be performed under purely local anesthesia, most patients desire not to
hear, feel or remember their surgery - a condition commonly associated with
general anesthesia (GA).
Tumor suppressor genes speed up and slow down aging in engineered mouse
ROCHESTER, Minn. -- Mayo Clinic researchers have developed an animal model that can test the function of two prominent tumor suppressor genes, p16 and p19, in the aging process. Scientists knew that both these genes were expressed at increased levels as humans and mice age, but their role in the a...
Now, 'virtual' Mouse Brains Available on the Net
A multi-institutional consortium that includes Duke University has created high resolution, three-dimentional microscopic images of tiny mouse
brains, which unveil every layer of the organ.
The researchers could materialise this task by extending the capabilities of conventional magnetic ...
Researchers Develop First Mouse Model of Lung Transplantation
Surgeons at Washington University School of Medicine in St. Louis have developed the first mouse
model of lung transplantation , and theyre hoping it will help explain why the success of the procedure in humans lags far behind other solid organ transplants.
Ultimately, the mouse
New Mouse Model to Aid in Cancer-causing Genes Hunt
Scientists has developed a more human-like mouse
model of cancer they say will aid the search for cancer-causing genes and improve the predictive value of laboratory drug testing.
The study was conducted by a team of researchers including Richard Maser, Ronald A. DePinho, Lynda Chin at the...
Computer Mouse can Cause Arm Pain
Frequent incorrect use of a mouse
when working on the computer can lead to a condition known as Repetitive Strain Injury (RSI), otherwise known as mouse
arm, warn experts .
"Tingling, numbness, and weakness in the lower arm and hands are the first signs of overstressing of the tendons and n...
Treatment Extends Survival in Mouse Model of Spinal Muscular Atrophy
Drug therapy can extend survival and improve movement in a mouse
model of spinal muscular atrophy (SMA), new research shows. The study, carried out at the NIH’s National// Institute of Neurological Disorders and Stroke (NINDS), suggests that similar drugs might one day be useful for treating human ...
Rett Syndrome Reversed in Genetic Mouse Model
The RSRF announced the results of a landmark study reversing the symptoms of Rett Syndrome (RTT) in a genetic mouse
model//. The findings, by Adrian Bird, Ph.D., of the University of Edinburgh and Chairman of the Rett Syndrome Research Foundation (RSRF) Scientific Advisory Board, appear online in S...
Scientists Isolate Leukemia Stem Cells in Mouse Model
Researchers at Dana-Farber Cancer Institute and Children's Hospital Boston and their colleagues have isolated rare cancer stem cells that cause leukemia in a mouse
model// of the human disease.
The leukemia stem cells isolated proved to be surprisingly different from normal blood stem cells ...
Scientists Discover New RNAs in Mouse Testicles
London, June 6. A genetic cousin of DNA has been discovered in mouse
testicles. These are a new class of small RNAs. Small RNAs are known
to regulate key processes in human health //.
RNA interference is one important way that the body can shut off genes
of the invading pathogens.
German Scientists Create Stem Cells From Mouse Testes
German Scientists claim to have transformed testicular cells obtained from male mice into embryonic stem cells//, biological building blocks that have the remarkable ability to transform into other cell types.
This research led to the belief the same could be achieved in humans, helping set...
Researchers Develop Mouse Model Of Brain Tumor
A team of researchers, led by Dr. Martine Roussel of the St. Jude Children’s Research Hospital has developed a mouse
model of medulloblastoma, the most common malignant brain tumor found in children. //
Basically, medulloblastomas are malignant tumors that are formed by cells which are not ye...
Canadian Scientists Create Human Cancer in Mouse
Canadian scientists claim to have injected human cancer into a mouse
for the first time - to learn more about the disease in its earliest stages and how to stop its spread//.
Previously, researchers would engineer mice to develop cancer but it was the animal form of the disease. They could al...
FDA Approves New 3000 IU Vial Size for Kogenate(R) FS, antihemophilic factor (recombinant)
...patients who have manifested life-threatening immediate hypersensitivity reactions, including anaphylaxis, to the product or its components, including mouse
or hamster proteins.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch , or ca...
Bellicum Pharmaceuticals Announces Initiation of Phase I/II Clinical Trial of Novel Vaccine for Patients With Advanced Prostate Cancer
...opment for patients with advanced, androgen independent prostate cancer. BP-GMAX-CD1 and follow-on product candidates have been successfully tested in mouse
models and human dendritic cells. The company owns or has in-licensed certain key technologies, and Chief Executive Officer Thomas J. Farrell has asse...
Finding key to cancer drug Gleevec's limitations
...n toward CML are able to resist the drug.
model we have developed for CML allows us to ident...t U-M and senior author of the study. Developing a mouse
model that closely reproduces the progression of h... testing several two-drug combinations using their mouse
model. Imatinib is being combined either with inte...
Innovation to Unveil Next Generation of PharmASSIST SmartCabinet at NACDS Pharmacy & Technology Conference
The new version of the PharmASSIST SmartCabinet incorporates a high-resolution, touch-screen display, a tuck-away keyboard and mouse
drawer, and 46 independently operating tablet-and-capsule dispensers, which count prescriptions simultaneously. The counting technology maintains its ...
DEET in Bug Spray Tied to Neural Damage in Mice
...ening very often. I also would guess that the actual concentration in the body is much lower than they had to use in the study to see an effect in the mouse
But by better understanding the mechanisms by which DEET works, scientists may be able to come up with better repellant products, said Pa...
Silenced genes as a warning sign of blood cancer
...ble to show that methylation patterns in murine DNA are largely corresponding to those found in humans suffering from leukemia. This confirms that the mouse
model is suitable for studying the disease.
"Since first deviations in methylation occur so early in mice, we should find out whether this is also t...
Are Microbes Headed Back to School this Fall?
Ticonderoga((R)) pencils, highlighters and permanent markers
C-Line((R)) sheet protectors
Fellowes((R)) keyboards, mice, mouse
pads and wrist rests
To learn more tips about classroom hygiene and to find out where to purchase school supply products with Microban a...
Researchers effectively treat tumors with use of nanotubes
...-infrared radiation, respond by vibrating, creating heat. If enough heat is conducted, tumor cells near the tubes begin to shrink and die.
Using a mouse
model, researchers injected kidney tumors with different quantities of MWCNTs and exposed the area to a three-watt laser for 30 seconds.
Unlocking the key to human fertility
...he microscopic space within the head of the sperm cell, the DNA needs to be very tightly coiled, or packaged. The Leeds study showed that in human and mouse
sperm, not all of the DNA is packaged in the same way. Whilst most of the paternal DNA is compressed in an extremely compact fashion, some is packaged...
Nanoparticle-delivered 'Suicide' Genes Slowed Ovarian Tumor Growth
...he treated tumors failed to grow at all, while all control tumors increased in size. Administration of nanoparticles to three different ovarian cancer mouse
models prolonged lifespan by nearly four weeks and suppressed tumor growth more effectively, and with minimal non-specific cytotoxicity, than in mice ...
Scientists Find Way to Make 'Good' Brown Fat
...lthDay News) -- Boston scientists have succeeded in making brown fat out of mouse
and human cells, a feat that takes scientists a step closer to victory in t...ta. The two work together to propel various types of cells (including adult mouse
and human skin cells) to morph into brown fat. Once transplanted into mice,...
Therapy should extend beyond childhood
...guideline group headed by Dr. Klker. Parallel to this, the same working group carried out translational studies to examine new therapy approaches in a mouse
Image Sensors 2009 Announces Final Program and New Interactive Brochure
...e brochure allows you to easily navigate within the document and will open in full screen mode for easy viewing. A live link pointer emerges when you mouse
over the links within the brochure and you may also use the web navigation at the bottom to jump through pages. Stay in the know by joining Image Sen...
Scientists Track Impact of DNA Damage in the Developing Brain
...e DNA strands in an organ system, in this case the mouse
brain and nervous system. While the results sugges...eloped a way to switch off Xrcc1 production in the mouse
brain and nervous system as development began. The...vous system. St. Jude researchers then developed a mouse
that carried an Xrcc1 gene outfitted with bioche...
Human cells secrete cancer-killing protein, UK study finds
... lacks the ability to cause "cell suicide."
Rangnekar first discovered the Par-4 gene in 1993. In 2007, Rangnekar's team introduced the gene into a mouse
embryo, creating a cancer-resistant "supermouse" that did not develop tumors. In fact, the mice possessing Par-4 actually live a few months longer tha...
Bcl6 gene sculpts helper T cell to boost antibody production
...hibits a T cell from differentiating into Th17, Th1 or Th2 cells, three other lines of helper cell
Finally, when the Bcl6 gene was knocked out in a mouse
model, Tfh was nowhere to be found. "Bcl6 is absolutely required for Tfh generation and it's also important because it blocks other pathways that woul...