Naturally fluorescent molecules may serve as cancer biomarker
Excess amounts of a naturally fluorescent molecule found in all living cells could serve as a natural biomarker for cancer, according to bioengineers.
NADH, or nicotinamide adenine dinucleotide, is a key coenzyme -- a non-protein molecule necessary for the functioning of an enzyme -- found most...
Researchers Report Combined Molecules in Red Wine by Far Exceed the Biological Activity of Plain Resveratrol, Consistent With the Composition of Longevinex(R)
SAN DIMAS, Calif., March 10 /PRNewswire/ -- A recent CBS 60 Minutes TV program drew considerable attention to resveratrol (rez-vair-ah-trawl), a red wine molecule believed to largely be responsible for the French Paradox, the fact the French have far more people living beyond 100 years and exhibit...
From molecules to populations: Fighting the epidemics of obesity and diabetes
Diabetes is exploding it now afflicts some 200 million individuals worldwide and is fast becoming the No. 1 epidemic of our time. In the U.S. alone, more than 22 million people have diabetes, which is the leading cause of end-stage renal disease, preventable amputations and blindness.
Researcher refining synthetic molecules to prevent HIV resistance
COLUMBIA, Mo. Evolving HIV viral strains and the adverse side effects associated with long-term exposure to current treatments propel scientists to continue exploring alternative HIV treatments. In a new study, a University of Missouri researcher has identified broad-spectrum aptamers. Aptamers ar...
How molecules out of balance lead to human multiple myeloma and other cancers
An international team of scientists has identified processes that are heavily implicated in human multiple myeloma and other B cell cancers, moving us closer to developing quick tests and readouts that could help in the tailored treatment of patients.
B cells, the white blood cells that produce...
Synthetic molecules hold promise for new family of anti-cancer drugs
Jerusalem, June 4, 2008 -- Synthetic molecules
designed by two Hebrew University of Jerusalem researchers have succeeded in reducing and even eliminating the growth of human malignant tissues in mice, while having no toxic effects on normal tissue.
For their work in developing these harbingers...
Study in mice suggests molecules in plants have beneficial effect on Alzheimer's disease
A set of molecules
found in certain plants appears to have a beneficial effect in brain tissue associated with Alzheimers disease, according to a new study conducted in mice. The study was led by researchers at the University of South Florida and Cedars-Sinai Medical Center. An article in the Jour...
Allergic response tied to lipid molecules in cell membrane
A team of Penn State University researchers is the first to demonstrate that lipid molecules
in cell membranes participate in mammals' reactions to allergens in a living cell. The finding will help scientists better understand how allergy symptoms are triggered, and could contribute to the creati...
New understanding of how big molecules bind will lead to better drugs, synthetic organic materials
Biological and medical research is on the threshold of a new era based on better understanding of how large organic molecules
bind together and recognise each other. There is great potential for exploiting the molecular docking processes that are commonplace in all organisms to develop new drugs t...
Novel molecules developed at UB can boost vaccine potency
BUFFALO, N.Y. -- Two novel proteins studied by a University at Buffalo professor of microbiology and immunology appear to have the potential to enhance the production of antibodies against a multitude of infectious agents.
Terry D. Connell, Ph.D., professor of microbiology and immunology in ...
Tiny RNA Molecules Control Breast Cancer's Spread
Finding could lead to better prognosis, treatments, researchers say
WEDNESDAY, Jan. 9 (HealthDay News) -- Researchers have zeroed in on a handful of tiny ribonucleic acid (RNA) molecules
that seem to control whether or not breast cancer travels to the lung and bone.
Researchers identify molecules with interesting anti-clotting properties
RICHMOND, Va. (Nov. 8, 2007) Virginia Commonwealth University researchers have discovered a new mechanism to inhibit key enzymes that play a major role in clotting disorders, which could lead to novel therapies to treat clots in the lungs and those localized deep in the body in areas such as the ...
Study Describes Molecules That Control Blood Pressure
The finding involving proteins could lead to new treatments, researchers say
FRIDAY, Nov. 2 (HealthDay News) -- Researchers are reporting a newly discovered molecular mechanism that makes blood pressure go up or down -- knowledge that could lead to new treatments for the hypertension t...
New class of RNA molecules may be important in human cancer
COLUMBUS, Ohio Research here shows that an obscure form of RNA, part of the protein-making machinery in all cells, might play an important role in human cancer.
These ultraconserved non-coding RNAs (UCRs) have been considered junk by some researchers, but a new report in the September issue o...
Major Advance in the Observation of DNA Molecules
EVRY, France, December 7 /PRNewswire/ -- The teams of Eric Le Cam, from
the "Molecular Interactions and Cancer" lab (UMR 8126 - Institut Gustave
Roussy/CNRS/Universite Paris Sud) and David Pastre, from the "Structure and
Activity of Normal and Pathological Biomolecules - SABNP" lab
Key Signaling Molecules in New Teeth Formation Identified
Xiu-Ping Wang and colleagues identify the key signaling molecules
that regulate epithelial stem cell proliferation in the stem cell niche, using a combination of mouse mutant analyses , organ culture experiments, and gene expression studies, although mammals have a limited capacity to regenerate te...
Researchers Identifies Molecules That is Effective in Fighting Against Breast Cancer
The Hamilton researchers used state-of-the-art computational techniques in a novel way to design molecules
that they predicted would be effective lead compounds for breast cancer research. Scientists from the Albany Medical College subsequently synthesized the predicted molecules
and showed that t...
Penn Scientists Engineer Small Molecules to Probe Proteins Deep Inside Cell Membrane
PHILADELPHIA -- Proteins, which form much of the molecular machinery required for life, are the targets of most drug molecules//. One third of all proteins are membrane proteins – embedded within the cell’s fatty outer layer. While scientists can easily study the other two-thirds using such tools a...
Pair of MicroRNA Molecules Controls Major Oncogene in Most Common Leukemia
Researchers at Ohio State University have discovered that two microRNA (miRNA) molecules
help control the oncogene responsible for a dangerous form of B-cell chronic// lymphocytic leukemia (B-CLL), the most common human leukemia in the world.
Their findings, published in the December 15 iss...
Protein Molecules in blood predict preeclampsia development
According to a team of researchers from the National Institutes of Health and Beth Israel Deaconess Medical Center, high levels of two proteins in the blood// of pregnant women seem to point out the subsequent development of preeclampsia. Preeclampsia is a near-fatal complication of pregnancy.
Sensor Can Detect "Unhealthy" Molecules In Breath
Researchers at the University of Manchester have evolved a method to diagnose lung disease that is based on the techniques employed to detect chemical warfare agents. Dr Paul Thomas led a team of researchers in using a sensor employed to check out explosives at the airports. //
The sensor, ca...
Cell molecules behind neuro degenerative diseases
Researchers from the University of North Carolina at Chapel Hill, in the current issue of PLoS Computational Biology, had reported that there may be possible molecular origin of at least nine human diseases of nervous system degeneration. //
These neuro degenerative diseases, including Hunting...
Live recordings of cell communication
...ith nano-scale resolution. This helps us characterise the properties of the molecules
involved in vesicle-fusion. The new method opens great new prospects for th...ain acceptor fluorescent molecules. Only when the two different fluorescent molecules
are near to each other will light be emitted, which researchers can measure...
New microchip technology performs 1,000 chemical reactions at once
... a technique often used to identify potential drug molecules
that bind tightly to protein enzymes to either act...offering a new method to quickly screen which drug molecules
may work most effectively with a targeted protein ...ct of the work as well.
"The precious enzyme molecules
required for a single in situ click reaction in a ...
Boehringer Ingelheim to Commence Phase III Study Investigating the Role of BIBW 2992 as First-Line Treatment for Non-Small Cell Lung Cancer (NSCLC) Patients with EGFR Mutations
...ition, Boehringer Ingelheim is developing inhibitors of polo-like kinase 1 (Plk1), a protein that is involved in the processes of cell division. These molecules
are in the early stages of clinical development.
Boehringer Ingelheim Pharmaceuticals, Inc.
Boehringer Ingelheim Pharmaceuticals, Inc., bas...
Nephros, Inc. Completes $1.25 Million Private Placement
...d with greater capacity, than existing ESRD treatment methods, particularly with respect to substances known collectively as "middle molecules." These molecules
have been found to contribute to such conditions as dialysis-related amyloidosis, carpal tunnel syndrome, degenerative bone disease and, ultimately, m...
Food additive may one day help control blood lipids and reduce disease risk
...aked goods. Lecithin is a mixture of fatty compounds called phosphatidylcholines. Various types of phosphatidylcholines house different kinds of fatty molecules
linked to a common core.
This new study demonstrates that in the liver, a specific type of lecithin binds with a protein called PPAR-alpha, allowing...
Higher drug doses needed to defeat tuberculosis, UT Southwestern researchers report
...T Southwestern uses cultured cells to gauge the effectiveness and proper dosage of anti-tuberculosis drugs.
"With this model, we can directly test molecules
that have the potential to shorten therapy and go straight to coming up with the doses that you would use in patients," Dr. Gumbo said. "What that mea...
Scientists Test New Way to Get Drugs to Cancer Cells
...oisotopes directly to tumors show promise, U.S. researchers report.
The nanoparticles are made with liposomes, small chemical spheres made of fatty molecules
that can be designed to carry a number of drugs and chemicals, and can be manipulated to control how long they remain in the bloodstream.
NHLBI stops study of pulmonary hypertension treatment in sickle cell patients
...uth or Central America. Patients with this disease have abnormal hemoglobin molecules
in their red blood cells. The abnormal molecules
deform the red blood cells, causing them to clump together and block blood ...
GeneGo Awarded NIH Grant to Develop Pharmacogenomics Software Suite
...and toxicology. The second product, MetaDrug 5.4( TM ) is designed for prediction of human metabolism, toxicity and biological effects for novel small molecules
compounds. MetaBase( TM ) represents the knowledge base for MetaCore.
For more information, please visit the company's web site at www.genego...
Molecule plays early role in nonsmoking lung cancer
...his colleagues began their study by comparing 28 cases of lung tumor tissue and nearby healthy lung tissue from never-smokers for changes in microRNA, molecules
that help cells regulate the kind and amount of proteins they make.
The cancer cells showed abnormally elevated levels of five microRNAs, with miR-2...
Male Fertility Supplement Improves Sperm Quality & Motility in Clinical Study
...l-carnitine, yields similarly impressive findings: L-carnitine supports "sperm metabolism", or the ability for sperm to break down complex molecules
to produce energy. L-carnitine has been shown in a number of clinical studies to enhance several fundamental sperm parameters, including sperm concent...
Grant for brain tumor and deafness research
...d can cause total deafness with potentially devastating effects on the lives of those involved.
"Great progress has been made in identifying target molecules
for treatment, and this research will go a long way towards establishing the best potential drug for non-invasive therapy. Ultimately this would avoid...
Breast Cancer Drug May Beat Fungal Infection
...up and die while halting surviving cells from progressing into a disease-causing state, their study found.
"It's still early, but if tamoxifen, or molecules
like it, turns out to be an effective treatment against serious fungal infections, it'll be a welcome addition to our arsenal," Dr. Damian Krysan, an...
Human cells secrete cancer-killing protein, UK study finds
...ratory with intracellular Par-4, the newly discovered secreted Par-4 acts selectively against cancer cells, leaving healthy cells unharmed. Few other molecules
are known to exhibit such selectivity.
One molecule, known as TRAIL, also exerts cancer-cell-specific effects. However, Rangnekar's most recent s...
Scientists discover key event in prostate cancer progression
...currently incurable stage of prostate cancer.
The study, published in the July 24, 2009, issue of the journal Cell , focuses on androgen receptors, molecules
located in the nucleus of cells of the prostate gland and other tissues. Male sex hormones androgens bind with these receptors to activate genes tha...
The 'see food' diet
...igh levels of omega-3 fatty acids resulted in slower lesion progression, with improvement in some lesions. These mice had lower levels of inflammatory molecules
and higher levels of anti-inflammatory molecules, which may explain this protective effect.
Tuo et al suggest that "a diet enriched in EPA and DHA...
Eliminating Cell Receptor Prevents Infections in Animal Study
... it bypasses identified adenovirus receptors in that organ. Instead the virus engages in complicated interactions with blood proteins and unidentified molecules
in the liver.
Therefore, Bergelson and colleagues set out to discover whether CVB interacts with its receptor to cause pancreatitis and myoca...
Weight-Loss Enzyme Identified
...ry day, the PRCP-blocked mice gained less weight than normal mice on a regular diet.
"Our research provides the first evidence that breaking down molecules
in the brain that regulate metabolism is an important component of weight control," senior author Sabrina Diano, associate professor in Yale's departm...