Molecule

Poisonous Parkinson's molecule discovered

Researchers in Texas have found a molecule which may harm the brain areas involved in Parkinson's disease. There is no firm diagnostic test for Parkinson's disease - the doctor has to rely on the clinical examination of the patient. But it's known that cells producing a chemical called dopamine - which controls muscle activity - in an area of the brain called the substantia nigra slowly die as th...

Glenmark’s new molecule to go through trial

Glenmark Pharmaceuticals Ltd today said its newly- found andti-diabetic/anti-obesity molecule will be put into clinical trials by later this year. Mr Glenn Saldanha, Executive Director, Glenmark pharmaceuticals, told newspersons that the company’s R&D team has established ‘proof of concept’ in animals for this molecule.// The global diabetes market is estimated to be in the region of...

Resistant tumors could be treated with the discovery of a new molecule within cancer cells

A new research study published in the journal, Cancer Cell reported that scientists have discovered why some tumors respond less well to drug treatment as compared to others. Researchers have found that high levels of a specific molecule within cancer cells seem to block the effect of drugs such as Taxol, which are used to treat a number of cancers in their later stages. In the study, the// resea...

Ways to counter radiation effects with new molecule discovery

Radiation inflicts serious damage to the DNA within our cells, which could lead to cancer. However, researchers have now found a molecule that triggers a protective mechanism in the body, which both repairs the damage and induces severely damaged cells to destroy themselves. The molecule called MDC1, which initiates this protection mechanism, was discovered by researchers at the Institute of Canc...

Same molecule found in meat, milk, tumors

A non-human molecule found in red meat and milk makes its way into the human system when eaten -- and seems to build up especially in tumors, say researchers.// The compound, called sialic acid, is found on the surfaces of animal cells but is not found in people, and may be one reason why animal-to-human organ and tissue transplants do not work well. Animals have a version called Neu5Gc...

New Molecule that can stop the growth of Viruses

New research shows a molecule that stops the growth of the AIDS virus in the blood may also inhibit the growth of other viruses.// Researchers say alpha-1 antitrypsin (AAT) -- a protein in the blood -- deactivates cells, stopping viruses from multiplying. In order for cells to grow, they must be in an active state. They say the concept is “...kind of like cutting a computer virus off fr...

Puberty may be due to GPR54 gene and KiSS-1 Molecule

The dawn of Genetic research has indeed unleashed several social and moral issues that are forcing governments, institutions and individuals to introspect within themselves.// However, it has also managed to shed new light on the understanding of human development. A recent announcement made by a U.S research team from the University of Pittsburg, has opened perhaps a new chapter in the...

Molecule responsible for muscle repair identified

Skeletal muscles repair by themselves from injuries. However at times due to age or disease these muscles are not able to heal itself.// Researchers have identified a molecule that when is deficient, is actually helpful to muscle regeneration. Researchers from University of Illinois-Chicago had reported in their findings that deficient plasminogen activator inhibitor-1 (PAI-1) promote...

New molecule to treat brain disorders found

In a breakthrough that will spell good news for patients with Alzheimer's disease, Lou Gehrig's disease and other brain disorders, researchers say, Adenosine, a small molecule that plays important roles in controlling the heartbeat and normal sleep may also prove useful in treating these disorders of the brain and nervous system. When tested on rat brain cells in the laborato...

Molecule aids fight E. Coli Infections

According to researchers, they have identified a key mechanism disease-fighting cells which are used to swallow a common microbe that can impose havoc with the digestive system and which has been implicated in many outbreaks of food poisoning.An analysis of the defense tactics of the immune system of the fruitfly Drosophila led investigators to pinpoint a molecule that engineers search-and-destro...

Molecule That Aids Bacterial Infections Identified

Researchers from University of California, San Diego, had discovered that a single molecule is responsible for helping bacterial infections like bacterial meningitis etc., in the body. // By blocking the molecule’s anchoring ability, researchers may be able to find a way to stave off the most common serious infection of the central nervous system and a major cause of childhood death a...

Cell molecules behind neuro degenerative diseases

Researchers from the University of North Carolina at Chapel Hill, in the current issue of PLoS Computational Biology, had reported that there may be possible molecular origin of at least nine human diseases of nervous system degeneration. // These neuro degenerative diseases, including Huntington’s disease, share an abnormal deposit of proteins inside nerve cells. This deposition of pr...

Molecule Behind Multiple Sclerosis Discovered

Researchers have discovered that a single molecule is the cause of an autoimmune disease in the central nervous system, called transverse myelitis (TM). This disease is related to multiple sclerosis//. In a study published in the October issue of The Journal of Clinical Investigation, researchers from Johns Hopkins University School of Medicine, had showed that the levels of the protei...

Therapeutic Monoclonal Antibody Production Is More Profitable Than Small Molecule Drugs

New study has suggested that therapeutics based on monoclonal antibodies (mAbs) are fare more likely to be commercially successful than their small molecule predecessors. According to a study completed by // consultancy Propagate Pharma, about half the mAbs launched so fare appear to be profitable. That means mAbs are recouping more in revenues than their estimated $1 billion to $1.8 billion cost...

New anti-aging molecule could be coming up in way

Scientists have discovered a new anti aging molecule, Klotho named after the Greek God who spins life’s thread. The protein product of the gene has been believed to play a very important role in the aging process. // Mice that lacked expression of the gene showed symptoms of aging, while over expression is associated with an increased life span. The protein is secreted in the blood. The...

Scientists Discover Prostate Cancer Triggering Molecule

Researchers at the University of North Carolina at Chapel Hill have discovered a molecule that triggers aggressive prostate tumors. The molecule//, labeled as Ack1is a part of the tyrosine kinase gene family and triggers aggressiveness in prostate tumors by messing up with their signals and directing cells to dump a tumor-suppressor protein. This protein usually fights cancer growth by s...

Passion Fizzling Out? Blame The “Love Molecule

You look at the love of your life and find that the passion has fizzled out. You no longer feel the blood rush to your brain or your heart thud in your chest // and are at a loss to understand this. Well, help is at hand. Blame the "Love Molecule." Italian researchers have found that the first year of romance is the best one since there is a high level of Nerve Growth Factor (NGF) that...

Sensor Can Detect "Unhealthy" Molecules In Breath

Researchers at the University of Manchester have evolved a method to diagnose lung disease that is based on the techniques employed to detect chemical warfare agents. Dr Paul Thomas led a team of researchers in using a sensor employed to check out explosives at the airports. // The sensor, called a microDMxTM sensor was developed by Sionex Corporation, is now being used by researchers...

So now here might come a memory molecule!!!

According to a recent study researchers might be able to isolates molecule that would be helpful and responsible for learning and memory.// The revolutionary study has been done independently by teams from Harvard Medical School and Children's Hospital Boston and they have identified a master protein that shows how neurons change as a result of individual experiences. Science...

Lost molecule holds the key to lung cancer

Lung cancer is soon becoming infamous with being the leading cause of cancer deaths in the world – what with nearly 1.2 million fresh cases every// year that includes more than 37,000 in the UK itself! According to recent research, the most common type of lung cancer, owes its birth to the impairment of a single type of protein molecule. The researchers, from Vanderbilt University in...

Polymer Molecule Layered On Carb Molecule to Increase Sensitivity

According to a new research at the Pacific Northwest National Laboratory, scientists have developed a new biosensor which is highly sensitive in detecting// blood sugar levels. They have taken a polymer (protein) and layered it on the carbon nanotube to increase the detection capacity. This configuration can accommodate a wide range of applications, from ultra-precise blood-sugar monito...

Discovery Of New Molecule Could Solve Cancer Spread Mystery

A new study published in the May issue of Cancer Cell says that scientists have identified a new molecule that could resolve the mystery of how cancer progresses.// This molecule was found to inhibit the progression of lethal malignant glioma cells both in vivo as well as in vitro. This study reinforces the concept that successful small molecule kinase inhibitors must display a broad...

Ranbaxy In-Licences NDDS Analgesic Molecule From Ethypharm

Ranbaxy Laboratories Limited today entered into an in-licensing agreement with Ethypharm S.A., France for novel drug delivery system (NDDS) analgesic // , Tramadol in the Indian market The agreement was signed with Ethypharm LL India (Ethypharm), the wholly-owned subsidiary of the French drug major for 50 mg strength, the company said in a statement. The product will be supplied from E...

A Synthetic Molecule Instigates Cancer Cells To Self-Harm

Scientists have devised a method to outwit cancer cells and instigate them to self-harm, ultimately causing death of cancer cells. This novel discovery could unlock reliable// treatments for cancer. This discovery works on the known principle that involves the activation of the body’s many defenses, to check the abnormal growth of cells; the way to achieve this is to get the faulty...

Protein Molecules in blood predict preeclampsia development

According to a team of researchers from the National Institutes of Health and Beth Israel Deaconess Medical Center, high levels of two proteins in the blood// of pregnant women seem to point out the subsequent development of preeclampsia. Preeclampsia is a near-fatal complication of pregnancy. These proteins not only obstruct the growth and functioning of blood vessels, but also indicat...

Molecule responsible for age associated macular degeneration identified

CLEVELAND--A dart-like molecule that sticks to proteins in the eye is the main trigger for the unchecked growth of blood vessels, according to researchers at Case Western Reserve University and the Cleveland Clinic Cole Eye Institute. //Uncontrolled blood vessel growth is one of the main reasons for the development of age-related macular degeneration (AMD), the leading cause of blindness among p...

Brain behind the Brawn: Vital Molecule in the Brain Controls Appetite

Combating obesity is one of the greatest challenges facing researchers today, and recent research holds promise for being a vital breakthrough to contain a growing epidemic.// The World Health Organization has estimated that there are a billion people in the world tackling overweight problems, of them nearly 300 million are obese. Scientists have narrowed their sights on a new molecul...

THC molecule turns out to a boon for Alzheimer’s patient

Delta-9-tetrahydrocannabinol (THC) is a compound being tested by researchers from Scripps Research Institute in La Jolla, California, for its ability to ensure levels// of a certain chemical is maintained in the brain, in order to prevent the formation of plaque, a characteristic feature in Alzheimer’s patients. Researchers said, "Our results...

Pair of MicroRNA Molecules Controls Major Oncogene in Most Common Leukemia

Researchers at Ohio State University have discovered that two microRNA (miRNA) molecules help control the oncogene responsible for a dangerous form of B-cell chronic// lymphocytic leukemia (B-CLL), the most common human leukemia in the world. Their findings, published in the December 15 issue of Cancer Research, demonstrate that miRNAs are emerging as powerful regulators of gene exp...

Hybrid Molecule Causes Cancer Cells to Self-Destruct

By joining a sugar to a short-chain fatty acid compound, Johns Hopkins researchers have developed a two-pronged molecular weapon that kills cancer // cells in lab tests. The researchers cautioned that their double-punch molecule has not yet been tested on animals or humans. Nevertheless, they believe it represents a promising new strategy for fighting the deadly disease. “For a long...

Missing Molecule Has Important Role in a Developmental Brain Abnormality

A molecule that is part of a complex signaling network in the developing brain plays //a critical role in periventricular heterotopia (PVH), a congenital brain malformation, Yale School of Medicine researchers report in Neuron. PVH often leads to a variety of neurological disorders such as epilepsy, mental retardation, and learning or memory deficits. It has many environmental and gen...

Leukemia Drug Turns Mini-Molecules Up, Cancer Genes Down

New research shows that a form of vitamin A used to treat acute promyelocytic leukemia induces changes in an unusual class of small molecules called microRNAs (miRNAs) in the// leukemic cells. The study also shows that three of these miRNAs inhibit the action of two genes important for cancer development, helping to explain how the drug works. The drug is called all-tran...

Key Signaling Molecules in New Teeth Formation Identified

Xiu-Ping Wang and colleagues identify the key signaling molecules that regulate epithelial stem cell proliferation in the stem cell niche, using a combination of mouse mutant analyses , organ culture experiments, and gene expression studies, although mammals have a limited capacity to regenerate teeth, mouse incisors contain stem cells and grow continuously throughout life. The rese...

Antioxidant Molecule Could Help Minimize Stroke-Linked Brain Damage

A novel peptide discovered by researchers at Weill Cornell Medical College could prove a potent weapon against stroke, a new study// finds. The compound, called SS31, is able to cross the blood-brain barrier and inhibit an oxidative stress molecule recently linked to stroke-related tissue damage. "In our experiments, we found that exposing mice to SS31 after an induced isc...

Penn Scientists Engineer Small Molecules to Probe Proteins Deep Inside Cell Membrane

PHILADELPHIA -- Proteins, which form much of the molecular machinery required for life, are the targets of most drug molecules//. One third of all proteins are membrane proteins – embedded within the cell’s fatty outer layer. While scientists can easily study the other two-thirds using such tools as antibodies, they have not had such methods to investigate the membrane-embedded portions of protei...

A New Target for Cancer Therapy-Integrin Alpha7 Molecule

Mutations in the cell adhesion molecule known as integrin alpha 7 (integrin 7) lead to unchecked tumor cell proliferation and aggressive cancer, report researchers at the University of Pittsburgh School of Medicine in a study being published today in the Journal of the National Cancer Institute. These findings suggest that integrin alpha7 represents an important new target for cancer therapy and...

Researchers Identifies Molecules That is Effective in Fighting Against Breast Cancer

The Hamilton researchers used state-of-the-art computational techniques in a novel way to design molecules that they predicted would be effective lead compounds for breast cancer research. Scientists from the Albany Medical College subsequently synthesized the predicted molecules and showed that they were indeed potential anti-breast cancer compounds in animal systems. A paper det...

Boffins Identify Molecule That Might Treat Food Allergy

Boffins have identified a key molecule Interleukin-12 (IL-12),that may provide resistance against food allergy. During a food allergy the immune system responds to a food protein as if it was harmful. The immune system produces immunoglobulin E (IgE) antibodies, which normally help the body fight parasites. In the most severe cases individuals can suffer life-threatening reactions,...

Human Pain-controlling Molecule's Structure Identified

Boffins have unveiled the structure of a key molecule called 'P2X receptor' that control pain in humans . The research might lead to the development of painkillers for recurring migraine and backache. The study was conducted by a team of researchers including Dr Chris Thompson, Professor Alan North and Dr Sam Fountain at The University of Manchester. Rese...

Scientists Revealed the Key Molecule That Controls Pain

Chronic pain, unlike the acute pain associated with trauma, has no apparent physiological benefit, often being referred to as the disease of pain . Scientists studying one of natures simplest organisms have helped to unravel the structure of a key molecule that controls pain in humans.The findings published in the top scientific journal Nature could rapidly advance research into t...