MicroRNA in Medical News

Exiqon Announces New Grant Program for MicroRNA Research

Exiqon A/S (NASDAQ OMX Copenhagen: "EXQ") today announced the launch of a new research grant program, open to researchers from academic and non-profit institutions across North America. (PRWEB) May 15, 2009 -- Exiqon A/S (NASDAQ OMX Copenhagen: "EXQ"...

Throwing the micro switch: MicroRNA may link smoking risk gene to neurobiology of addiction

Philadelphia, PA, April 23, 2009 During the past several years, significant progress has been made in identifying susceptibility genes for nicotine dependence through genetic linkage and association analyses. Although a large number of genes have been associated with tobacco smoking, only a very...

Gladstone scientists identify single microRNA that controls blood vessel development

Scientists from the Gladstone Institute of Cardiovascular Disease (GICD) and UCSF have identified a key regulatory factor that controls development of the human vascular system, the extensive network of arteries, veins, and capillaries that allow blood to reach all tissues and organs. The researc...

Need microRNA processing? Get Smad

BOSTON (embargoed until June 11, 2008, 1:00 p.m. ET) Researchers at Tufts University School of Medicine and Tufts Medical Center have found that Smad proteins regulate microRNA (miRNA) processing. Understanding the role of Smad proteins enables researchers to investigate abnormal miRNA processing ...

Single microRNA fine-tunes innate immune response

Findings: A single microRNA, microRNA-223, in mice controls the production and activation of granulocytes, white blood cells essential for host defense against invading pathogens. Relevance: This is the first microRNA shown to play a crucial role in the innate immune response. Absence of microR...

Sigma-Aldrich Announces mirPremier(TM) microRNA Isolation Kit for miRNA Purification

Provides researchers tool for 50% faster miRNA preparation with no detectable large RNA and further supports Sigma's commitment to the rapidly developing area of RNAi ST. LOUIS, Nov. 1 /PRNewswire-FirstCall/ -- Sigma-Aldrich(TM) (Nasdaq: SIAL) is pleased to introduce ...

Role of MicroRNA in Cancer Suppression Identified

Rosetta Genomics Ltd, a leading microRNA company, announced today research published in the journal Molecular Cell by scientists from the Weizmann Institute of Science and Rosetta Genomics . The findings suggest the potential for a specific, single microRNA (miR-34a) to be used as a drug candidate ...

Pair of MicroRNA Molecules Controls Major Oncogene in Most Common Leukemia

Researchers at Ohio State University have discovered that two microRNA (miRNA) molecules help control the oncogene responsible for a dangerous form of B-cell chronic// lymphocytic leukemia (B-CLL), the most common human leukemia in the world. Their findings, published in the December 15 iss...

Cancer diagnosis easier from microRNA

MicroRNA profile analysis has been developed as a tool to diagnose cancer by scientists of Broad Institute// of MIT and Harvard. Researchers have also been able to develop a technology that will be able to test the microRNA profile through an easy and not expensive diagnostic test. MicroRNA (m...

Isis Pharmaceuticals to Present at Canaccord Adams' 29th Annual Global Growth Conference

...is and Alnylam Pharmaceuticals are joint owners of Regulus Therapeutics Inc., a company focused on the discovery, development and commercialization of microrna therapeutics. Isis also has made significant innovations beyond human therapeutics resulting in products that other companies, including Abbott, are ...

GeneGo Awarded NIH Grant to Develop Pharmacogenomics Software Suite

...ery( TM ) platform allows an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microrna assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological ...

Webcast Alert: Isis Pharmaceuticals' Second Quarter 2009 Financial Results Conference Call

...is and Alnylam Pharmaceuticals are joint owners of Regulus Therapeutics Inc., a company focused on the discovery, development and commercialization of microrna therapeutics. Isis also has made significant innovations beyond human therapeutics resulting in products that other companies, including Abbott, are ...

Study Shows a Link Between Schizophrenia & Genetic Mutations

...k between schizophrenia and ultra-rare variants in microrna genes on the X-chromosome has been identified. Mut...ohn J. Rossi, PhD reports the first association of microrna dysfunction with schizophrenia. This breakthrough ...quired", says Dr Sommer, "this study suggests that microrna gene mutations can contribute to schizophrenia. If...

Small Molecule Might Play Big Part in Lung Cancer

...of lung cancer that typically strikes people who have never smoked, opening up the possibilities for new treatments for this deadly malignancy. The microrna miR-21 was found particularly elevated in adenocarcinomas that affect never-smokers, especially in individuals who tested positive for mutations in th...

Study in Nature: MicroRNAs hold promise for treating diseases in blood vessels

... why myocardin may occur in higher levels in Alzheimer's disease, which is turning out to be a problem of "vascular plumbing." "The finding that a microrna controls levels of myocardin, the master regulator of VSMC identity and function, forms the starting point in efforts to design new classes of treatme...

Exiqon Announces 2009 North American Grant Award Winners

...ofit institutions across North America, engaged in microrna research. (PRWEB) July ...ofit institutions across North America, engaged in microrna research. The 2009 Grant Program winner...applications clearly illustrates the importance of microrna investigation in current biomedical research, and ...

RNA snippet suppresses spread of aggressive breast cancer

...ut 21-23 nucleotides long. Within a cell, a single microrna can fine-tune the expression of dozens of genes si...-step process that could be influenced by a single microrna at several points. The screened samples were c...ncer or non-metastatic cancer. After analysis, the microrna miR-31 stood out because of its inverse correlatio...

Isis Pharmaceuticals to Present at Jefferies' 3rd Annual Healthcare Conference

...is and Alnylam Pharmaceuticals are joint owners of Regulus Therapeutics Inc., a company focused on the discovery, development and commercialization of microrna therapeutics. Isis also has made significant innovations beyond human therapeutics resulting in products that other companies, including Abbott, are ...

Isis Pharmaceuticals to Present at Needham's 8th Annual Life Sciences Conference

...is and Alnylam Pharmaceuticals are joint owners of Regulus Therapeutics Inc., a company focused on the discovery, development and commercialization of microrna therapeutics. Isis also has made significant innovations beyond human therapeutics resulting in products that other companies, including Abbott, are ...

Isis Pharmaceuticals to Present at Goldman Sachs' 30th Annual Global Healthcare Conference

...is and Alnylam Pharmaceuticals are joint owners of Regulus Therapeutics Inc., a company focused on the discovery, development and commercialization of microrna therapeutics. Isis also has made significant innovations beyond human therapeutics resulting in products that other companies, including Abbott, are ...

Isis Highlights New Clinical Data on Anti-Cancer Antisense Drugs Featured at ASCO

...is and Alnylam Pharmaceuticals are joint owners of Regulus Therapeutics Inc., a company focused on the discovery, development and commercialization of microrna therapeutics. Isis also has made significant innovations beyond human therapeutics resulting in products that other companies, including Abbott, are ...

NYP/Weill Cornell physician-scientists present at 2009 American Transplant Congress in Boston

...other news from the conference. Alterations in microrna Predict Rejection and May Be Novel Treatment Targe...In addition to serving as a novel diagnostic test, microrna profiles may predict the development of transplant...e to develop safe and personalized treatment using microrna profiles to guide therapy. From Concept to Re...

John P. Cogswell, Ph.D., receives 2009 Alzheimer Award

...lois Alzheimer and a cash award. Dr. Cogswell's work examines changes in microrna expression and their role in the sporadic form of the disease. MicroRNAs ar...lls involved in immune-surveillance of the brain, these data suggested that microrna responses in CSF cells might be sentinels of the disease. "More work is ...

MicroRNA regulation of tumor-killing viruses avoids unwanted viral pathology

...tments and better vaccines for a broad range of viral diseases. Cellular microrna molecules regulate the stability of mRNA in different cell types, and this ...s found that introducing sites into the virus genome that are recognized by microrna 122 leads to hepatic degradation of important viral mRNA, thereby diminishi...

Webcast Alert: Isis Pharmaceuticals To Provide General Corporate Update in Conjunction with 2009 Annual Meeting of Stockholders

...is and Alnylam Pharmaceuticals are joint owners of Regulus Therapeutics Inc., a company focused on the discovery, development and commercialization of microrna therapeutics. Isis also has made significant innovations beyond human therapeutics resulting in products that other companies, including Abbott, are ...

GeneGo and OmicSoft Announce Integration

...overy(TM) platform allows an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microrna assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological ...

Isis Reports Strong Financial Results and Highlights for First Quarter of 2009

...ted to Regulus' continued efforts to build its team to support its internal microrna programs and its GSK collaboration. Regulus generated a loss from operatio...., a company focused on the discovery, development and commercialization of microrna therapeutics. Isis also has made significant innovations beyond human ther...

American Transplant Congress 2009: New Investigator Forum Presents Cutting Edge Research

... Current Transplantation Controversies Special Interactive Audience Sessions Biologic Immunosuppression Agents NanoMedicine RNA and microrna biology Cholangiocarcinoma in Liver Transplantation Transplant Tourism Clinical Trials Impact of the Acceptable Mismatch in Europe on ...

Olivier Voinnet awarded 2009 EMBO Gold Medal

... that ultimately were instrumental to ascertain the first biological role of RNA silencing, that is, antiviral defense." Following the discovery of microrna and short interfering RNA in a wide range of different organisms, one key question that has kept Voinnet busy over the past years is "how do viruses a...

InteRNA Technologies and Radboud University Nijmegen Medical Centre to Develop microRNA-based Therapeutics for Prostate Cancer

...s, April 22 /PRNewswire/ -- InteRNA Technologies B.V. and Radboud University Nijmegen Medical Centre have entered into a research agreement to develop microrna (miRNA)-based therapeutics for prostate cancer. Under the research collaboration with professor Jack Schalken (Laboratory of Experimental Urolo...

Gene Studies Reveal Cancer's Secrets

...resented at the meeting showed that genetic variants in what's known as the microrna processing pathway may predict a woman's risk for ovarian cancer. "Ovari... teleconference. For the study, Wu's and team evaluated 70 SNPs in eight microrna pathway genes. These were taken from 380 ovarian cancer cases, as well as f...

Genetic source of rare childhood cancer found; gene is implicated in other cancers

...,000 human genes. The short bits of genetic material it produces during its dicing activities are termed microRNAs. "Prior research showed that the microrna profiles of cancer cells are different from those of normal tissue, which pointed toward a possible role for DICER1 in cancer," says senior author Pau...

UCSF Team Closer to Creating Safe Embryonic-Like Stem Cells

... not included. The transfection involved a simple process in which the tiny microrna molecules were mixed with a lipid, allowing them to pass through the cell m...ein. They were debuted in 1993, when scientists reported the discovery of a microrna in the microscopic roundworm C. elegans. Since then, the field has "ex...

UCSF team closer to creating safe embryonic-like stem cells

... not included. The transfection involved a simple process in which the tiny microrna molecules were mixed with a lipid, allowing them to pass through the cell m...ein. They were debuted in 1993, when scientists reported the discovery of a microrna in the microscopic roundworm C. elegans. Since then, the field has "explode...

Stem Cells Spur New Eggs in Ovaries of Adult Mice

...er stem cell news, researchers reporting Sunday in the journal Nature Biotechnology said that they were able to use bits of genetic material called microrna to revert adult mouse cells back into embryonic cells. These new embryonic cells are, like stem cells, capable of transforming into multiple diffe...

Isis Scientist Awarded 2009 Ebert Prize

...is and Alnylam Pharmaceuticals are joint owners of Regulus Therapeutics Inc., a company focused on the discovery, development and commercialization of microrna therapeutics. Isis also has made significant innovations beyond human therapeutics resulting in products that other companies, including Abbott, are ...

MicroRNA undermines tumor suppression

...Research and the National University of Singapore have discovered the first microrna (miRNA) capable of directly tamping down the activity of the well known tum... activity. CAMBRIDGE, Mass. (March 17, 2009) A small piece of RNA, or microrna (miRNA), ratchets down the activity of the tumor-suppressor gene p53, accor...

Isis Reports Strong Financial Results and Highlights for Fiscal Year 2008

...ide variety of diseases. Isis is a joint owner of Regulus Therapeutics Inc., a company focused on the discovery, development and commercialization of microrna therapeutics. Isis also has made significant innovations beyond human therapeutics resulting in products that other companies, including Abbott Molec...

Washington University Becker Library Makes MetaCore Accessible Throughout the University

...scovery (TM) platform allows an integration and expert analysis of different kinds of experimental data (mRNA expression, proteomics , metabolomics, microrna assays and other phenotypic data) and relevant bioactive chemistry (metabolites, drugs, other xenobiotics) within the framework of curated biological ...

Prestigious fellowship for young Nottingham researcher

... in cells. Dr Jopling's research focuses on miR-122, a specialised liver microrna which interacts with hepatitis C virus (HCV) in an unusual way and plays an...in developing our understanding of gene expression and the basic biology of microrna activity. In the future, the work may also have implications for medical ad...