Potent metastasis inhibitor identified
Researchers at Children's Hospital Boston have isolated a potent inhibitor of tumor metastasis
made by tumor cells, one that could potentially be harnessed as a cancer treatment. Their findings were published in the online Early Edition of the Proceedings of the National Academy of Sciences duri...
Identification of 5 genes involved in the metastasis of breast tumors to the lung
This release is available in Spanish .
The identification of five genes involve in the metastasis
of breast tumours to the lung is the principal finding of a scientific team made up of two bodies from the University of Navarra, the Applied Medical Research Centre (CIMA) and the University H...
Molecular Cause of Breast Cancer Metastasis Discovered
Signaling events in tumor pave the way for lung invasion, study shows
THURSDAY, April 3 (HealthDay News) -- Certain cancers tend to spread to specific tissues, and now researchers have gained a molecular handle on how that happens.
Working with breast tumors, Joan Massague, chairman...
Cancer stem cell subpopulation drives metastasis of human pancreatic cancer
Scientists have identified a distinct subpopulation of cancer stem cells (CSCs) that is responsible for metastasis
of a deadly human pancreatic cancer. The research, published by Cell Press in the September issue of the journal Cell Stem Cell, provides insight into the role of CSCs in cancer initi...
M. D. Anderson launches graduate program in cancer metastasis
HOUSTON - A one-of-a-kind graduate program that focuses on the most lethal aspect of cancer will open this fall at The University of Texas M. D. Anderson Cancer Center with support from a highly competitive grant from The University of Texas System.
The Graduate Program in Cancer Metastasis
Lung cancer cells activate inflammation to induce metastasis
A research team from the University of California, San Diego School of Medicine has identified a protein produced by cancerous lung epithelial cells that enhances metastasis
by stimulating the activity of inflammatory cells. Their findings, to be published in the January 1 issue of the journal Na...
UNC researchers find clue to stopping breast-cancer metastasis
CHAPEL HILL If scientists knew exactly what a breast cancer cell needs to spread, then they could stop the most deadly part of the disease: metastasis. New research from the University of North Carolina at Chapel Hill School of Medicine takes a step in that direction.
Carol Otey, Ph.D. and UNC...
Jefferson researchers show antibody to breast cancer-secreted protein blocks metastasis
(PHILADELPHIA) Scientists at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia have made a key discovery about the mechanism of breast cancer metastasis, the process by which cancer spreads. Focusing on a gene dubbed "Dachshund," or DACH1, they are beginning to pinpoint new t...
'Smart bomb' nanoparticle strategy impacts metastasis
A new treatment strategy using molecular "smart bombs" to target metastasis
with anti-cancer drugs leads to good results using significantly lower doses of toxic chemotherapy, with less collateral damage to surrounding tissue, according to a collaborative team of researchers at the University of C...
A new weapon for attacking tumor invasion and metastasis
In vitro, AMD3100 has shown a significantly inhibitory effect on invasion and migration in colorectal cancer cell line. This effect can be further enhanced at higher concentration. This study, performed by a team led by Professor Ji-Kun Li from the Shanghai Jiao Tong University is described in a r...
Jefferson, Ohio State team find gene signature profile for metastasis
(PHILADELPHIA) A common signature of tiny, specific pieces of non-coding genetic material known as microRNAs (miRNAs) may be directly involved in the spread of cancer to other parts of the body. Researchers at the Kimmel Cancer Center at Jefferson in Philadelphia and Ohio State University Medical ...
Human breast tumors' 'microenvironment' primes them for metastasis
The environment within primary breast tumors can empower cells that break free and enter the bloodstream to successfully invade other organs, researchers report in the April 4th Cell, a publication of Cell Press.
Specifically, through studies of hundreds of human breast tumors, the researchers ...
Inflammation Promotes Metastasis of Prostate Cancer
A new research strongly suggests that inflammation associated with the progression of tumors actually plays a key role in the metastasis
of prostate cancer.//
According to this research conducted at the University of California, San Diego (UCSD) School of Medicine "mounting an immune response"...
Inflammation May Play Role in Metastasis of Prostate Cancer
Researchers strongly suggests that inflammation associated with the progression of tumors actually plays a key role in the metastasis
of prostate cancer. //
The research identifies a mechanism, which triggers metastasis, which is the spread of cancer in late stages of prostate cancer developme...
"Trojan Horse" Agent Halts Bone Metastasis in Mice
A novel vascular targeting agent completely prevented the development of bone tumors in 50 percent of the mice tested in a preclinical //study, providing early evidence that it could treat, or thwart, growth of tumors in bone, a common destination for a number of cancers when they start to spread. ...
Cancer cell behavior during Metastasis – New finding
A recent study in rats proposes that the highly malignant tumor cells possess a "toggle switch" that allows them to convert into highly mobile cells// , which attack other tissues and nest in their new environment.
According to the Duke Comprehensive Cancer Center researchers, this finding o...
Gene Responsible For Metastasis Found By Korean Scientists
A study was conducted by the Korean scientists from the Korea Research Institute of Bioscience and Biotechnology//.
The lead researcher Im Dong-soo said that the research team has found a human gene that aids in the growth and spread of cancer cells.
The researchers were very happy about t...
Gene That Causes Metastasis of the Primary Tumor, Identified
Professor Philip Rudland, Dr Guozheng Wang and Dr Roger Barraclough from the University's Cancer and Polio Research Fund Laboratories have discovered a new gene that causes the spread of cancer. // An additional member of the S100 family of protein genes, S100P is the main cause for the spread of c...
Breast Tumor Metastasis Stimulated by Post Pregnancy Circumstances
Breast Tumor Cells may develop due to changes in the tissue environment of the breast that occur after pregnancy, according to a paper by McDaniel. This study has found a place in the February issue of The American Journal of Pathology. //
The stages of pregnancy, lactation, and involution ...
Preventing Bone Metastasis In Patients With Breast Cancer
Based on findings of a recent study researchers say the drug clodronate is an effective treatment for patients with breast cancer that has spread to their bones. Researchers studied more than 1,000 patients // with breast cancer. Patients received standard therapy plus 1,600 milligrams of oral clod...
Understanding Lung Cancer Metastasis
Around 165,000 cases of lung cancer are diagnosed in the United States annually, and of these, 20 percent to 25 percent are classified // as small cell lung carcinoma (SCLC). Prognosis for these patients is poor, and the disease frequently travels to the brain and central nervous system.
Crucial Gene may Be Indicator of Breast Cancer Metastasis
Researchers at Fox Chase Cancer Center have zeroed in on a crucial gene, thought to be the reason for the spread of breast cancer and resistance// to long-term estrogen deprivation. The gene may be beneficial in ascertaining the risk factors of breast cancer reappearance, and would enable a good id...
Radiofrequency Ablation Useful in Treating Ovarian Cancer Metastasis
Percutaneous radiofrequency ablation, a procedure that uses a high frequency electric current to kill tumor cells, is effective in achieving local control// in selected patients with metastasis
from ovarian cancer, according to a preliminary study conducted by the department of radiology at Massach...
New Model for understanding Tumor Metastasis
Researchers from Children's Memorial Research Center, Northwestern University have found a new model that shows how tumor cells interacts with the surrounding normal skin cells in the presence of microenvironment of tumor cells. // The process of metastasis
spread and transformation from normal ski...
Measuring disseminated cancer cells in bone marrow - valuable tool for detecting early breast cancer metastasis
Stephan Braun and colleagues have reported in the New England Journal of Medicine, that the detection of disseminated tumor cells in bone marrow samples is a more reliable determinant of metastasis
and patient survival.
The disease progression is measured by taking biopsy samples from breas...
Researchers Identify Sipa 1 Gene, Responsible For Cancer Metastasis
Hunter and colleagues have identified a candidate gene, Sipa1, with an amino acid polymorphism that influences metastasis
in cancer. Cancer mortality is most often the result of metastasis
rather than the primary tumor.//Previous studies from Kent Hunter’s group demonstrated that the genetic backgr...
MEK4, genistein and invasion of human prostate cancer cells
...es examined, and have provided a possible mechanism to link high dietary consumption of genistein-containing foods with lower rates of prostate cancer metastasis
and mortality," the authors write.
Chicago team uses artificial intelligence to diagnose metastatic cancer
...asound could potentially predict with promising accuracy which patients had metastasis
and which did not," says Drukker.
Next they plan to start an observer s...ll use the computer program to see if it enhances their ability to diagnose metastasis
-- again, based on retrospective cases for which the answer can later be re...
Smoking increases potential for metastatic pancreatic cancer
...m the Kimmel Cancer Center at Jefferson. Their study was published in the August edition of the journal Surgery .
The culprit behind the increased metastasis
potential appears to be an isoform (variant type) of a protein called osteopontin, according to Hwyda Arafat, M.D. Ph.D., an associate professor of Su...
New Gene May Signal Aggressive Breast Cancer
...P may represent a new way to slow down tumor growth.
The study provides new insight into cellular processes underlying tumor cell proliferation and metastasis
that may help in developing new breast cancer treatments, according to an accompanying commentary.
The National Cancer Insti...
Amgen Announces KRAS Safety Update to U.S. Prescribing Information for Vectibix(R) (Panitumumab)
...tal Cancers. The guideline updates included the recommendation that a determination of the KRAS gene status of either the primary tumor or a site of metastasis
should be part of the pre-treatment work-up for patients diagnosed with metastatic colorectal cancer.
About Colorectal Cancer
Ready for relapse: Molecule helps breast cancer cells to survive in the bone marrow
...r cells and thereby extend the period during which metastasis
may emerge after the diagnosis and removal of a br...ucing signal that was abundantly expressed in bone metastasis
tissue. These results demonstrate that Src hyperac...c cell survival provides mechanistic insights into metastasis
latency, and suggests strategies to hasten the att...
Research Reveals Clues to Breast Cancer's Spread
"We sought to identify signaling pathways that support the survival of metastasized breast cancer cells and thereby extend the period during which metastasis
may emerge after the diagnosis and removal of a breast tumor," senior study author Dr. Joan Massague, of the cancer biology and genetics programs at M...
Cell Pathway May Be Key to Lung Cancer's Spread
"Lung tumors are initiated by mutations in other genes, so we were surprised that a hyperactive WNT pathway would be responsible for metastasis
in lung cancer," said the study's senior author, Joan Massague, who chairs Sloan-Kettering's biology and genetics program.
Nguyen said the finding ...
Lab Study Finds Protein That May Inhibit Cancer Spread
... is no approved therapy for inhibiting or treating metastasis
-- the migration of cancer cells from the original cancer site to other parts of the body. metastasis
is one of the leading causes of cancer death.
R... secrete a protein called prosaposin that inhibits metastasis
by promoting production of factors that block the ...
New Prostate Cancer Biomarker Discovered
...ue of Cell Cycle .
"We previously showed that the absence of stromal caveolin-1 is also associated with advanced tumor stage, early recurrence and metastasis
of breast cancer," Dr. Michael Lisanti, a professor in the departments of cancer biology, medical oncology, and biochemistry and molecular biology at ...
Targeting tumor behavior may lead to new liver cancer drugs
... says, "this could be a more relevant way of looking at cancer because we want to block certain disease changes and specific effects such as invasion, metastasis
or chemotherapy resistance."
$16.8 million study will breathe new life into cancer battle
...eaths are associated with metastases.
Recent advances in biological research have meant that there is now a greater understanding of the process of metastasis
and why hypoxia plays such a key role. The researchers in this study aim to build on these advances and translate biological findings into clinically ...
AACR CEO Margaret Foti receives honorary M.D. from the University of San Pablo CEU
...eights, and we are proud to honor her with this degree," Fernando Vidal-Vanaclocha, M.D., professor at Basque Country University and pioneer of cancer metastasis
research in Spain, said at today's ceremony.
Vidal-Vanaclocha presented Foti with the degree of M.D. "honoris causa." The degree is the first of i...
Joan Massagué wins BBVA Foundation Frontiers of Knowledge Award in Biomedicine
...ng research into the genetic and cellular bases of metastasis
and remains an acknowledged leader in this field. ....
Research into the genes involved in cerebral metastasis
and their mode of action, "is still very much at t...y stage", says Massagu. "These are the first brain metastasis
genes to be identified, with clinical data".