Transplanted fatty livers associated with worse prognosis for patients with HCV
A new study suggests that patients with hepatitis C (HCV) who need a liver transplant should not receive an organ with high levels of fatty deposits (a.k.a. hepatic steatosis). HCV recurrence was more frequent and earlier among those transplanted with such livers. These findings are in the January...
New System Improves Distribution of Donated Livers
Gains reported for blacks, but women lagging behind men, study finds
TUESDAY, Nov. 25 (HealthDay News) -- Thanks to a new liver transplant allocation system that gives preference to patients with the greatest need, rather than time spent on a waiting list, racial disparities among thos...
Artificial liver may extend lives
...stically higher in the ELAD group compared with the control.
have been attempted since the 1960s. Because previous designs didn't use hu...ng those with chronic liver diseases like hepatitis, as well as those whose livers
were damaged, such as by taking too much acetaminophen pain medicine. If no...
Some donor factors affect outcomes for HCV-positive liver transplant recipients
... as fatty liver disease, which is common in overweight individuals.
Researchers led by Patrizia Burra of Padova, Italy examined the impact of donor livers
with steatosis on recipients with and without HCV. They included 116 consecutive liver transplants on 56 HCV-positive and 60 HCV-negative recipients a...
Majority of doctors skeptical of organ transplantation practices in China
...rgan obtained in an unsafe or unethical manner.
In 2005, the World Health Organization (WHO) reported the transplantation of 66,000 kidneys, 21,000 livers
and 6,000 hearts. Approximately 10 percent of these procedures occurred via transplant tourism. Leading destination countries for transplant tourism i...
Transplanted liver cells function in older animals but do not proliferate as much as in younger ones
...odels, raising hopes that use of cells could overcome the shortage of donor livers
and the problems of surgery, but the procedure has not been as successful i...0 years in humans). These healthy liver cells were then implanted into the livers
of young rats (10 weeks, the equivalent of young adulthood) and "senescent"...
Fish in U.S. Rivers Tainted With Common Medications
...e diphenhydramine (Benadryl), an anticonvulsant and two types of antidepressants were among the seven types of pharmaceuticals found in the tissue and livers
of fish from waterways in or near Chicago, Dallas, Philadelphia, Phoenix and Orlando, Fla. Each river is considered "effluent-dominated," because they...
Researchers Use Gene to End High Blood Sugar in Mice
...ethod might someday help people awaits further study
WEDNESDAY, March 18 (HealthDay News) -- Delivering a gene called neurogenin3 into the livers
of diabetic mice activates adult stem cells that promote steady insulin production, say researchers at the Baylor College of Medicine in Houston.
American Chemical Society's Weekly PressPac -- March 4, 2009
... mannose or galactosamine, two sugars that accumulate selectively in the liver. The sugar-coated dots became three times more concentrated in the mice livers
than the regular dots, demonstrating their higher specificity, the researchers say. - MTS.
"In Vitro Imaging and in Vivo Liver targetin...
Technique may help stem cells generate solid organs, Stanford study shows
... hope to encourage the cells to become entire transplantable organs such as livers
Gurtner, who is also a member of Stanford's Cancer Center, ...ssels to a modified piece of equipment called a bioreactor designed to keep livers
and kidneys healthy outside the body. The modified bioreactor pumps an oxyg...
Conjoined Twins Separated by Surgical Team at Children's Hospital of Pittsburgh of UPMC During Complex, 24-Hour Procedure
...e girls were conjoined from the breast bone to the groin. Among the many challenges facing the team was the fact that the twins shared a colon and had livers
that were connected. They also shared a third leg.
"This complex separation was the culmination of 18 months of preparation and planning. The sur...
Pathologically elevated blood fat levels in obesity: Researchers discover molecular causes
...ramatically up to 30 percent of their body weight. At the same time, their livers
produced substantially more LSR, and blood fat levels dropped back to norma...r. "We have found first evidence suggesting that LSR is overproduced in the livers
of these patients so that too much fat accumulates in the liver, while peri...
Problems Tied to Obesity Also Seem to Affect Sleep
...Polotsky, of the Johns Hopkins Asthma and Allergy Center, said in the same news release. "The hypoxic stress of OSA may induce oxidative stress in the livers
of patients with severe obesity, leading to further inflammation."
Enzyme levels and other findings, though, suggest that obesity and sleep apnea ...
Sleep disordered breathing and obesity: Independent effects, causes
...f the chronic intermittent hypoxemia that often characterizes OSA acts as a 'second hit'. The hypoxic stress of OSA may induce oxidative stress in the livers
of patients with severe obesity, leading to further inflammation."
The clinical implications of the findings are clear: obesity and obstructive sle...
Molecular events involved in liver regeneration
...F-kappa B was delayed by almost 24 h. Programmed cellular death, known as apoptosis, was partially increased at 24 h and at 7 d postoperatively in the livers
of animals which underwent 90% resection in comparison to rats which only had 70% of their liver resected.
The findings show clearly that extended ...
Estrogen pills can benefit women with metastatic breast cancer
...t metastatic breast cancer responded to estrogen therapy. All study participants had estrogen-receptor positive tumors that had spread to their bones, livers
or lungs. The women were postmenopausal with an average age of 59.
Coming into the study, all the participants were taking aromatase inhibitors to ...
Stem cells with potential to regenerate injured liver tissue identified by Penn researchers
...ansion of these stem cells, which could then be used to help patients whose livers
can no longer repair their own tissue. About 17,000 Americans are currently... isolate the Foxl1-bearing stem cells and transplant them back into damaged livers
to restore function.
"At this point, we haven't identified the molecular...
Organ Donation: An Advancing Science Hindered by Supply Shortages
...d to make kidney failure much more prevalent in the future, leading to even greater demand for donated kidneys, Fleming added.
The waiting list for livers
is next longest, with more than 16,000 patients awaiting help. More than 2,600 people are waiting for a heart, while an estimated 2,100 people need a ...
CSHL scientists trace causal link between a tumor suppressor gene and liver cancer
...ntroduced into normal mouse liver cells, the production of DLC1 protein is blocked, or 'silenced.' The team observed that nearly all of the mice whose livers
had been transplanted with the engineered cells developed liver cancer, and that the gene's reintroduction stopped the cancer. However, this was on...
A common denominator of inflammations and fatty liver
...r cachexia. In particular, they searched for a molecule called RIP140, previously identified by Herzig as a regulator suppressing fat breakdown in the livers
of healthy mice. Indeed, the investigators found a high activity of RIP140 in the cancerous mice and, accordingly, signs of fatty liver in these anima...
What roles does TSP-1 play in liver fibrogenesis?
...mine induced cirrhosis, TSP-1 expression has been found to correlate with the progression of fibrosis. Furthermore, TSP-1 expression was higher in rat livers
with high vascular densityin other words, angiogenesis. This study, performed by a team led by Dr. Glsm zlem Elpek, is described in a research article...
New nanotube sensor can continuously monitor minute amounts of insulin
...t has demonstrated the ability to free diabetics from insulin injections for several years. It works by transplanting insulin-producing cells into the livers
of diabetics to replace the cells that the disease has disabled or destroyed.
The new insulin detection method was developed by a team of Vanderbi...
Dallas area cornea shortages could benefit from national study
Cornea transplants have a high success rate (80 percent to 90 percent) and dont have the same rejection issues common to solid organs, such as livers
and hearts. Nor do they require tissue matching. Donors with vision problems such as near- or far-sightedness or even glaucoma are not excluded unless...
How to effectively avoid many common complications and liver damage in bile duct exploration?
...choledochoscopic exploration of common bile duct was performed in patients with gallstones in the left lobe of liver and common bile duct. Ligments of livers
were dissociated by laparoscopic instruments under pneumoperitoneum conditions. The Trocar puncture point near the xiphoid was extended to about 5 cm....
Protein deficiency leads to faster fat burning in mice, study shows
...s looked under their skin, they saw the mice had less fat distribution in the skin itself and less fat tissue overall. They also had less fat in their livers
and muscles. The fat cells they did have were smaller than fat cells in other mice.
And despite the propensity for obesity from their original gene...
Combined stenting and photodynamic therapy improves survival in late stage liver cancer patients
...ritis (itching) with a decrease of bilirubin to less than 75 percent of the pre-treatment value within 30 days.
Cholangiocarcinoma (cancer of the livers
bile ducts) is the second most common liver cancer and is associated with significant morbidity and mortality, diagnosed in about 2,000 new cases ever...
Novel link between excessive nutrient levels and insulin resistance
...ng the way for a relentless progression of insulin resistance.
Though it may not be as simple as that, when Xiaoyong put OGT into overdrive in the livers
of mice, the animals developed insulin resistance and abnormal blood lipid levels, emphasizing the importance of the hexosamine pathway for the develo...
Transplanted Liver Lining Cells May Cure Hemophilia
...n mice," Gupta said.
In the study, Gupta's team worked with a mouse model of hemophilia. They transplanted healthy liver endothelial cells into the livers
of these mice, according to the report in the Feb. 14 online issue of the Journal of Clinical Investigation .
Three months after transplanting the...
New Jefferson trial to test radiation-emitting beads against advanced liver cancer
... entails injecting tiny beads that emit small amounts of radiation into the livers
main artery while also blocking the blood supply feeding the cancers growth...active isotope Yttrium-90 are injected through a catheter directly into the livers
hepatic artery, which also supplies blood to tumors. The microspheres, in a...
Mayo Clinic Proceedings contributors discuss impact of donor organ allocation system
... ROCHESTER, Minn. -- Liver transplant is a life saving treatment option for people with end-stage liver disease. Unfortunately, the need for donor livers
far exceeds the supply. Each year only about one-third of people who need a donor liver will receive one, and some patients die while waiting. In the ...
Molecules may help predict survival in liver cancer
...specimens from 43 liver tumors, 28 of which were paired with nearby nontumor tissue, and specimens from six normal livers. Two-thirds of the cancerous livers
also had hepatitis and cirrhosis.
The researchers examined the levels of 196 different microRNAs in liver-cancer cells vs. nearby noncancer cells, an...
How does Fu-Zheng-Jie-Du-Decoction act on PTEN expression in hepatocellular carcinoma?
... this problem. The research group imbedded hepatoma carcinoma tissue in the livers
of 48 male athymic mice. The mice were distributed randomly into two groups...ompared with the chemotherapy group. There was less tumor metastasis in the livers
of the TCM group than in the chemotherapy group. Particularly the results o...
Cell-death receptor links cancer susceptibility and inflammation
Mice engineered without the TRAIL receptor on their cells versus healthy controls developed larger and more tumors in their livers
and other organs after being challenged with a chemical carcinogen or radiation. The team also bred TRAIL receptor knock-out mice with mice geneticall...
Research Reveals How Cells Store Fat
...d to block activity of the genes into an experimental animal, the zebrafish. The fish were fed a high-fat diet for six hours, but examination of their livers
and intestines found almost no fat droplets.
Mouse models that lack the genes are being developed to see what happens to an animal that cannot pack...
MDs' reactions to pharma marketing influenced by brand, side effects: Management Insights
The Insights in the current issue are:
Managerial Turnover and Strategic Change by Dirk Sliwka
Choosing Among Living-Donor and Cadaveric livers
by Oguzhan Alagoz, Lisa M. Maillart, Andrew J. Schaefer, Mark S. Roberts
Template Use and the Effectiveness of Knowledge Transfer by Robert J. Jensen...
Controlling for size may also prevent cancer
...same effect occurred in mammals, the research team genetically altered mice to make high levels of Yap protein, but only in liver cells. These animals livers
grew to be five times the size of a normal mouse liver and often were dotted with large tumors.
We were totally amazed, says Pan. Five times is ju...
Diet Change Can Curb Fatty Liver Disease
...r six months, both groups of mice weighed the same. However, the mice on the high-glycemic diet had twice the amount of fat in their bodies, blood and livers
than those on the low-glycemic diet.
The findings were published in the September issue of the journal Obesity .
"Our experiment creates a very...
Natural Protein Could Help Spot, Treat Liver Cancer
...nd elsewhere found that NGF and its receptor trk/ANGF were expressed in the livers
of patients with liver cirrhosis and/or hepatocellular carcinoma (HCC). The two molecules were not detected in the livers
of healthy people.
The findings indicate that NGF plays an important rol...
Study Questions Genetic Screening for Treatable Diseases
...evere and can be treated, the researchers said.
According to the National Gaucher Foundation, the most common symptoms of the disease are enlarged livers
and spleens; anemia; reduced platelets that can result in easy bruising and clotting difficulties; bone "infarctions" that can lead to damage to the s...
The Mutter Assassins Go to the Theater!
one-of-a-kind treasures include: -- The plaster cast of the torso of world-famous Siamese Twins, Chang & Eng, and their conjoined livers
-- Joseph Hyrtl's collection of skulls -- Preserved body of the "Soap Lady" -- Collection of 2,000 objects extracted from people's throats -- Canc...