Lipoprotein in Medical News

A High-Density Lipoprotein Raising Drug That Has a Lower Discontinuation Rate Than That of Extended Release Niaspan Would Earn a 20 Percent Patient Share in the Dyslipidemia Drug Market

Crestor Will Remain the Clinical Gold Standard Drug Through 2016, According to a New Report from Decision Resources WALTHAM, Mass., July 29 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms focusing on pharmaceutical and healthcare issues, ...

High lipoprotein Levels in women Linked to Cardiovascular Risk

Recent studies have revealed that increased levels of lipoprotein(a)are linked with an increased risk of cardiovascular events// in healthy women according to Boston-based investigators. The researchers do not however recommend generalized screening of lipoprotein(a) in the population as a whole...

Cholesterol Screening Shouldn't Rely on Kids' Weight

...weight or obese. Since then, a University of Michigan team have examined the relationship between body mass index and total and low-density ("bad") lipoprotein cholesterol. They found that screening all overweight or obese children would identify only about 50 percent of children with abnormal cholesterol lev...

FDA Approves LIVALO(R) for Primary Hypercholesterolemia and Combined Dyslipidemia

...tributes to a more effective inhibition of the HMG-CoA reductase enzyme to inhibit cholesterol production, and potentially affords greater low-density lipoprotein cholesterol (LDL-C) clearance and reduction of plasma cholesterol. Importantly, pitavastatin is only minimally metabolized by the liver through the cy...

VAP(R) Cholesterol Test Highlighted in Groundbreaking Book on Longevity

...dations for direct LDL measurement, which is accurate with non-fasting samples. It is the only advanced lipid profile that routinely reports all three lipoprotein parameters considered necessary by the American Diabetes Association and American College of Cardiology expert consensus guidelines. The VAP Test is a...

Genes Linked to Cholesterol in Cells Are Identified

... The 20 genes are likely to be "immediately relevant" for maintaining cholesterol levels in the cell, as well as controlling the uptake of low-density lipoprotein (LDL) cholesterol, the researchers explained in the July 8 issue of Cell Metabolism . "High cholesterol in the blood is considered to be responsib...

China Pharma Holdings, Inc. Announces SFDA Approval for Rosuvastatin Clinical Trials

...ients and our shareholders over time." (1) Source: BMJ 2003 June: 326 (7404):1423. Law MR et al. "Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis." (2) Source: AstraZeneca 2007 Annual Report and Form 20-...

Soyfoods a Healthy Choice for Men

... both the total amount of cholesterol and the so-called "bad" low-density lipoprotein (LDL) cholesterol. In addition, soy protein may also help maintain or moderately increase the "good" high-density lipoprotein (HDL) cholesterol, (6) and may help lower triglycerides, which both are lin...

Another Blood Fat Fuels Heart Attack Risk

...yocardial infarction with increased levels of lipoprotein(a)," the researchers wrote. The risk was highest in people whose LPA had a smaller number of lipoprotein attachments, they noted. Caution is needed in interpreting the results because all the people in the studies were white, Nordestgaard said. "People...

Two Studies at AACE 2009 Annual Meeting Highlight Effects of Welchol(R) (colesevelam HCl) on Blood Glucose and LDL-C in Patients with Type 2 Diabetes

...ated as an adjunct to diet and exercise to: - reduce elevated low-density lipoprotein cholesterol (LDL-C) in patients with primary hyperlipidemia (Fredrickson Ty... Accessed April 8, 2009. 6) Brunzell JD, Davidson M, Furberg CD, et al. lipoprotein management in patients with cardiometabolic risk: consensus statement from ...

DASH Diet Has Extra Benefits for Women's Health

...top Hypertension [DASH] diet may contribute to prevention of heart failure in some cases because it effectively reduced blood pressure and low-density lipoprotein (LDL, or "bad") cholesterol levels in clinical trials," wrote Emily B. Levitan, of Beth Israel Deaconess Medical Center in Boston, and colleagues. ...

Vitamin D Linked to HDL Cholesterol - Shaklee Corporation Research Links Vitamin D with Key Biomarkers for Metabolic Syndrome and Heart Disease

...2008. Total vitamin D intake and intake of vitamin D from dietary supplements were both strongly associated with serum vitamin D level. High density lipoprotein cholesterol (HDL-C or "good cholesterol") concentration increased as vitamin D intakes increased. Each 10 ng/mL increase in serum vitamin D was assoc...

Novel role of protein in generating amyloid-beta peptide

... It is this contact that the researchers sought to block. Kang explains that the researchers identified the RANBP9 protein by studying low density lipoprotein receptor-related protein (LRP), a protein that rapidly shuttles Aβ out of the brain and across the blood-brain barrier to the body, where it brea...

New target for maintaining healthy blood pressure discovered

...ground and in ones that contained an additional mutation in the low-density lipoprotein receptor gene. These manipulations effectively rendered the mice unable to ...esions were smaller and less abundant in mice that had both the low-density lipoprotein and PG F2-alpha receptors knocked out, as was macrophage infiltration and i...

JCI online early table of contents: April 13, 2009

...ages is vital to the development of atherosclerosis; however, the method of lipoprotein uptake in vivo remains poorly defined. In a new study, Howard S. Kruth and ...umulation. The authors therefore conclude from these results that targeting lipoprotein pintocytosis should be considered when developing novel atherosclerotic the...

Saving Money While Protecting Your Health in Tough Economic Times

...raditional tests had failed to find. The diagnostic assesses the number of lipoprotein particles in the blood -- which, if the number becomes too high, triggers t... the NMR LipoProfile test ( www.lipoprofile.com ) to identify patients with lipoprotein markers that are common in people with metabolic syndrome and insulin resis...

New research suggests common anti-seizure medications may increase risk of cardiovascular problems

...diovascular disease. Just 6 weeks after the patients' drugs were switched, there were significant declines in total cholesterol, non-high-density lipoprotein (commonly referred to as 'bad') cholesterol, triglycerides and C-reactive protein, suggesting the older, commonly-used drugs might substantially incre...

Drug Fails to Slow Progression of Atherosclerosis

... of the inner wall of a major artery. Increasing thickness indicates increasing plaque in the artery. After six months, levels of "bad" low-density lipoprotein (LDL) cholesterol had increased by 7.3 percent among people taking pactimibe and by 1.4 percent among those taking the placebo. This increase disappea...

EuroPRevent 09: Changing hearts and minds in the drive to prevent cardiovascular disease

...those randomised to a one-year exercise programme than in controls. There were also improvements in systolic blood pressure and levels of high-density lipoprotein cholesterol. 4. An echocardiographic study shows that the heart muscle of black female athletes adapts differently to identical sporting disciplines ...

Largest Study to Date Compares Cholesterol Treatment in HIV Patients & Patients Without HIV Infection

... the Kaiser Permanente health system that started cholesterol treatment during 1996 to 2005. The researchers compared changes in levels of low-density lipoprotein cholesterol (bad cholesterol) and triglycerides (another fat in the blood) after the start of cholesterol treatment in patients with and without HIV i...

Experimental Drug May Prevent Plaque Buildup

...aried by dosage, ranging from an average of 69 percent for those taking 50 mg to 96 percent for people taking 500 mg. Average levels of low-density lipoprotein cholesterol (the bad type) decreased by 8 percent among people given A-002, compared with a 1.7 percent decline in the placebo group. Concentrations ...

Statins Pay Off on a Health-Policy Level, UCSF Study Finds

... model called the Coronary Heart Disease (CHD) Policy Model to assess the incremental cost-effectiveness over a 30-year period of lowering low-density lipoprotein (LDL) cholesterol with statins in persons who have not previously had a heart attack . Findings are published in the February 17 issue of the &q...

Researchers identify novel genetic markers linked to increased risk of heart attack

...er region, this time localized on chromosome 6, which is associated with MI risk. The LPA gene at this locus regulates the concentration of a specific lipoprotein (Lp(a)), a particle which transports lipids in the blood. This finding, too, may be useful in the future for developing new therapeutic interventions....

Pathologically elevated blood fat levels in obesity: Researchers discover molecular causes

...Group "Molecular Metabolic Control" at the German Cancer Research Center, and his team have now shown that lipid transporter LSR (lipolysis-stimulated lipoprotein receptor) appears to be responsible for this. LSR, a molecule found in the bowel and primarily in the liver, is responsible for the uptake of fat from...

GEN Reports on Strategies to Overcome Blood-Brain Barrier

...es of biomolecules that are transported into the brain via RMT include insulin, insulin-like growth factor (IGF), leptin, transferrin, and low-density lipoprotein (LDL). In RMT, molecules in the circulation may bind to specific receptors on the luminal surface of brain capillaries (i.e., the surface that i...

Synthetic HDL Could Fight Heart Disease

... Sponge-like molecule sops up bad lipoproteins, researchers say FRIDAY, Jan. 30 (HealthDay News) -- A synthetic high-density lipoprotein (HDL) -- the "good" cholesterol -- may hold promise for combating chronically high cholesterol levels and the deadly cardiovascular disease it can cau...

Top 10 Heart-Stroke Advances for 2008

...fatal stroke and cardiovascular death in people who wouldn't normally be prescribed a cholesterol-lowering statin, because their levels of low density lipoprotein ("bad") cholesterol were below 130. The findings triggered discussion about expanding the use of statins. U.S. researchers advanced efforts to grow...

Most heart attack patients' cholesterol levels did not indicate cardiac risk

... cholesterol guidelines. Specifically, these patients had low-density lipoprotein (LDL) cholesterol levels that met current guidelines, and close to half had...than half of patients hospitalized for a heart attack had poor high-density lipoprotein (HDL) cholesterol levels, according to national guidelines. Published...

Synthetic HDL: A new weapon to fight cholesterol problems

...rsity scientists now offer a promising new weapon -- synthetic high-density lipoprotein (HDL), the "good" cholesterol -- that could help fight chronically high cho...e main protein component of naturally occurring HDL. The final high-density lipoprotein nanoparticles are each about 18 nanometers in diameter, a size similar to n...

FDA Backs Cholesterol Drug Vytorin

... risk for cardiovascular disease, the agency said. In its statement Thursday, the FDA reiterated its position that "elevated amounts of low-density lipoprotein (LDL) . . . are a risk factor for cardiovascular diseases such as heart attack, stroke and sudden death, and that lowering LDL cholesterol reduces the...

'Mediterranean'-Style Diet Best for Blood Sugar Control

...x diet, compared with a decrease of 0.18 percent in the alternate group. Those in the low-glycemic group also saw an increase in their high-density lipoprotein (HDL or "good") cholesterol of 1.7 mg/dL, compared to an HDL decrease of 0.2 mg/dL in the high-cereal-fiber group. Although the reduction in HbA1c ...

MDdatacor and Wellmark Release Quality Improvement Program Results

...-based guidelines, Wellmark's quality improvement program measured the percentage increase in diabetic patients receiving an annual HgA1C, low-density lipoprotein (LDL) and blood pressure tests, as well as improved clinical outcomes as measured by lowered test scores for each of those measures. Prior ...

BioIQ and Alere to Provide At-Home Biometric Screening Tests to Employees

... to a certified laboratory for analysis. Measurements include high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, triglycerides, hemoglobin/A1c, and fasting glucos...

Physicians Anticipate Higher Prescribing Based on JUPITER Study

... (CV) events by 44% compared with placebo among men and women with elevated high-sensitivity C-reactive protein (hs-CRP) but low to normal low density lipoprotein cholesterol (LDL-C). News about JUPITER spread quickly: Two-thirds of the physicians surveyed were already aware of the study results within d...

New Evidence Found for CRP as an Independent Marker for Heart Disease, Stroke

...reenings, includes testing for this risk indicator among its services. Healthcare professionals traditionally view high levels of low-density lipoprotein (LDL) or "bad cholesterol" as the primary blood measurement for stroke and heart disease risk. "Attention to CRP should not be avo...

Lipoprotein Levels May Predict Women's Hypertension Risk

...UESDAY, Nov. 11 (HealthDay News) -- High levels of lipoprotein particles may increase the risk of high blood pres...ds of participants in the Women's Health Study. lipoprotein particles carry cholesterol and triglycerides thro...onance imaging to determine the number and size of lipoprotein particles can better predict a woman's risk of dev...

Study Finds Folic Acid Not Cardioprotective, Though Safe

...rom the SEARCH trial of 80mg versus 20mg per day of simvastatin -- the largest direct comparison of more versus less intensive lowering of low-density lipoprotein cholesterol (LDL-C). Previous studies have found that statin therapy reduces the relative risk of MVE by about 20 percent per 40 milligram per decil...

Statin Reduces Heart Attack, Stroke Rates in Patients With Normal Cholesterol but Elevated C-Reactive Protein

... 24 months) raise the question of whether other adverse effects might be seen over a longer time period, but they were not evident here. Low-density lipoprotein (LDL) is a component of total cholesterol thought to contribute to plaque buildups that narrow arteries, a process called atherosclerosis. JUPITER par...

Triglyceride Levels Continue to Rise in the United States Despite Increased Use of Cholesterol-Lowering Medications

...etermined by blood levels of total cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol and low density lipoprotein (LDL) cholesterol. HealthCore, a subsidiary of WellPoint, is a health out...

Cholesterol-lowering drugs may also lower PSA, but whether they cut cancer risk is still not known

...in the blood; when the level of so-called "bad" cholesterol, or low density lipoprotein (LDL) is too high and concentrations of "good" cholesterol, or high density lipoprotein (HDL) too low, it can lead to cardiovascular disease. ...