Abbott's TRILIPIX(R) (Fenofibric Acid) in Combination With Rosuvastatin Calcium Helps Patients With Mixed Dyslipidemia and Type 2 Diabetes Meet American Diabetes Association Lipid Targets

Post-hoc analysis of two large clinical trials showed combination therapy helped more patients reach combined targets for HDL, triglycerides and LDL than the pre-determined therapy alone NEW ORLEANS, June 8 /PRNewswire-FirstCall/ -- Abbott's (NYSE: ABT ) TRILIPIX (R) (fenofibric acid) delay...

Does probiotic intervention induce the serum global lipid profile change?

The new global metabolic profiling techniques, like lipidomics as a branch of metabolomics, have made it possible to measure large numbers of different metabolites, and are currently being applied to increase our understanding of the health and disease continuum. A Finland research group inves...

Allergic response tied to lipid molecules in cell membrane

A team of Penn State University researchers is the first to demonstrate that lipid molecules in cell membranes participate in mammals' reactions to allergens in a living cell. The finding will help scientists better understand how allergy symptoms are triggered, and could contribute to the creati...

AUDIO from Medialink and the National Lipid Association: What's Your Triglycer-IQ?

NEW YORK, Aug. 10 /PRNewswire/ -- Most Americans know they should eat better and take better care of themselves, but is the message doctors give on how to do it really getting through to patients? The National Lipid Association has more on a new study that shows not enough people understand on...

Study Demonstrates Martek's Algal DHA Oil Improves Blood Triglyceride Lipid Levels

COLUMBIA, Md., Sept. 4 /PRNewswire-FirstCall/ -- Martek's life'sDHA(TM) from microalgae is effective in reducing the level of triglycerides in male hypertriglyceridemic patients, according to a study published in the current issue of The American Journal of Clinical Nutrition. In this study DH...

Use of certain lipid measures not more effective in predicting coronary heart disease

The lipid measure apolipoprotein (apo) B: apo A-I ratio is not a better predictor of coronary heart disease risk than traditional lipid ratios that include total cholesterol and HDL-C, according to a study in the August 15 issue of JAMA. Current risk-prediction instruments and guidelines for co...

New Therapy for Lipid Disorder Demonstrates Varied Results

Preliminary research suggests that use of a novel, potent drug to treat cholesterol disorders decreases triglycerides and increases// HDL-C, the 'good' cholesterol, but also raises some safety concerns, according to a study. Several different classes of drugs are used to treat lipid disorder...

Chinese Red Yeast Rice Lowers Lipid Levels

Chinese red yeast rice (RYR) is known to contain several ingredients with medicinal properties. One of them is lovastatin, and several trials have confirmed// its possible lipid-lowering effects. This analysis was conducted to assess the effectiveness and safety of RYR extract in changing li...

The ideal composition of intravenous lipid emulsion

The body responds to a diverse range of insults, such as surgery, infection and injury by the activation of a wide range of cell types of the immune system, creating a number of potent cellular actions and mediators.// The inflammatory response, although essential for fighting infection, may damage...

Electronic Health Records Help Cardiac Patients Remain Healthy

... of 421 patients found that patients discharged from the program kept their lipid and blood pressure levels at controlled, healthy levels by receiving electr...ed from the program had electronic reminders in their chart to ensure their lipid panels were ordered annually, with the results sent directly to their prima...

FDA Approves LIVALO(R) for Primary Hypercholesterolemia and Combined Dyslipidemia

...h which many other medications are metabolized. In pivotal Phase III trials, LIVALO effectively reduced LDL-C and improved other parameters of lipid metabolism in special patient populations, including the elderly, patients with diabetes and patients at higher cardiovascular risk. The overall safet...

Food additive may one day help control blood lipids and reduce disease risk

...ve it may be possible to improve the treatment of lipid disorders and minimize drug side effects by adding...sts long have known that PPAR-alpha is involved in lipid and glucose metabolism. When doctors prescribe fib...f of the Division of Endocrinology, Metabolism and lipid Research. "When we gave the animals fibrate drugs ...

Mathematical modeling predicts response to Herceptin

...thematical model that used 56 differential equations to analyze the change in concentrations of 56 separate biological entities including proteins and lipid second messengers. Researchers worked with 122 breast cancers treated with Herceptin and found that quantitative PTEN protein expression was a key...

Abbott Reports Strong Second Quarter Results; Confirms Double-Digit Earnings Growth Outlook for 2009

...uvastatin calcium achieved individual and combined lipid targets in patients with mixed dyslipidemia and ty...s more patients simultaneously reach all three key lipid targets - HDL, triglycerides and LDL - than the pr...iation's 2009 Scientific Sessions. Extended lipid Management Relationship with AstraZeneca: Announc...

Dynamic molecular mechanism to keep brain activity stable

...ished on July 13, 2009. The research group focused on two types of palmitoylating enzymes, DHHC2 and DHHC3. Protein palmitoylation, the most common lipid modification with the 16-carbon fatty acid palmitate, provides an important mechanism for regulating synaptic proteins in neurons. Here, the research ...

Pluronic L-81 is a potential anti-diabetic drug?

... study, Genetically diabetic (db /db ) mice were fed on chow supplemented with or without L-81 for 4 wk. The body weight, plasma glucose level, plasma lipid profile, and adipocyte volume of the db /db mice were assessed after treatment. Toxicity of L-81 was also evaluated. To understand the molecular mecha...

VAP(R) Cholesterol Test Highlighted in Groundbreaking Book on Longevity

...futurist Ray Kurzweil, identifies the VAP advanced lipid profile as one of the future technologies in cardi...est. The test can identify a far greater number of lipid abnormalities -- the No. 1 risk factor for heart d... with non-fasting samples. It is the only advanced lipid profile that routinely reports all three lipoprote...

DOR BioPharma Appoints Christopher P. Schnittker, CPA, as Vice President of Administration and Controller

...te GVHD. Oral BDP may also have application in treating other gastrointestinal disorders characterized by severe inflammation. Additionally, DOR has a lipid Polymer Micelle (LPM(TM)) drug delivery technology for the oral delivery of leuprolide for the treatment of prostate cancer and endometriosis. Th...

Metabolic factors may play a role in risk for breast cancer

...sistance syndrome, consists of a constellation of factors including abdominal obesity, high blood glucose levels, impaired glucose tolerance, abnormal lipid levels and high blood pressure. Affecting roughly 47 million Americans, the metabolic syndrome is also associated with poor diet and lack of physi...

Metabolic Syndrome May Make Breast Cancer More Likely

...in resistance syndrome, consists of a cluster of such conditions as abdominal obesity, high blood glucose levels, impaired glucose tolerance, abnormal lipid levels and hypertension. The study included 4,888 women, ages 50 to 79, who did not have diabetes at the start of the study and were periodically t...

Polycystic ovarian syndrome: New light on its causes and its effect on brothers

...lin resistance (group 1). They also performed a serum analysis to determine lipid levels. As a control, nine brothers of sisters with PCOS but without insuli...e continuing to test brothers of women with PCOS for insulin resistance and lipid levels to collect more data from a larger group. "At this stage we would he...

Patients with moderate to severe periodontitis need evaluation for heart disease risk

...in the USA. In addition, there is now strong evidence that people with periodontitis are at increased risk of atherosclerotic CVD the accumulation of lipid products within the arterial vascular wall. The explanation for the link between periodontitis and atherosclerotic CVD is not yet clear, but a lead...

Peregrine Pharmaceuticals Completes Planned Patient Enrollment in Bavituximab Phase I Cancer Trial

...out Phosphatidylserine (PS)-Targeting Agents The rapid and disorganized growth that is the hallmark of cancer results in the exposure of the lipid phosphatidylserine (PS) on the surface of tumor blood vessels. Since these phospholipids are typically not exposed on the surface of normal tissues, ...

Amira Pharmaceuticals Announces Initial Positive Phase 1 Clinical Data for AM211, a Novel Product Candidate for the Treatment of Respiratory Diseases

...the discovery and early development of new drugs to treat inflammatory disease. Our discovery team is building on unparalleled insights into bioactive lipid pathways and complex signaling processes controlling many conditions including asthma, chronic obstructive pulmonary disease, cardiovascular and fibro...

Boston Heart Lab Named 'Most Promising Early Stage Company' 2009 by Silicom Ventures

...rtlab.com ) Boston Heart Lab enables cardiologists and other clinicians to prescribe personalized treatment plans for cardiovascular disease and lipid disorders that offer patients the best opportunity for improved health outcomes, based on a panel of tests that provides the most comprehensive assess...

Omega-3 Fatty Acids Key to Fetal Development - Possible Mercury Contamination Concerns in Some Fish Oil Avoided With Plant-based DHA in PreNexa(R) Prenatal Vitamins

...ansen HS, Jorgensen MH, et al. "The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina." Prog lipid Res. 2001;40:1-94. (Calculated using Table 1 data 22 6n-3/Total n-3). 5. Martinez M. "Tissue levels of polyunsaturated fatty acids during early hum...

Peregrine Pharmaceuticals Awarded Broad New U.S. Patent for Vascular Imaging Applications of Its PS-Targeting Platform

... About Phosphatidylserine (PS)-Targeting Antibodies The rapid and disorganized growth that is the hallmark of cancer results in the exposure of the lipid phosphatidylserine (PS) on the surface of tumor blood vessels. Since PS typically is not exposed on the surface of normal tissues, it represents a un...

Patients with lower urinary tract symptoms more likely to suffer from metabolic syndrome

...ure 130 mm Hg or greater or diastolic blood pressure 85 mm Hg or greater, or antihypertensive medication use; 3) HDL cholesterol less than 40 mg/dl or lipid medication use; 4) self-reported type 2 diabetes or increased blood sugar or diabetes medication use; 5) triglycerides greater than 150 mg/dl. An i...

Video: 'BeautyScoop(R) Is a Trip to Your Nutritionist and Dermatologist in One Single Packet.' Lauren Slayton, NYC Nutritionist & Owner of FoodTrainers

...le multivitamin preparations. BeautyScoop(R) is a beauty breakthrough that easily outperforms the competition with its patent-pending, peptide and lipid formula and clinically proven results. Doctor-developed, after nearly a decade of research and development, BeautyScoop (R) is a wholly origin...

Genomas Presents Drug-Specific Genetic Determinants of Statin Safety and Efficacy at the XV International Symposium on Atherosclerosis

...s, and reduction in regimen adherence. In this study, 442 outpatients treated with atorvastatin, rosuvastatin and/or simvastatin were studied in lipid clinics at Hartford Hospital (Hartford, CT) and the University of California, San Francisco . Researchers genotyped 384 SNPs (single nucleotide polym...

Amira Pharmaceuticals to Present Preclinical Data from LPA1 Receptor Antagonist Program at FASEB Summer Research Conference

...the discovery and early development of new drugs to treat inflammatory disease. Our discovery team is building on unparalleled insights into bioactive lipid pathways and complex signaling processes controlling many conditions including asthma, chronic obstructive pulmonary disease, cardiovascular and fibro...

Students May Be Solution to Shortage of Medical Professionals

...l focus on improving the health of patients with heart disease, including diabetes, high blood pressure, blood clotting and high cholesterol and other lipid disorders; and provide multidisciplinary clinical education in rural communities. School of Dental Medicine: Students will increase the number of r...

Omega-3 EPA: Treatment for a Heart Condition

...re showing that when combined in concentrated supplement form it was inhibiting the beneficial effects of EPA. Dr Puri, now Professor, and Head of the lipid Neuroscience Department at Hammersmith Hospital, was and is still adamant that as the ratio of EPA to DHA in a supplement rises, so does its efficacy....

ASCO Research Foundation Grant Will Support Study of Peregrine's Bavituximab in Lung Cancer

... Phosphatidylserine (PS)-Targeting Immunotherapies The rapid and disorganized growth that is the hallmark of cancer results in the exposure of the lipid phosphatidylserine (PS) on the surface of tumor blood vessels. Since these phospholipids are typically not exposed on the surface of normal tissues, ...

Arete Therapeutics Presents Positive Clinical and Preclinical Data for AR9281

...t receives 28 days of treatment. Endpoints for the trial include safety, tolerability, reduction of blood pressure and various measures of glucose and lipid metabolism, with results expected in the first quarter of 2010. The Phase I clinical program for AR9281, consisting of two double-blind, placebo-...

Roche to Commence Phase III Trials with Innovative Treatment Designed to Lower Cardiovascular Risk in Diabetes Patients with Recent Heart Attack

...patients, showed that aleglitazar had a balanced synergistic effect on both lipid and glucose control with a good safety and tolerability profile in patients...clinical endpoints were changed from baseline in fasting plasma glucose and lipid profiles. Notably, significant dose-dependent reductions versus placebo wer...

Middle-aged women experience more stress but have lower blood pressure

... Both blood pressure and serum lipid levels have improved in Swedish middle-aged women during the past 30 years. Levels of perceived mental stress, however, have increased significantly. ...

News briefs from the June issue of CHEST

...SORDER IN CHILDREN New research suggests that the urine concentration of lipid mediators may determine the severity of sleep-disordered breathing (SDB) in children. Cysteinyl leukotrienes (CysLTs), lipid mediators associated with inflammatory conditions such as asthma, have been...

American Academy of Dermatology Issues New Guidelines For the Management of Psoriasis With Systemic Medications

...ly impaired liver or kidney function and chronic, abnormally elevated blood lipid values. For this reason, patients should be monitored with lipid profiles and liver enzymes once every two weeks after starting acitretin. ...

Abbott and AstraZeneca Extend Relationship to Include Co-Promotion of TRILIPIX(R) (fenofibric acid)

...e or in combination with a statin to treat certain lipid disorders. Under the terms of the agreement, Astr...ms were not disclosed. "Abbott's portfolio of lipid therapies is designed to help physicians manage a patient's total lipid profile," said Jeffrey Stewart, divisional vice pr...