LPS in Medical News

CU-Boulder study shows brain's immune system may cause chronic seizures

...ia called lipopolysaccharide, or LPS, to the brain, activating the micro-glial cells. The glial cells very rapidly clustered around the area where the lps was applied and created an immune reaction in that locale. The glial cells then released their cytokines, causing the neurons to become excitable e...

Chemical liberated by leaky gut may allow HIV to infect the brain, Einstein scientists find

...animal studies had shown that exposure to elevated lps levels compromised the integrity of the BBB. "So w...combination of HIV-infected monocytes and elevated lps levels would amplify the ability of HIV to cross t... team injected control mice with very low doses of lps that were comparable to the levels in the bloodstr...

JCI online early table of contents: Feb. 7, 2008

... as IFN-gamma, which was shown to cause damage to the colonic mucosa. The upregulation of IFN-gamma expression was eliminated if the bacterial product lps was removed from the explant cultures. As IFN-gamma expression could be restored by the addition of a bacterium that lives naturally in the human colo...

Who is the arch-criminal in the development of hepatopulmonary syndrome?

...ogression and severity of HPS were closely associated with increased plasma lps level, and that there was a paralleling deterioration between the lung func...pment of hepatopulmonary syndrome. Therefore, the strategy directed against lps will certainly be effective in the prevention and treatment of HPS. ...

JCI online early table of contents: Dec. 6, 2007

...ttempts to identify the mechanisms responsible for lps removal during septic shock have been unsuccessful... an uncontrollable inflammatory response following lps challenge, with a higher subsequent mortality rate...to foreign substances in the blood, in response to lps challenge and infection with Gram-negative bacteri...

Evotec Reports Positive Top-Line Results in Phase II Study With EVT 201 in Elderly Insomniacs With Daytime Sleepiness

...ean WASO (mins) / % 101.4 86.2 / 15% 65.3 / 36% change from placebo p=0.0140 p= Adjusted mean lps (mins) / % 46.5 30.5 / 34% 26.5 / 43% change from placebo p=0.0091 p=0.0014 The PSG analysi...

Pest Control research Leads to Pain Control Discovery

... enzyme inhibitors (a previously undescribed soluble epoxide hydrolase inhibitor or sEHIs) in lipopolysaccharide (LPS)-challenged mice. 'We used lps as an inflammatory agent, which is a component of some bacterial cell walls,' said, co-author Steven Jinks. His laboratory examined the effects of the...

ROZEREM? Can Be A Better Option For Insomnia Patients

...howed that a statistically significantly greater percentage of adults with chronic insomnia treated with ROZEREM 8 mg demonstrated at least 50 percent lps reduction compared to those who received placebo at week 1 (63 percent vs. 40 percent (P Those results were sustained throughout the study (63 p...