For the Treatment of Rheumatoid Arthritis, Market Share for TNF-alpha Inhibitors Will Decrease Through 2018

Actemra/RoActemra Will Emerge as the Preferred Biological Drug for TNF-Refractory Patients, According to a New Report from Decision Resources WALTHAM, Mass., May 18 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare iss...

SCAI Statement on 'A National Study of the Effect of Individual Proton Pump Inhibitors on Cardiovascular Outcomes in Patients Treated with Clopidogrel Following Coronary Stenting: The Clopidogrel Medco Outcomes Study'

LAS VEGAS, May 6 /PRNewswire/ -- Results of the Clopidogrel Medco Outcomes Study presented today during SCAI's Annual Scientific Sessions found the anti-clotting benefits of clopidogrel (Plavix) may be reduced when taken concurrently with commonly used heartburn medications called proton pump inhi...

Proton pump inhibitors increase risk of heart attacks for patients on common cardiac drug

Patients taking the common cardiac drug clopidogrel following a heart attack are at a significantly higher risk of a recurrence if they are also taking widely used acid-lowering medications called proton pump inhibitors, a new study published online in CMAJ has found ( http://www.cmaj.ca/cgi/rap...

Onyx Pharmaceuticals Acquires Option to License Novel Highly Specific JAK2 Inhibitors From S*BIO

EMERYVILLE, Calif., Jan. 6 /PRNewswire-FirstCall/ -- Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX ) today announced that it has acquired an option to license rights to SB1518, an orally available, potent, and selective inhibitor of Janus Kinase 2 (JAK2), and SB1578, also a JAK2 inhibitor, from S*BIO...

S*BIO Announces Collaboration with Onyx for JAK2 Inhibitors in the North American and European Markets

S*BIO Receives $25 Million Upfront Payment and Equity Investment and Eligible to Receive Additional $525 Million in Option & License Fees and Milestone Payments SINGAPORE, Jan. 6 /PRNewswire/ -- S*BIO Pte Ltd today announced that the company has entered into a Development Collaboration, a...

GlaxoSmithKline and Dynavax Announce Worldwide Strategic Alliance : – Developing First-in-Class Endosomal TLR Inhibitors for Autoimmune and Inflammatory Diseases –

GlaxoSmithKline (LSE:GSK) (NYSE:GSK) and Dynavax Technologies Corporation (NASDAQ:DVAX) today announced a worldwide strategic alliance to discover, develop and commercialize novel inhibitors of endosomal Toll-like Receptors (TLRs) for the treatment of immuno-inflammatory diseases. TLRs are key re...

Overcoming inhibitors of cell death improves cancer therapy efficacy

Individuals with glioblastoma multiforme (GBM), one of the most aggressive types of brain tumor, have an extremely poor prognosis. Although pre-clinical studies indicated therapeutics inhibiting a group of proteins known as receptor tyrosine kinases (RTKs) would likely be beneficial to individuals...

Myostatin inhibitors may improve recovery of wartime limb injuries

Inhibiting a growth factor that keeps muscles from getting too big may optimize recovery of injured soldiers, researchers say. They are studying two myostatin inhibitors in mice with limb injuries, first to see which works best and then to identify the best delivery mechanism, says Dr. Mark Ham...

Team discovers new inhibitors of estrogen-dependent breast cancer cells

Researchers have discovered a new family of agents that inhibit the growth of estrogen-dependent breast cancer cells. The finding, described today at a meeting of the Endocrine Society, has opened an avenue of research into new drugs to combat estrogen-dependent breast cancers. "This cell-based...

Effect of tumor necrosis factor a inhibitors on heart failure risk in RA Patients

A chronic autoimmune disease, rheumatoid arthritis (RA) is characterized by persistent inflammation of the synovial membrane and progressive joint destruction. Beyond loss of mobility, sufferers face a high risk of heart failure. An inflammatory cytokine known for contributing to the development...

For Treatment of Type 2 Diabetes, 89 Percent of Surveyed Endocrinologists Identify a Need for Additional GLP-1 Analogues and 71 Percent Say the Same About DPP-IV Inhibitors

WALTHAM, Mass., July 20 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that most surveyed clinicians identify a need for additional therapies from the GLP-1 analogue and DPP-IV inhibitor drug clas...

Genomic Health Announces Study Establishing the Utility of Oncotype DX(R) in Node-Negative and Node-Positive Breast Cancer Patients Treated with Aromatase Inhibitors

SAN ANTONIO, Dec. 13 /PRNewswire-FirstCall/ -- Genomic Health, Inc. (Nasdaq: GHDX ) today announced findings from a European study demonstrating that the Oncotype DX Recurrence Score(R) result is a significant independent predictor of distant recurrence in both node-negative and node-positive, h...

FDA Approves NOVO NORDISK's NovoSeven(R) RT (Coagulation Factor VIIa [Recombinant] Room Temperature Stable) for Hemophilia Patients With Inhibitors

First Recombinant Room Temperature Stable Treatment for Hemophilia With Inhibitors Offers More Flexibility and Convenience to Patients PRINCETON, N.J., May 13 /PRNewswire-FirstCall/ -- Novo Nordisk today announced that the US Food and Drug Administration (FDA) has approved NovoSeven(R) RT ...

Gastric juice for diagnosis of H. pylori infection in patients on proton pump inhibitors

This study determined the efficiency of a gastric juice PCR test for the detection of H. pylori infection in patients receiving PPI therapy and compared it with histology and gastric biopsy PCR. This study, led by Dr Javed Yakoob, is described in a research article to be published in the March...

Silencing small but mighty cancer inhibitors

Researchers from Johns Hopkins and the University of Pennsylvania have uncovered another reason why one of the most commonly activated proteins in cancer is in fact so dangerous. As reported in Nature Genetics this week, the Myc protein can stop the production of at least 13 microRNAs, small piece...

Src Inhibitors in Breast Cancer Therapy

Estrogen, which binds estrogen receptor alpha (ER-alpha), is a risk factor for breast cancer development. However, one-third of new breast cancers lack detectable ER-alpha . These ER-alphanegative cancers are more aggressive and have a worse prognosis than do ER-alphapositive breast cancers, a...

Green Tea and COX-2 Inhibitors Combine to Slow Growth of Prostate Cancer

Drinking a nice warm cup of green tea has long been touted for its healthful benefits, both real and anecdotal. But now researchers have found// that a component of green tea, combined with low doses of a COX-2 inhibitor, could slow the spread of human prostate cancer. In the March 1 issue of...

ACE Inhibitors For Vascular Disease Patients

Researchers at the Laval University Heart and Lung Institute in Quebec have found that drugs used to treat heart failure also reduced the risk of death, heart attacks// and stroke in people with hardened arteries and hence should be considered in all vascular disease patients. ACE inhibitors...

Aromatase Inhibitors Better Than Tamoxifen For Treating Receptor-Positive Early Breast Cancer

Researchers have found that aromatase inhibitors like anastrozole are more effective in treating postmenopausal women with hormone receptor-positive early breast cancer// than tamoxifen according to study published in the "The Lancet Oncology" journal. Researchers followed more than 6,000 post...

LipB Protein Inhibitors Help To Fight Against TB

According to a recent study conducted by the researchers at the Hamburg Outstation of the European Molecular Biology Laboratory (EMBL) and the Max Planck Institute for //Infection Biology (MPIIB) has found the structural image of a protein needed for the TB bacteria to survive which could be target...

COX-2 inhibitors Lessen Breast Cancer Risk

Selective usage of COX-2 inhibitors like rofecoxib (Vioxx) and celecoxib (Celebrex) reduces breast cancer risk by 71%, according to a study. The Ohio State University College of Medicine and Public Health's Randall Harris led the // research which came to this conclusion. The nonsteroidal anti-inf...

Aromatase Inhibitors drug Femara after Tamoxifen therapy protects from breast cancer recurrence

Aromatase Inhibitors drug, Femara given after 5 years of Tamoxifen therapy is found to give protection against occurrence of Breast cancer recurrence. Breast cancer is the second leading cause of cancer// in women. Breast cancer mostly occurs in post menopausal women and various risk factors are at...

Phase 3 trials of two multi-kinase inhibitors against cancer

Sorafenib and stutent multi-kinase inhibitors against cancer is undergoing phase 3 trials// and these two drugs gained more appreciation in this years ASCO (American Society of Clinical Oncology) conference. This drug is gaining interest due to its multiple mechanism of action – known as Multi-kina...

FDA Approves New 3000 IU Vial Size for Kogenate(R) FS, antihemophilic factor (recombinant)

... INFORMATION ABOUT KOGENATE(R) FS The most serious adverse reactions are systemic hypersensitivity reactions and the development of high titer inhibitors necessitating alternative treatments to AHF. The most common adverse reactions observed in clinical trials were inhibitor formation in previously unt...

Decision Resources' Updated Rheumatoid Arthritis Report Now Includes Forecast for Rigel Pharmaceuticals' Fostamatinib Disodium

...he report finds that, owing to its impressive efficacy, the spleen tyrosine kinase (Syk) inhibitor fostamatinib disodium will likely precede TNF-alpha inhibitors such as Amgen/Wyeth/Takeda's Enbrel and Abbott/Eisai's Humira in the treatment cascade for rheumatoid arthritis. Phase II data shows that fostamatinib...

DEET in Bug Spray Tied to Neural Damage in Mice

...en identified. Interestingly, the class of drugs known as cholinesterase inhibitors are used to treat Alzheimer's and can delay the decline of symptoms for up ...r study found a strong association between exposure to acetylcholinesterase inhibitors and the Gulf War illness suffered by many veterans. Organophosphates have a...

Silenced genes as a warning sign of blood cancer

...s. Such labels are found particularly often in genes which act as important inhibitors of pathogenic cell growth. Cancer researchers do not know why healthy ce... differ in their methylation patterns and why it is particularly the cancer inhibitors that are frequently switched off. The study of these questions is a very pr...

Surveyed Physicians Will Treat Over 50 Percent of Hepatitis C Genotype 1-Infected Patients With the Protease Inhibitor Telaprevir

...rt also finds that 40 percent of surveyed managed care organization's (MCOs) pharmacy directors indicate that they will place only one of the protease inhibitors on their formularies. Of these pharmacy directors, 10 percent expect to choose telaprevir while 30 percent say that they do not have a preference rega...

Five Questions About Eczema

...onally been topical corticosteroids. (17) Among the newer forms of treatment are prescription medications called topical calcineurin (cal-SEE-nur-in) inhibitors (TCIs). TCIs belong to a category of medicines called immuno-modulators. (18) Scientists believe that TCIs target T cells in the skin which play a s...

K-State Researcher, Collaborators Study Virulence of Pandemic H1N1 Virus; Work at K-State Would Protect Pig Industry If the Virus Jumps to Swine Populations

...tein; the other type includes drugs like Tamiflu that target the neuraminidase protein. He said that this pandemic H1N1 is already resistant to the M2 inhibitors but still is sensitive to Tamiflu. "Some pandemic flu isolates from humans have now shown resistance to the Tamiflu," Richt said. "So the big i...

New microchip technology performs 1,000 chemical reactions at once

...nzyme. In this study, scientists produced a chip capable of conducting 1,024 reactions simultaneously, which, in a test system, ably identified potent inhibitors to the enzyme bovine carbonic anhydrase. A thousand cycles of complex processes, including controlled sampling and mixing of a library of reagen...

Zogenix and Astellas Enter Exclusive Co-Promotion Agreement in the US for Newly Approved Sumavel(TM) DosePro(TM)

... and is not generally recommended for use with selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors SNRIs or MAO inhibitors. Sumavel DosePro should be used during pregnancy...

Boehringer Ingelheim to Commence Phase III Study Investigating the Role of BIBW 2992 as First-Line Treatment for Non-Small Cell Lung Cancer (NSCLC) Patients with EGFR Mutations

...chemotherapy treatments for patients with advanced NSCLC, is ongoing. In the area of cell-cycle kinase inhibition, Boehringer Ingelheim is developing inhibitors of polo-like kinase 1 (Plk1), a protein that is involved in the processes of cell division. These molecules are in the early stages of clinical develo...

Professor Bruce Beutler Joins aTyr Pharma's Scientific Advisory Board

...ammatory disease. Dr. Beutler is the inventor of Enbrel(R), the prototype for the most successful class of biotherapeutics ever developed: recombinant inhibitors of TNF that are used to treat inflammatory diseases such as rheumatoid arthritis. aTyr Pharma's discovery candidates for anti-inflammatory and ...

Savient Pharmaceuticals Receives Complete Response Letter from U.S. Food and Drug Administration for KRYSTEXXA(TM)

...therapy occurs in patients who have failed to normalize serum uric acid and whose signs and symptoms are inadequately controlled with xanthine oxidase inhibitors at the maximum medically appropriate dose or for whom these drugs are contraindicated. Conference Call Information Savient will host a li...

Preventing toxic shock syndrome and other severe diseases

...tibiotics, but that won't have any affect on the toxins," explains McCormick. "By understanding how these toxins work, we can look at developing drug inhibitors that will target and neutralize the toxins." On the flip side, McCormick believes these toxins could be utilized to fight cancer. "We know these t...

Alternative Therapies for Fighting Eczema Hold Promise, But Dermatologists Caution They Are No Substitute for Proven Medical Treatments

...ese alternative treatments." While topical corticosteroids (the mainstay in the treatment of eczema), antibacterial agents, topical calcineurin inhibitors and moisturizers are among the most effective medical treatments dermatologists prescribe to treat eczema, Dr. Lio suggested certain alternative thera...

New drug for children with high-risk leukemia

...li. "Those children at the highest risk for leukemia may be treated with inhibitors of JAK2," he says. "And because of the existence of polycythemia in adults,...covery offers "potential hope" to children who suffer from leukemia. "JAK2 inhibitors are not based on chemotherapy. The first experiences with these treatments ...

MULTAQ(R) (dronedarone) for Atrial Fibrillation or Atrial Flutter Now Available in the United States

... should not be given to patients who are or may become pregnant (Category X) or nursing. MULTAQ should not be coadministered with strong CYP 3A inhibitors or medicinal products that prolong the QT interval. In patients with new or worsening heart failure, the suspension or discontinuation of MULT...

Critical link in cell death pathway revealed

...ute researchers and has led them to recommend caution when drugs called IAP inhibitors are used to treat cancer patients with underlying liver conditions. A tea...derlying liver conditions who were being treated with IAP inhibitors. These inhibitors would block the production of XIAP, thereby interfering with the normal cel...