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Amgen and Wyeth Statement on FDA Announcement About Tumor Necrosis Factor (TNF) Blockers

... failure of its products or product candidates. Further, the discovery of significant problems with a product similar to one of Amgen's products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on Amgen's business and results of operations. ...

Amgen Announces KRAS Safety Update to U.S. Prescribing Information for Vectibix(R) (Panitumumab)

...s or failure of our products or product candidates. Further, the discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. ...

Mini-Strokes May Cause Vision Loss

... Hong Kong researchers implicate silent infarcts in glaucoma TUESDAY, July 7 (HealthDay News) -- A study of people who suffer the mini-strokes called silent cerebral infar...

Amgen Highlights Data to Be Presented at ASCO

...ss or failure of our products or product candidates. Further, the discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. ...

A potential new target for treatment of hormone refractory prostate cancer

...hat do not respond to androgen ablation and is required for prostate tumor growth under androgen depleted conditions. Taken together, the findings implicate RNF6 as an important regulator of AR transcriptional activity. "Our work suggests that ubiquitination of AR, and possibly other transcription factors,...

Penn vet researchers identify a critical growth factor that stimulates sperm stem cells to thrive

...s in the interstitial space between seminiferous tubules. Collectively, these results identify Csf1 as an extrinsic stimulator of SSC self-renewal and implicate Leydig and myoid cells as contributors of the testicular stem cell niche. ...

Study Pinpoints New Gene for Cystic Fibrosis

...brosis Foundation, which partially funded the study. Though it's too early to recommend changes in genetic screening or counseling, the findings do implicate IFRD1 in particular, and neutrophil activation in general, as potential targets for drug development. The results were published online Feb. 25 in ...

Drug Reduces Inflammatory Arthritis Symptoms, Lesions

...he study. "Our findings show that ustekinumab is efficacious and safe for treatment of active psoriatic arthritis. Our study is one of the first to implicate the role of interleukin 12/23 P40 cytokines in the pathophysiology of this disorder. Larger and longer term studies are needed to further characterize...

UNC study hints at new approaches to prevent transplant rejection

..., they found that the cells did in fact cause graft-versus-host disease, with the most severe damage to the lung and skin. Not only did these findings implicate TH17 cells in the disease, but they also generated one of the first mouse models to display acute GVHD skin changes consistent with the most common m...

Twin study: Diabetes significantly increases risk for Alzheimer's disease and other dementia

... the sample of older adults. In addition, approximately 30 percent of older adults with diabetes have not been diagnosed. The results of the study implicate adult choices such as exercise, diet and smoking, as well as glycemic control in patients with diabetes, in affecting risk for Alzheimer's disease and...

Delusions associated with consistent pattern of brain injury

...e right frontal lobe damage. Other research showed that Reduplicative Paramnesia and Capgras syndrome cases with unilateral brain lesions strongly implicate the right hemisphere, usually the frontal lobe of the brain. Among 69 patients with Reduplicative Paramnesia, lesions were primarily in the right hemi...

Researchers gain new insight on wonder of cell division

...usly CYK-4 had been thought to only down-regulate a different GTPase called RhoA, which promotes linear microfilament assembly. Thus these new results implicate the down-regulation of branched microfilaments at the cell cortex as a critical step in cell division. "We have found a completely new way of think...

New Research Will Benefit Four Million Americans Suffering from Chronic Fatigue Syndrome

...els are higher in CFS patients because their brains contain high levels of toxic compounds that cause a condition called oxidative stress (which could implicate chronic inflammation), or because mitochondrial dysfunction is causing malfunctions in the production of brain energy. If this study is successful, br...

Type-1 diabetes not so much bad genes as good genes behaving badly, Stanford research shows

...t it was seven years ago, in what he described, tongue-in cheek, as "an interesting study that started at the dawn of history." Rather than try to implicate a faulty gene, Fathman's team looked for genes in the diabetic twin that act differently from the same genes in the other twin who doesn't get diabe...

Colon Cancer Oncogene Discovered

... SUNDAY, Sept. 14 (HealthDay News) -- Researchers have identified a new genetic player in the development of colon cancer. The findings implicate CDK8, a protein that regulates gene expression in the proliferation of colorectal cancer, the researchers found. Should the results be validated, t...

Genetic region linked to a 5 times higher lung cancer risk

...oked or didn't smoke. Published in the Sept. 13 issue of the Journal of the National Cancer Institute, this study is the fourth since April 2008 to implicate this genetic region in the development of lung cancer, and it strengthens the possibility that testing for variations in this region could become a va...

Connecting cancer genes

...ining the DNA of more than 500 lymphomas to find the cancer causing mutations. The study found just over 10,000 mutations in total, which together implicate almost 350 regions in the mouse genome in cancer formation. 50 of these regions correspond to genes known to be involved in human cancers while the ot...

Genetic links to impaired social behavior in autism

...n between some of the genes identified in animal studies as controlling affiliative behaviors in ASD. The strongest statistical findings of the study implicate the prolactin gene, the prolactin receptor gene, and the oxytocin receptor gene in these affiliative behavior deficits. John H. Krystal, M.D., Edit...

Scripps Florida scientists develop a process to disrupt hepatitis C virion production

...in infectious virus production without altering HCV RNA replication. These data provide the first evidence for a function of domain III of NS5A and implicate NS5A as an important regulator of the RNA replication and virion assembly of HCV, Tellinghuisen says. The ability to uncouple virus production from RN...

Scientists confirm new virus responsible for deaths of transplant recipients in Australia

...the New England Journal of Medicine and are now online. After failing to implicate an agent using other methods including culture, PCR and viral microarrays, ...he organ donor and increasing titer of antibody in a recipient were used to implicate the virus as the cause of disease. The arenavirus lymphocytic choriomeningi...

Mislabeled Supplement Spurred Prostate Cancer: Report

..., McGuffin said. "I'll tell you what the FDA calls these," he said. "They call them illegal drugs. The fact that someone found one of these should not implicate every herbal product and every vitamin product as somehow being adulterated with drugs or not containing what it should. That's just not true." And...

Mislabled Supplement Spurred Prostate Cancer: Report

..., McGuffin said. "I'll tell you what the FDA calls these," he said. "They call them illegal drugs. The fact that someone found one of these should not implicate every herbal product and every vitamin product as somehow being adulterated with drugs or not containing what it should. That's just not true." And...

This Holiday Season Some Dream of a White Christmas - The Accelerated Cure Project Dreams of Developing a Cure for Multiple Sclerosis

... a set of genes that coincide with a particular virus. Over time, discovery of patterns such as this would help to eliminate some potential causes and implicate others. Building The Repository Recognizing that researchers don't have the time or resources to collect enough samples that could be used in mult...

Low-carb diet reduces inflammation and blood saturated fat in metabolic syndrome

...reducing carbohydrate led to considerably greater reductions in a number of pro-inflammatory cytokines, chemokines, and adhesion molecules. These data implicate dietary carbohydrate rather than fat as a more significant nutritional factor contributing to inflammatory processes. Richard Feinman, PhD, profes...

FDA Panel Backs Tougher Warning for Tamiflu

...believe the label needs changing. "The review and analysis of all the information available in this safety summary of neuropsychiatric events does not implicate or indicate a significant causal role of zanamivir. Therefore, no revisions are warranted for the U.S. Prescribing Information and the FDA-approved Pa...

FDA Panel Backs Stronger Warning for Tamiflu

...believe the label needs changing. "The review and analysis of all the information available in this safety summary of neuropsychiatric events does not implicate or indicate a significant causal role of zanamivir. Therefore, no revisions are warranted for the U.S. Prescribing Information and the FDA-approved Pa...

FDA Mulls Tougher Warning Label on Kids' Flu Drugs

...believe the label needs changing. "The review and analysis of all the information available in this safety summary of neuropsychiatric events does not implicate or indicate a significant causal role of zanamivir. Therefore, no revisions are warranted for the U.S. Prescribing Information and the FDA-approved Pa...

New insights into inflammation in osteoarthritis

...ppears normalsuggests that other joint structures may be involved in triggering this inflammation. Recent studies of inflammation in spinal arthritis implicate the enthesis, which is the attachment site of ligament or tendon to bone as being a potential driving factor in joint inflammation. Intrigued...

Level of oxytocin in pregnant women predicts mother-child bond

... involved in maintaining close relationships. Animals with no oxytocin exhibit slower pup retrieval and less licking and self-grooming. These findings implicate oxytocin in the bonding process, but little research has been done on this relationship in humans. Ruth Feldman, psychology professor at Bar-Ilan ...

The impact of physical activity on weight-bearing knee joint

...e of 50. Whether physical activity is beneficial or detrimental to weight-bearing joints, knees in particular, has been open to debate. Some studies implicate physical activity in provoking knee OA, while others suggest that physical activity may actually protect the knee joint from the disease. Confounding...

Radiologists identify early brain marker of Alzheimer's disease

...hich may aid in early diagnosis of Alzheimers disease, according to a study published in the October issue of Radiology. The findings of this study implicate a potential functional, rather than structural, brain markerseparate from atrophythat may help enhance diagnosis and treatment monitoring of Alzheimer...

Tissue-Growth Gene Tied to Scleroderma

...said co-author Gisela E. Lindahl, a principal research fellow at the Royal Free and University College Medical School in London. But the study does implicate the connective-tissue growth factor ( CTGF ) gene in scleroderma, which affects some 30,000 Americans and is estimated by the Scleroderma Foundation t...

Brain Cells Activity: New Treatment Target for Psychiatric Diseases

... "If this neuron is too excited, people may get manic or have seizures," says Dr. Mei. "Patients with schizophrenia, for example, show symptoms that implicate alterations in inhibitory neurotransmission in addition to excitatory neurotransmission." Dr. Mei co-authored a companion paper in Neuron with...

Obesity And Environmental Chemicals: Research Probes Potential Link

...onfounding factors to obesity.” With the research just getting underway, the scientists are duly cautious about predicting outcomes. If findings implicate PBDEs in obesity, Carey notes, the news would be good and bad. “From a scientific standpoint, it would be very interesting if these animals bega...

A Single Biological Mechanism Behind Several Autoimmune Disorders

... A recent study has found supporting evidence to implicate insulin-like growth factor receptor (IGF-1R) in the development of Graves’ disease.// In a previous research, Terry J. Smith, M.D. and Raymond D...

In Search of Truth - 'Lie Detector

...at the polygraph, devoid of a scientific basis, is entirely based on a person’s ignorance and fear, and that a couple of deviant responses can falsely implicate a person, and ruin him for life. It is therefore imperative that more research is carried out to dissipate the air of ambiguity surrounding the ...

Filling a Niche -- Role of Rb in Mammalian Stem Cells

...b in trophoblast stem cells results in an overexpansion of trophoblast cells, aberrant placental formation, and embryonic death. These findings implicate a role for the Rb pathway in the development of the human placenta and may provide a link between Rb, and possibly other cell cycle regulators, and pr...

How Blood Flow Dictates Gene Expression

..., they had an abnormally high cardiac output, as measured by ultrasound, while the overall structure of their blood vessels was normal. These findings implicate loss of vessel tone as the primary defect in Klf2 knockout mice. Now that Klf2 has been established as an important regulator of blood flow in live ...

The GreeneChip- First Tool to Provide Differential Diagnosis of Infectious Diseases

...variety of laboratory and clinical settings. The GreeneChip system and its application in an outbreak investigation when other methods failed to implicate a microorganism in a fatal hemorrhagic fever case is described in the January 2007 issue of the CDC's Emerging Infectious Diseases (online December 6 ...

Hope For Bedwetting Children

...dren who were dry provided one more opportunity to find the physiological difference between them on dry and wet nights, Kamperis said. Results implicate sodium Circadian variations in urine output were evident for all groups. However, polyuric children excreted twice as much urine during the nigh...
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