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HLA in Medical News

StemCyte, Inc. Reaches 1,000th Cord Blood Stem Cell Shipment for Transplant Milestone

...udies are increasing at an incredible pace and this will result in the treatment of some of the most devastating diseases. StemCyte's large library of hla typed product as well as our experience and expertise in this field will position us very well to take advantage of these emerging therapies," explain...

Mayo researchers help discover genetic cause for primary biliary cirrhosis

...ociation which had been identified in previous research. "Although both the hla region and the IL12 pathway are equally involved with susceptibility to primary biliary cirrhosis, hla is very complicated to dissect genetically, with multiple pathways," says D...

Researcher IDs Narcolepsy as Autoimmune Disease

... it needs to eliminate to protect the body. Previous studies had linked the hla variant to narcolepsy, a condition nearly half the study subjects had. ...Mignot, director of Stanford's Center for Narcolepsy, said it's likely that hla and the T-cell variant interact in a way that kills hypocretin cells, altho...

Narcolepsy is an autoimmune disorder, Stanford researcher says

...dreds of thousands of genetic variations of 1,800 people carrying the same hla gene variant. Of the group, 800 had narcolepsy, and the goal was to find wh...ntaining neurons via an autoimmune attack." Mignot said it's likely that hla and this T cell variant interact in a way that kills hypocretin cells. How ...

HIV handicaps itself to escape immune system pressure

...s remarkable resistance comes from an individual's hla genes. Long-term non-progressors tend to have hla genes that help the immune system recognize and fi...ng HIV-infected people with particularly effective hla genes has observed how the virus mutates and evolv...

Genetic risk factors play role in autoantibody-negative rheumatoid arthritis

... of their specificity and predictive value and for hla SE (human leukocyte antigen shared epitope) allele...r both ACPA-positive and ACPA-negative RA. The hla SE alleles contributed 11 percent to the total gen...genetic variance of ACPA-negative RA. In the past, hla genes were estimated to contribute 37 percent to t...

The immune system's role in hepatitis C recurrence after liver transplantation

...lls and the killer cell immunoglobulin-like receptors (KIR) which recognize hla Class I antigens. Researchers, led by Francesca Poli of Italy, examined the role of KIR genotypes and their hla ligands in both HCV disease recurrence and its progression after liver tran...

PGD Technology Offers More Than Designer Babies

...s have been used for chromosomal translocations, common in miscarriages, X-linked genetic illness; gender identification for family balancing; and for hla typing for use in cancer therapy. About Pacific Fertility Center Pacific Fertility Center is a fertility medical practice and egg donor ag...

FDA Clears New Immune Response Claim for the CryoValve(R) SG Pulmonary Human Heart Valve

...a comprehensive review of the scientific literature on allograft heart valves shows that implantation of the CryoValve SG reduces the risk of inducing hla class I and class II alloantibodies, based on Panel Reactive Antibody (PRA) measured at up to one year, compared to the standard- processed pulmonary ...

Even Mismatched Cord Blood Can Help Kids

...t conditions. "In order to match a donor to a recipient, doctors compare hla typing, a test usually performed on a blood sample," Prasad explained. "In every individual, hla typing includes the specific genetic make-up at three locations -- within t...

Gen-Probe to Acquire Tepnel Life Sciences, Fast-Growing European Molecular Diagnostics Company, for 92.8 Million Pounds Sterling ($132.2 Million) in Cash

...cts will facilitate its diversification into the transplant typing market. hla testing is used to match donors and recipients in anticipation of transplan...ts development and supply agreement with Luminex. The worldwide market for hla tests is estimated at $260 million in 2008, and is forecast to grow at a lo...

Common infant virus may trigger type 1 diabetes

...risk group for diabetes type 1 and the rest from a low risk group. The "high-risk" group included babies who had been identified at birth to carry the hla genotype conferring the highest known risk for type 1 diabetes. The group not carrying the high-risk genotype included babies born at the same time an...

Research on the effects of stem cell source and patient age on transplantation outcomes

...t, 243 were matched at eight out of eight possible hla loci and 111 were matched at seven hla loci. In those receiving a peripheral blood stem cell transplant, 518 were matched at eight hla loci and 210 at seven...

Understanding donor-recipient genetics could decrease early kidney transplant complications

...ions in HLA-A proteins are associated with DGF." hla cell-surface proteins allow the body to identify i...id autoimmune reactions. Every person has a unique hla signature. hla proteins also identify foreign invaders in the bod...

LABS Inc. Adds Dr. Carol Pancoska as Laboratory Director

...as led a distinguished career in the field of immunology for over thirty years. She has held various Laboratory Director positions, most recent at the hla Laboratory, Community Blood Center of Paramus New Jersey. She has been a lecturer and Professor regarding pathology issues for over twenty-five years ...

Golden Meditech Increases Stakes in Cordlife, Largest Cord Blood Bank Operator in Southeast Asia

...d bank business beyond China, to the rest of the world's most-populated countries in Asia- Pacific regions, but also helps improve the success rate of hla (human leukocyte antigen) marching in Asia as well, which can benefit a large number of patients in need of stem cell transplants. He emphasized tha...

Rare case explains why some infected with HIV remain symptom free without antiretroviral drugs

...e virus that infected the wife. Genetic testing also confirmed that both husband and wife had an overactive strand of genetic material tied to gene hla B57, found in previous studies to be more common in those whose HIV infection was suppressed or slowed. "The presence of this genetic spot is a d...

Immune molecule that plays a powerful role in avoiding organ rejection identified

... HLA-G dimer's target is another MHC molecule, which is essentially an individual's unique tissue signature; HLA-G itself is a type of MHC. In fact, hla - human leukocyte antigen - matching is done for organ and bone marrow transplants to try minimize the recipient's reaction to the new organ. Transpla...

Researchers from 5 countries to test hygiene hypothesis with EU funding

...1 diabetes is six times higher and the prevalence of celiac disease five times higher among Finnish children than among Russian Karelian children. The hla gene variants that predispose people to autoimmune diseases are however approximately equally common in both populations. The studies have also reveal...

Myanmar Cyclone Relief Fund

...ral Hospital and to the Emergency Medical Relief Team headed by Professor U hla Myint, President, Myanmar Medical Council. This established Myanmar traveli...ation supplies. Dr. Kyi Minn, adviser, World Vision will assist Professor U hla Myint's team. We request financial contributions only and promise the del...

A functional immune system can be derived from embryonic stem cells, preliminary study finds

...umbilical cord blood, and peripheral blood from donors. The antigens on the surface of donated cells must be compatible (determined by a method called hla matching) with those of the patient to prevent rejection. The use of embryonic stem cells, which have low levels of these antigens and may therefore b...

AST to Address New Concept in Organ Allocation at March 13-16 Winter Symposium

... is calculated based on several candidate-specific factors, including age, diabetes status, BMI, albumin, degree of sensitization (PRA), and degree of hla mismatch with a potential donor. The goal of this new system is to provide the most kidneys possible to those who will benefit most. There are many is...

New Therapies Could Change Organ Transplants

...ng immunosuppressive drugs nine to 14 months after the transplant. Kidney function has stayed stable for up to 5.3 years since the transplantation. hla refers to human leukocyte antigens, which is one of the primary ways donors and recipients are matched. HLAs, found on the surface of virtually all ce...

Human embryonic stem cell lines created that avoid immune rejection

...f human embryonic stem cells. In a paper entitled, hla Homozygous Stem Cell Lines Derived from Human Part...etic stem cell lines, designated as HpSC-Hhom, are hla (human leukocyte antigen) homozygous. This makes it possible to match the hla types of a donor and recipient, reducing the chanc...

Scientists Spot Key to Kidney Transplant Success

...bstances. Antigens vary from person to person, and hla typing helps determine how many antigens a donor shares with a recipient. If individuals are not hla matches, the recipient may produce antibodies to t...ection. But even donor-recipient pairs who are hla matches can end in rejection. That has suggested t...

New study may explain Vioxx side-effects

... pain medications were taken off the market in 2004 because they caused dangerous heart problems in some people. A group of scientists, led by Timothy hla at the University of Connecticut, may now have figured out how these drugs trigger these life-threatening side-effects. The new study will be publishe...

A New Study Throws Limelight in HIV Vaccine Production

...vades the human bodys immune system. Specifically, hla class 1 is a controlling part of the human immune ...ponse. The ability of HIV to escape recognition by hla class 1 leaves the body incapable of finding and f...n-based investigation of how natural variations in hla class 1 can influence HIV genetic sequence, as wel...

Chennai Hospital Conducts Bone Marrow Transplantation Successfully

... for matching human antigen leukocytes between donor and recipient - called hla typing - was absent in India. "On that count it was risky to go ah...em cell transplant from an unrelated donor on the basis of a low-resolution hla typing report. It was a gamble because we knew that there was only a 30 per...

Three Gene Variants Could Hold Key for HIV Vaccine: Study

...n (HLA) system, which plays a "major role" in the immune system by identifying foreign invaders and "tagging" them for destruction. Two of the hla genes, known as HLA-A and B, are turned off by the HIV virus when it enters the body, which keeps the immune system from recognizing the virus as fore...

Experts Identify Vaccine Target for HIV

...tigen (HLA) system, which plays a major role in the immune system by identifying foreign invaders and tagging them for destruction. Two of the hla genes, known as HLA-A and B, are turned off by HIV when it enters the body, which keeps the immune system from recognizing the virus as foreign. HLA-C...

Who Receives a Kidney Transplant First?

...ted Network for Organ Sharing (UNOS) coordinates the nation's transplant system through a point system based primarily on wait time, sensitization and hla matching. When a match occurs, the kidney is offered to the person at the top of the national list. A recent editorial in the American Journa...

Cord Blood Transplant Benefits Blood Cancer Patients

... blood transplants, doctors generally try to have the donors and recipients hla types match as closely as possible. Wagner added that increasing the i...aft versus host disease, a potentially lethal complication, especially when hla types are mismatched. Rates of leukemia relapse also are lower with mismatc...

New Developments in Rheumatoid Arthritis

...tty exciting. Early on in the rheumatoid arthritis research game, when hla popped out as a major genetic player in the condition in the 1980s, Dr. Gre...trulline, which seems to be a key player in the condition. Indeed, the hla associations with RA have now been shown by Dr. Gregersen and others to dir...

Who Receives a Kidney Transplant First?

...ted Network for Organ Sharing (UNOS) coordinates the nation's transplant system through a point system based primarily on wait time, sensitization and hla matching. When a match occurs, the kidney is offered to the person at the top of the national list. A recent editorial in the American Journal ...

Kidney Trade: Curbing the Sale

...tal, Vedanayagam Hospital and nine other hospitals, for not maintaining form III and form IV relating to organ transplant. Not performing the required hla tests on donor and recipients. Record –keeping was of poor standards in these hospitals and one of them had actually falsified records. Most of th...

Research Improves Kidney Transplant Chances for Sensitized Patients

...em based primarily on wait time, sensitization and hla matching. When a "perfect match" occurs, the kidne...ad assays, which gives a more specific analysis of hla antibodies by identifying a single antibody at a t...kidney. With the older technique of cross matching hla cells with the blood of a potential recipient, we ...

Can Early Nutritional Modification Prevent Type 1 Diabetes?

...he study. To be eligible the newborn infant has to have at least one family member (mother, father and/or sib) affected by type 1 diabetes and carry a hla genotype conferring increased risk for type 1 diabetes. The initial recruitment target of 2032 eligible infants was reached at the be-ginning of Septe...

Genes determine the capacity to fight HIV in early stages

...c versions of key immune-system molecules// called hla Class I that have been inherited, as well as on th...s General Hospital (PARC/MGH) report that specific hla Class I/HIV viral fragment combinations are associ...system in early infection and that the versions of hla Class I previously associated with slower HIV-1 di...

Researchers Uncover Gene That Raises Risk for Type 1 Diabetes

...t of individuals with known high risk genes in the hla region on chromosome 6 will develop type 1 diabete...ooking primarily at genetic regions outside of the hla region. The current research from the Barbara Davi...evaluated the influence of additional genes in the hla region. Beginning in 1993, more than 30,000 ...

Metropolis Health Plans Middle East hub in Dubai

...id Metropolis Health Services managing director G.S.K. Velu. "The hub will offer a range of services like genetic mapping, molecular biology and hla (Histocompatibility Antigens) and tissue typing and other tests that are currently sent from the UAE to European countries for diagnosis and take a lo...
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