Hormones May Affect Neurological Disease Risk
...significance of estrogen-coupled regulation of the dat
by both direct and indirect (kinase-mediated) interactions between estrogen receptors and the dat
should provide insights into how neurological diseases which involve the dat
are related to developmental, gender and life-stag...
Cocaine's effects on brain metabolism may contribute to abuse
...m in dopamine-transporter deficient mice (known as dat
knockouts) and in littermates that had normal dopa...nked to chronically high levels of dopamine in the dat
knockout mice. It also suggests that dopamine leve...n, learning, and motor function.
knockout mice have been suggested as an animal mod...
Drug abuse leads to long standing changes in the brain
...ral intelligence and motor function.
Results showed that, on average, dat
levels in the striatum of the brain were 24 percent lower in methamphetamin... cells and leads to reduced dopamine levels. The current finding of reduced dat
levels in chronic methamphetamine abusers indicates that in humans, too, th...