Clinical

How do patients benefit of clinical trials

Many patients undergoing trials of new cancer treatments do not realise that future patients are more likely to benefit than themselves.There can be no progress in treating cancer - or any other disease - unless there are clinical trials. Henceforth what do patients expect from a trial. Doctors in California gathered views from more than 200 patients involved in trials of new cancer treatments....

Magnetic resonance angiography in clinical medicine

Cardiovascular, eurovascular and other vascular diseases are the leading causes of death. Imaging of blood vessels thus important in depiction of stenotic, occlusive, aneurismal, inflammatory or vascular malformations.Conventional x-ray angiography and digital subtraction angiography (DSA) are used to depict vascular lesions with high accuracy via intravascular administration of contrast (dye) ma...

Clinical trials need to be more frank

Doctors should keep their patients informed about being paid to enrol them in a clinical trial. Post-marketing surveillance or phase 4 clinical trials - are a signicnificant part of medical research. It involves giving patients a new drug// and the family doctor reporting any problems that might arise. The post-marketing phase will involve many more patients than those who can take part in previ...

AEterna's acquisition of Zentaris being followed up with its new product pipeline and clinical development strategy

AEterna Laboratories Inc., a biopharmaceutical company focused on the development of novel therapeutic treatments in oncology and endocrinology recently acquired the new German based biopharmaceutical company, Zentaris AG. Following this acquisition// the new entity has in the pipeline six clinical stage products and two preclinical stage products, in oncology and one product already approved and...

Physicians Lack Clinical Guidelines For Treating Elderly With Multiple Illnesses

According to an article in JAMA, clinicians lack guidelines for treating the elderly with many illnesses. The aging of the population and the increasing prevalence of chronic diseases pose challenges to the development and application of clinical practice guidelines (CPGs Clinical practice guidelines are based on clinical evidence // and expert consensus to help decision making about...

The Growing Rise In Clinical Research Could Lead To A Compromise In Quality Of Research And Ethics

Clinical research is on the rise in India, hence experts say they are concerned that the unchecked boom may result in some of the newer organizations compromising on quality and ethical standards while conducting drug trials. // The president of the Indian Society of Clinical Research (ISCR), Dr. Shoibal Mukherjee has recently said that a newly created platform for dialogue and discus...

Clinical Comparisons Between ADHD Drugs Are Less

Research has shown that there are few clinical comparisons available between the drugs for ADHD. As a result, parents seeking the best individual drug for their children with attention deficit hyperactivity disorder // have little hard evidence to help make that choice. There are few head-to-head clinical comparisons of many ADHD medications, despite the relatively large variety of dru...

Outsourcing clinical trials to India

Clinical research in India costs has become very easy and cheap compared to other countries, which has lead to an increased outsourcing of clinical research to India. Outsourcing in the field of IT can be taken as a boom to the economics and development of India, but Outsourcing in // clinical trials is a great havoc to India, as humans are becoming a source of experimental animals a...

Erectile dysfunction: an early warning sign of clinically silent coronary artery disease?

Erectile dysfunction (ED) is the inability of a man to achieve or maintain an erection sufficient for his sexual needs or the needs of his partner. Most men experience this at some point in their lives//, usually by age 40, and are not psychologically affected by it. Some men, however, experience chronic, complete ED (impotence), and often leads to diminished self-esteem. According to a...

India to maintain Public domain Registry database of clinical trials conducted in India.

India to set up a registry database which will contain all datas and research results of all clinical trials which would be available in a public domain which will provide transparent results and information for patients.// The detail of the new registry database was announced by Drug Controller General of India Ashwani Kumar. He announced the details of the registry during a two day work...

A Novel System For Clinical Banking Of Umbilical Cord Blood

Researchers from Italy have designed a closed circuit, where Umbilical cord blood (UCB) collection and RBC depletion are performed, in order to reduce the contamination risk and to speed the nucleated cell separation//. Their findings appear in the journal Blood Cells, Molecules, and Diseases (available online 19 August 2005)Umbilical cord blood is a source of hematopoietic progenitor...

Clinical Renal Trails Do Not Have Sufficient Women Participants

New findings that are being presented during the American Society of Nephrology’s 38th Annual Meeting and Scientific Exposition in Philadelphia, Pennsylvania, say that women are not being adequately represented during medical trials // more specifically renal trials. Through analyses of the recently conducted renal trials showed this shortcoming. It is theorized that this may be the r...

Diagnosis of Alzheimer's years before clinical signs emerge

Brain researchers are developing tests that can identify the beginnings of Alzheimers years before the first clinical signs of the disease emerge. The researchers, who presented their results on 14 // November at the annual meeting of the Society for Neuroscience in Washington DC, say the tests allowed them to single out people who went on to develop the condition. If those results ar...

Clinical Trials of New Drug Febuxostat Show Promise in Gout Treatment

A new drug called febuxostat has been found to reduce plasma levels of uric acid more effectively in Gout than the currently used drug allopurinol. If the results of the clinical trial are successful//, then it would mean the end of a 40 year search for successful treatment of Gout. Gout is characterized by accumulation and deposition of needle shaped uric acid crystals in the joints, t...

Clinical Trials Of New Anti-Cancer Drug To Be Initiated In New Zealand

A novel anti-cancer drug claimed to attack the human cancer cells in a unique way will be distributed to patients for the first time in New Zealand. The clinical trial would be held at New Zealand's Waikato Hospital, according // to health reports released on Wednesday. Auckland University cancer researcher Professor Bill Wilson described PR-104 as a "unique anti-cancer drug that is conv...

Green Tea Consumption Found To Improve Clinical Outcome In Cancer Patients

Studies conducted on the health effects of tea and alcohol has established that the former might offer protection against leukemia while the latter can increase the chances of committing a crime.// Researchers from the Mayo clinic analyzed the effects of green tea, which is claimed to have numerous health benefits and found that three out of four adult leukemia patients who drank the be...

Cancer Clinical Research in India

India would be the focus for conducting clinical trials of new drugs developed and would make India a Hub for clinical trials as it has the largest potential of patients and diseases. Pharmaceutical companies say that by 2010 // International pharmaceutical companies would invest more than $ 1.5 billion in clinical trials in India. The Indian Science and Technology, Indian Council for Medical Res...

New Generation Clinical Trials Could Save Time And Money, Improve Patient Care

In this era of personalized medicine, one should reevaluate new medicines and treatments for cancer, says Prof. Donald Berry//, Ph.D., Dr. Berry, professor and chair of the Department of Biostatistics and Applied Mathematics at The University of Texas M. D. Anderson Cancer Center, sees a need to rethink how clinical trials are designed and conducted in the U.S. He thinks the current 50...

Clinical Impact of Activity and Abdominal Pressure on Pelvic Floor Dysfunction Need to Be Further Analyzed

Pelvic floor disorders involve a weakening of the muscles or ligaments that support the uterus, bladder, and rectum. Following surgery for pelvic-floor disorders many of the activities are restricted. //In mild cases, the organs protrude into the vagina, whereas in severe cases, they may actually protrude outside the body. Treatment involves special Kegel exercises for mild cases and...

Mayo Clinic and Indian Health Service Form Clinical Practice Collaboration

Mayo Clinic and the Department of Health and Human Services, on behalf of the Indian Health Service (IHS), will sign a Memorandum of Understanding pledging to collaborate in seeking ways to reduce the burden //of cancer and other diseases in American Indian and Alaska Native communities. The public signing will incorporate several American Indian ceremonial elements, including drummers...

Tamiflu to be examined on clinical efficacy for WHO

Roche’s flu drug Tamiflu, for bird flu, has to be examined for effectiveness in the fight against bird flu in humans. This has been called on by World Health Organization. // WHO, in a statement from Geneva, said that no clinical evidence of the anti-viral drug's efficacy against the deadly H5N1 virus is there. Therefore urgent studies need to be undertaken. Still, WHO also...

Vitamin D In Pole Position At Clinical Endocrinologists Meet

The American Association of Clinical Endocrinologists (AACE) Fifteenth Annual Meeting and Clinical Congress to be held at the Hyatt Regency Chicago between April 26-30 will discuss important benefits //of vitamin D and the problems associated with vitamin D deficiency. Vitamin D has been in the new recently and everything from preventing cancer to heart disease has been attributed to...

Image-Guided Biopsy Can Alter Clinical Decisions In Kidney Patients

Researchers from the University of Michigan say that percutaneous image-guided biopsy is of a great help in kidney disease and can help significantly in accurately// diagnosing and predicting clinical outcomes. The researchers arrived at these conclusions after reviewing reviewed 153 kidney biopsies in 126 patients. They found that the biopsy results altered the decisions in 60 percent of the pat...

Results of Clinical Trials Vary According to Source of Funding

It has been found that cardiovascular clinical trials published between 2000 and 2005 varied in their results depending on whether they were funded by for-profit //organizations or by not-for-profit organizations.These were the finding of a study in the May 17 issue of JAMA. Surveys of randomized trials published between 1990 and 2000 raised awareness in the medical community that tri...

Clinical Trials Involving Humans Should Be Registered: WHO

In an effort to respond to growing public demand for transparency in clinical trials involving humans, the UN health agency// has asked research institutions and firms to register all such studies and include details like source of funding, material support and sponsors. 'Registration of all clinical trials and full disclosure of key information at the time of registration are fundame...

India Set To Become Hub For Clinical Trials

India is fast emerging as an attractive destination for conducting global clinical trials due to availability of vast pool of patients and also well trained medical professionals and sophisticated technological infrastructure. // The clinical research outsourcing market in India was valued at Rs 3.1 billion in 2005 and is expected to grow to Rs 13.2 billion by 2010. Most of the US and...

India Not A Guinea Pig For Clinical Trials: Ramadoss

Asserting India is "guarded" on issues related to clinical trials, Union Minister for Health and Family Welfare Anbumani Ramadoss has denied that the country has 'opened out as a guinea pig'//. 'If you do clinical trials in India you have to be transparent. We are very, very guarded. We will not allow our population to suffer,' Ramadoss told reporters at the Indian Embassy here. <...

GE Healthcare to Conduct Clinical Trials in India

GE Healthcare, a division of the $150-billion General Electric Company, has entered into a strategic alliance with Manipal Health Systems (MHS) to conduct clinical studies //of its diagnostic products in India. The trials will be conducted at the Bangalore-based Manipal Hospital, where GE Healthcare has set up the world's first integrated development centre (IDC) with its equipment bou...

Clinical-trials Show Increased Therapeutic Activity of Pycnogenol than Daflon

A new research has found that Pycnogenol? is more effective than Daflon?, a combined form of diosmin and hesperidin commonly used to treat chronic venous insufficiency// (CVI). According to the journal of Clinical and Applied Thrombosis/Hematosis, the supplementation of Pycnogenol? shows increased symptom reduction in the patients suffering from Chronic venous insufficiency. It is an...

Lupin Gets DCGI Nod For Phase II Clinical Trials On Desoside-P

Pharma company Lupin Ltd today said it has received approval from the Drugs Controller General (India) (DCGI) to conduct Phase II clinical trials for the molecule LL-42 18 (Desoside-P).// The company received permission to continue Phase II clinical trials on the Psoriasis pure compound, LL-42 18, after DCGI found the clinical Phase I data of the molecule to be satisfactory....

Cadila to Commence Phase I Clinical Trials On ZYH2

Cadila Healthcare Ltd today said it has received approval from Drug Controller General of India (DCGI) to conduct Phase I clinical trials on its New Molecular Entity// (NME) - ZYH2, used for treating diabetes. In pre-clinical studies on 'ZY H2' displayed that it has the potential to improve insulin resistance and lower blood glucose in diabetic conditions without causing hypoglycemia,...

Violence at Work Significantly Boosts Clinical Depression Risk

Employees subjected to real or threatened violence at work run a major risk of becoming clinically depressed, indicates research in the Journal of Epidemiology// and Community Health. The magnitude of the risk was in direct proportion to the amount of workplace violence experienced, the study shows. The findings are based on the occupations of more than 14,000 hospital p...

Clinical Trial For Cancer Vaccine

A clinical trial for a vaccine that could be an answer to preventing many forms of cancer relapse is likely to get underway this year. //Oxford Biomedica, a biotech company from Oxford University will be conducting the trials for the vaccine TroVax. Scientists at the Paterson Institute for Cancer Research in Manchester were the ones who initially touted the idea for this vaccine. They...

CDC To Conduct Pre-clinical Trails Of BioDiem's Intranasal Bird Flu Vaccine

The US-based Center for Disease Control and Prevention (CDC) has signed a two-year cooperative deal with Melbourne-based pharmaceutical development company//, BioDiem, to conduct pre-clinical trials on a candidate vaccine developed by BioDiem and its Dutch partner Akzo Nobels Nobilon. The CDC in Atlanta, the US government's leading site for research into the prevention and monitoring o...

Coversyl Demonstrates Clinical Benefits in Elderly Patients

Coversyl(R) in PEPCHF Trial, has been the first agent to demonstrate clinical benefits in elderly heart failure patients with diastolic dysfunction.// The drug appears to provide a number of clinical benefits toelderly people with chronic heart failure according to the results of a study of ACE inhibitor Coversyl(R) that was presented at the World Congress of Cardiology today. The s...

Pre-Clinical Study Suggests How Steroid Can Reverse Post-Traumatic Stress

Researchers at UT Southwestern Medical Center, working with mice, have shown how the body’s own natural stress hormone can help lastingly decrease the fearful response associated with reliving a traumatic memory.// Days after experiencing a traumatic event – a mild electrical shock – mice in the study still showed a fearful response when re-exposed to the place where it happened, a con...

Arimidex-Herceptin Combo Therapy For Breast Cancer-Clinical Trial Findings

News of interest for post menopausal women with breast cancer positive to hormone receptors and HER2 -addition of both Herceptin (trastuzumab) from Roche// and Arimidex (anastrozole) from AstraZeneca to their treatment improves the length of progression free time by 4.8 months. A Phase III clinical trial sponsored by Roche showed that Arimidex alone inhibited the progression by just 2....

Gene Tests to Identify Ovarian Cancer Have Little Clinical Value

Many genomic tests that are currently used to diagnose and guide treatment of ovarian cancer are not shown to decrease the number of women who die from the disease or improve their quality of life, //according to a new evidence report supported by a partnership of the Agency for Healthcare Research and Quality, the Centers for Disease Control and Prevention’s Division of Cancer Prevention and Con...

Clinical Trial Shows Liquid Eggs Enriched with Omega-3 Deliver Heart Health Benefits

Eating omega-3 enriched liquid eggs can improve blood triglyceride levels, boost heart health, and help families reach their daily recommended intake of omega-3, according// to the results of a clinical trial published this month in Food Research International. The trial – conducted by University of Guelph researchers Emily L. Rose and Bruce J. Holub – showed that a breakfast consisti...

Adhering to Clinical Guidelines Decreases Blood Clots in the Elderly

A multifaceted intervention designed to increase adherence with clinical guidelines for preventing deep-vein blood clots may decrease the rate of such blood clots among// elderly patients, according to a report in the October 23 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. Older adults and those in the hospital are at increased risk for deep vein thrombos...