AML in Medical News

EpiCept Releases New Data Demonstrating Prolonged Five-Year Leukemia-Free Survival for AML Patients Treated with Ceplene(TM) + IL-2

First Drug Regimen Shown to Prevent AML Relapse TARRYTOWN, N.Y., Dec. 10 /PRNewswire-FirstCall/ -- EpiCept Corporation (Nasdaq and OMX Nordic Exchange: EPCT) today released new clinical data that demonstrate a durable improvement in leukemia-free survival (LFS) over five years amon...

Low micro-RNA level linked to high gene activity in AML

COLUMBUS, Ohio A new study suggests that a type of acute leukemia may occur in part because abnormally low levels of one small molecule result in the over-activity of genes important to the disease. The research involved patients with acute myeloid leukemia (AML) and a gene mutation called N...

High-Dosage of Epirubicin and Cyclophosphamide may cause AML

Adjuvant chemotherapy with epirubicin and cyclophosphamide for early breast cancer// patients increased the risk of Acute myeloid leukemia or Myelodysplastic syndrome. Recent study published in Journal of clinical oncology reports that early breast cancer patients undergoing chemotherapy with ...

Genome of Leukemia Patient Reveals Common Mutations

...gest they play a role in the development and progression of cancer, they said. The researchers sequenced the genome of a man who was diagnosed with aml at age 38 and had been in remission for more than three years. He was selected for genome sequencing because he had typical clinical and molecular fea...

Comprehensive Look at Rare Leukemia Finds Relatively Few Genetic Changes Launch Disease

...es the need for more detailed look at the complete aml genome MEMPHIS, Tenn., July 27 /PRNewswire...data raise the possibility that the development of aml may require fewer genetic alterations than other c...rs have lots of alterations," he explained. aml accounts for about 20 percent of childhood leukemi...

Toronto researcher's discovery points to a new treatment avenue for acute myeloid leukemia

...odies targeting cancer stem cells significantly reduced the growth of human aml cells that had been transplanted into immune-deficient mice, a laboratory m...Ontario lead the fight against this terrible disease." The research on aml builds on the discovery by Dr. Dick that there is a population of cells wit...

New Drug Could Work Against Leukemia

... Researchers see promise for treatment of aml and other cancers THURSDAY, July 2 (HealthDay News) -- A new targeted therapy shows promise in treating acute myeloid leukemia, a highly t...

Study IDs benefit of donor SCT for adults with acute myeloid leukemia

...w guidelines for treatment of the disease. For all aml patients other than the minority with "good-risk" ... the authors state. The customary treatment for aml involves an initial "induction" phase that uses a ...rgely been based on a chromosome analysis of their aml cells. For...

Donor Stem-Cell Transplant Best For Acute Myeloid Leukemia

...m cells appear to offer the best shot at survival, a new analysis shows. aml is the most common form of acute leukemia, striking about 12,000 adults a y...sk. The researchers found that patients with poor- and intermediate-risk aml who received allogeneic stem cell transplants -- the donor stem cells -- in...

Vion Pharmaceuticals to Present Data on Onrigin(TM)at the ASCO(R) Annual Meeting

...antation-Specific Comorbidity Index (HCT-CI) in Elderly de novo Poor Risk aml Patients Treated with Laromustine" will be presented at the Orange County C... with Infusional Ara-C in Elderly Patients Over Age 60 with Newly Diagnosed aml or High-Grade MDS" will be presented at the Orange County Convention Center...

Sunesis Announces New Data on Voreloxin for Acute Myeloid Leukemia and Ovarian Cancer Will Be Presented at ASCO

...s Phase 1b/2 clinical trial in relapsed/refractory aml will be presented during the American Society of C...ytarabine in relapsed or refractory aml patients." Location: Level 2, West ...he REVEAL-1 trial) in previously untreated elderly aml patients and in a Phase 1b/2 clinical trial combin...

Celator(R) Pharmaceuticals to Present at 2009 BIO International Convention

... the company's progress with two ongoing Phase 2 clinical trials of CPX-351 in newly diagnosed acute myeloid leukemia (AML) patients and first-relapse aml patients. The presentation will be held on Wednesday, May 20, 2009 at 3:40pm EDT in Room 311 of the Georgia World Congress Center. About Celato...

Sunesis Reports Financial Results for the First Quarter 2009

...combination with cytarabine in relapsed/refractory aml and single-agent voreloxin in women with platinum-...voreloxin and cytarabine in relapsed or refractory aml patients." Location: Level 2, West Hall F1 ...he REVEAL-1 trial) in previously untreated elderly aml patients and in a Phase 1b/2 clinical trial combin...

Researchers find drug that inhibits acute leukemia cell growth

...rned on by a nerve growth factor (NGF) ligand, the aml cells start to rapidly grow." Ghisoli and rese...ns off NGF, which led to a 50 percent reduction of aml cells in mice with no immune system. When studied ...They also found AZ23 to be more effective in human aml cell lines that expressed higher levels of TRKA. T...

Sunesis Pharmaceuticals Announces Up To $43.5 Million Financing

...at has the potential to support voreloxin through late stage development in aml and to the anticipated filing of an NDA. In the midst of a difficult financ...the proceeds thereof to support voreloxin through late stage development in aml and to the anticipated filing of an NDA. Words such as "potential," "expec...

Celator(R) Pharmaceuticals to Present at Future Leaders in the Biotech Industry Conference

... the company's progress with two ongoing Phase 2 clinical trials of CPX-351 in newly diagnosed acute myeloid leukemia (AML) patients and first-relapse aml patients. The presentation will take place on Thursday, April 2, 2009 at 4:00PM EDT in Room 411 of the Millennium Broadway Hotel & Conference Cent...

Celator(R) Pharmaceuticals Enrolls First Patient in Its Phase 2 Study of CPX-351 in Acute Myeloid Leukemia in First Relapse

... 60 who have pathological confirmation of relapsed aml after an initial complete response to prior therap...ighted that our second Phase 2 study of CPX-351 in aml is underway and appreciate the support of LLS and ...ood & Drug Administration for the treatment of aml and is also currently being studied in a Phase 2 r...

Video: The MDS Foundation Says Published Data Confirms VIDAZA(R) Significantly Extends Survival in Patients with the Malignant Condition MDS

...ansfusion for at least 14 weeks." The published data refer specifically to categories of MDS known as intermediate-2 or high-risk MDS, as well as aml with 20 to 30 percent bone marrow blasts. VIDAZA has been available in the United States for four years and it was recently approved in Europe. ...

Leukemia stem cells have more in common with embryonic stem cells than adult stem cells

...ior study author Dr. Michael L. Cleary, from the Department of Pathology at Stanford University. Dr. Cleary and colleagues used a mouse model of human aml to investigate the genes that maintain LSC frequencies and leukemia cell hierarchies. The researchers found that LSCs are maintained in a self-rene...

Biopure Submits IND Application for Proposed Clinical Trial in Patients with Acute Myeloid Leukemia

...pany met with the FDA in July 2008 to discuss an acceptable patient population for a new clinical trial. At that time the company proposed a trial in aml patients who will not accept blood transfusions and consequently are unable to undergo potentially life-saving induction chemotherapy because of the p...

Celator(R) Pharmaceuticals Presents Phase 1 Results With CPX-351 in Patients With Advanced Leukemia at the American Society of Hematology Meeting

...mission without full platelet recovery) of 44 with aml and 1 patient of 3 with acute lymphocytic leukemia...(ALL) following treatment with CPX-351. Of the 10 aml CRs, 7 occurred at the two highest dose levels, al...ne treatment. "The standard of care for aml hasn't changed in 30 years and there is an urgent ...

Older age doesn't affect survival after bone marrow transplant

...py regimen, according to an intensive analysis of every such transplant for aml or MDS conducted in North America between 1995-2005, said senior researcher...t data. The retrospective study of 551 transplants for MDS and 565 for aml showed that age had no statistically significant impact on transplant-relat...

Research on the effects of stem cell source and patient age on transplantation outcomes

...a-zoster virus, while all other patients were still in remission. Non-Myeloablative Hematopoietic Stem Cell Transplantation in Older Patients With aml and MDS: Results From the Center for International Blood and Marrow Transplant Research (CIBMTR) [Abstract #346] Sergio Giralt, MD, The University o...

Higher Chemo Drug Dose Prolongs Lives of Leukemia Patients

... the U.S. National Cancer Institute (NCI) show. aml is a cancer of the blood and bone marrow. This stu...people in the United States will be diagnosed with aml in 2008. Most cases occur in adults, and about hal... in those younger than 60. Only about one-third of aml patients survive the disease, and the odds of surv...

First-Ever Mapping of Cancer Patient's Genome

... be the last one that occurred, possibly the tipping point that caused the cancer. The complexity of the genetic changes linked to this one case of aml should not be viewed as discouraging, Gibbs said. "I don't think there is reason for pessimism," he said. "It is complicated, but that doesn't mean we...

Gene mutation improves leukemia drug's effect

... Dr. Clara D. Bloomfield, an internationally known aml specialist at the Ohio State University Comprehens...or RAS mutations might help doctors identify which aml patients should receive high-dose cytarabine as th...erapy. "This appears to be the first example in aml of a mutation in an oncogene that favorably modifi...

Microenvironment a main driver of aggressive multi-lineage leukemia disease type

...g rearranged to send instructions to create either aml or ALL. This process can start before birth, and w...LL translocations are associated with 7 percent of aml cases and 10 percent of ALL cases, they are found ...gh MLL-AF9 fusion is most commonly associated with aml in people, it is occasionally found in ALL as well...

Vion Pharmaceuticals Announces Presentation of Data from Phase III Trial of Cloretazine(R) (VNP40101M) and Cytarabine in Relapsed Acute Myelogenous Leukemia at the ASCO(R) Annual Meeting

...tion merits further evaluation in first relapse of aml with modifications to address the observed toxicit...he opportunity to move forward in first relapse of aml with a revised protocol of this combination. Howev...as designed to accrue patients in first relapse of aml whose first complete remission (CR) was more than ...

NYP/Columbia physician-scientists present at ASCO 44th annual meeting

... conditioning or after allogenic stem cell transplantation in children with aml is safe and may prevent malignant relapse. They note that therapy may help ...pse in following allogeneic stem cell transplant in children with high-risk aml or following reduced-intensity AlloSCT in standard-risk AML. Kinesin ...

Bayer Announces Availability of Reformulated Liquid Leukine(R)

...other week during Leukine administration. Nearly all patients reported leukopenia, thrombocytopenia, and anemia. Adverse events occurring in >10% of aml patients receiving Leukine in controlled clinical trials and reported in a higher frequency than placebo were: fever, skin reactions, metabolic distur...

New Therapy Kills Human Leukemia Cells in Mice

... "These NK cells demonstrate significant cytotoxic activity against human aml and ALL cell lines and patient leukemia blasts. Most importantly, mouse models of human aml and ALL were sensitive to NK cell infusions," Zweidler-McKay said. Mor...

Researchers expand natural killer cells in cord blood to fight leukemia

...K Cells Spare Normal Cells While Attacking ALL and aml Graft-versus-host disease is a common side effec...trate significant cytotoxic activity against human aml and ALL cell lines and patient leukemia blasts. Most importantly, mouse models of human aml and ALL were sensitive to NK cell infusions," says...

Molecular change may reveal risk of leukemia relapse

...ch also shows that the microRNAs involved in these aml patients regulate genes involved in inflammation a...changes in levels of microRNAs with the outcome of aml patients who lack the chromosome abnormalities tha...mmation in the transformation of normal cells into aml cells, Marcucci notes. In the future, we may find ...

Genetic Changes May Dictate Course of Acute Myeloid Leukemia

...val rate decreases. Only 10 percent of people with aml over the age of 60 will survive two years, accordi...to Kamen. Scientists used to see eight kinds of aml under the microscope, but with advances in genetic...ny more forms of the disease. In about half of aml patients, chromosomal changes help guide doctors t...

Sunesis Pharmaceuticals Presents Nonclinical Data on SNS-595 at the Annual Meeting of the American Association for Cancer Research

...ce Mechanisms Research Supports Current Clinical Development of SNS-595 in aml and Ovarian Cancer and Potential in Additional Indications SOUTH ... no longer effective. These findings support the ongoing clinical trials in aml and ovarian cancer, and indicate that SNS-595 may also be well-suited to th...

An unexpected way to cause leukemia

...s acute myeloid leukaemia (AML), a type of leukaemia affecting one lineage of white blood cells, in mice. 10 percent of all patients suffering from aml have this mutation, but we could never be sure if it causes the disease. By precisely reproducing the human mutation in the mouse we now proved a caus...

Genzyme Delivers Strong Fourth Quarter to Conclude Outstanding Year

...ug application in the United States later this year to include an adult aml indication, following the completion of its CLASSIC II clinical trial involving older adult aml patients. The company also expects to provide additional clinical data...

St. Jude Finds Risk Factors for Severe RSV Infection in Immunocompromised Children

...espiratory track infection, due to RSV. The frequency of this type of infection was highest (42 percent) in patients who had undergone HSCT or who had aml or SCIDS. Five patients (31 percent) with LRTI died, an overall mortality rate of 8.6 percent. All deaths occurred in lower respiratory track infectio...

St. Jude finds risk factors for severe RSV infection in immunocompromised children

...espiratory track infection, due to RSV. The frequency of this type of infection was highest (42 percent) in patients who had undergone HSCT or who had aml or SCIDS. Five patients (31 percent) with LRTI died, an overall mortality rate of 8.6 percent. All deaths occurred in lower respiratory track infectio...

New IDSA Clinical Practice Guidelines Recommend NOXAFIL(R) (Posaconazole) for Antifungal Prophylaxis in Certain High-Risk Patients

...ophylaxis of IFIs in the following adult patients at high risk of developing these infections: patients receiving remission-induction chemotherapy for aml or MDS expected to result in prolonged neutropenia and HSCT recipients who are undergoing high-dose immunosuppressive therapy for GVHD. NOXAFIL also w...