Coming Soon: Lung-Cancer Spray?

...-terminal modulator protein (CTMP), which inhibits akt signaling. Previous research has shown 90 percent of non-small cell lung carcinomas involve the akt signaling pathway, according to the study. Res...lentivirus-mediated CTMP overexpression suppressed akt activity and inhibited tumor progression," Cho wro...

Vaporized viral vector shows promise in anti-cancer gene therapy

...t interest. Dr. Cho and colleagues targeted the akt signaling pathway, which has been shown to be an i...cinomas were associated with the activation of the akt signaling pathway. They chose a lentiviral vector,...the lentiviral vector with a negative regulator of akt signaling, carboxyl-terminal modulator protein (CT...

U-M researchers link pathway to breast cancer stem cells

...re of cancer will require killing these cancer stem cells. In the current study, researchers looked at a drug called perifosine, which inhibits the akt pathway. Tumors in mice were treated with perifosine or docetaxel, a standard chemotherapy drug. The docetaxel alone showed no effect on the number of...

Cellular target may prove useful in treating deadly brain tumors

...rs also showed that blocking NK1R activity reduced akt activity, which then led to greater cell death. ...h levels of phosphorylated or chemically altered akt did not respond to treatment, Kwatra said. "Th...the importance of discovering the origin of active akt in glioblastomas," he said. "We propose that the e...

Drugs From Vegetables May Target Melanoma Tumors

...e. "Selenium deficiency is common in cancer patients, including those diagnosed with metastatic melanoma. Besides, selenium is known to destabilize akt proteins in prostate cancer cells," Robertson said. When the researchers tested the combination drug on different human melanoma cell lines, they f...

Vegetable-based drug could inhibit melanoma

...c melanoma," explained Robertson, whose findings appear in the March edition of Clinical Cancer Research . "Besides, selenium is known to destabilize akt proteins in prostate cancer cells." To study the effectiveness of the new drug -- isoselenocyanate -- researchers injected mice with 10 million can...

An Achilles heel in cancer cells

...ublished in the Dec. 9 issue of Cancer Cell . akt is a signaling protein, called a kinase, that is h...companies have been trying to find ways to inhibit akt to improve cancer therapy, he said, but most candi...survival," Hay said. "Tumor cells with hyperactive akt are not only resistant to the external stresses th...

Keryx Biopharmaceuticals' KRX-0401 (Perifosine) Data Selected for Oral Presentation at the 50th Annual Meeting of the American Society of Hematology

...inal Results of a Phase II Trial of the Novel Oral akt Inhibitor Perifosine in Relapsed and/or Refractor...TITLE: Phenotypic and Functional Effects of Novel akt Inhibitor Perifosine on Immune System Session N...st-in-class, oral anti-cancer agent that modulates akt and a number of other key signal transduction path...

Arno Therapeutics Appoints William F. Hamilton to Board of Directors

...e PDK1 inhibitor that blocks the PI3K/Akt pathway undergoing IND-enabling studies. AR-42 is an orally available, targeted inhibitor of the Pan-DAC and akt pathways also undergoing IND-enabling studies. Arno is actively pursuing additional compounds to expand its portfolio. For more information on Arno pl...

How do Lactobacilli treat Helicobacter pylori-related diseases?

...optosis of intestinal epithelia treated with tumor necrosis factor α, interferon-γ or IL-1α and promoted cell growth through activating akt and blocking p38 mitogen-activated protein kinase and stress-activated protein kinase/c-Jun amino-terminal kinase signaling. So LBG-S in this experime...

Monogram Announces 2008 Second Quarter Financial Results

... of: -- heterodimers of HER1 and HER2 (HER1:HER2) -- heterodimers of HER2 and HER3 (HER2:HER3) -- the HER3:PI3K complex, which is related to the akt signaling pathway for tumor cell survival -- the truncated form of HER2, known as p95. These activated protein complexes are believed to mediate r...

Novel enzyme inhibitor paves way for new cancer drug

...ne of those three proteins, and sometimes others, are mutated in cancer, Marmorstein says. Studies with human melanoma cells showed that E5 blocked akt activity, thereby inhibiting the growth of cells. Further studies in 3D cultures of melanoma cells showed the agent also prevented melanoma cell invas...

A potential sugar fix for tumors

... when deprived of growth factors. To study how akt might affect these processes, Coloff and colleagues introduced a cancer-causing form of akt called myrAkt, into cells that depend on growth factor to survive. The mutant form of akt allowed cells to maintain glucose usage and surviv...

Calorie restriction inhibits, obesity fuels development of epithelial cancers

...signaling in downstream molecular pathways such as akt and mTOR." "Calorie restriction, which we refer...es not affect the rate of malignant conversion. akt and mTOR pathways are known to be important for sk...pment in this model system. In addition, increased akt and mTOR signaling are linked to the growth, proli...

Calorie restriction limits Calorie restriction inhibits, obesity fuels development of epithelial can

...signaling in downstream molecular pathways such as akt and mTOR." "Calorie restriction, which we refer...es not affect the rate of malignant conversion. akt and mTOR pathways are known to be important for sk...pment in this model system. In addition, increased akt and mTOR signaling are linked to the growth, proli...

Calorie restriction limits and obesity fuels development of epithelial cancers

...signaling in downstream molecular pathways such as akt and mTOR." "Calorie restriction, which we refer...es not affect the rate of malignant conversion. akt and mTOR pathways are known to be important for sk...pment in this model system. In addition, increased akt and mTOR signaling are linked to the growth, proli...

Cancer-related protein may play key role in Alzheimer's disease

..., FL (Feb. 27, 2008) -- The cancer-related protein akt may profoundly influence the fate of the tau prote...u proteins can poison nerve cells in the brain. akt is known to increase cancer cell survival capabili...time a new function for the cancer-related protein akt one that may help promote Alzheimers disease path...

Inverted DNA turns quiet developmental gene into a potent driver of t-cell lymphoma

...ules that could bind and inhibit DLX5 could provide a more useful drug for therapeutic development than could molecules that inactivate AKT2. The akt family of proteins is crucial to survival in both cancerous and non-cancerous cells, so AKT2 is a potentially risky target for drug development since ...

Oncoproteins double-team and destroy vital tumor-suppressor

...uppressor had an average volume of more than 600 cubic millimeters. ERK, akt and IKK are three separate cancer-causing kinases - proteins that phosphory...percent of human cancers." "Pharmaceutical companies work to target ERK, akt and IKK separately," Hung notes. "But activating their forkhead target woul...

Anti-parasite drug may provide new way to attack HIV

... to prevent cell suicide and extend cell lifespan. akt has been implicated in cancer, where cells live to...deleted on chromosome 10) normally interferes with akt signaling, and thus, limits cell lifespan. That is...hase, we will conduct studies seeking to show that akt inhibition ends the survival of HIV-infected macro...

Keryx Biopharmaceuticals, Inc. Announces Poster Presentations Highlighting Observed Clinical Activity of KRX-0401 (Perifosine) to be Presented at the Upcoming American Society of Hematology Meeting in Atlanta, Georgia

...ber of different signal transduction pathways including Akt, MAPK, and JNK. akt isoforms have been found to be overexpressed in renal, breast, prostate, an...her features associated with poor prognosis. The effects of perifosine on akt are of particular interest because of 1) the importance of this pathway in ...

Early Results of Phase 2 Trial of Perifosine (KRX-0401) for the Treatment of Recurrent Malignant Gliomas Presented at the 12th Annual Scientific Meeting of Society for Neuro-Oncology

...ber of different signal transduction pathways including Akt, MAPK, and JNK. akt isoforms have been found to be overexpressed in renal, breast, prostate, an...ther features associated with poor prognosis. The effects of perifosine on akt are of particular interest because of 1) the importance of this pathway in ...

VioQuest Pharmaceuticals Announces Third Quarter and Nine Months 2007 Results

...evaluable for response. At the 35 mg/m2 dose, akt modulation was observed in two out of three patients evaluable, and there was a reduction of akt immunohistochemistry or IHC scores from +2 to ... development: VQD-002 which inhibits activation of akt that is seen at abnormally high levels in breast, ...

JCI table of contents: Oct. 25, 2007

...c hypertrophy. In the study, atrogin-1 was shown to antagonize Akt-mediated cardiac hypertrophy. Atrogin-1 was found not to inhibit the function of akt directly but to work by enhancing the activity of proteins known as Forkhead proteins, which repress Akt-dependent cardiac hypertrophy. Further analys...

Clinical studies in the pipeline: the therapies of tomorrow in trials today

... OSI-906 blocks IGF-1R activation of the key cancer cell signaling pathways akt and MAP kinase, researchers say. In laboratory studies of 28 human tumor ce...er drug development. IGF-1 is one of most potent natural activators of the akt and MAPK signaling pathways which promote cell growth and cell survival. No...

VioQuest to Present Data on Oncology Compounds VQD-002 and Lenocta(TM) at AACR-NCI-EORTC International Meeting

...acodynamic study of the inhibitor of activation of akt (p-Akt), triciribine phosphate monohydrate (TCN-PM...ials. For VQD-002, which we believe is the leading akt inhibitor in clinical development, we have documented akt modulation in both the leukemia and solid tumor tr...

Jefferson researchers uncover new evidence of prolactin's possible role in breast cancer

...ion was experimentally disrupted in breast cancer cells, prolactin signaling through Stat3 and ERK was completely blocked. Signaling through Stat5 and akt was reduced but still present. Until now, prolactin was believed to signal only through Jak2 to mediate its effects, says Lynn Neilson, Ph.D., a ...

Genetic Mutation That Makes Common Cancers Resistant to Drugs Identified

...n of the gene AKT1 in breast, colorectal, and ovarian cancers. The akt pathway is among the most commonly activated cellular pathways in human can... the information gained to stratify patients going into clinical trials for akt inhibitors," he added. The researchers say that their findings may ...

New Oncogene for Brain Cancer

... been shown to develop astrocytomas. Activation of akt fuels cell growth and survival. None of the three ...ered alone. The researchers tried a combination of akt and IGFBP2 and no tumor formed, suggesting that th...liomas. The combination also activated the akt pathway, which PDGFB does not induce by itself. Co...

“Bridge” Protein Spurs Deadliest Stages of Breast Cancr

...cancer cell growth. They studied pathways known as akt and Erk, well-known parts of the Neu oncogene path... mice lacking Gab-2 and found that while levels of akt signals were unaffected by Gab-2’s absence, Erk si...were significantly reduced. “It appears that akt and Erk pathways have distinctive roles in mammary...

Scientists Identify Gene That May Indicate Predisposition To Schizophrenia

... signal pathway. The AKT-mediated signal pathway has been shown to be impaired in patients with schizophrenia, and antipsychotic medication may induce akt activation, to compensate for the impairment. Additionally, activation of the inflammatory response has been observed in those with schizophrenia and ...

Systemic Pre-Surgical Treatment Can Prolong Survival Of Kidney Cancer Patients

...ated patients. The one exception was a slight increase in the expression of akt in the treated group, which meant that blocking the VEGF signaling pathway with bevacizumab might have resulted in feedback to the akt pathway, which is known to be involved in cell signaling. 'At the momen...

Genes Identified To Protect Heart Muscles

...gene, Akt. The protective effect of HO-1 was dependent on the activation of akt and vice-versa, indicating that these two protective genes work co-dependen...rom H202-induced Apoptosis through Functional Codependence between HO-1 and akt will appear in the September issue of Arteriosclerosis, Thrombosis and Vasc...

Protein’s role in regulating cell death sets direction for Alzheimer’s, Parkinson’s and cancer reseach

...ll death in response to other challenges, including some chemotherapeutic drugs. This study showed that calpain contributes to the activation of akt and JNK, two key players in the signaling pathways that control cellular responses to different death stimuli. These discoveries suggest that calpain ...

Turmeric Found To Slow Down Melanoma Growth

...itor of apoptosis, IKK. However, it did not suppress two other signaling pathways associated with melanomas and tumor proliferation, B-Raf/MEK/ERK and akt pathways. Based on the studies, we conclude the curcumin is a potent suppressor of cell viability and inducer of apoptosis in melanoma cell lines...

New medicine for ovarian cancer

...l activities, cell divisions and how the cell will respond to chemotherapy. akt pathway remains highly active for a lot of different types of cancer, and y.... That was one of the reasons that the scientists did not target the enzyme akt but a new enzyme. The researchers of the Fox Chase Cancer Center in Ph...

New target for antidiabetic agents identified

...atic glucose output when glucose is available from food. //Mice lacking the akt gene demonstrate insulin resistance similar to that seen in humans with typ...s. Dr. Montminy's team found that TRB3 acts as a negative modulator of akt and that its expression is increased under fasting conditions. By binding t...