rat in Biological Technology

Transposagen Creates a Rat Model of the Human Immune System

LEXINGTON, Ky. , Aug. 6 /PRNewswire/ -- Transposagen Biopharmaceuticals, Inc. based in Lexington, KY announced today that its scientists and collaborators from the Medical College of Wisconsin have created and characterized the world's first rat model of severe combined immunodefi...

Technique for Creating Authentic Rat Embryonic Stem Cells Published in Cell

CAMBRIDGE, England, December 29 /PRNewswire-FirstCall/ -- - Technology Licensed Exclusively by Stem Cell Sciences - ("Stem Cell Sciences", "SCS", "the Company") Stem Cell Sciences plc (AIM:STEM, ASX:STC) is pleased to announce that pioneering research describing a techniqu...

Samaritan Partners 'Forgetful' Rat Model to Taconic to Commercialize

The Samaritan Alzheimer's Rat Model - Mimics Human Alzheimer's - Speeds 'Race for Time' to Find Cure - Saves Valuable Research Money LAS VEGAS, Oct. 1 /PRNewswire-FirstCall/ -- Samaritan Pharmaceuticals (OTC Bulletin Bo...

ExonHit Launches Rat Genome SpliceArray(TM) Products to Expand High Resolution Gene Expression Profiling for use in Disease Modeling and Toxicogenomics

PARIS, May 6 /PRNewswire-FirstCall/ -- ExonHit Therapeutics S.A. (Alternext: ALEHT), a drug and diagnostic discovery company, announces today the availability of its new SpliceArray(TM) for use in disease modeling and toxicogenomic applications by the basic and pre-clinical research communitie...

UW-Madison rat experiment could lead to stem-cell treatment for ALS

Madison, Wis. Scientists at the University of Wisconsin-Madison have sucessfully injected stem cells into rats' spines in a way that could lead to treatments for degenerative diseases but they did not use the controversial embryonic stem cells. The researchers inserted human stem cells deriv...

Quantitation of a Dinitro Flavonoid (DNF) in Rat Plasma Using the Varian 1200L LC/MS/MS System

D. Garteiz, R. Morrow, and B. Alexander, TexMS Analytical Services, Houston, TX C. Schmidt, Varian, Inc., Walnut Creek, CA Introduction Flavonoids are compounds that make up the pigments in fruits, vegetables, and herbs. There have been reports of flavono...

A Novel Process for Gene Expression Profiling of Rat and Mouse Tissues from Formalin-Fixed Paraffin-Embedded Sections Using Microarrays

Abstract This application note describes a method for extracting and isolating total RNA from rodent tissues that have been fixed in formalin and embedded in paraffin, and the subsequent amplification of mRNA from these tissues for use in microarray experiments. We have used this...

Primary cells, rat heart muscle

Multiporator Transfection Protocol Protocol No. 4308 915.035 12/1999 ...

Primary cells, rat heart endothel

Multiporator Transfection Protocol Protocol No. 4308 915.036 12/1999 ...

An Optimal DNA Microarray Substrate for the Identification of Fetal and Somatic Liver Stem Cells of the Rat

Dr. Frank Stahl GBF Gesellschaft fr Biotechnologische Forschung mbH (Society for Biotechnological Research) Introduction DNA microarrays are a key technology in modern molecular biotec...

World Renowned Scientists Gather to Share Latest Information on Answer to Wildlife Reproductive Fertility Control

...nable food supplies to millions." The company is currently applying their revolutionary technology to the control of the Southeast Asian rice rat in order to increase rice production. It is projected that the application of SenesTech's product, ContraPest, will result in food for at least an add...

OMT announces a breakthrough in the development of a novel human antibody platform

...oclonal antibody platform. "Creating a knockout rat was the biggest challenge OMT faced", said Dr. Rol... author of the paper. "Inactivation of endogenous rat antibody expression is essential for human antibod...gamo BioSciences, Inc. to knockout a gene encoding rat immunoglobulin. The mutations in...

Heart disease: Research off the beating patch

...ased heart, the group has already shown that the patch improves left ventricular function and blood flow when implanted into damaged heart muscle in a rat model of myocardial infarction. Dr. Goldman believes that the construct developed in his lab provides a better vehicle to introduce cells into dama...

EnVivo Pharmaceuticals Announces Reversal of Cognitive Deficits in Alzheimer's Disease Transgenic Mouse Model With Gamma-Secretase Modulator

...hronic dosing with EVP-0962 reverses these deficits back to normal (wild type) levels. EVP-0962 also displays an excellent safety profile in a 14-day rat toxicology study, confirming suitability for clinical development. "We are very excited about these findings since they represent to us the f...

SenesTech Announces New Vice President of Business Development

...utheast Asia. Currently being field tested in Indonesia, ContraPest will dramatically improve rice yields in Southeast Asia by reducing the rice field rat population. "Our private investors will be very pleased with George's expertise in taking us public," stated Hale from SenesTech's world headqua...

UCF team's advanced nerve cell system could help cure diabetic neuropathy, related diseases

... really start looking at these things in a way that just wasn't possible before," says Hickman. Though the myelination work has involved embryonic rat cells, the Hickman team was also the first to culture adult motoneurons and hopes to eventually extend myelination work to those as well. Such an adva...

Carbon Design Innovations, Inc. Introduces Carbon Nanotube Probe Technology for Atomic Force Microscopy, CNT-Probes Deliver New Level of AFM Imaging Performance

...earch. "The carbon nanotube AFM probes from C|D|I reveal the most accurate surface morphology, especially for cellular samples such as rat basophilic lymphocytes cells," states Dr. G. Y. Liu, University of California, Davis. "All observations reflect upon the superior geometry ...

Assessment of safety and efficacy of human embryonic stem cell therapy

... research, which appears online ahead of print in the journal Stem Cells , shows long-term functional rescue using hESC-derived cells in both the RCS rat and Elov14 mouse, animal models of retinal degeneration and Stargardt, respectively. The cells survived transplantation for prolonged periods (>220 d...

Keryx Biopharmaceuticals Reports Positive Phase 2 Study Results of Zerenex (Ferric Citrate) for the Treatment of Hyperphosphatemia in End-Stage Renal Disease Patients

...enal Drug Products. The FDA also reviewed the final reports for the 90-day rat and 16-week canine toxicology studies. The FDA indicated that the results ... reviewed the protocols for the ongoing chronic toxicology studies (6-month rat and 42-week canine), which can be completed after the Phase 3 program has b...

ZyGEM Releases Application Note Showing its DNA Extraction Kits Rapidly Produce High Yields of Quality DNA

... using STRs or SNPs, RFLP analyses, etc. prep GEM(TM) kits are proven on a range of animal samples including blood, micro-biopsies (ear tags), meat, rat tails, fish, fish tails and insects. forensic GEM(TM) kits have been formulated for high-throughput DNA extraction from crime scene and othe...

Preclinical Data From Amgen's Oncology Pipeline to be Presented at AACR

...m - 12:00 pm) -- Involvement of the CSF-1/CSF-1R interaction in the control of angiogenesis Overview: Two different neutralizing rat anti murine CSF-1R monoclonal antibodies (mAb), M279 and AFS98 were evaluated for their effect on mouse corneal angiogenesis and corne...

Life sticks: UC San Diego bioengineer's sticky insights published in journal Science

...echanical context. The project began when he was approached by a surgeon puzzled by the results he was getting after injecting stem cells into damaged rat heart tissue in hopes of regenerating healthy heart tissue. "As a matrix biologist and a mechanical engineer I said, 'Perhaps we need to look at w...

ZyGEM Corp. and VWR International Europe BVBA Sign Agreement to Distribute Breakthrough DNA Extraction Technology in Europe

... using STRs or SNPs, RFLP analyses, etc. prep GEM(TM) kits are proven on a range of animal samples including blood, micro-biopsies (ear tags), meat, rat tails, fish, fish tails and insects. forensic GEM(TM) kits have been formulated for high-throughput DNA extraction from crime scene and othe...

GeneCopoeia Introduces Genome-Wide MicroRNA (miRNA) Functional Analysis Tools

...all known miRNAs for human (750), mouse (450), and rat (270). These lentiviral vector based expression co...ression clones cover genome-wide human, mouse and rat genes. These expression ready constructs are made ...ete set of validated primers for human, mouse, and rat miRNAs, which allows specific and sensitive quanti...

SenesTech Scientists Attend International Workshop on Fertility in New Zealand

...to chemical fertility management in the rice field rat of Southeast Asia as it is the only non-government...), which is being developed to counteract the rice rat plague in the rice producing countries of the worl...ields in Southeast Asia by reducing the rice field rat population. Over half of the worlds 6 billion peop...

Nanogenerators produce electricity from running rodents and tapping fingers

...ut electrical signal. The research team encountered a number of obstacles related to its four-legged subjects. Wang's team first tried to outfit a rat with the power-generating jacket, but found that the creature wasn't very interested in running. At the suggestion of Wang's daughter, Melissa, t...

SenesTech, Inc. Appoints Susan Airhart to Board of Directors

...amatically improve rice yields in Southeast Asia by reducing the rice field rat population. Over half of the worlds 6 billion people rely on rice as a prim...-toxic, environmentally sound product that can dramatically reduce the rice rat population resulting in a significant reduction in the devastation caused b...

Rules-Based Medicine, Inc. Launches Human Kidney Damage Biomarker Panel

... Complements the RBM rat Kidney Panel developed in conjunction with the Critical Path Initiative ...oped using a translational medicine approach. In 2008, RBM commercialized a rat Kidney MAP based on an ambitious study funded by the FDA's Critical Path In...

Sigma-Aldrich Acquires Seppro(R) Depletion Technology From GenWay Biotech

...eins from human serum or plasma, as well as other high and medium abundant proteins. Additional products are available for the depletion of mouse and rat samples, as well as the industry's only depletion system for the removal of Rubisco. The library of 700 polyclonal IgY antibodies acquired from...

USC researchers derive first embryonic stem cells from rats

...e world will change because of the availability of rat ES cells," says Qi-Long Ying, Ph.D., assistant pro...ease model we want," he says. "The availability of rat ES cells will greatly facilitate the creation of rat models for the study of different human diseases, ...

ExonHit Launches Mouse Genome SpliceArray(TM) for use in Human Disease Modeling Studies

... products represent the achievement of more two years of work by our R&D team after the launch of the Human genome SpliceArray(TM) in 2007 and the rat genome SpliceArray(TM) earlier this year. "ExonHit has added another important species to its target discovery services portfolio. This additi...

Stem Cell Sciences Licenses Stem Cell Technology to Leading Provider of Genetically Modified Models for Pharmaceutical Research

... has licensed IRES technology to a leading provider of genetically modified rat and mouse models for medical and pharmaceutical research. Under the terms o...cells, which is crucial for the successful creation of transgenic mouse and rat disease models. Dr Alastair Riddell, CEO of SCS, said "A key element of o...

Sangamo BioSciences Announces Results From Diabetic Neuropathy Clinical Trial SB-509-601

...EGF- A). VEGF-A has been demonstrated to have direct neurotrophic and neuroprotective properties. In preclinical animal efficacy studies in a diabetic rat model (Diabetes, June 1, 2006; 55(6): 1847-1854), SB-509 has proven effective in protecting motor and sensory nerve function from disease- induced ner...

SenesTech, Inc. Commences Product Registration Process With Australian Government

...ve ingredient and the first ContraPest(R) product with the government of Australia. In parallel with laboratory research and testing in the rice field rat species, registration of ContraPest(R) bait will open the door for marketing this unique rodent population management product to the agricultural mini...

Northern Antibiotics Presents New Data on Novel Polymyxin Compounds at the Joint ICAAC/IDSA 2008

...listin and polymyxin B. They are also in line with the previous finding (Vaara M. et al., 2008) that the affinities of NAB739 and NAB7061 for isolated rat kidney brush border membrane are significantly lower than that of polymyxin B. These two studies were presented in the Poster Session #290 on Tuesda...

SenesTech, Inc. Initiates Research Field Trials for ContraPest(R) in Indonesia

...he IRRC in Sukamundi, Java. The group will initiate the first field trials of the active ingredient in ContraPest(R). This 21st century alternative to rat poison will be used to cause permanent reproductive failure in female rice field rats (Rattus argentiventer). The environmentally neutral active ing...

Morria Biopharmaceuticals Plc Announces Results From its Pre-Clinical Screening of Novel Anti-Inflammatory Compounds

...y and assess the anti-inflammatory properties of Morria's proprietary multi-functional anti-inflammatory compounds. The Immunoprofiler(TM) Screen uses rat macrophage cells which are stimulated using endotoxin (LPS), a potent inflammation-inducing agent. The assay measures key inflammatory mediators, whic...

New ImmunoSet(TM) ELISA Development Kits

...ays. Assay Designs has an aggressive plan for the development and release of the ImmunoSet products beginning with kits for the detection of mouse and rat heme oxygenase-1 (HO-1) and p53/MDM2 complexes. "With this initial launch of unique antibody sets for our new ImmunoSet product line, Assay Designs ...

Arizona-Based SenesTech, Inc., Partners With Australia to Stop Starvation Due to Rice Shortages

...sisted for centuries, it is possible that we may be able to start reversing this process. Research shows that just a ten percent reduction in the rice rat population can feed over 380 million people. The numbers are simply staggering," she said. The development of the technology is being completed at N...

Genetic Engineering and Biotechnology News (GEN) Reports on Early ADMET Use

...ny's in vitro toxicology team relies on cell-based assays to assess the cytotoxic potential of drug candidates using cell lines derived from human and rat hepatocytes. CeeTox, a contract research organization, also takes a cell-based approach when looking at toxicity potential using a number of differe...