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Measuring siRNA-mediated knockdown of IL-8 mRNA

By Genospectra, Inc., 6519 Dumbarton Circle, Fremont, CA 94555. A critical step in siRNA-mediated gene expression knockdown studies is the validation of expression inhibition. The QuantiGene Reagent System and the Molecular Devices LMax II microplate luminometer were used to measure IL-8 mRNA in PMA-induced HeLa cells, following siRNA t...

Who owns software developed for your company?

Even when there is a written contract, the specifics of ownership of the intellectual property in the software are often no...

UW scientist wins Pew grant to study little-known immune cells

Jenny Gumperz, an assistant professor of medical microbiology and immunology, will receive $60,000 per year for the next four years from the Pew Charitable Trusts, an independent nonprofit organization that annua...

Rodney Dykehouse of Froedtert and Medical College of Wisconsin warns against tech for its own sake

For the CIO, implementing electronic medical r...

Housekeeping Genes: Universal Positive Controls in siRNA Knockdown Experiments

RNA interference is a powerful technique for geneknockdown experiments in academic research and animportant tool for target identification and target validationin therapeutic research. A growing number of different cell lines are us...

Reagents for Up and Down-Regulation of miRNA Activity in Mammalian Cells

More than 200 miRNAs have been cloned and sequenced from human and mouse samples. Each miRNA apparently regulates multiple genes, and miRNAs are thought to regulate as many as 10% of human genes [1]. Several reports predict mR...

Germantown drug company hires pharma veteran James Davidson as COO

The appointment, which is part of a global expansion strategy, places Davidson in charge of the company's technical operations. During his 23 year...

Breaking down Wisconsin's angel capital numbers

The figures were outlined in a recent report titled Risk Capital in Wisconsin: A Progress Report for 2006, which was produced by NorthStar Economic...

Getting noticed in Genetown: Wisconsin biotech on display

That's not the case in...

CIO Leadership Series: Tanya Townsend, Saint Clare's Hospital

How many other information technology directors have an opportunity to start fresh with a new building, new network architecture, new people, and new processes? Not many, and when the still-to...

Doyle wants sales tax applied to digital downloads

The proposed tax, put forth two years after a similar proposal died at the committee le...

Dunn to step down as Medical College dean

Dunn, 70, will become a distinguished professor in the M...

State to fund two minority-owned tech businesses

said Aristotle Ventures, Inc., and <a href="http...

An upside down view of the future

. Lush, green, and blessed with majestic mountains, fertile valleys, sulfurous lava fields, and breathtaking water views. Oh, and a couple million sheep. After a day-and-a-half on airplanes (thank God I was able to fly business class), my weary, Northern hemispheric-orientated body touches down...

Start-ups "down under" not captivated by Web 2.0

I returned last week from a 15-day tour of some of Australia and New Zealands hottest IT start-ups. I specifically describe these as IT companies because unlike in the States, where the Web 2.0 movement has spawned hundreds of new companies, the Australasia marketplace hasnt been captivated by the same frenzy. Indeed, of the nearly 50 companies I met in a seven-stop...

Father of life patents downplays historic role

Chakrabarty, the first person to successfully patent life forms, visited Wisconsin this we...

Conference to address small town development

The conference is scheduled to take place on Sept. 20 from 8 a.m. to 5 p.m. and Sept. 21 from 8 a.m. to noon at th...

Protein lab could prosper under new owner

, a producer of active pharmaceutical components with annual sales of $60 million, has been purchased by the publicly traded buyout firm <a...

Doctor using new media to break down barriers

Fred Kron probably has never been identified as a revolutionary, but he might be in the process of becoming one. Kron, a physician with ties to the entertainment industry, has starte...

Eau Claire business contest down to 7 applicants

From a total...

Merge execs step down following investigation

The stock market fallout that was predicted by company offi...

Summer marks countdown to DEMOfall

While the lunar calendar may not agree, Memorial Day marks the traditional start of summer. So this morning, millions of Americans have brushed off the three-day weekend to return to work, sure in the knowledge that school will soon adjourn for the year, vacations are around the corner, and the next three months will pose plenty of opportunity to consume one's weigh...

Who owns what invention in the workplace?

A first question to be asked: Is there an employment agreement signed by the employee that includes the obligation to assign all inventions develo...

Merge president steps down in wake of shareholder suits

Bill Mortimore, who founded the company and served as its chief executive officer from 1987 to 2000, has been appointed...

Why Milwaukee needs its own thriving research base

Don't suggest to UW-Milwaukee Chancellor Carlos Santiago that research projects on his campus will get ahead by pilfering from programs at UW-Madison. He'll probably laugh at you. "Let's get real," Santiago told listeners at a recent Madison forum on the future of higher education in Wisconsin. "(UW-Milwaukee research programs) are not competing with UW-Madison. These are institutions at...

Small colleges get their own grant program

The nation's small colleges produce some novel scientific research, but they don't always have the resources to invest in advanced rese...

Cracking down on identity theft

Identity thieves, armed...

Renaissance earnings down 46 percent

Renaissance is a provider of computerized assessment and progress...

Madison's downtown wireless network almost ready

A downtown wireless network called Mad City Broadband that will cover the area around the Capitol is almost ready to go live. Cellnet, a firm in Atlanta, Georgia, is building the system and will sell bandw...

Johnson Controls sales up, profits down

That was despite earnings growth bolstered by quarterly sales of $7.5 billion, up from $6.6 billion a year ago, partly from acquisitions of York International and Delphi's battery business....

Are guest worker programs causing backlash amid IT downsizing?

Last week, I heard two guests on CNBCs Kudlow Show discuss the American workforce and what was happening with various jobs. One gentleman was from the CATO Institute and the other was a Democratic representative (Pascrell) from New Jersey. The inference from the CATO Institute director that there is a shortage of skilled people in IT in the U.S. is very questionable. He is putting forth...

Human stem cells grown free of animal contamination

University of Wisconsin-Madison researchers led by stem-cell pioneer James Thomson have grown two proof-of-concept human cell cultures under cleaner and better-defined lab conditions than previous cultures. The research, published in the journal Nature Biotechnology, could pave the way for stem-cell treatments with lower risk of causing infections because of animal-cell contamination. Gr...

30 days to success: Three simple steps to create your own international startup

The idea of being self-employed seems daunting to many professionals. It's estimated that 80 percent of businesses fail within the first five years. If you're the 'glass is half-...

Boston equity firm becomes majority owner of Cedarburg-based Mortgagebot

Following...

Marquette targets illegal downloading

The school is the first university working with the , a non-profit consortium of technologies companies inclu...

The future of work II: standard of working up, quality of work life down

Humans love to keep score. Nowadays there seems to be a scorecard or measurement index for just about everything from the cost of living to the cost of dying and everything in between. The problem with many of these measures is that they take a pure economic view of whatever is being measured. But conclusions about the economy or business can often be misleading whe...

Third Wave reports down quarter, which CEO calls temporary

Third Wave makes clinical molecular diagnostic products, including reagents for the study of infectious diseases an...

Brown Deer start-up wants to serve up foreign film through broadband box

He forsees a new wave of media through broadband Internet access, which reached a majority of U.S. homes mid-2004, according to a survey by NetRatings, and serves a larger per-capita market in Korea, Japan and Singapore. Given a push, that network could...

Northwoods Software co-owner distills 30 years of business experience

Early in his management career, Bob Weisenberg read a lot of books on management and leadership. One day, when he was about one-third of the way through yet another book, he realized he had read it before. Now retired after a 30-year career in the software industry, Weisenberg says the way to excel at leadership is by getting good at applying a very limited number of skills, not by readi...

Human stem cells stand on their own

Tackling a pressing and controversial technical barrier in stem cell biology, scientists at the WiCell Research...