Sigma-Aldrich Introduces MISSION(R) LentiPlex(TM) Pooled shRNA Libraries to Enable Rapid Whole Genome Screening in Primary Cells, Stem Cells or Tumor Cells

ST. LOUIS, March 3 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL ) today announced the global release of the MISSION(R) LentiPlex(TM) Pooled Human and Murine shRNA Libraries ( http://www.sigma-aldrich.com/lentiplex ). Using the shRNA collections of The RNAi Consortium (TRC), the ...

Transgenomic Awarded SBIR Grant to Support Development of SURVEYOR(R) Endonuclease Adaptor-ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation

OMAHA, Neb., Nov. 20 /PRNewswire-FirstCall/ -- Transgenomic (OTC Bulletin Board: TBIO) today announced that it has been awarded a Phase I Small Business Innovation Research (SBIR) award by the National Science Foundation (NSF) to support the development of its proposed SURVEYOR Endonuclease Adapto...

Transgenomic Introduces SURVEYOR(R) Endonuclease Adaptor-Ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation

High Throughput Technology Identifies DNA Variations Between a Reference Genome and Test Genome OMAHA, Neb., June 17 /PRNewswire-FirstCall/ -- Transgenomic (OTC Bulletin Board: TBIO) today announced that it is developing SURVEYOR Endonuclease Adaptor-ligated Libraries (...

Sigma-Aldrich Signs Agreement With CPC Scientific for the Distribution of PEPscreen(R) Custom Peptide Libraries

ST. LOUIS, Jan. 29 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL ) today announced that it has signed a distribution agreement with CPC Scientific, a leading provider of high quality custom peptide synthesis, GMP peptides and peptide APIs for the pharmaceutical and biotechnology indu...

Sigma-Aldrich Joins Phase 2 of The RNAi Consortium to Validate shRNA Libraries

Sigma-Aldrich to Provide Full Functional Validation Data for Its MISSION(R) shRNA Collection ST. LOUIS, May 7 /PRNewswire-FirstCall/ -- Sigma-Aldrich(TM) (Nasdaq: SIAL) and the second phase of The RNAi Consortium (TRC2) have commenced functional validation of the Conso...

Normalizing cDNA libraries using the EppendorfThermomixer

During many experiments in molecular biology, the individual mRNA expression pattern of a cell is examined in order to investigate the reaction of a cell to exogenous influences such as viral infections or medical treatment. To ...

Constructing Directional cDNA Libraries from Limited Amounts of RNA

Generate cDNA libraries with as little as 50 ng of RNA Barry R. Neiditch Cherie Dewar Tanya Hosfield Marie Callahan John C. Bauer Mike Kobrin Quinn Lu Dianne Eckhardt Stratagene Melanie Lenhart Paul Young Human Genome Sciences, Rockville, Maryland Stratage...

Computer access brings more Wisconsinites to libraries

Libraries in Wisconsin are finding that having more computers with Internet access, among other factors, is boosting visitors and circulation. Even though funding has been sparse, grants from non-profit organizations have allowed libraries to expand their computer sections, which allow people to ch...

Assessing Gene Function with siRNA Libraries

Andrea Kroenke 1 , Anne Grabner 1 , Christoph Sachse 1 , Kathy Latham 2 , and Christophe Echeverri 1 1 Cenix BioScience GmbH, 2 Ambion, Inc. Sets of siRNAs foc...

Generate High-Quality, Directional Plasmid cDNA Libraries

Produce larger primary libraries with new plasmid library construction kits Quinn Lu Marie Callahan Tanya Hosfield Barry Neiditch Alan Greener John C. Bauer Mike Kobrin Stratagene Stratagenes pBluescript II, pcmv-script and pAD-GAL4-2.1 XR library construct...

Functional Cloning Using ViraPort Retroviral cDNA Expression Libraries

Retroviral libraries with high-titer efficiency and larger insert potential Functional Cloning Using ViraPort Retroviral cDNA Expression Libraries Katherine Felts Kim Zaharee Latha Sundar Jamie Limjoco Anna Waesche Peter Vaillancourt Stratagene ...

Sigma-Aldrich Acquires ChemNavigator, Inc., to Provide Researchers With Industry-Leading Chemical Compound Selection and Procurement Services

...ypically leads to a selection of compounds that can be compiled into target libraries based upon the identified SARs and molecular designs. Target compounds must...ction to delivery of custom packaged chemical building blocks and screening libraries ready for testing. "ChemNavigator is well-recognized for its fast a...

New method may accelerate drug discovery for difficult diseases like Parkinson's

...other mechanism. In addition, more potent structures may be possible, so the cyclic peptides' known structure can be used as a starting point for more libraries which may produce even more effective versions. Lindquist also says the technique is not limited to just yeast or just Parkinson's disease. "There'...

METTLER TOLEDO Introduces an Affordable Reaction Block for Solid Phase Peptide Synthesis (SPPS)

...). Columbia, MD (PRWEB) June 21, 2009 -- Peptide libraries are widely investigated and routinely screened for their drug-like properti...form for solid phase peptide synthesis enabling the synthesis of arrays and libraries from 6 to 96 peptides and is a viable alternative to traditional techniques...

ForteBio Launches New Assay Capabilities for High-Sensitivity Protein Quantitation and Fragment Screening on Its Octet(R) Platform

...RED system - by enabling kinetic characterization and screening of fragment libraries that include compounds in the 150 to 300 dalton range. "Fragment-based lead... our new analysis software capabilities, enable rapid screening of fragment libraries in a microplate format." ForteBio's Octet biosensors are configured in...

EUCODIS Bioscience Signs Research Agreement With Genencor

...o of commercial enzymes and for industrial partners - our technology of in vivo recombination has reliably shown its capacity to generate high-quality libraries of active enzymes with significant improvement of the desired activities in a single cycle of recombination." About EUCODIS Bioscience E...

Sigma-Aldrich Introduces MISSION(R) esiRNA for Low Cost, High Specificity Pooled RNAi Screening

...logy into a wider range of tests. Dr. Caroline Shamu, director of the ICCB-Longwood Screening Facility, which provides high-throughput screens of RNAi libraries for Harvard Medical School researchers, said, "We are looking forward to screening the MISSION esiRNA library at ICCB-Longwood." esiRNA are end...

ChemAxon Launches Marvin and JChem Version 5.2; Web Services, native .NET API, Homology Groups, 3D Alignment and Structural Frameworks

...r homology groups and repeating units. Our Markush project works toward robust support for Chemical IP, including identification of overlap of Markush libraries without enumeration. Developments of core search features include a new chemical hashed fingerprint to improve search performance and added sup...

Zinc oxide gives green shine to new photoconductors

...r for their materials to be used for solar energy, Stupp says, they must build entire "macroscopic libraries" of these books. And, like the books, the libraries must be highly ordered. "Right now our library is a little disordered, but we are working on optimizing our materials for use in solar energy devic...

New Brain Fitness Survey Reinforces Importance of Brain Awareness Week

...ms (5%) -   "Lack of information and products available to people - perhaps a drive to get the products and information in public libraries would help." Note: The full results and analysis of the complete survey will be included in the upcoming SharpBrains market report, The State...

Pharmexa and Affitech to Combine Operations to Create a New Antibody Therapeutics Company

... Martin Welschof, CEO of Affitech, also commented: "Affitech has developed a fully integrated antibody discovery platform consisting of human antibody libraries with high functionality, based on phagemid display technology plus several screening technologies with high degree of versatility. Through partnership...

HiveMind Marketing to Enhance Search Results for Chemistry Solutions Leader ChemBridge

...idge Corp., a leader in discovery chemistry services and screening compound libraries for pharma, biotech and research institutions. ChemBridge will retain HiveM...idge Corp., a leader in discovery chemistry services and screening compound libraries for pharma, biotech and research institutions. ChemBridge will retain HiveM...

Burnham Announces Assay Development and License Agreement with Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

...es in stem cell research and drug discovery technologies. In September 2008, Burnham was awarded a prestigious six-year , $98 million Molecular libraries Probe Production Centers Network (MLPCN) grant from the National Institutes of Health, and is one of four comprehensive small-molecule screening and d...

SENOMYX ANNOUNCES THIRD QUARTER 2008 FINANCIAL RESULTS

...eves is the primary receptor responsible for human salt taste. Senomyx developed new screening assays based on SNMX-29, and screening of the Company's libraries is ongoing. The recent discovery of sodium chloride (table salt) enhancers that are active in the assays is a significant step forward. In addition, s...

RainDance Technologies Delivers RDT 1000, Sequence Enrichment Solution to The Genome Center at Washington University School of Medicine in St. Louis

...nder RainDance's Early Access Partner program, RainDance will provide its new RDT 1000 and expert training to the GC, along with customized PCR primer libraries to selectively amplify loci of interest for their research initiatives. Elaine Mardis, Ph.D., Co-Director of The Genome Center, said GC researchers ...

RainDance Technologies Delivers RDT 1000, Sequence Enrichment Solution to JCVI

...nce delivers its RDT 1000 and expert training to selected premier organizations in genomic research. RainDance will also provide customized PCR primer libraries designed to selectively amplify loci of interest for research initiatives at JCVI. "The program provides an opportunity for some of the world's leadin...

Sigma-Aldrich Welcomes Memorial Sloan-Kettering Cancer Center to the RNAi Partnership Program

...le for which we are fully equipped. Access to Sigma-Aldrich's MISSION shRNA libraries will greatly enhance our current gene scanning capabilities and will enable...rtium, followed by licensing agreements with MIT to make and sell the shRNA libraries developed by TRC and, subsequently, the introduction of Sigma-Aldrich's MIS...

Update: The Lilly TB Drug Discovery Initiative Begins Work on New Compounds to Fill Early-Stage TB Drug Pipeline

...accelerate early-stage drug discovery by bringing together specialists from around the world for the systematic exploration of vast, private molecular libraries in search of new TB treatments. Headquartered in Seattle, The Lilly TB Drug Discovery Initiative includes representatives of government agencies, phil...

The Lilly TB Drug Discovery Initiative Begins Work on New Compounds to Fill Early-Stage TB Drug Pipeline

...accelerate early-stage drug discovery by bringing together specialists from around the world for the systematic exploration of vast, private molecular libraries in search of new TB treatments. Headquartered in Seattle, The Lilly TB Drug Discovery Initiative includes representatives of government agencies, phil...

Quark Pharmaceuticals Announces Poster Presentations at RNAi Europe 2008

... facilitates siRNA therapeutic development. "Construction of Complex RNAi libraries for Positive and Negative Phenotypic Selection of Target Genes," a poster s...nuing development of Quark's BiFAR target discovery platform, these complex libraries can provide a high throughput tool to help identify targets for siRNA thera...

David Hsia, Ph.D. Joins Kinex Pharmaceuticals' Board of Directors

.... About Kinex Pharmaceuticals Kinex is a drug discovery and development company that is focused on the use of its platform technology and compound libraries to identify and develop peptide-competitive kinase inhibitors. The Company's clinical compound KX2-391 is a selective Src kinase inhibitor that is cur...

Affitech and Omeros Enter Into Antibody Discovery and Development Agreement

...usive intellectual property position, will continue to advance the development of its MASP-2 program. Affitech will apply its expansive human antibody libraries and proprietary antibody discovery and screening technologies, including its AffiScreen(TM) platform and engineering methods, to generate fully human ...

Transgenomic Reports Second Quarter 2008 Results

...aboratory businesses. One example of our novel research efforts is our recently announced SEAL technology, or SURVEYOR(R) Endonuclease Adaptor-ligated libraries (SEAL). This cost-effective and high-throughput enabling technology for whole genome analysis evolved from our highly sensitive SURVEYOR Nuclease muta...

Zenobia Therapeutics, Inc. Receives Michael J. Fox Foundation for Parkinson's Research Award for Work on PD-implicated Protein LRRK2

...Zenobia's Scientific Advisory Board. "The fragment-based screening method has the potential to identify and develop novel compounds not present in the libraries of large pharmaceutical companies. It also is more likely to identify small ligands with a better chance of good penetration into the brain, making it...

Genetic Engineering & Biotechnology News reports on novel hit-to-lead drug discovery

... that can often provide valuable insight into complex disease models. Pharmacopeia's screening platform is based on its ECLiPS (encoded combinatorial libraries on polymeric support) technology. Three steps are involved in the firm's screening process. A primary high-throughput approach screens eluate from mul...

GEN Reports on Novel Hit-to-Lead Drug Discovery Strategies

...t can often provide valuable insight into complex disease models. Pharmacopeia's screening platform is based on its ECLiPS(R) (encoded combinatorial libraries on polymeric support) technology. Three steps are involved in the firm's screening process. A primary high-throughput approach screens eluate from mul...

Nuevolution Announces Research and Development Collaboration with Merck & Co. Inc.

...llow fragment-based drug screening at an unprecedented scale. Nuevolution will screen multiple multi-million member diverse fragment based screening libraries for hit identification. Through the design, synthesis and screening of target focused Chemetics(R) follow-up libraries, the parties will also work tog...

Nuevolution Announces Drug Discovery Alliance With Lexicon Pharmaceuticals

...ntification and hit-to-lead optimization by exploration of ultra large chemistry space through the screening of multiple fragment-based small molecule libraries of more than 100 million compounds per library. The validated targets have been identified through Lexicon's Genome5000TM program where the company ...

SimBioSys Utilizes Revolutionary Hardware Technology to Open New Frontiers in Molecular Modeling

... processor configuration. With this improvement in performance, much larger libraries of chemical compounds can be screened in a comparable time, or alternativel.../eHiTS_on_the_Cell.pdf Virtual screening is the evaluation of very large libraries of compounds using algorithms and computer programs to filter massive amoun...

Sloning and the Kornberg group at Stanford University starting evaluation project regarding the synthesis of a Statistically Randomized Gene Library

... technology for the synthesis of diverse genetic libraries. Diverse genetic libraries are essential in the screening for new and improved therapeutic proteins or...applications. Sloning uses Slonomics™ to synthesize customised mutant libraries for its customers from the biopharmaceutical, industrial biotech, agribiote...