Vitro in Biological Technology

FDA Clears Caspofungin (Cancidas(R)) Susceptibility Testing for TREK Sensititre(R) YeastOne(R) in Vitro Diagnostics (IVD) Product Line

CLEVELAND, July 7 /PRNewswire/ -- TREK Diagnostic Systems, a Magellan Biosciences business and premier provider of diagnostic systems and susceptibility products for microbiology labs, has received clearance from the U.S. Food and Drug Administration (FDA) to include caspofungin in its line of Yea...

Frost & Sullivan: In Vitro Diagnostics Market

A Market with High Potential as Diagnostics become Centre Stage and Instrumental for the Move to Preventive Medicine KUALA LUMPUR, Malaysia, March 23 /PRNewswire/ -- While the in-vitro diagnostic (IVD) market is still very much focused among the Big Three: US, Europe and Japan, which consti...

Celsis In Vitro Technologies and Promega to Offer Fast, Reliable Solutions for ADME-Tox Testing With Primary Hepatocytes

BALTIMORE, Feb. 9 /PRNewswire/ -- Celsis In Vitro Technologies (Celsis IVT), a division of Celsis International plc, a Chicago-based life science products and laboratory services company, and Wisconsin-based Promega Corp will take the trial and guesswork out of ADME-Tox testing in primary hepa...

t2cure Acquires Patent Family on In Vitro Potency Testing of Stem Cells for Cardiovascular Application

FRANKFURT, Germany, November 25 /PRNewswire/ -- t2cure, a biopharmaceutical company developing regenerative medicine therapeutics from a patient's own stem cells, today announced that it has acquired a family of patents and patent applications from Innovectis, the technology transfer arm of Frankf...

The world of in vitro diagnostics is another Midwest success story

I am in a real quandary this week: I have a number of juicy topics I wanted to review with you, including my recent participation in the annual Israel biotech/medical device conference (BIOMED 2006), recent participation in meetings about Indian and my growing insights into the Indian biotech mar...

In Vitro Measurement of the Second Messenger cAMP: RIA vs. FlashPlate

Introduction Abnormalities in neurotransmission within the brain can lead to several disease states, including anxiety, depression or schizophrenia. Extensive research has been carried out to discover the mode of action of various transmitters, in order to understand and comba...

Use of FlashPlate Technology for In Vitro Measurement of 125I-Labeled TGF-1 Binding on Chimeric Extracellular Domain of Type II Transforming Growth Factor Receptor

Sylviane Komesli, Martine Page, and Patrick Dutartre Dpartement dImmunologie, Laboratoires Fournier S.A., France Abstract TGF- type I and type II receptors form ligand dependent heteromeric signaling complexes, in which transforming growth fact...

Use of FlashPlate Technology for In Vitro Measurement of [35S]-GTPγS Binding in CHO Cells Expressing the Human 5-HT1B Receptor

J. Watson and J.V. Selkirk SmithKline Beecham Pharmaceuticals, UK Abstract FlashPlate is a 96-well white polystyrene microplate with scintillant-coated wells designed for highvolume, in-plate radiobinding assays. This study investigates the use...

Analysis of in vitro micronucleus assays using the IN Cell Analyzer 3000 Micronuclei Formation Analysis Module

Key words: Micronucleus assays • toxicology • image analysis • IN Cell Analyzer Micronucleus induction is a key characteristic of genotoxic compounds and analysis of micronuclei formation resulting from DNA strand breakage (clastogens) o...

RNAClean - RNA & cDNA in vitro Reaction Purification

Agencourts RNAClean kit provides a simple, flexible and highly reproducible method for purifying nucleic acid products generated in common enzymatic RT and IVT reactions such as cDNA and cRNA. The kit is formatted for microarray gene expression analysis...

RNArticles: RNA Amplification Used to Develop a New In Vitro HCMV Assay

Gene arrays can be used to simultaneously measure the expression levels of thousands of genes in a single experiment. One limitation of this technology is that large amounts of RNA may be required for each array hybridization experiment -- typ...

Your Data: Silencing Neural Cell Adhesion Genes with In Vitro Transcribed siRNAs

Ambion has developed a system for siRNA synthesis and purification based on in vitro transcription, the Silencer siRNA Construction Kit (patent pending). This kit produces transfection-ready siRNA ...

Your Data: Silencing Hepatitis C Virus Replication With In Vitro Transcribed siRNAs

The Silencer siRNA Construction Kit uses an in vitro transcription reaction and column purification to prepare transfection-ready siRNAs. With this kit, multiple siRNAs can be prepared in ~24 hours. Below ...

GeneChip Sample Cleanup Module for cleanup of cDNA and in vitro transcribed cRNA

A crucial step in gene expression analysis is target labeling. To improve the critical steps in the target-labeling process, QIAGEN has developed the GeneChip Sample Cleanup Module specifically for use with Affymetrix GeneChip ...

NeurogesX Reports Second Quarter 2009 Results

...minophen, have been evaluated in in vivo and in vitro preclinical studies and have demonstrated approxi...phen to a liver protectant, has been evaluated in vitro and in vivo . Equivalent dose levels of NGX-1576...en evaluated in proof of concept in vivo and in vitro preclinical studies for its potential to deliver ...

Viral Genetics Creates Subsidiary to Develop Cancer Therapy

...ings have performed over 400 metabolic disruption technology experiments with a large panel of disrupting compounds for proof of principal--either in vitro or in animal models. Dr. Newell, who has been on the cutting edge of metabolic disruption of tumor cells for many years helped develop the process f...

NeurogesX Announces New PDUFA Date for Qutenza(TM) New Drug Application

...oduct pipeline includes pre-clinical compounds, which are prodrugs of acetaminophen and various opioids. The company has evaluated these compounds in vitro and in vivo and is currently seeking development partners for these programs. Safe Harbor Statement This press release cont...

Rib-X Pharmaceuticals Reports Positive Phase 2 Study Results for Radezolid in Community-Acquired Pneumonia

...and vancomycin-resistant enterococci. Radezolid has also completed a Phase 2 trial in uncomplicated skin and skin structure infections (uSSSI). In in vitro studies, radezolid has demonstrated greater potency than linezolid against a variety of Gram-positive organisms; radezolid is also active against lin...

Techne Corporation Releases Unaudited Fourth Quarter Results for Fiscal Year 2009

...d R&D Systems China Co. Ltd., (R&D China), located in Shanghai, China. BiosPacific is a worldwide supplier of biologics to manufacturers of in vitro diagnostic systems and immunodiagnostic kits. R&D China and R&D Europe distribute biotechnology products. ...

Techne Corporation Declares Dividend

... R&D Systems China Co. Ltd., (R&D China), located in Shanghai, China. BiosPacific is a worldwide supplier of biologics to manufacturers of in vitro diagnostic systems and immunodiagnostic kits. R&D China and R&D Europe distribute biotechnology products. ...

Advanced Life Sciences Receives Complete Response Letter From FDA for Restanza(TM) (Cethromycin) in Community Acquired Pneumonia

...ic that is in development for the treatment of CAP. It has shown higher in vitro potency and a broader range of activity than macrolides against Gram-posit...ve bacteria associated with respiratory tract infections, and, again in in vitro tests, it appears to be effective against penicillin-, macrolide- and fluo...

NeurogesX to Hold Conference Call to Discuss Second Quarter 2009 Financial Results

...oduct pipeline includes pre-clinical compounds, which are prodrugs of acetaminophen and various opioids. The company has evaluated these compounds in vitro and in vivo and is currently seeking development partners for these programs. Safe Harbor Statement This press release contains f...

Anadys Pharmaceuticals Receives FDA Clearance of Phase II Protocol to Study ANA598 in Combination With Interferon-Alpha and Ribavirin in HCV Patients

...ird quarter 2009. Anadys has presented in vitro data supporting the use of ANA598 in combination ...lar, data has shown that ANA598 is synergistic in vitro with interferon-alpha as well as representative H...ors. Furthermore, ANA598 retains full activity in vitro against mutations conferring resistance to proteas...

IIVS Announces Initiation by EPA of a Pilot Program to Evaluate Non-Animal Eye-Irritation Methods

.... Johnson & Son, Inc. - provided data from in vitro as well as previously conducted animal studies on...ate the credence the EPA's leadership gives to in vitro methods and hope that this will lead to EPA guide...y 18-month project encompasses the use of three in vitro assays: the Bovine Corneal Opacity and Permeabilit...

Caliper Life Sciences Reports Second Quarter 2009 Results

...enhancing medicines and diagnostic tests more quickly and efficiently. Caliper is aggressively innovating new technology to bridge the gap between in vitro assays and in vivo results and then translating those results into cures for human disease. Caliper's portfolio of offerings includes state-of-the-ar...

Video of EpiDerm Skin Irritation Test (SIT) Method Now Available

... published in the Journal of Visualized Experiments (JoVE). Titled, "An In vitro Skin Irritation Test (SIT) using the EpiDerm Reconstructed Human Epidermal ...ut MatTek - MatTek Corp. is the world's largest independent producer of in vitro human epithelial tissue equivalents. With over 15 years of publicly availa...

Investigational Urine NGAL Biomarker Shows Promise to Monitor Cyclosporine Toxicity in Cardiac Transplant Patients

... Sudarshan Hebbar, M.D., medical director, Abbott Diagnostics. About Abbott's Diagnostics Businesses Abbott is a global leader in in vitro diagnostics and offers a broad range of innovative instrument systems and tests for hospitals, reference labs, molecular labs, blood banks, physician...

Abbott HIV Test Demonstrates Earlier Disease Detection

...tection of HIV p24 antigen, HIV-antibody, or HIV-2 antibody. About Abbott ' s Diagnostics Businesses Abbott is a global leader in in vitro diagnostics and offers a broad range of innovative instrument systems and tests for hospitals, reference labs, molecular labs, blood banks, physician...

Junying Yu, Leading Stem Cell Researcher, Joins Cellular Dynamics International

...zed medicine to realization." Dr. Yu said, "I'm excited to join the team of scientists at CDI working towards personalized therapeutics. In vitro drug testing can be severely limited by the lack of physiologically relevant models arising from non-human animal models or models that do not approp...

Caliper Life Sciences' Second Quarter 2009 Financial Results Conference Call Notice

... enhancing medicines and diagnostic tests more quickly and efficiently. Caliper is aggressively innovating new technology to bridge the gap between in vitro assays and in vivo results and then translating those results into cures for human disease. Caliper's portfolio of offerings includes state-of-the-art...

Champions Biotechnology Partners with Do-Coop Technologies to Advance Its Novel Oncology Compound Into Biomerk Tumorgraft(TM) Testing

...rget MAPT (Microtubule-Associated Protein Tau) deficient tumors. In both in vitro and in vivo models, SG410 has demonstrated promising activity against prost...e to market by allowing researchers to use the same delivery system from in vitro to in vivo research, avoiding a key factor in late-stage failure. Biotech c...

BioWa Announces License of POTELLIGENT(R) Technology to Merck KGaA

...e-knockout CHO cell line as a production cell. Research shows that POTELLIGENT((R)) Technology dramatically enhances ADCC activity of an antibody in vitro , and significantly increases potency and efficacy of the antibody in vivo . A number of POTELLIGENT((R)) antibodies are being investigated in human...

Instrumentation Laboratory to Announce 'Passion & Results' Award Winners

...umentation Laboratory Instrumentation Laboratory ( www.ilus.com ), founded in 1959, is a worldwide developer, manufacturer and distributor of in vitro diagnostic instruments, related reagents and controls for use primarily in hospitals and independent clinical laboratories. The company's product li...

Monitoring Circulating Tumor Cells With the CellSearch(R) System Can Predict Prognosis in Metastatic Breast Cancer

...s. "Veridex is committed to providing oncologists with high-value in vitro diagnostic solutions, such as the CellSearch(R) CTC test, to help them mak...y, is an organization dedicated to providing physicians with high-value in vitro diagnostic oncology products. Veridex's products may significantly benefit...

MacroGenics Announces the Initiation of a Phase 2 Clinical Trial to Evaluate the Safety and Efficacy of Monoclonal Antibody MGAWN1 in Subjects with Suspected Central Nervous System Infection Due to West Nile Virus

...es the envelope (E) protein of WNV. MGAWN1 exhibits potent neutralizing and fusion-inhibitory activity against WNV in laboratory studies conducted in vitro and in vivo. MGAWN1 has a specific activity that is orders of magnitude higher than that of an intravenous immune globulin (IVIG) product when tested ...

Shanghai ChemPartner and Agios Expand Integrated Drug Discovery Research Collaboration

...f novel therapeutics in the emerging field of cancer metabolism. ChemPartner will provide integrated services in the areas of protein science, HTS, in vitro enzyme assay, cell biology, in vivo pharmacology, etc., for Agios' innovative R&D program to discover novel clinical candidates for oncology indic...

VisEn Launches New Cat-K FAST(TM) Fluorescence Molecular Imaging Agent

...ng systems, or for general use along with other non-quantitative fluorescence in vivo imaging systems. VisEn agents are also designed to enable in vitro biomarker readouts in cells and tissues using standard fluorescence microscopy and cellular-based imaging systems. With a focus on translational res...

Cellular Dynamics International and Roche Expand Existing Cardiotoxicity Screening Agreement

...spectrum of compounds. While it is already standard practice to perform in vitro testing of drug candidates on cardiomyocytes, the cell models currently us...er, said, "CDI well understands the limitations associated with current in vitro testing models that do not appropriately reflect the target cell populatio...

Caliper Life Sciences Introduces Staccato Protein Workstation for Automated Protein Sample Preparation & Analysis

... enhancing medicines and diagnostic tests more quickly and efficiently. Caliper is aggressively innovating new technology to bridge the gap between in vitro assays and in vivo results and then translating those results into cures for human disease. Caliper's portfolio of offerings includes state-of-the-art...

NeurogesX Added to Russell 3000 Index

...oduct pipeline includes pre-clinical compounds, which are prodrugs of acetaminophen and various opioids. The company has evaluated these compounds in vitro and in vivo and is currently seeking development partners for these programs. Safe Harbor Statement This press release contains...