Investigational Urine NGAL Biomarker Shows Promise to Monitor Cyclosporine Toxicity in Cardiac Transplant Patients
CHICAGO, July 22 /PRNewswire-FirstCall/ -- Research presented at the American Association for Clinical Chemistry (AACC) annual meeting today indicates that monitoring cardiac transplant patients with the
Urine NGAL assay on Abbott's ARCHITECT immunoassay analyzer may help clinicians to m...
BASF Podcast: The Chemical Reporter - Why Does Your Urine Smell so Different After You've Eaten Asparagus?
LUDWIGSHAFEN, Germany, June 10 /PRNewswire/ -- It doesn't take long after
you've polished off a plateful of the delicious vegetable before you are
forcefully reminded of it in the restroom. Some people are surprised by the
strange odor rising from the bowl after urinating. The unmistakable olf...
Arizona Pain Society and Dr. Robert Barkin, Rush University Medical Center, Present Program on Comprehensive Urine Drug Testing Sponsored by Dominion Diagnostics
An Educational Program: Discriminating Real Science from Faux Science
NORTH KINGSTOWN, R.I., Dec. 27 /PRNewswire/ -- At a recent meeting of
the Arizona Pain Society, Dominion Diagnostics sponsored an extensive
educational program entitled "A Comprehensive Review of
Urine Drug Testing:
Which T...
Glutamine in Urine or Blood Plasma
Minimum Analytical Instrument Requirement:
Adept HPLC System 1, isocratic
UV/Visible HPLC detector
Typical Method:
Column: Nucleosil SB, 10, 250 x 4.6mm
Mobile Phase: 0.1M KH2PO4 pH 4.0
F low Rate: 0.8 mL/minute ...
Screening of Corticosteroids in Urine by Negative Atmospheric Pressure Chemical Ionization LC/MS/MS
G. Vjial, M. Lamor, V. Pop and G. Bican, Doping Control Laboratory, Bucharest, Romania
Introduction
Corticosteroids are a class of components often abused and misused in sport. They are very potent drugs in the treatment of inflammations and asthma [1]. Corticostero...
Analysis of ()-11-Nor-9-Carboxy-Delta-9-THC in Urine by Negative Ion Electrospray LC/MS/MS
J. Beck and C. Schmidt, Varian, Inc.
Introduction
Marijuana is one of the most commonly used illegal recreational drugs in the United States. The compound that gives the high from smoking marijuana is tetrahydrocannabinol or THC. Toxicology, forensic, and clinical l...
Rapid Screening of Amphetamine Drugs in Urine by Positive Ion Electrospray LC/MS/MS
Z. Yang and S. Sadjadi, Varian, Inc.
Introduction
Amphetamine drugs are often abused and misused in sports, in the work place, and by recreational users. Forensic, clinical, and doping laboratories are frequently asked to analyze for the presence of amphetamines in ...
Analysis of urine and seawater samples by ultrasonic nebulization with a high resolution ICP spectrometer
Tran T. Nham Varian Australia Pty Ltd Mulgrave, Victoria, Australia
Introduction
Because of the low detection limit capability of the ultrasonic nebulizer when combined with an ICP spectrometer, it has been widely used to determine trace and ultratrace levels in wat...
Detection of Morphine and Morphine-Glucuronide in Saliva or Urine with a Rapid and Simple Method Without Derivatization on the Varian 500-MS
Jason S. Wood, Ph.D. Varian, Inc.
Introduction
Testing for drugs of abuse (DoA) is becoming more prevalent in various environments, including forensics and social justice environments as well as in sporting events. Non-heroin opiates such as morphine, oxycodone, and...
Improved Quantitative Selectivity of Clenbuterol in Human Urine using
High Resolution on the TSQ Quantum Mass Spectrometer
Mark Churchill 1 , Mark Harrison 1 ,
John Henninge, 2 and Hanne Lund 2
1 Thermo Finnigan, Stafford House, 1 Boundary Park, Boundary Way, Hemel
Hempstead, HP2 7GE, UK;
2 Aker University Hospital, Hormone Lab...
Amicus Therapeutics Announces Second Quarter 2009 Financial Results
...safety and tolerability, kidney GL-3 as measured in urine, and an assessment of renal function (including glomerular filtration rate (GFR) and 24-hour
urine protein).
Additionally, the FDA and Amicus reached agreement on an improved methodology for the histological evaluation of GL-3 in the kidney b...
Palatin Technologies, Inc. Receives U.S. Patent Allowance for Heart Failure Drug Candidate
... dose-related decreases in blood pressure, increases in plasma cGMP (cyclic guanosine monophosphate), a natural messenger nucleotide, and increases in
urine volume and sodium excretion. There were no serious or severe adverse events.
PL-3994 incorporates a novel and proprietary amino acid mimetic de...
Exosome Diagnostics Appoints Former Roche Executive Greg Zdechlik as Chief Operating Officer
...y is based on the discovery that circulating nanovesicles called exosomes contain unique genetic markers that can be reliably harvested from blood and
urine and used diagnostically. For more information, visit www.exosomedx.com .
...
UCSF researchers help crack parasite genome, identify drug leads
... infects humans via the skin, taking approximately 6 weeks to reach adulthood and reproduce. For disease transmission, those eggs must be evacuated in
urine or feces into fresh water, where the next parasitic stage seeks out a snail host to continue the life cycle.
"It's a wonderfully evolved pathogen,...
Stanford researchers find a quicker, cheaper way to sort isotopes
...opean, Zare said.
Doctors and pharmacologists can use isotopic analysis to measure the targeting precision of a specific drug by testing samples of
urine and breath to see if the right organs have properly metabolized it. Also, climatologists can learn more about the ancient earth by studying carbon dio...
Exosome Diagnostics and DxS Diagnostic Innovations Collaborate to Develop Blood-Based Tests for Key Cancer Mutations
...mpany's core technology is based on discoveries by Harvard and Massachusetts General Hospital researchers that circulating nanovesicles in blood and
urine called exosomes contain unique genetic markers that can be reliably harvested for personalized medicine cancer diagnostics. For more information, vis...
AEterna Zentaris to Report Data from Safety Study of Phase 3 Program in Benign Prostatic Hyperplasia with Cetrorelix Ahead of Schedule
...ge to urinate, waking at night to urinate (nocturia), difficulty starting a
urine stream (hesitancy and straining), decreased strength of the
urine stream (weak flow), feeling that the bladder is not completely empty, an ur...
AEterna Zentaris Opens Extended Study for Cetrorelix in Benign Prostatic Hyperplasia
...ge to urinate, waking at night to urinate (nocturia), difficulty starting a
urine stream (hesitancy and straining), decreased strength of the
urine stream (weak flow), feeling that the bladder is not completely empty, an ur...
Vantia Therapeutics Appoints Rachel Morten as Head of Regulatory Affairs
...cting ducts of the kidney by binding to vasopressin 2
receptors, decreasing
urine volume. Clinical data indicate that VA106483 is
generally well tolerated an...d an effective anti-diuretic that increases urine
concentration and reduces
urine output.
Vantia's initial indication for VA106483 is nocturia. A Phas...
Vancouver General Hospital is the First Canadian Institution to Implement Copan WASP(R): Walk-Away Specimen Processor
...SP the first instrument of its kind to use a single universal platform to automatically plant and streak most bacteriology specimens, including swabs,
urine and fecal samples, regardless of the specimen's container style or specimen type.
(Photo: http://www.newscom.com/cgi-bin/prnh/20090409/LA97060...
Transgenomic Completes Licensing Option With Dana-Farber Cancer Institute on Cold-PCR for Enrichment of DNA Mutations
...ction of cancer-related mutations where critical mutations are present at a very low percentage compared to normal DNA. Examples would be in blood and
urine or where the tissue collected contains mostly normal cells. This would allow clinicians to use less intrusive methods for genetic analysis or allow mo...
Corgenix to Exhibit AspirinWorks(R) Test at ACC.09
...al platelet tests, which require freshly drawn blood that must be evaluated within at least four hours, the AspirinWorks Test is performed on a random
urine sample that can be obtained in any doctor's office or patient service center, making the test convenient for both physician and patient.
Physicia...
AEterna Zentaris and Sanofi-Aventis Sign a Development, Commercialization and Licensing Agreement for Cetrorelix in Benign Prostatic Hyperplasia
...ge to urinate, waking at night to urinate (nocturia), difficulty starting a
urine stream (hesitancy and straining), decreased strength of the
urine stream (weak flow), feeling that the bladder is not completely empty, an ur...
Noridian Medicare Now Covers Renessa(R) Treatment for Incontinence in Women
...n who
suffer from the debilitating effects of SUI," she continued.
Female Stress Urinary Incontinence
SUI is the involuntary leakage of
urine associated with laughing,
coughing, sneezing and recreational activities. The condition is caused by a
variety of factors, most commonly childbirth, a...
Isis Initiates Phase 1 Clinical Trial of SGLT2 Antisense Drug
...n in the kidney. Decreasing SGLT2 levels promotes glucose excretion in the
urine and reduces blood sugar levels, making it an attractive target for the trea...d on human subjects who have mutations in the SGLT2 gene and have increased
urine glucose levels but are otherwise asymptomatic. ISIS-SGLT2Rx effectively an...
International Guidelines for First-Line use of Freelite(TM) in Diagnosis and Management of Multiple Myeloma to be Published in "Leukemia"
...is obviates the need
for analysis of 24-hour
urine samples and eliminates the associated
patien...spicion of AL amyloidosis, in which case a 24-hour
urine sample
should be run in addition to the seru... paraprotein and it is
present in the blood and/or
urine in about 99% of cases. Normal antibody
levels are ...
Watson's GELNIQUE(TM) (oxybutynin chloride) Gel 10% Approved by FDA for the Treatment of Overactive Bladder
...f GELNIQUE was superior to placebo at relieving OAB symptoms, including a reduction in incontinence episodes and urinary frequency, and an increase in
urine void volume. The treatment was well tolerated in the study with a low incidence of adverse events and no treatment-related serious adverse events. T...
Nile Therapeutics Announces Positive Results from Phase 1b Safety and Pharmacodynamics Study of CD-NP in Patients with Heart Failure
...d frequently in the management of heart failure patients. The average total
urine volume during the 24-hour infusions of CD-NP at 3, 10 and 20 ng/kg/min was ... in which patients received standard doses of furosemide, the average total
urine volume was 2,217 ml.
"Worsening renal function is an independent p...
UCF professor develops vaccine to protect against black plague bioterror attack
...administered freeze-dried plant cells to five-week-old diabetic mice for eight weeks. By the end of this study, the diabetic mice had normal blood and
urine sugar levels, and their cells were producing normal levels of insulin.
Daniell figured the same approach might work with a vaccine. He genetically ...
Winning University of Melbourne Ph.D. research boosts the search for sensitive sensors
... or explosives in the air or liquid.
They could even result in more sensitive pathology, detecting minute amounts of drugs or hormonal changes in
urine tests.
Dr Gomez's PhD at the University of Melbourne examined the optical properties of nano-cystals of cadmium selenide, an element commonly used ...
Morria Biopharmaceuticals Plc Announces Positive Clinical Results for MRX-4 in its Phase II Clinical Study in Allergic Rhinitis Patients
...RX-4 followed by an
intranasal dose of allergen on the morning of the seventh day with a
clinical follow-up and scoring over the next 24 hours. Blood,
urine and
pharmacokinetics (PK) analyses were also conducted.
MRX-4 efficacy was assessed by its reduction of six clinical
categories: rhinorrhea, nasal i...
Corgenix to Exhibit AspirinWorks(R) Test, Discuss New CHARISMA Trial Results at AHA 2008 Meeting
... functional platelet tests, which require freshly drawn blood
that must be evaluated within at least four hours, the AspirinWorks Test
only requires a
urine sample that can be obtained in any doctor's office or
patient service center, making the test convenient for both physician and
patient.
Physicians ...
FDA Approves Additional Indication for Norditropin(R) for Small for Gestational Age (SGA) in Children
...sually mild and temporary. Side effects may include
headaches, muscle pain, joint stiffness, weakness, high blood sugar
(hyperglycemia), sugar in your
urine (glucosuria), swollen hands and feet
due to fluid retention, and redness and itching in the area you inject.
If you have any of these symptoms, disc...
Northern Antibiotics Presents New Data on Novel Polymyxin Compounds at the Joint ICAAC/IDSA 2008
...much higher urinary recovery than observed for colistin. Accordingly, and
in contrast to colistin and polymyxin B, the NAB compounds are excreted
into
urine to a significant extent. This indicates that the reuptake of the
NAB compounds in the proximal tubuli of the kidneys is less intense than
that of coli...
FDA Approves Astellas' Vaprisol(R) (Conivaptan Hydrochloride Injection) Premixed in 5% Dextrose for the Treatment of Hyponatremia
...overed and developed by Astellas Pharma Inc. headquartered in
Tokyo, Japan, Vaprisol is a drug that blocks the activity of AVP, resulting
in increased
urine output without loss of valuable electrolytes such as
sodium and potassium. This effect, known as "aquaresis," helps to increase
serum sodium levels in...
PLC Systems Expects Common Stock To Be Delisted From American Stock Exchange
...uid replacement capability, is
intended to minimize the risk of over- or under-hydration during medical
procedures where creating and maintaining high
urine outputs is deemed
beneficial to patients.
Headquartered in Franklin, Massachusetts, PLC pioneered the CO2 Heart
Laser System, which cardiac surgeons...
Nile Therapeutics Announces Positive Interim Data from Phase 2a Study of CD-NP in Patients with Heart Failure
...P elicited a statistically significant
increase in
urine output during infusion at both dose levels adminis...infusion of CD-NP, there was an increase in hourly
urine output
of 48 mL/hr (p=0.01) compared to the pre-do...kg/min CD-NP resulted in an increase in the hourly
urine output of 93
mL/hr (p<0.01) compared to the pre-do...
AEterna Zentaris Completes Patient Recruitment for Second Efficacy Trial of its Phase 3 Program with Cetrorelix in Benign Prostatic Hyperplasia
...ge to urinate, waking at night to urinate (nocturia),
difficulty starting a
urine stream (hesitancy and straining), decreased
strength of the
urine stream (weak flow), feeling that the bladder is not
completely empty, an ur...
UCF professor develops vaccine to protect against black plague bioterror attack
...administered freeze-dried plant cells to five-week-old diabetic mice for eight weeks. By the end of this study, the diabetic mice had normal blood and
urine sugar levels, and their cells were producing normal levels of insulin.
Daniell figured the same approach might work with a vaccine. He genetically ...
PLC Systems Receives Delisting Notice From American Stock Exchange
...uid replacement capability, is
intended to minimize the risk of over- or under-hydration during medical
procedures where creating and maintaining high
urine outputs is deemed
beneficial to patients.
Headquartered in Franklin, Massachusetts, PLC pioneered the CO2 Heart
Laser System, which cardiac surgeons...