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Tissues in Biological Technology

BioLife Solutions Submits FDA Master File on HypoThermosol(R) Preservation and Storage Media for Cells, Tissues

Materials, Components and Manufacturing Process Documentation for Customer Clinical Applications BOTHELL, Wash., Nov. 5 /PRNewswire-FirstCall/ -- BioLife Solutions Inc. (OTC Bulletin Board: BLFS), a leading developer and marketer of proprietary hypothermic storage and cr...

Genomic Analysis of Formalin-Fixed Paraffin Embedded (FFPE) Tissues through the use of Whole Genome Amplification (WGA)

The past is a source of knowledge, and the future is a source of hope. S. Ambrose (1936-2002) Ernest Mueller Preserved samples from medical, forensic, museum and other archival collections represent a rich source of study material, much of it meticulously collected...

Genome Wide Profiling of Paired Cancerous and Normal Breast Tissues and Rapid Interpretation of Gene Expression Data

Introduction Microarrays offer a powerful means of studying human gene activity and thereby providing insight into cellular, molecular, and biological changes. Applied Biosystems has developed the Expression Array System, a complete system for gene expression studies. It incl...

A Novel Process for Gene Expression Profiling of Rat and Mouse Tissues from Formalin-Fixed Paraffin-Embedded Sections Using Microarrays

Abstract This application note describes a method for extracting and isolating total RNA from rodent tissues that have been fixed in formalin and embedded in paraffin, and the subsequent amplification of mRNA from these tissues for use in microarray experiments. We have used this...

Using the VersaFluor Fluorometer to Quantitate GUS Expression in Plant Tissues Bombarded With the Biolistic PDS-1000/He System

Nicholas N. Lyssenko and Mark L. Tucker, Soybean and Alfalfa Research Lab, USDA, ARS, Bldg. 006, BARC-West, Beltsville, MD, USA 20705 Introduction In 1987 Jefferson et al. described the use of β-glucuronidase (GUS) as a marker to ...

Preparation of PCR Quality Template DNA from a Wide Range of Tissues Using InstaGene Matrix

Paul Burr, Wellcome Clinical Scholar, Department of Veterinary Pathology, University of Glasgow, Bearsden Rd, Glasgow. G61 1QH. Introduction A method that can be conveniently used to prepare DNA from a wide range of tissues for analysi...

Stabilizing RNA in Fresh and Frozen Tissues for RNA Isolation

RNA later Tissue Collection: RNA Stabilization Solution for Freshly Dissected Tissue and Cells. Problem: Successful RNA isolation requires rapid processing or appropriate storage of the tissue or cell...

Genomic DNA Preparation from RNAlater Preserved Tissues

The following protocol is suitable for 100 mg tissue samples. Mouse kidney, lung, and spleen genomic DNA have been successfully extracted with approximate yields of 70 g DNA per 100 mg tissue. Required Materials ...

R-Tech Ueno Notifies R&D Items

...In other words, VAP-1 is a protein that demonstrates two different functions. The increase in VAP-1/SSAO activity is observed in the serum and various tissues of patients with diabetes mellitus, atopic dermatitis, obesity, arteriosclerosis, heart disease, etc. In this regard, VAP-1 inhibitor inhibits the exc...

Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors

...candidate, which is targeted to the repair of soft tissues (particularly diabetic ulcers), the Company's orth...y key roles in the regeneration and repair of soft tissues (skin, ligaments, tendons and cartilage) and hard tissues (bone). Based on Cardium's other regenerative dev...

Varian Medical Systems to Showcase a Wide Spectrum of New and Updated Products That Improve Radiotherapy Treatment Processes at 2009 AAPM Meeting

...ans. Biological evaluation , which presents information about the probability of achieving tumor control alongside the risk of damaging healthy tissues for a given treatment plan, so that the most helpful, least harmful approach can be more easily identified. Brachytherapy dosimetry (the Acuro...

NIH funds support UAB joint replacement research

...res are recurrent, or revision, surgeries. Vohra said the nanostructured diamond-coated devices should reduce the metal ion release to the surrounding tissues and perform better during long-term implantation in the human body, which could significantly cut the follow-up surgery rate. ...

Improving Transfusion Safety: Fenwal, Verax Biomedical Sign Agreement for Rapid, Point-of-Care Bacteria Test

...inistration (FDA) and CE Marked in Europe. Development is underway to apply the Verax PGD(R) technology to detect bacteria in other blood components, tissues for transplantation and cell-based therapies. The Verax PGD(R) test, based on proprietary technology developed by Verax, consists of an easy-...

VisEn Launches New Cat-K FAST(TM) Fluorescence Molecular Imaging Agent

...th other non-quantitative fluorescence in vivo imaging systems. VisEn agents are also designed to enable in vitro biomarker readouts in cells and tissues using standard fluorescence microscopy and cellular-based imaging systems. With a focus on translational research and results, all of VisEn's technol...

YM BIOSCIENCES REPORTS DAIICHI-SANKYO ENROLLS FIRST PATIENTS IN PHASE II, FIRST-LINE LUNG CANCER TRIAL WITH NIMOTUZUMAB

...'s differentiated mechanistic attributes result in it selectively targeting tissues over-expressing EGFR while avoiding normal tissue. The debilitating and dan...targeted drugs result from their indiscriminant targeting of normal healthy tissues in addition to their binding to tumor." YM and its licensee Kuhnil Pharma...

Sigma-Aldrich and Atlas Antibodies Announce 2,300 New, Highly Validated Prestige Antibodies(RM)

...ein Atlas (HPA) program. The HPA program generates expression and localization patterns of proteins in a large portion of both normal and cancer human tissues and organs resulting in the antibody-based profiling presented in the publicly available Human Protein Atlas (HPA) ( http://www.proteinatlas.org )...

Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference

...hat include ammonia and hydroxyl ions. By doing so at the site of cancerous tissues in the body, L-DOS47 is believed to modify the microenvironmental condition...survival. As well, the local production of ammonia at the site of cancerous tissues is thought to readily diffuse into the cancer cells to exert a potent cytot...

Fallopian tubes offer new stem cell source

... Human tissues normally discarded after surgical procedures could be a rich additional sou...ore, the search for sources to obtain multipotent stem cells from discarded tissues and without ethical problems is of great interest. Tatiana Jazedje, and...

Environmental Tectonics Corporation Announces Additional Hyperbaric Monoplace Chamber Sale to St. John Wound Center

...s embolism and decompression sickness. It is also used to promote and support healing in the management of conditions in which oxygen transport to the tissues has been disrupted by traumatic injury, infection, inflammation, or edema. St. John Health System operates hospitals in Tulsa, Owasso, Sapulpa an...

BioSyntech Reports Positive Results from Pivotal Trial for BST-CarGel(R) Cartilage Repair Device

...air tissue quality due to BST-CarGel treatment was found during analyses of tissues biopsied from the knees of 22 patients. The ongoing multicenter pivotal tri...l methods (i.e. analyses by microscope) to process and analyze the biopsied tissues from 13 BST-CarGel patients and 9 microfracture patients, and using third p...

Carbon Design Innovations, Inc. Introduces Carbon Nanotube Probe Technology for Atomic Force Microscopy, CNT-Probes Deliver New Level of AFM Imaging Performance

...robes, which exhibit little convolution in AFM imaging. We certainly hope to see these advantages among other biological specimens such as, proteins, tissues and biopolymeric materials." "AFM researchers understand that the next leap in AFM productivity will be based on improved probe technol...

The World's Smallest Hero! Rexin-G, Targeted Therapy for Metastatic Cancers

...d's smallest hero ( www.epeiusbiotech.com ). Imagine if you will, a tiny particle that can travel freely within the human body seeking out cancerous tissues and metastatic tumors that have spread far and wide. Imagine an entire army of these tiny nano-particles seeking out and accumulating to high concent...

PeriCor Therapeutics Reports Positive Preclinical Results of GP531 at the European Heart Failure Congress in Nice

...to be elevated in heart failure patients but not sufficiently to be cardioprotective. By augmenting a patient's own adenosine release in stressed tissues of the heart and its microvasculature, GP531 may have the potential to protect the heart muscle from further damage, alter the deterioration of cellul...

Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on GenSpera, Inc.

...gned to attack existing tumor vasculature, potentially debilitating the tumor's nutrient supply and causing cancer regression without affecting normal tissues within the body. In preclinical evaluation, G-202 demonstrated anti-tumor effects on the growth of breast, renal, bladder, and prostate cancers. Due t...

Poxel SAS Set up to Find Innovative Solutions for Metabolic Diseases Management

...either Merck KGaA nor Merck Serono is shareholders of Poxel. About Type 2 Diabetes: Type 2 Diabetes is defined by a failure of sensitive tissues to respond to insulin, a hormone involved in glucose and fatty acid metabolism, Type 2 diabetes hence being known as non-insulin-dependent diabetes. 9...

Doctors in New Hampshire Now Treating Cancer with Non-Invasive Image-Guided Radiosurgery Using Novalis Tx(TM) Technology

...et his tumor while avoiding, as much as possible, the delicate healthy lung tissues around it. To further ensure treatment accuracy, Wentworth Douglass clinici...or to each treatment and deliver the dose in a way that aims to avoid other tissues already weakened by the patient's chronic pulmonary disease. The Novalis Tx...

Resverlogix's Success in Inflammation Program Results in 2 Patents Filed

...cules would offer significant cost savings to health systems over current biologic agents." Inflammation is a normal response of the body to protect tissues from infection, injury or disease. Though it promotes healing, if uncontrolled, the inflammatory response may become harmful. Acute or chronic inflamm...

Fate Therapeutics Granted Exclusive License for Stem Cell Modulators by Children's Hospital Boston and Massachusetts General Hospital

...ring work of the Company's scientific founders and other leaders in the field. Adult stem cells are naturally-occurring cells found in almost all tissues or organs in the body and are primarily responsible for maintaining and repairing their native tissue. An adult stem cell has unique properties, in t...

Quark Pharmaceuticals Presented At ARVO Data Showing That PF-04523655 Enters Retinal Cells And Elicits Its Pharmacologic Effect Via Target Gene Knock-Down Without Activating TLR3

...ding Quark with freedom to operate in the siRNA intellectual property arena, as well as the ability for non-invasive delivery of siRNA to other target tissues including the eye, ear, lung, spinal cord and brain. PF-04523655 (RTP801i-14), currently in Phase II clinical trials, is a synthetic, chemically ...

CryoLife Reports Record First Quarter Revenues of $26.7 Million

... partially offset by reduced revenues from cardiac tissues primarily from the Company's standard processed pu...'s protein hydrogel technologies and SynerGraft(R) tissues and products. As of March 31, 2009, the Compa...ronment and its effect on demand for the Company's tissues and products and changes in foreign currency excha...

World BioBank(TM) Launch Benefits Advanced Medical Research

...zed intake, processing and release procedures assure the highest quality samples and data. Sample types routinely collected and housed include: solid tissues (snap frozen and matched formalin-fixed paraffin embedded diseased and normal internal controls) from surgical resections, image-guided biopsies, bone...

Z Therapy Is The First In North Texas To Offer Revolutionary Treatment Option For Neck Pain Sufferers

...y that is designed to quickly alleviate neck pain. Often overlooked through common tests such as CT scans, MRIs and x-rays, WAD affects soft muscle tissues in the neck. Measuring neck strength, flexibility and range of motion, the MCU can provide a statistical evaluation of the neck compared to normal re...

Quark Pharmaceuticals to Present at American Society for Pharmacology and Experimental Therapeutics Annual Meeting

...ding Quark with freedom to operate in the siRNA intellectual property arena, as well as the ability for non-invasive delivery of siRNA to other target tissues including the eye, ear, lung, spinal cord and brain. PF-4523655 (RTP801i-14), currently in Phase II clinical trials, is a synthetic, chemically m...

CryoLife Announces Release Date and Teleconference Call Details for 2009 First Quarter Financial Results

...entations. About CryoLife, Inc. Founded in 1984, CryoLife, Inc. is a leader in the processing and distribution of implantable living human tissues for use in cardiac and vascular surgeries throughout the U.S. and Canada. The Company received FDA clearance for the CryoValve(R) SG pulmonary human ...

Genstruct to Present Results of Collaboration with Top Pharmaceutical Company at American Association for Cancer Research's Annual Meeting

...gy -- that the networks that regulate cellular processes are conserved across tumor and tissue types, even when the transcriptional responses of these tissues are markedly different." About Genstruct Founded in 2002, Genstruct is a systems biology company focused on elucidating the complexity of...

Life sticks: UC San Diego bioengineer's sticky insights published in journal Science

...bioengineer is the first author on an article in the journal Science that provides insights on the "stickiness of life." The big idea is that cells, tissues and organisms hailing from all limbs of the tree of life respond to stimuli using basic biological "modules." For example, the researchers outlined si...

Transgenomic Completes Licensing Option With Dana-Farber Cancer Institute on Cold-PCR for Enrichment of DNA Mutations

...o detection in a routine, cost-effective and high throughput protocol. This level of detection will allow straightforward tumor analysis via surrogate tissues such as blood and urine. About Transgenomic Transgenomic is a global biotechnology company that provides unique products and services for a...

Trubion Pharmaceuticals, Inc. Announces Initiation of Phase 1 Study of SBI-087 for the Treatment of Systemic Lupus Erythematosus (SLE)

...7 resulted in more potent B-cell depletion in peripheral blood and lymphoid tissues than rituximab. The objective of the preclinical study conducted by Wyeth w...d in dose-dependent B-lymphocyte depletion in peripheral blood and lymphoid tissues that was more profound and sustained in SBI-087-treated groups compared wit...

Beverly Hills Surgeon Dr. Payman Simoni Applauds Obama Administration's New Direction in Stem Cell Research

...ably younger in their one year follow-up," explained Dr Simoni. "The reason is, the stem cells in the fat injections bond with the patient's tissues in their face, adding to lost bone and muscle tissue while improving the quality of the skin." Dr. Simoni uses fat injections as part of his face...

CryoLife to Present at Sidoti's 13th Annual New York Emerging Growth Institutional Forum

... www.cryolife.com . About CryoLife Founded in 1984, CryoLife, Inc. is a leader in the processing and distribution of implantable living human tissues for use in cardiac and vascular surgeries throughout the U.S. and Canada. The Company received FDA clearance for the CryoValve(R) SG pulmonary human ...
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