Tic in Biological Technology

Milwaukee's software mecca

...ings don't happen accidentally," observed Guy Mascari, director of the Technology Innovation Center (TIC) at the Milwaukee County Research Park. The tic has thirty-five entrepreneurial tenants, two-thirds of whom are focused on writing software. Mascari sees parallels between the engineers who left ...

Identification of Phase I and Phase II Metabolites of Buspirone on the Q TRAP LC/MS/MS System

...asses of expected transformations, i.e. precursor ion of 138 for hydroxylation occurring on the A side. Figure 2 compares a normal full scan tic trace from a liquid chromatography gradient run to a precursor ion scan of mass 122 and demonstrates the gain in selectivity. Up to two precursor ion ...

Using the Agilent 2100 bioanalyzer for quality control of protein samples prior to MS-analysis

...nutes and some minor peaks at 7.4 minutes and 11.2 minutes However, the tic showed two prominent signals (figure 2C) one at 5.1 minutes, which cor... only a minor impurity in the UV but was obviously easy to ionize. Both tic signals were analyzed, where the first mass spectrum turned out to be v...

Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier Software Package

...urrent (TIC) of the full-scan MS analysis showing elution of the drug intermediate (m/z 486) at a retention time of 8.5 minutes. (b) tic with contributions from the drug intermediate (m/z 486 and 487) and background ions (m/z 391, 392, and 393) subtracted out, revealing three ...