Stage

Early Stage: Step 6 - Taxes, taxes, taxes!

- Now you have formed an entity. As part of the decision as to the type of entity to use, you should have concerned yourself with taxes...

Early Stage: Step 5 - Forming the entity

- By now you have clarified what your intellectual property is - the domain name, trademarks, etcetera. You are now prepared to form an entity. In this column, we will discuss the entity choices y...

State's investment in early-stage businesses is changing perceptions

Attorney Joe Hildebrandt has been a part of many deals connecting promising young Wisconsin companies with investors, some close at home and others in the financial centers of the nations East and West coasts. Over the years, Hildebrandt told a legislative committee last week, he's battled the notion that Wisconsin is a "flyover state" that nei...

InstaGene Matrix: Prepare DNA Templates for PCR With No Phenol/Chloroform Extractions and No Deproteinization Steps, Rev C

Prepare DNA from blood, cultured cells, or bacteria: Just incubate sample with InstaGene matrix at 56C for 1530 min, then boil for 8 min. InstaGene matrix absorbs cell lysis products, producing an improved substrate for PCR amplification. Use whol...

Preparation of PCR Quality Template DNA from a Wide Range of Tissues Using InstaGene Matrix

Paul Burr, Wellcome Clinical Scholar, Department of VeterinaryPathology, University of Glasgow, Bearsden Rd, Glasgow. G61 1QH. A method that can be conveniently used to prepare DNA from a wide range of tissues for analysis in the Polymerase Chain Reaction is described. The method is both quick...

Venture Investors' early-stage fund grows to $115 million

The Madison-based venture capital firm, which raised $69 million in the initial closing, said the additional funding places Early Stage Fund IV among the largest Midwest...

Internet-enabled niche markets take center stage

An entire conference, , is centered on what some are calling a seismic shift toward niche...

Early Stage: Step 11 - Other forms of finance

- You've started your new company, named it, and perhaps raised some equity funds, perhaps through investors. If you still need additional funding, what other choices do you have? Before discussing...

Early Stage 10: The nuances of federal laws

Any business that offers or sells securities is subject to both state...

Early Stage, Step 9: Raising capital in the securities landscape

- The idea is developed. Lawyers and accountants are on board. The intellectual property has been protected. The entity is formed. The name...

Early Stage, Step 8: Misclassifying workers brings risk

- Wisconsin's unemployment insura...

Early Stage 7, Part I: Just what is an employee?

- Your entity is formed and you are ready to begin hiring workers. As discussed in the previous article, you generally must withhold and pay fed...

Early Stage, Step 4: Cautionary trademark tales

- In my last column for Stage 3, I indicated we would be moving on to forming the entity. In the meantime, I received a thoughtful response about the last column that bears addressing. As a remi...

Early Stage, Step 3: Naming the entity

- In Step 1 of our Early Stage series, we explained how to protect your intellectual property, and in Step 2 we discussed choosing a domain name. Now, in Step 3, we'll address choosing a trademark...

Early-stage quality brings investment, Meier says

The most recent sample of evidence was produced in the <a href="http://www.pw...

Early-stage executives hear from investors

In evaluating MatriLab, a Milwaukee-based biotech with scientific ties to the , they counseled technology start ups t...

Early Stage Step 2: Choosing a domain name

- So now that you know you have a patentable technol...

Waisman director leading early stages of the Wisconsin Institutes for Discovery

But even as architects design the (WID), campus leaders are busy forging its identity....

Early Stage Symposium session will help emerging companies prepare for investors

"Venture Readiness Tools for Commercialization Success" will be held Oct. 20 as a track within the larger conference at Madison 's Monona Terrace Convention Center . Compa...

Wisconsin early-stage companies must position themselves to get capital

- On Sand Hill Road in Menlo Park, Calif., which is the venture capital version of Wall Street, the talk these days is of a "boomlet" in deal-making. Technology firms that only a few years ago were lucky to get a meeting with a venture capitalist are now entertaining multiple offers to finance deals. The New York Times reported last week that on...

Conference will focus on financing of early-stage ventures

The event, to be held at the Monona Terrace in Madison, will run from Oct. 19-20. It is being organized by the Wisconsin Tech...

With Sarbanes-Oxley, compliance takes center stage for CIOs

If, five years ago, you asked a group of chief information officers for their number-one issue, they might have said storage capacity, security or bandwidth. Today, the consensus issue is compliance, particularly with the new spate of securities legislation, highlighted by Congress's passage of the Sarbanes-Oxley Act of 2002, or SOX, as it has come to be called. SOX, which was passed lar...

More Midwest Seed-Stage Life Science VCs

The Dave Clark Five song Bits and Pieces is a good metaphor for the apparently holey (as in Swiss cheese) tapestry of Midwest VC seed and early stage financing efforts to get life science companies off the ground. This weeks column will try to knit together some of these pieces so the tapestry doesnt fall apart. Last weeks column evoked responses from a number of readers who remarked on...

Five seed-stage funding groups filling Midwest Life Science void

CHICAGO Anyone who has traveled to London and taken the tube (the subway for New Yorkers or the L for Chicagoans) is constantly besieged by tape loops of mind the gap, which is a warning for the dark hole or space between the subway car and the concrete waiting area as one gets on or off the tube. In other words, beware of the void as it can be dangerous for your health. In l...

An analysis of Wisconsins new venture capital and early stage finance programs

If high tech is the engine of future economic growth, Wisconsin is running low on investment fuel. A recent study by the California-based Milken Institute ranks our state 32nd out of 50 in availability of the risk capital that technology entrepreneurs need to turn innovative ideas into marketplace successes. That may soon change thanks to the recent enactment of 2003 Wisconsin Act 255 by Govern...

Neah Power Systems A seed stage venture capital model

Developing a viable technology company requires insight, discipline, and a relentless focus on developing technology, business and marketing plans. Many successful startups create a high-value company by defining a big problem with a large focused market opportunity for the development of new products. is a company that is...

Stem Cells Illuminate Early Stages of Human Development

MADISON - When introduced to the world in 1998, human embryonic stem cells were considered heralds of a new age of transplant medicine. The prospect of an unlimited supply of cells and tissue of all kinds to treat disease captured public imagination and enthusiasm. But lost in the glitz of the cells' potential to treat an array of devastating and sometimes fatal diseases was another qual...

Seed-Stage Venture Financing

Seed-Stage Ventur...