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Ras in Biological Technology

/R E P E A T -- Oncolytics Biotech Inc. Announces U.S. Phase 2 Combination Clinical Trial for Non-Small Cell Lung Cancer Patients with K-RAS or EGFR-Activated Tumours/

... replicates in cancer cells that have an activated ras pathway. Approximately two thirds of all cancers have an activated ras pathway, including most metastatic disease. A larg...cluding mutations in EGFR, Her2 or K-RAS along the ras pathway lead to...

Oncolytics Biotech Inc. Announces U.S. Phase 2 Combination Clinical Trial for Non-Small Cell Lung Cancer Patients with K-RAS or EGFR-Activated Tumours

... replicates in cancer cells that have an activated ras pathway. Approximately two thirds of all cancers have an activated ras pathway, including most metastatic disease. A larg...cluding mutations in EGFR, Her2 or K-RAS along the ras pathway lead to...

SGX - Lilly Merger Offer Receives Positive Opinions From Proxy Advisory Firms

...covery activities are focused on a portfolio of other protein and enzyme targets that have been implicated in human cancers, including JAK2, RON, ALK, ras and IKKe. More information on the pipeline and drug discovery platform can be found at http://www.sgxpharma.com and in the Company's various filings...

SGX Pharmaceuticals Announces Financial Results for the Three and Six Months Ended June 30, 2008

...covery activities are focused on a portfolio of other protein and enzyme targets that have been implicated in human cancers, including JAK2, RON, ALK, ras and IKKe. More information on the pipeline and drug discovery platform can be found at http://www.sgxpharma.com and in the Company's various filings...

Lilly to Acquire SGX Pharmaceuticals

...covery activities are focused on a portfolio of other protein and enzyme targets that have been implicated in human cancers, including JAK2, RON, ALK, ras and IKKe. More information on the pipeline and drug discovery platform can be found at http://www.sgxpharma.com and in SGX's various filings with th...

SGX Pharmaceuticals Submits Investigational New Drug Application for SGX393

...covery activities are focused on a portfolio of other protein and enzyme targets that have been implicated in human cancers, including JAK2, RON, ALK, ras and IKKe. More information on the pipeline and drug discovery platform can be found at http://www.sgxpharma.com and in the Company's various filings...

SGX Pharmaceuticals Announces First Quarter Financial Results and Gives Pipeline Update

... other than SGX393. Oncology Drug Discovery In addition to the JAK2 and ras programs described previously, the Company's drug discovery portfolio inclu...rgets that have been implicated in human cancers, including JAK2, RON, ALK, ras and IKKe. More information on the pipeline and drug discovery platform can ...

Pharsight Achieves $7.6 Million In Quarterly Revenue

...ments during the quarter," said Mr. O'Connor. "Our ras offering, now staffed with 12 people, generated 86...ution for regulatory studies. -- Expanded the ras team in response to global demand for the group's ...als. -- Achieved continued strong revenue growth; ras revenue up 86% quarter over quarter. Additio...

SGX Pharmaceuticals Schedules Teleconference and Webcast to Discuss First Quarter 2008 Results and Provide Pipeline Update

...scovery activities are focused on a portfolio of other protein and enzyme targets that have been implicated in human cancers including JAK2, RON, ALK, ras and IKK. More information on the pipeline and drug discovery platform can be found at http://www.sgxpharma.com and in the Company's various filings ...

Oncolytics Biotech Inc. Announces 2008 First Quarter Results

...at have not been successfully treated with conventional therapeutics. The product being developed by the Company may represent a novel treatment for ras mediated cancers which can be used as an alternative to existing cytotoxic or cytostatic therapies, as an adjuvant therapy to conventional chemother...

Oncolytics Biotech Inc. Announces Issuance of 26th U.S. Patent

...." The claims describe methods of treating cancer using adenoviruses that are modified to selectively replicate in cancer cells that have an activated ras pathway. "This patent expands our adenovirus portfolio both geographically and with respect to which adenovirus variants can be used," said Mary Ann...

Pharsight's Reporting and Analysis Services Business Unit to Leverage New Validated Data Management System

...e Server(TM)). Pharsight's scientists within the ras business unit provide analysis and reporting for r...alysis, and reporting efforts. The PKS system that ras will use has been validated and is compliant with ...ient requires timely and compliant PK/PD modeling. ras already uses our software such as WinNonlin and Wi...

Pharsight Achieves $7.4 Million in Quarterly Revenue

...inue to reap the benefits of our investment in our ras business and our successful efforts to diversify o...-- Achieved quality assurance milestone; audits of ras unit conducted by three global biopharmaceutical companies. -- Expanded the ras team in response to global demand for the group's ...

Pharsight's Reporting and Analysis Services Business Reaches Quality Assurance Milestone

...nt organizations that have performed audits of the ras unit's capabilities are a Top 50 pharmaceutical co...eading biotechnology company. The audits covered ras operating practices and procedures for study analysis and reporting, ras facilities, and...

Oncolytics Biotech Inc. Announces Issuance of 24th U.S. Patent

...eoplasia." The claims describe methods of using the reovirus to treat cancers that have inactivated PKR, whether the PKR is inactivated by mutation of ras or by other factors. PKR is a host cellular protein responsible for preventing virus replication within a cell. Tumour cells lacking the activity of P...

Presentation of Phase IIa Results for Cytos Biotechnology's Hypertension Vaccine at the American Heart Association Scientific Sessions 2007

...eceptors and subsequent narrowing of blood vessels should be decreased. The ras has already been successfully targeted by three major classes of antihypert...atory blood pressure monitoring devices. Angiotensin II: a molecule of the ras inducing vasoconstriction of blood vessels and other effects to raise blood...

Oncolytics Biotech Inc. Announces 2007 Third Quarter Results

...ocus on the interaction of the immune system and the reovirus, the use of the reovirus as a co-therapy with existing chemotherapeutics, the use of new ras active viruses as potential therapeutics, and to investigate new uses of the reovirus as a therapeutic. For the remainder of 2007, we still expect th...

The let-7 microRNA Family Regulates RAS: Implications for Development and Oncogenesis

... let-7 miRNAs regulate human ras oncogene expression and are often ...n let-7 miRNA reduction and ras protein induction in human lu... significant up-regulation of ras protein expression. let-...

Mutation detection for the K- rasand P16 genes

... this with sequencing analysis. The human K-ras gene is a member of the ras family of GTPases1. Mutant, activated forms of ras proteins, which are frequently observed in cancer, have an impaired GTP...

Efficient and Reliable Linear Amplification of cRNA

...nverted into double-stranded (ds) cDNA using the ras Microarray cDNA Synthesis Kit (eight independent...e group of ds cDNA samples was purified with the ras Microarray Target Purification Kit, then amplifi...olymerase and labeled with Biotin-UTP, using the ras Microarray RNA Target Synthesis Kit (T7). The re...

Increased Sensitivity in Microarray Analysis

...ples when labeled targets were prepared with the ras Microarray Kits as shown in Table 1. ...o be present when targets were prepared with the ras Microarray Kits. Of these, 9,331 were also detecte... Using the ras Microarray Kit workflow for target preparation, ...

Product overview

...onality and contaminating activities. Thus, you can be confident that you will obtain reliable, consistent results with every lot of ras Taq DNA Polymerase. Pwo DNA Polymerase initially isolated from...

Advantages of Roche Applied Science amplification products

...ontinuously perfect the Polymerase Chain Reaction. By exploiting their traditional experience in producing biochemicals and enzymes, ras has developed and perfected a broad range of new associated technologies and more powerful enzyme preparations. Today, these highly ...
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