Navigation Links
RNAs in Biological Technology

Gladstone scientists identify role of tiny RNAs in controlling stem cell fate

SAN FRANCISCO, CA March 6, 2008--Researchers at the Gladstone Institute of Cardiovascular Disease (GICD) and the University of California, San Francisco have identified for the first time how tiny genetic factors called microRNAs may influence the differentiation of pluripotent embryonic stem (ES)...

Santaris Pharma - Interim Report for the Period 1 January to 30 June 2009

...er and teratoma samples using deep sequencing. During H1 2009 the Company made presentations at several scientific conferences: - Small rnas and cancer/Paris/France - Keystone, Scientific Advisory Board Meeting/Colorado/USA - Executing the promise of RNAi/Cambrigde/MA/USA - C...

Stem cells' 'suspended' state preserved by key step, scientists report

...ther candidate genes. (RNAi is a naturally occurring process in which small rnas bind to other rnas to increase or decrease their activity.) In this case, the scientists used ...

febit First to Offer Newly Published Mouse Genome on a Chip for DNA/RNA Detection and Enrichment

...ntifies 439 long, non-coding RNAs. Thus, a complete analysis of protein gene expression, microRNA profiles and expression patterns of long non-coding rnas is possible and can reveal many previously hidden secrets of mammalian biology and disease processes. Flexibel technology for fast-paced researc...

Monsanto, BASF Scientists Disclose Discovery of Gene Conferring Drought Tolerance in Corn Plants

...orn contains the cspB gene, from Bacillus subtilis . CspB codes for an RNA chaperone, which are commonly occurring protein molecules that bind to rnas and facilitate their function. The gene was first identified in bacteria subjected to cold stress conditions and further research has demonstrated tha...

MIT reels in RNA surprise with microbial ocean catch

...ion has yielded an unexpected boon: the presence of many varieties of small rnas snippets of RNA that act as switches to regulate gene expression in these ...a tough situation, for instance? The discovery of naturally occurring small rnas is a first step towards addressing such questions." ...

Roche Madison Moves to New Facility

... of medicines, known as RNAi therapeutics, is on the horizon. RNAi therapeutics targets the cause of diseases by potently silencing specific messenger rnas (mRNAs), thereby preventing disease-causing proteins from being made. RNAi therapeutics has the potential to treat disease and help patients in a fund...

Isis and Partners Present New Research at the American Association for Cancer Research 2009 Annual Meeting

...different classes of RNAs, including microRNAs and other non-coding RNAs. We and our collaborators have shown that antisense inhibition of non-coding rnas can impact splicing patterns in cells to modulate the expression of multiple proteins that may be involved in disease," said C. Frank Bennett, Ph.D., ...

Nobel Laureates to Speak at Keystone Symposia RNA Silencing Conference

...mbros of the University of Massachusetts Medical School and Gary Ruvkun of Harvard Medical School /Massachusetts General Hospital for work on small rnas and gene regulation. The four-day conference will bring together more than 400 leading researchers from around the world working in different bra...

Researchers develop new way to see single RNA molecules inside living cells

...using them to investigate viral pathogenesis and other biological phenomena. "We are excited to use this imaging strategy to study how single viral rnas travel from the nucleus of a cell to a virus assembly site, how mRNAs are regulated by location and time, and RNA trafficking in neurons," added Santa...

Virginia Tech researchers discover how mosquitoes avoid succumbing to viruses they transmit

...uito and virus are virus-derived short-interfering rnas (viRNAs), which are generated by the mosquito's im...5, 2008. The article is, "Alphavirus derived small rnas modulate pathogenesis in disease vector mosquitoes... cellular small RNAs. "The proportion of the small rnas that are viRNAs was surprising," the article state...

Promising Clinical Data on Gen-Probe's APTIMA(R) HPV Test Presented at Major European Medical Meeting

...ied nucleic acid test that detects 14 high-risk HPV types that are associated with cervical cancer. More specifically, the assay detects two messenger rnas (mRNAs), E6 and E7, that are made in higher amounts when HPV infections progress toward cervical cancer. Gen-Probe believes targeting these mRNAs may ...

Rosetta Genomics Leverages its MicroRNA Platform Technologies to Launch Plant Biotech Initiative

...o develop novel solutions using the unique potential microRNAs hold." About microRNAs MicroRNAs (miRNAs) are naturally occurring, short non-coding rnas that regulate gene expression in plants, humans, and have been recently discovered in algae. The ability to selectively regulate gene expression throu...

Two Luminaries Join Cequent Scientific Advisory Board: Judy Lieberman, M.D. Ph.D., and Patrice Courvalin, M.D.

...orking to harness RNAi for use against HIV and other viruses and they have developed novel strategies for cell-specific targeting of small interfering rnas to confer in vivo protection from viral disease. In related work, Dr. Lieberman's laboratory is also working in the emerging field of miRNAs by develo...

Gen-Probe Launches in Europe CE-Marked APTIMA(R) HPV Assay for Detection of Human Papillomavirus

...ied nucleic acid test that detects 14 high-risk HPV types that are associated with cervical cancer. More specifically, the assay detects two messenger rnas (mRNAs), E6 and E7, that are made in higher amounts when HPV infections progress toward cervical cancer. Gen-Probe believes that targeting these mRNAs...

Gen-Probe Reports Strong Financial Results for First Quarter 2008, Raises Full-Year Guidance

...ed to detect 14 high-risk HPV types that are associated with cervical cancer. More specifically, the assay is designed to detect two messenger rnas (mRNAs), E6 and E7, which are produced in higher amounts when HPV infections progress toward cervical cancer. Gen-Probe expects to enroll app...

OPKO Health Announces Issuance of U.S. Patent Covering the Use and Administration of Certain Anti-VEGF siRNA's, Including Its Phase III Compound Bevasiranib

...en issued a key patent by the United States Patent and Trademark Office (USPTO) for methods related to the use and administration of small interfering rnas (siRNAs) for targeting vascular endothelial growth factor (VEGF), including OPKO's siRNA drug candidate, bevasiranib, which is currently in a Phase II...

Rosetta Genomics Reports Fourth-Quarter and Full-Year 2007 Financial Results

...nts Rosetta Genomics presented at the following conferences and events: - American Association for Cancer Research (AACR) - The Role of Non-coding rnas in Cancer, October 31-November 3, 2007, Cambridge, MA - Gene-Cards symposium, November 11, 2007, Weizmann Institute of Science - CELCC-ESMO predic...

Rosetta Genomics Will Host and Webcast its R&D Day on Friday, October 26, 2007

...n will be available following the event. About microRNAs MicroRNAs (miRNAs) are a recently discovered, naturally occurring form of RNAi. These small rnas act as protein regulators and have the potential to form the basis for a new class of diagnostics and therapeutics. Since many diseases are caused by ...

Rosetta Genomics to Host and Webcast its R&D Day on Friday, October 26, 2007

...n will be available following the event. About microRNAs MicroRNAs (miRNAs) are a recently discovered, naturally occurring form of RNAi. These small rnas act as protein regulators and have the potential to form the basis for a new class of diagnostics and therapeutics. Since many diseases are caused by ...

Mechanism for the in-vivo transport of siRNA

... of a target gene in the liver at the same time. It turned out that there are several such fatty acids. But what is it in the blood to which all these rnas conjugated with so-called lipophilic substances bond" The ETH Zurich researchers discovered that, depending on the fatty acid used, the binding partne...

NYU Medical Center Collaborates With Rosetta Genomics to Develop a microRNA-Based Diagnostic Test for Melanoma

...tly the prognosis of melanoma patients." About microRNAs MicroRNAs (miRNAs) are a recently discovered, naturally occurring form of RNAi. These small rnas act as protein regulators and have the potential to form the basis for a new class of diagnostics and therapeutics. Since many diseases are caused by ...

miRNeasy Mini Kit and miRNeasy 96 Kit

...es and cells Efficient enrichment of miRNA - isolate rnas <200 nucleotides High-purity RNA - suitab... size. In the data shown in Figure 3, the presence of very small rnas was clearly visible after purification using the miRNeasy Kit, i...

Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions

... animal (meanSD). The integrity of the RNA was assessed and was found to be of high quality (Fig. 2). Peaks corresponding to the 28S and 18S ribosomal rnas were clearly visible on the BioAnalyzer profile (A) and pseudo-electropherogram (B). There was no detectable genomic DNA contamination, as evidenced b...

RNA Interference and Gene Silencing: History and Overview

... provided the first clue. They identified rnas of ~25 nucleotides in plants undergoing c...were absent in non-silenced plants. These rnas were complementary to both the sense and antisense...d into 21-23 nucleotide small interfering rnas (siRNAs), which have also been called "gu...

Nuclease Protection Assays: The Basics

...he detection, quantitation and mapping of specific rnas in a complex mixture of total cellular ...ternal Standards or Reference rnas for Accurate Quantitation of RNA ...icrograms of various mouse tissue total rnas were hybridized overnight with approximately 50,00...

Array Analysis: The Basics

...d for each sample analyzed. A typical experiment involves isolating RNA from two tissue or cell samples. The rnas are reverse transcribed using labeled nucleotides and target specific, oligo dT, or random-sequence primers ...

Your Data: Silencing of a Pro-apoptotic Transcription Factor Using Synthetic siRNA

...onstruction Kit . While this kit is very cost effective when rnas of several different sequences need to be made, it can be ad...d by 2123 nucleotide RNA fragments, termed short interfering rnas (siRNAs), which bind and tag the complementary portion of th...

Visualizing siRNA in Mammalian Cells: Fluorescence Analysis of the RNAi Effect

... Introduction Small interfering rnas (siRNAs) can induce specific post-transcriptional gene silen... A, Weber K, and Tuschl T (2001) Duplexes of 21-nucleotide rnas mediate RNA interference in cultured mammalian cells. Nat...

Test More siRNAs for Less

...he expression of specific genes in live cells. In mammalian cells, RNAi can be induced by transfecting small interfering rnas (siRNAs), comprising double-stranded RNA molecules ~21 nt in length with 2 nt 3' overhangs. In order to find an siRNA wi...

SUPERIOR RNA FOR DEMANDING APPLICATIONS

... regions of the human brain and other human rnas from diverse normal and diseased ti... salt. Ambion's prepared rnas are available for researchers who choose to avoid these challenges. Our FirstChoice rnas are available from a variety of human, ...

siRNA Design: It's All in the Algorithm

... wherein short double-stranded rnas called short interfering rnas (siRNAs) direct the degradation of transcripts con... RISC can only direct degradation of cellular rnas that are complementary to the...

RNAi: A How To for New Users

...NA (dsRNA) triggers the RNAi pathway. The cytoplasmic nuclease Dicer first cleaves the long dsRNA into 2123 bp small interfering rnas (siRNAs), that then unwind and assemble into RNA-induced silencing complexes (RISCs) (Figure 1). The antisense siRNA strand then guides the...

RNAi as a Tool for Mammalian Gene Analysis: Applications of siRNAs

...on studies occurred with the seminal Elbashir et al. (1) publication describing the use of small interfering rnas (siRNAs) in mammalian cells in 2001. In less than two years, siRNAs have become the cornerstone of many rese...

Rapidly Synthesize Large Amounts of Capped RNA

...m/catalog/CatNum.php?8045">Anti Reverse Cap Analog (ARCA). A base modification in this cap analog generates rnas with ARCA incorporated only in the functional, translatable orientation, resulting in higher protein yields....

Precursor miRNAs for Successful miRNA Functional Studies

...miRNAs) are small, regulatory rnas that are expressed in animals and plants and affec... Strand Specificity of Small rnas For a synthetic miRNA to be...antly, strand specific. Small rnas like miRNAs and siRNAs exhibit strand specificity,...

More siRNA Vectors for RNA Interference

... Small Interfering rnas (siRNAs) are short, double-stranded...s relatively large amounts of small rnas in mammalian cells and that it term...s comparing the expression of small rnas under the control of the U6 promoter and several o...

Optimize Transfection of siRNAs for RNAi

... can be achieved in many cell types. Good Transfection is Critical The ability of small interfering rnas (siRNAs) to silence gene expression is proving to be invaluable for studying gene function in cultured mammalian cells. ...

Getting Started with MicroRNA Research

... identified class of cellular rnas that regulate protein expression at the ... regulatory miRNAs than on the levels of messenger rnas that encode the proteins [3]. MicroRNAs... mechanism similar to short interfering rnas (siRNAs) in that both of these types of small, ...

Optimizing siRNA Transfection for RNAi

... can easily be done. Efficient Transfection is Critical The ability of small interfering rnas (siRNAs) to silence gene expression is proving to be invaluable for studying gene function in cultured mamma...
Other Tags
(Date:7/10/2014)... NEW YORK , June 27, 2014 /PRNewswire/ ... against Provectus Biopharmaceuticals, Inc. ("Provectus" or the "Company")(NYSE-MKT: ... action, filed in United States District Court, Middle ... Division, is on behalf of a class consisting ... otherwise acquired Provectus securities between December 17, 2013 ...
(Date:7/10/2014)... SPRINGS, Florida , July 1, 2014 ... wallets pave way for convenience and improved security: NXT-ID, Inc. ... Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: ... and MasterCard Corporation (NYSE: MA) NXT-ID, Inc., (OTCQB: NXTD) ... is pleased to announce that the second series of 30 ...
(Date:7/10/2014)... July 2, 2014 It is a great ... the appointment of the world-renowned Thoracic and Cardiovascular surgeon, ... Dr. Ginsburg, with over 34 years of ... Hospital and Good Samaritan Regional Medical Center. Dr. Ginsburg ... late 1980,s and is considered an expert in the ...
Breaking Biology News(10 mins):SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5Avery Biomedical Devices, Inc. announces the appointment of Mark E Ginsburg, M.D. to its Board of Directors 2
(Date:7/12/2014)... injuries increase in the summer as people gather around fire ... most vulnerable to these seasonal fire hazards: children. "Young ... by putting their hands on the side of cooking grills," ... Loyola University Medical Center in Maywood, Ill., said in a ... play with fire, you get burned, is true -- ...
(Date:7/12/2014)... “After my mom’s stroke, she loss the use of her ... use of his left side. Eating became a difficult task for ... like them enjoy eating again,” said an inventor, from Fayetteville, N.C. ... HALL PLATE (P C H PLATE). , The PATRICIA CAROL HALL ... eat for individuals who suffer from stroke, experience tremors or loss ...
(Date:7/12/2014)... With prom shopping reaching its final ... is ready to showcase its new and trendy apparels. ... evening dresses in its online shop. Additionally, it is ... these elegant gowns. According to the company’s sales manager, ... 26, 2014. , He says, “Now, worldwide clients ...
(Date:7/12/2014)... “Critical Care Therapeutics in Major Developed ... PCCs and Recombinant Products to Drive Market,” which ... in the US, UK, France, Germany, Italy, Spain, ... of market size for 2013, along with market ... that are being treated using the five major ...
(Date:7/12/2014)... Utah Valley Entrepreneurial Forum Top 25 ... being bestowed to companies in revenue, and pre-revenue startups. ... with recognition for new ideas as well as companies ... , 25 Under 5 highlights outstanding Utah entrepreneurs and ... 5 years old. Award recipients were recognized at their ...
Breaking Medicine News(10 mins):Health News:Burn Injuries More Common in Summer 2Health News:VogueQueen.com Updates Its Summer Collection With New And Trendy Evening Dresses 2Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 2Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 3Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 4Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 5Health News:Critical Care Therapeutics in Major Developed Market is Expected to Grow at a CAGR of 4.7% to $2.5 Billion in 2019 6Health News:SquareHook is Recognized for UVEF 25 Businesses Under 5 Years-Watch Out 2
Other Contents