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Peptide in Biological Technology

METTLER TOLEDO Introduces an Affordable Reaction Block for Solid Phase Peptide Synthesis (SPPS)

METTLER TOLEDO offers an affordable reaction block for solid phase peptide synthesis and purification of peptide libraries: MiniBlock. For a limited time, you can register to win a MiniBlock® for Solid Phase Peptide Synthesis (SPPS). Columbia, MD (PRWEB) June 21, 2...

Lethality of H1N1 Influenza Virus Increasing According to Latest Analysis of Virus Peptide Genomic Data

Boston Biotech Firm Reports First Rise in 76 Years of Replikin Count* of H1N1 Lethality Gene BOSTON, June 10 /PRNewswire/ -- An analysis of the latest peptide genomic data for the H1N1 influenza virus indicates that the current global outbreak of H1N1 is increasing in its capacity for lethali...

Swine Flu (H1N1) Infectivity to Increase Markedly and Lethality to Remain Low According to Latest Replikin* Peptide Genomic Data

Boston-based biotech firm Replikins Ltd. ( www.replikins.com ) last week analyzed the most recent peptide genomic sequence data available and determined that the infectivity of the H1N1 virus will increase markedly, while its lethality will remain relatively low for the immediate future. The comp...

H1N1 Influenza "Swine Flu" Peptide Vaccine Now Available For Testing Worldwide

Replikins, Ltd. has announced that it has produced a synthetic H1N1 swine flu vaccine, Replikins PanFlu™, which is ready for testing worldwide. The company has developed the vaccine based on the same Replikins peptide technology which provided the surprise advance warning one year ago that ...

Pepscan Achieves a Breakthrough With CLIPS Immunogen Technology: Synthetic Peptide Antigen is Able to Induce Fully Functional Antibodies Against a Formerly Intractable GPCR Target CXCR7

LELYSTAD, The Netherlands, April 6 /PRNewswire/ -- Today, Pepscan reports that it has achieved a major scientific breakthrough through the use of its CLIPS-based synthetic peptide immunogen technology. By constructing synthetic 3D mimics of the ligand binding-site on CXCR7 it has induced funct...

Global Biopharmaceutical Leader in Peptide Research Expands Commitment in San Diego/U.S. With New R&D Facility and Ready-To-Market Prostate Cancer Treatment Degarelix

Ferring Pharmaceuticals and Ferring Research Institute Introduce New Research Base and First Molecule Discovered by the Company in San Diego SAN DIEGO, Feb. 11 /PRNewswire/ -- Leading global biopharmaceutical company, Ferring Pharmaceuticals, and its affiliate Ferring Research Institute have ...

Sigma-Aldrich Signs Agreement With CPC Scientific for the Distribution of PEPscreen(R) Custom Peptide Libraries

ST. LOUIS, Jan. 29 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL ) today announced that it has signed a distribution agreement with CPC Scientific, a leading provider of high quality custom peptide synthesis, GMP peptides and peptide APIs for the pharmaceutical and biotechnology indu...

A New Way to Predict Outbreaks: Replikin Peptide Concentration in H5N1 Influenza Virus Genome as a Marker for Lethal Outbreaks

BOSTON, Nov. 12 /PRNewswire/ -- WHO and CDC have stated that the predictive accuracy of their annual formulations for human influenza vaccines is "suboptimal" -- often correct less than 50% of the time, especially for seniors. Perhaps in part because we are not yet accurate in our predictions ...

New England Peptide Forms Scientific Advisory Board

Peptide manufacturer appoints globally renowned scientists Gardner, Mass. (PRWEB) October 28, 2008 -- New England Peptide, LLC (NEP), has named three internationally renowned specialists to its newly formed scientific advisory board. Vincent Bille, Tomi Sawyer and V...

Novel Mass Spectrometry-based Assay Reveals Degradation and Low Levels of Bioactive B-type Natriuretic Peptide (BNP) in Patients with Heart Failure

TEMPE, Ariz., Oct. 16 /PRNewswire/ -- A team of researchers from Intrinsic Bioprobes Inc. has reported on a novel quantitative mass spectrometry immunoassay for the detection of bioactive B-type natriuretic peptide (BNP), in an article published online on Oct. 14 in the journal of Circulation:...

New England Peptide Names Director of Chemical Development

New England Peptide, LLC (NEP), has named Robert P. Hammer, Ph.D., director of chemical development. Gardner, Mass. (PRWEB) September 30, 2008 -- New England Peptide, LLC (NEP), has named Robert P. Hammer, Ph.D., director of chemical development. Hammer comes to NE...

New England Peptide Implements Quality Management System, Prepares for ISO 9001: 2008 Registration

New England Peptide, LLC (NEP), is developing a formal quality management system at its Gardner, Mass., facility, focusing on continuous process improvement and customer satisfaction. Gardner, Mass. (PRWEB) July 15, 2008 -- New England Peptide, LLC (NEP), is developing ...

Chromatide and Novasep Have Extended Their Partnership to Develop Large Scale Solid Phase Peptide and Oligonucleotide Synthesis Technology.

POMPEY, France, May 16 /PRNewswire/ -- Chromatide and Novasep have extended their partnership to develop large scale solid phase peptide and oligonucleotide synthesis technology. The resulting systems and equipment will meet the growing needs of biotechnology and pharmaceutical industries for ...

Nektar's PEGylation Technology Enables Peptide Mimetic, Highlighted by Data Presented at 45th ERA-EDTA Congress

SAN CARLOS, Calif., May 12 /PRNewswire-FirstCall/ -- Nektar Therapeutics (Nasdaq: NKTR ) highlighted today that its proprietary PEGylation technology is used in the novel therapeutic, Hematide(TM), a synthetic, peptide-based erythropoiesis-stimulating agent that is under development by Takeda...

Teva Pharmaceutical's Altered Peptide Ligand Copaxone Boasts the Greatest Patient Share Among First- and Second-Line Therapies for the Treatment of Multiple Sclerosis

Lack of Flulike Side-Effects Drives Physician Prescribing of Copaxone over an Interferon-Beta Therapy, According to a New Report from Decision Resources WALTHAM, Mass., March 11 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory f...

LC-MALDI and MALDI-MS/MS for the Analysis of Complex Peptide Mixtures

Joseph Fox 1 , Joanne B. Connolly 2 , Matthew E. Openshaw 2 1 Shimadzu Scientifi c Inc., Columbia, US; 2 Shimadzu Biotech/Kratos, UK Introduction LC-MALDI provides several advantages over conventional single spot (i.e. no separation) acqu...

Complex Peptide Mixture Analysis on the Finnigan LTQ Linear Ion Trap Mass Spectrometer

Chromatography and Mass Spectrometry Application Note Melissa Chen, Diane Cho, Thermo Electron Corporation, San Jose, CA Introduction Rapid identification of low abundance proteins in complex mixtures is one of the key objectives for the use of mass spe...

Direct Monitoring of Solid-Phase Peptide Synthesis by MALDI-TOF MS

Overview Mass spectrometry has proven to be a valuable tool in verifying and improving peptide synthesis. Matrix Assisted Laser Desorption Ionization (MALDI) Time-of-Flight (TOF) MS is particularly useful in that it is rapid, easy to use and requires relatively little maintena...

Multiplexed Quantitative Peptide Assays for Protein Biomarkers of Cardiovascular Disease in Human Plasma

Overview As the study of protein biomarkers increases in importance, extensive lists of candidate markers are being developed based on protein pathway information and discovery-based proteomics experiments. Even larger numbers of candidate genomic markers exist fr...

The development of a calcitonin-gene related peptide (CGRP) receptor-binding assay using the LEADseeker Multimodality Imaging System

Key words: CGRP • receptor binding assay •LEADseeker • SPA Imaging Beads Calcitonin-gene related peptide (CGRP) is believed to have an important physiological role in the central nervous and cardiovascular systems. Indeed, using CG...

Detecting Gastrin-Releasing Peptide Receptor by in situ PCR on Archived Tissue

In situ Adapter for the RoboCycler 40 Temperature Cycler allows rapid amplification of rare mRNA Donald D. Lorimer * Robert E. Carroll * Richard V. Benya Department of Medicine, University of Illinois at Chicago Figure 1: RoboCycler 40 Tempera...

Synthetech Reports First Quarter Fiscal 2010 Results

...ny specializing in organic synthesis, biocatalysis and chiral technologies. We develop and manufacture amino acid derivatives, specialty amino acids, peptide fragments and proprietary custom chiral intermediates and specialty resins, primarily for the pharmaceutical industry. Synthetech produces advanced p...

Nile Therapeutics, Inc. Announces Dosing of First Patient in Phase 2 Study of CD-NP for the Treatment of Acute Heart Failure

...ther areas of unmet medical needs. Nile is initially focusing its efforts on developing its lead compound, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure, and CU-NP, a novel rationally designed natriuretic peptide. More information on Nile can be fo...

Palatin Technologies, Inc. Receives U.S. Patent Allowance for Heart Failure Drug Candidate

...tion Number 11/694,260, titled "Cyclic Natriuretic peptide Constructs." Allowed claims cover a family of cyclic compounds that bind to natriuretic peptide receptor A (NPRA), including PL-3994, Palatin's le... "PL-3994 and related compounds are first-in-class peptide mimetics with extended half-lives and favorable ph...

PROLOR Biotech Acquires License Option from Yeda for Development of Long-Acting Anti-Obesity Drug

...Weizmann Institute of Science . Under the terms of the evaluation and option agreement, PROLOR may obtain from Yeda a license to develop a number of peptide drug candidates, including an anti-obesity peptide, utilizing a delivery technology developed at the Weizmann Institute. The Weizmann Institute of S...

Nile Therapeutics, Inc. Completes $3.4 Million Private Placement

...ther areas of unmet medical needs. Nile is initially focusing its efforts on developing its lead compound, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure, and CU-NP, a novel rationally designed natriuretic peptide. More information on Nile can be fo...

EnVivo Pharmaceuticals Announces Reversal of Cognitive Deficits in Alzheimer's Disease Transgenic Mouse Model With Gamma-Secretase Modulator

...imer drugs known as gamma-secretase modulators (GSMs). As a gamma-secretase modulator, EVP-0962 selectively inhibits the production of the toxic AB42 peptide without affecting the total amount of AB. As EVP-0962 does not affect other gamma secretase substrates required for normal function, such as Notch, i...

Evidence for a New Genetic Link to Therapeutic Efficacy for Alzheimer's Disease

...nzyme gene (IDE) on ADAS-Cog scores were evaluated over the study course. In addition to degrading insulin, the Ide protein also degrades amyloid beta peptide and has been implicated in playing a role in Alzheimer's disease. In the population of patients who were both APOE4(-) and lacked the C/C pol...

New drugs faster from natural compounds: A UC San Diego breakthrough

...ckly identified this fact. These algorithms make sense of the flood of tiny peptide fragments that are generated by machines called mass spectrometers that bla...First, the authors present new algorithms that computers use to piece these peptide fragments back together in order to determine the chemical structure of a c...

Novel drug discovery tool could identify promising new therapies for Parkinson's disease

...east and in other kinds of cells. Joshua Kritzer, Ph.D., a chemist and postdoctoral fellow in Dr. Lindquist's lab, designed and executed the cyclic peptide strategy. His procedure involves exposing yeast cells to short snippets of DNA that the cells can absorb and use to make cyclic peptides. Then, he fli...

Nile Therapeutics, Inc. To Raise $3.4 Million in Private Placement

...ther areas of unmet medical needs. Nile is initially focusing its efforts on developing its lead compound, CD-NP, a novel rationally designed chimeric peptide in clinical studies for the treatment of heart failure, and CU-NP, a novel rationally designed natriuretic peptide. More information on Nile can be fo...

DOR BioPharma Announces Issuance of European Patent for its LPM(TM) Oral Drug Delivery Technology

...hose biotechnology products derived from synthetic peptide chemistry or recombinant DNA," said Christopher J....owards clinical development of an oral form of the peptide hormone drug leuprolide using the LPM(TM) technology. Leuprolide is a synthetic peptide agonist of gonadotropin releasing hormone (GnRh) t...

AEterna Zentaris: New Data Published on its Ghrelin Antagonist Compound, AEZS-123 (JMV2959), Supports its Use in Alcohol Addiction

...lished on line on June 29, 2009 in the early edition of the journal. About AEterna Zentaris' Ghrelin Antagonist Program Ghrelin is a natural peptide hormone produced by the stomach that increases appetite and induces accumulation of fat tissue. The discovery of ghrelin and its receptors opens up ne...

PROLOR Biotech Awarded Two U.S. Patents for Its Longer-Acting Human Growth Hormone and Longer-Acting Erythropoietin

...harmaceutical compounds as well as certain associated methods. PROLOR's CTP technology is based on a short amino acid sequence, the Carboxyl Terminal peptide that occurs naturally in humans. When attached to a therapeutic protein, CTP extends the time that the protein is active in the body. "These two...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

...peptides. The L.E.A.P.S. constructs containing the antigenic disease epitope linked to an Immune/T-cell binding ligand (I/TCBL) can be manufactured by peptide synthesis or by covalently linking the two peptides. Depending upon the type of L.E.A.P.S. construct and I/TCBL used, CEL-SCI is able to direct the o...

Lytix Biopharma and KAEL-GemVax Announce Joint Clinical Trial to Combine LTX-315 and GV1001 Cancer Immunotherapy

... the release of warning signals from the stressed and dying cells that trigger activation of the immune system. On the other hand GV1001, a telomerase peptide vaccine in phase III trials, is one of the best documented anti-cancer vaccines currently in development, with a potentially broad utility against a r...

Calvert Research Licenses Novel Technology to Treat Age Related Macular Degeneration from Tulane University

...T1 were developed in the laboratory of Dr. David H. Coy and his team at the peptide Research Laboratory at Tulane University. AMD is a leading cause...y Calvert T1 combine the known anti-proliferative effects of a somatostatin peptide analog with a cytotoxic drug chemically linked to the peptide, resulting in...

AEterna Zentaris Presents Data Supporting Evaluation of AEZS-108 in Prostate Cancer at ASCO Meeting

...tical company focused on endocrine therapy and oncology, today announced that it presented results supporting the evaluation of its targeted cytotoxic peptide conjugate compound, AEZS-108 (formerly AN-152), in prostate cancer. The presentation was made during yesterday's poster session at the American Societ...

CEL-SCI Developing Immune-Based Treatment Against Swine and Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology

...d from the L.E.A.P.S. technology, showed adjuvant activity when used with a peptide based malaria vaccine and a DNA based malaria vaccine in animal challenge s...e linked to an Immune/T-cell binding ligand (I/TCBL) can be manufactured by peptide synthesis or by covalently linking the two peptides. Depending upon the ty...

AEterna Zentaris to Present Data Supporting Evaluation of AEZS-108 in Prostate Cancer at Upcoming ASCO Meeting

... biopharmaceutical company focused on endocrine therapy and oncology, today announced that results supporting the evaluation of its targeted cytotoxic peptide conjugate compound, AEZS-108, in prostate cancer, will be presented as a poster at the American Society of Clinical Oncology (ASCO) Annual Meeting, to...
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