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Nucleotide in Biological Technology

Genotyping Single Nucleotide Polymorphisms with Molecular Beacons

Stratagenes custom molecular beacon synthesis assists in detecting SNPs quickly and easily Fei Bao University of Colorado Health Sciences Center, Denver, Colorado We used Stratagenes custom molecular beacons ff, to detect a single nucleotide polymor...

Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon Allelic Discrimination Kits

Allelic discrimination kits with excellent specificity, sensitivity, and assay throughput Xiuyuan Hu Lingyu Chen Stratagene Because of their unique hairpin conformation, molecular beacon probes can recognize single base differences, making them ideal fo...

Pharmasset to Present at Canaccord Adams Conference

...re being conducted through a strategic collaboration with Roche. Our other clinical stage candidates are PSI-7851, an unpartnered, next generation HCV nucleotide analog which recently began Phase 1 clinical studies and Racivir, for the treatment of HIV, which has completed a Phase 2 clinical trial. Pegas...

SEQUENOM Announces Launch of MassARRAY Compact 96 System

...ke changes to assays and biomarkers throughout the validation process. MassARRAY technology supports key genomic applications, including single nucleotide polymorphism (SNP) genotyping, quantitative gene expression, and copy number variation (CNV) analysis, providing a multi-faceted view of a researcher'...

Idenix Pharmaceuticals Reports Second Quarter and Six Month 2009 Financial Results

...y that it had successfully completed a proof-of-concept study of its lead HCV antiviral development program, IDX184, a novel once-daily liver-targeted nucleotide prodrug. This double-blind, placebo-controlled, monotherapy, dose-escalation study in HCV genotype-1-infected patients evaluated the safety and antivi...

Frost & Sullivan Awards Precision Biosciences for Technology Innovation and Molecular Design Process in the Genomics Market

...egree of specificity is uncommon in natural proteins and is an inherent property of the I-CreI enzyme, which can recognize and modify a distinctive 22 nucleotide DNA 'address' in the genome of certain algae. "Precision successfully adapted this natural DNA editing system for use in biotechnology by modifyi...

Pharmasset Reports Fiscal Second Quarter 2009 Financial Results

...t healthy volunteer in the phase 1 trial with PSI-7851, a second generation nucleotide inhibitor of HCV. "Our HCV pipeline continues to make ...gic collaboration with Roche; PSI-7851, an unpartnered, next generation HCV nucleotide analog, which recently began Phase 1 clinical studies and Racivir, for the ...

Beyond associations: Colorectal cancer culprit found

... in this search by the genome-wide association study (GWAS), a technique that scans the genome for known common genetic variants, also known as single nucleotide polymorphisms, or "SNPs," that are more prevalent in patients with a specific disease. However, a SNP associated with a disease is not necessarily th...

Idenix Pharmaceuticals Reports Data From Three Hepatitis C Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver

...tations include data on IDX184, a once-daily, oral nucleotide polymerase inhibitor prodrug currently being evalu...ign an optimal combination therapy." IDX184 nucleotide Prodrug Polymerase Inhibitor IDX184 is a liver-targeted, oral nucleotide prodrug designed to enhance the formation of its a...

SeqWright to Invest in LaserGen's Novel Lightning Terminators(TM)

...ength, while lowering cost. These benefits are achieved through LaserGen's nucleotide chemistry by attaching a special terminating group directly to the base, fr...pon cleavage, however, Lightning Terminators(TM) restore the incorporated nucleotide back to its natural state. This distinguishes the LaserGen chemistry from ...

Idenix Announces Data Presentations from Three HCV Discovery and Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver (EASL)

...e as follows: ANTIVIRAL ACTIVITY OF THE LIVER-TARGETED nucleotide HCV POLYMERASE INHIBITOR IDX184 CORRELATES WITH TROUGH SERUM LEVELS OF THE ...time: 16:00 - 18:00 IDX184, A LIVER-TARGETED nucleotide HCV POLYMERASE INHIBITOR: RESULTS OF A FIRST-IN-MAN SAFETY AND PHARMACOKINE...

Frost & Sullivan Lauds BioTrove for Providing Research-Enabling Life Sciences and Drug Discovery Technologies

...euticals to assist research efforts with the company's innovative technologies. These research endeavors ranged from lead compound discovery to single nucleotide polymorphism (SNP) genotyping on the OpenArray(R) system to investigating novel therapeutic targets with the RF-MS system. Researchers often appreciat...

California Grants SeqWright License to Operate as a Clinical Laboratory

...nced today that it has been granted a California clinical laboratory license. This license enables SeqWright to utilize its DNA sequencing and Single nucleotide Polymorphism (SNP) Genotyping expertise in order to provide genetic tests to California residents and represents a significant step forward in the shi...

Discovery of a new retinal gene involved in childhood blindness

...is detailed screen are then subjected to a second DNA chip, this one to identify significant stretches of homozygosity in SNP markers. SNPs are single nucleotide repeats, which are natural variations in the human genome. These homozygous regions may contain new genes and are carefully probed based on functional...

Idenix Pharmaceuticals Reports Fourth Quarter and Year End Financial Results

... million in development, regulatory and sales milestones. During 2008, Idenix completed a phase I, healthy volunteer study of IDX184, its lead nucleotide polymerase inhibitor for the treatment of hepatitis C, and advanced the drug candidate into proof-of-concept testing in treatment-naive HCV-infected p...

Pharmasset Reports Fiscal First Quarter 2009 Financial Results

... 30, 2009, Pharmasset filed an IND for PSI-7851, a nucleotide inhibitor of HCV, with the FDA and expects to init... filing an IND for PSI-7851, our second generation nucleotide for HCV and, strengthening our balance sheet by ra...tiating phase 1 studies with its second generation nucleotide inhibitor for HCV, PSI-7851 in the first quarter o...

Isis Initiates Phase 1 Clinical Trial of SGLT2 Antisense Drug

...tisense drug for a kidney target, ISIS-SGLT2Rx is also unique due to its 12 nucleotide length rather than the more typical 18 - 21 nucleotide sequences that comprise Isis' other drugs, an attribute that reduces the co...

Genomic Health Announces Fourth Quarter and Year-End 2008 Financial Results and Business Progress, Provides 2009 Financial Guidance

...is is possible in DCIS that is adjacent to invasive ductal carcinoma of the breast. - Results indicating that multiple single nucleotide polymorphisms in the genes that encode ER were not associated with the level of ER expression in breast cancer. This suggests that ...

23andMe and mondoBIOTECH Partner to Advance Research of Rare Diseases

...logy for genome-wide association studies and has the unique capability to include custom markers. This feature enabled 23andMe to select SNPs (single nucleotide polymorphisms), or variants that provide coverage of genes associated with drug response, information that is proving to be critical for the developme...

Rosetta Genomics and Collaborators Unveil Colon Cancer Screening Diagnostic; Identified Candidate MicroRNA Biomarkers in Serum

...etta's underlying serum-microRNA platform is extremely sensitive, and has demonstrated detection sensitivity on the order of a single molecule, single nucleotide specificity, and up to 700 fold test-to-control increase of certain serum microRNA biomarkers." said Dr. Ayelet Chajut, EVP R&D Molecular Biology ...

World's First Low Radiocarbon Food May Reduce Risks of Cancer and Birth Defects, and Possibly Even Slow the Aging Process

...p to 99% of the radiocarbon in the most critical food components. They will also be growing algae to produce affordable low radiocarbon amino acid and nucleotide nutritional supplements that can be used in infant formula, baby foods, and child and maternal dietary supplements. All ordinary food, whether...

Transgenomic Awarded SBIR Grant to Support Development of SURVEYOR(R) Endonuclease Adaptor-ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation

...of non-variant DNA, but is not limited to assessment of known common single nucleotide polymorphisms (SNPs). It thus bridges the current technology gap between ha... reference sample, allowing recognition of both the sequence of the variant nucleotide and the sequence context of the mutation. The library can be sequenced dire...

Idenix Pharmaceuticals Reports Second Quarter and Six Month Financial Results

...tly amended to also evaluate a 100 mg/day dose. -- Idenix has submitted an investigational new drug (IND) application for IDX184, a once-daily, oral nucleotide prodrug candidate for the treatment of chronic hepatitis C, to the United States Food and Drug Administration (FDA) and has initiated a phase I single...

DNA Study Unlocks Mystery to Diverse Traits in Dogs

...downers Kennels in Gilroy, California and Mars' Waltham Center for Pet Nutrition in the United Kingdom, studied simple genetic markers known as Single nucleotide Polymorphisms, or SNPs, to find places in the dog genome that correlate with breed traits. Because many traits are "stereotyped" -- or fixed within br...

Transgenomic Introduces SURVEYOR(R) Endonuclease Adaptor-Ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation

...s not limited to assessment of known common single nucleotide polymorphisms (SNPs). It thus bridges the current ...ng recognition of both the sequence of the variant nucleotide and the sequence context of the mutation. The libr... of mismatches arising from the presence of single nucleotide polymorphisms (SNPs) or from small insertions or d...

Ortho Biotech Oncology Research & Development Unites Johnson & Johnson Biopharmaceutical Oncology R&D Assets

... Bond EE, Robins H, Lutzker SG, Arva NC, Bargonetti J, Bartel F, Taubert H, Wuerl P, Onel K, Yip L, Hwang SJ, Strong LC, Lozano G, Levine AJ. A Single nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumour Suppressor Pathway and Accelerates Tumour Formation in Humans. Cell; 2004; 119: 591-602. ...

Honey bee invaders exploit the genetic resources of their predecessors

...ccurred. The researchers were looking for tiny variations in the sequences of nucleotides that make up all genes. Certain versions of these single nucleotide polymorphisms (SNPs, or snips) are more common to African honey bees, while others occur more frequently in honey bees in western Europe, eastern Euro...

Center for Molecular Medicine Selected to Provide DNA Analysis for Children's Oncology Group Leukemia Study

...ome is the complete DNA sequence present in every cell of an organism. "The location of naturally occurring variations in human DNA, known as Single nucleotide Polymorphisms (SNPs), serve as signposts or markers in the genome. Associating these SNP markers with diseases in different individuals provides oppor...

Anadys Pharmaceuticals Reports Third Quarter 2007 Financial Results and Operational Highlights

...g for the treatment of certain cancers. Included within this restructuring were the decisions to discontinue further development of ANA380, a nucleotide analog for the treatment of hepatitis B virus (HBV) infection, halt all work on early discovery projects, and effect an immediate reduction in...

Gene Codes Corporation Announces Version 4.8 of Sequencher Software for DNA Sequence Assembly & Analysis

...hich allows researchers to quickly and easily find DNA mutations and Single nucleotide Polymorphisms (SNPs) in their sequences. SNPs are single nucleotide changes in the DNA associated with diversity and certain diseases. Sequench...

Consortium publishes Phase II map of human genetic variation

... treat and prevent disease. The second-generation haplotype map, or Phase II HapMap, contains more than 3.1 million genetic variants, called single nucleotide polymorphisms (SNPs) three times more than the approximately 1 million SNPs contained in the initial version. The more SNPs that are on the map, the ...

454 sequencing uncovers significant genetic variation

..." appears online (ahead of print) today in the journal Science. Previous studies of human genomic variation tended to look at changes called single nucleotide polymorphism, variations that involve just one nucleotide, commonly referred to as SNP. However, the study published today suggests that structural va...

454 Sequencing(TM): Science Paper Suggests That Structural Variation Plays an Important Role in Genetic Variation

...s," appears online (ahead of print) today in the journal Science. Previous studies of human genomic variation tended to look at changes called single nucleotide polymorphism, variations that involve just one nucleotide, commonly referred to as SNP. However, the study published today suggests that structural va...

Whole Genomes From Microbes to Man

...e of the right technology at the right time. Recent publications report that insertions and deletions (indels) appear to be more important than single nucleotide polymorphisms (SNPs) in accounting for sequence variation, evolutionary change and gene defects. Although Optical Mapping does detect SNPs, the system...

Third Wave Achieves Milestone, Delivers 200,000 SNP Assays to RIKEN In Japan

...Inc. (Nasdaq: TWTI) today announced it delivered a total of 200,000 single nucleotide polymorphism (SNP) assays to RIKEN in Japan for use in various large scale ... worldwide initiative intended to create a map of common patterns of single nucleotide polymorphisms, or SNPs. SNPs are single-based variations scattered through...

Third Wave Releases Gene Test

... The analysis panel provides access to a variety of important genetic changes in the 2D6 gene that affect individual drug response, including single nucleotide polymorphisms, single and multiple base-pair deletions and whole gene deletion and duplication. While 2D6 genotyping is complex, the performance chara...

Heat-loving microbes may lead Lucigen to new products

...ompany president and CEO David Mead said. The institute makes its data publicly available. Were going to get to look at rougly 200 million bases of nucleotide sequence data, and theres going to be literally thousands and thousands of new genes in there, Mead said. The microbes, collected at Obsidian Hot Spri...

FlexiPlate siRNA

...tential to cause off-target effects are selected. SNP avoidance siRNA design is optimized to avoid all known single nucleotide polymorphisms (SNPs) using the RefSNP database. This increases siRNA potency, as an siRNA spanning a SNP will vary in its effect...

Monitoring Receptor-Mediated Changes in [Ca2+]i Using Single-Wavelength and Dual-Wavelength Indicators on the FlexStation Workstation

...fluorometer and the possible benefits of a homogeneous assay system. BACKGROUND CHO-M1 cells contain endogenous nucleotide receptors (P2Y 2 ) 3,4 that are linked to activation of phospholipase C, generation of inositol phosphates (IPs), activation of protein kinase C (PKC...

Measurement of Molecular Beacons in the SpectraMax Gemini Spectrofluorometer (MaxLine Application Note #36)

...s which bind together to form a stem. Thestrained loop portion contains the nucleotide that is complementary to theintended target. A fluorophore is covalently bo...ing on the temperature, they will react with targets containing one or more nucleotide mismatches. 2 4 Temperature control is especially important for discrimin...
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