Mutation in Biological Technology

Exiqon Diagnostics Partners With MedTrust Online to Promote KRAS Mutation Analysis and Other Innovative Molecular Oncology Diagnostic Services to Oncologists

TUSTIN, Calif., May 29 /PRNewswire/ -- Exiqon Diagnostics, announced today a strategic commercial partnership with MedTrust Online, an innovative, comprehensive internet based solution provider for oncologists that offers clinically useful knowledge on the latest topics in cancer treatment. Exiqo...

Roche Signs Exclusive Distribution Deal with DxS for K-RAS and EGFR Cancer Mutation Tests

Tests identify genetic mutations that can affect patient response to certain cancer drugs PLEASANTON, Calif., June 2 /PRNewswire/ -- Roche and DxS Ltd. have signed an exclusive distribution agreement for the DxS TheraScreen K-RAS Mutation Test and TheraScreen EGFR 29...

Rapid, High Throughput Mutation Discovery Using Fluorescent SSCP on the ABI PRISM 3100 and 3100Avant Genetic Analyzers

Abstract Single-strand conformation polymorphism (SSCP) analysis on the ABI PRISM 3100 and the 3100 Avant Genetic Analyzers provides fast, easy detection of small variations in DNA sequences, including singlebase substitutions, insertions, or deletions. SSCP An...

A Multiple Mutation Model System as a Test Development and Training Tool for Denaturing Gradient Gel Electrophoresis

Michael Hepburn and Glenn A. Miller, Ph.D., Molecular Profiling Laboratory, Genzyme, Framingham, MA Introduction The search for sequence variations in genomic DNA is important in the study of genes that play a role in the devel...

Tissue Specificity for Mutation Parallels Tissue Specificity for Cancer

Measure mutations in any tissue with the Big Blue transgenic rodent mutation assay Johan G. de Boer Barry W. Glickman Centre for Environmental Health, University of Victoria, Victoria, BC Canada With Stratagenes Big Blue transgenic rodent mutation assay,* which carrie...

Organize Your Data from the Big Blue Mutation Assay

Record, analyze, and report data with the MutaTrak electronic notebook G. (Paul) Kotturi Mark J. Dycaico Stratagene Marc Hamovitch Doug Schroeder Solana Consulting Group, Solana Beach, CA Stratagene introduces the MutaTrak electronic notebook to record Big Blue...

A Positive Selection Assay for Mutation Analysis in Big Blue Animals

Cost-effective and easy-to-use l Select-cII mutation assay kit A Positive Selection Assay for Mutation Analysis in Big Blue Animals Mark J. Dycaico Gabriela M. Tobal Stratagene Stratagene now offers an alternative way to perform mutational analysis in ...

Webcast Alert: Transgenomic Inc. Announces Second Quarter 2009 Earnings Release Conference Call Webcast

... products and services for automated high sensitivity genetic variation and mutation analysis. Their offerings include systems, products, discovery and laborato...ces divisions utilize these technologies and expertise to provide a menu of mutation scanning tests for over 700 cancer-associated genes and more than 60 valida...

SEQUENOM Announces Launch of MassARRAY Compact 96 System

...p; marketing at SEQUENOM. "MassARRAY technology enables detection of the most common molecular biomarker classes - somatic mutations via the OncoCarta mutation panel, SNPs, CNVs, methylation patterns, expression signatures - with an unmatched combination of quantitative accuracy and sensitivity. This is the t...

CEL-SCI Corporation Releases Letter to Shareholders

...xico. At this meeting the WHO's Director General was underscoring the unstoppable nature of swine flu and its potential to mutate - "Constant, random mutation is the survival mechanism of the microbial world. Like all influenza viruses, H1N1 has the advantage of surprise on its side." At the same time, the ...

Exosome Diagnostics and DxS Diagnostic Innovations Collaborate to Develop Blood-Based Tests for Key Cancer Mutations

...The collaboration will use DxS' industry leading Scorpions(R) real-time PCR mutation Test Kits in conjunction with ExosomeDX's x OS(TM) technology which harves...utations for predicting patient response to targeted therapies. Blood-based mutation measurement is particularly valuable in circumstances where tissue bioavail...

PTC Therapeutics Receives $2.6 Million in Government Grants

...pivotal trial of ataluren (PTC124(TM)) in nonsense mutation Duchenne and Becker muscular dystrophy (nmDMD/BMD)...ed as a new approach for the treatment of nonsense mutation genetic disorders. Nonsense mutations create a pr... is a potential therapy for patients with nonsense mutation genetic disorders. Ataluren has demonstrated ...

MEDomics Announces MitoDx(TM), the First NextGen Mitochondrial Genome Diagnostic Test

...s not suspect the disease or because the causative mutation is missed by current methods. " To my knowle... S. Sommer, MD, PhD, with the mission of providing mutation Expert-based Diagnosis ("MED") to support the phys...n analysis of the patient's genome ("omics"). The mutation experts at MEDomics provide unparalleled quality i...

Transgenomic, Inc. Announces Appointment of New Board Members

...ces lab, plus focusing our WAVE system and related mutation detection technology for greater diagnostic and cl...r automated high sensitivity genetic variation and mutation analysis. Their offerings include systems, product...heir technology and expertise to provide a menu of mutation scanning tests for over 700 cancer-associated gene...

Transgenomic, Inc. Reports First Quarter 2009 Results

... products and services for automated high sensitivity genetic variation and mutation analysis. Their offerings include systems, products, discovery and laborato...ces divisions utilize these technologies and expertise to provide a menu of mutation scanning tests for over 700 cancer-associated genes and more than 60 valida...

Reminder: Transgenomic Inc. Announces First Quarter 2009 Earnings Release Conference Call Webcast

... products and services for automated high sensitivity genetic variation and mutation analysis. Their offerings include systems, products, discovery and laborato...ces divisions utilize these technologies and expertise to provide a menu of mutation scanning tests for over 700 cancer-associated genes and more than 60 valida...

Transgenomic and Power3 Medical Introduce NuroPro(R) Tests for Alzheimer's and Parkinson's Diseases at AAN Annual Meeting

... products and services for automated high sensitivity genetic variation and mutation analysis. Their offerings include systems, products, discovery and laborato...ratory Services utilize their technology and expertise to provide a menu of mutation scanning tests for over 700 cancer-associated genes and more than 60 valida...

Webcast Alert: Transgenomic Inc. Announces First Quarter 2009 Earnings Release Conference Call Webcast

... products and services for automated high sensitivity genetic variation and mutation analysis. Their offerings include systems, products, discovery and laborato...ces divisions utilize these technologies and expertise to provide a menu of mutation scanning tests for over 700 cancer-associated genes and more than 60 valida...

Sangamo BioSciences Receives $100,000 Grand Challenges Explorations Grant for Innovative Global Health Research

...t advances in global health. The initiative is highly competitive, receiving more than 3,000 proposals in this round. People born with a genetic mutation in their CCR5 gene, a critical receptor for HIV entry, are naturally resistant to HIV infection. Sangamo has designed and engineered zinc finger DNA-b...

Chromosome breakpoints contribute to genetic variation

...than other parts of the chromosome. In 2005, Lewin's team showed that breakpoint regions also have higher numbers of segmental duplications, a type of mutation that increases the copy number of genes and the sequences that flank them. "To me, this was completely counterintuitive. I thought we would have th...

Transgenomic Completes Licensing Option With Dana-Farber Cancer Institute on Cold-PCR for Enrichment of DNA Mutations

...ic's WAVE DHPLC and Surveyor Nuclease products for mutation detection in cancer and mitochondrial diseases," s...is will be particularly valuable in cancer-related mutation detection of free DNA in blood and body fluids and in producing a mutation profile of primary tumors to predict resistance to...

Polycystic Kidney Disease Assay at Cornell University Uses Transgenomic's Surveyor Nuclease & WAVE Technology

...ng Transgenomic's Surveyor Nuclease technology for mutation scanning of PKD1 and PKD2 , two important genes...VEYOR Nuclease's effectiveness in disease specific mutation discovery has been well documented in many peer-re...r automated high sensitivity genetic variation and mutation analysis. Their offerings include systems, product...

Patent for Making Combination Chemotherapy Work Better

... Mark Zamoyski of San Jose, California discloses an improved method of treating lung, brain, pancreatic, breast and colon cancers that are driven by a mutation known as HER1 overexpression (also called EGFR or c-ErbB-1). The patent presents a case for why today's concurrent HER1 blocker / S-Phase cytotoxic p...

Catalyst Biosciences Expands Scientific Advisory Board With Leading Experts in Protease Therapeutic Discovery and Development

...use of Thrombotic Thrombocytopenia Purpura. The laboratory is also searching for genetic modifiers of thrombotic diseases, including the common human mutation Factor V Leiden. Studies of the bleeding disease combined deficiency of factors V and VIII by the Ginsburg lab identified mutations in two genes that...

Cytopia Scientific Presentation on JAK2 Inhibitor Program at American Chemical Society Conference

...lar disrupting agent (VDA), CYT997, has also been presented at the same conference. About JAK2 The discovery of a specific single activating mutation in the JAK2 enzyme in MPDs in 2005 has focused attention on developing a therapy for these diseases through selective inhibition of JAK2. T...

Transgenomic, Inc. Reports Fourth Quarter and Fiscal Year 2008 Results

...ing a full product line of key cancer pathway gene mutation kits to complement our WAVE and Surveyor products ... product combo will be enhanced with specific gene mutation kits based on our experience in clinical trial ass...r automated high sensitivity genetic variation and mutation analysis. Their offerings include systems, product...

Reminder - Webcast Alert: Transgenomic Inc. Announces Fourth Quarter 2008 Earnings Release Conference Call Webcast

... products and services for automated high sensitivity genetic variation and mutation analysis. Their offerings include systems, products, discovery and laborato...ces divisions utilize these technologies and expertise to provide a menu of mutation scanning tests for over 700 cancer-associated genes and more than 60 valida...

Discovery of a new retinal gene involved in childhood blindness

...total of fifteen genes involved in LCA, but SPATA7 is the first gene with a mutation that disrupts the protein transport between two important compartments of t...pass through this transport pathway; thus SPATA7 plays a major role and its mutation may affect many aspects of vision. "Until now we were not aware that th...

Transgenomic Awarded Clinical Laboratory Certification in California

... products and services for automated high sensitivity genetic variation and mutation analysis. Their offerings include systems, products, discovery and laborato...ratory Services utilize their technology and expertise to provide a menu of mutation scanning tests for over 700 cancer-associated genes and more than 60 valida...

Webcast Alert Cancellation: Transgenomic Inc. Cancels Fourth Quarter 2008 Earnings Release Conference Call Webcast

... products and services for automated high sensitivity genetic variation and mutation analysis. Their offerings include systems, products, discovery and laborato...ces divisions utilize these technologies and expertise to provide a menu of mutation scanning tests for over 700 cancer-associated genes and more than 60 valida...

Webcast Alert: Transgenomic Inc. Announces Fourth Quarter 2008 Earnings Release Conference Call Webcast

... products and services for automated high sensitivity genetic variation and mutation analysis. Their offerings include systems, products, discovery and laborato...ces divisions utilize these technologies and expertise to provide a menu of mutation scanning tests for over 700 cancer-associated genes and more than 60 valida...

VAP Cholesterol Test Helps In Search For New Heart Disease Drugs

...hers have found an association between a rare gene mutation and heart protection. The information reported in ...ted journal, Science, identified a specific gene mutation ( APOC3 R19X) present in 5 percent of a Lancaster...igator, said participants who were carriers of the mutation had one of their inherited APOC3 genes "switched...

Lentigen and Expression Therapeutics Sign Hemophilia Co-Development Agreement

...ative agreement to co-develop novel cell and protein therapies for Hemophilia A. Hemophilia A is an inherited blood clotting disorder caused by a mutation in the factor VIII gene resulting in a deficiency of factor VIII protein. Lentigen and Expression Therapeutics will develop two types of treatments fo...

Sangamo BioSciences Initiates Phase 1 Trial of CCR5-ZFP Therapeutic to Treat HIV/AIDS

...t was observed that individuals carrying a natural mutation of their CCR5 gene, CCR5-delta32, were highly resi...and matched donors who also carry the CCR5-delta32 mutation are likely to be rare. Small molecule or antibody ...ins. A small fraction of the population carries a mutation in their CCR5 gene, called the delta32 mutation. ...

Chronic Lung Disease - Axentis Pharma Attracts Investment Interest

...ereditary disease amongst Caucasian populations. The disease is caused by a mutation in the CFTR (cystic fibrosis transmembrane conductance regulator) gene found on chromosome 7. This mutation causes increased secretion deposits on mucous membranes. Lung complications...

First Patient Dosed in Phase 2 Clinical Trial of NKTR-102 in Ovarian Cancer

...ment in progression-free survival as compared to standard irinotecan monotherapy. It is estimated that up to 45% of colorectal cancer cases have this mutation in the KRAS gene and do not respond to EGFR-inhibitors, such as cetuximab. The NKTR-102 Phase 2 studies in ovarian, breast, and cervical cancer...

Transgenomic Receives Accreditation From College of American Pathologists

... instruments and consumables with our related expertise in high sensitivity mutation detection analysis. We plan to immediately pursue the benefits of the accre...ratory Services utilize their technology and expertise to provide a menu of mutation scanning tests for over 700 cancer-associated genes and more than 60 valida...

Transgenomic Signs Letter of Intent for an Agreement to Exclusive License With Option to Acquire Power3 Medical Products' Neurodegenerative Diagnostics

... and Reference Laboratory Services. Transgenomic Pharmacogenomics and Laboratory Services utilize their technology and expertise to provide a menu of mutation scanning tests for over 700 cancer-associated genes and more than 60 validated diagnostic tests to meet the needs of pharmaceutical and biotech compan...

Transgenomic Awarded SBIR Grant to Support Development of SURVEYOR(R) Endonuclease Adaptor-ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation

...s and Reference Laboratory Services. Transgenomic Pharmacogenomics and Laboratory Services utilize their technology and expertise to provide a menu of mutation scanning tests for over 700 cancer-associated genes and more than 60 validated diagnostic tests to meet the needs of pharmaceutical and biotech compan...

Stem Cell Sciences Enters into Services Agreement with Huntingdon's Disease Research Group, CHDI Foundation Inc.

...ington's disease is a familial disease caused by a mutation in the huntingtin gene. Each child of a parent with a mutation in the huntingtin gene has a 50-50 chance of inher...years. One person in 10,000 is believed to carry a mutation in the huntingtin gene. There is currently no way ...