Multimodality in Biological Technology

Nucletron Announces Oncentra(R) Brachy* Treatment Planning Solution for Multimodality Environment

VEENENDAAL, The Netherlands, April 28 /PRNewswire/ -- - New Anatomy-Based Solution for HDR/PDR Brachytherapy Represents the Next Generation in DICOM-Compatible, Integrated Cancer Treatment Planning Nucletron, a knowledge-based leader in radiation oncology, today announced the introduction ...

Integration of the LEADseeker Multimodality Imaging System with automated plate loading and incubation using Overlord Instrument software

Key words: LEADseeker • imagin g • automatio n • integratio n The LEADseeker™ Multimodality Imaging System is a CCD-based optical imaging instrument that efficiently detects and quantitates light from a range of radiometric, lum...

Development of a CRF1 neuropeptide receptor binding assay using LEADseeker Multimodality Imaging System

Key words: CRF 1 • GPCR • receptor binding assay • LEADseeker • SPA Imaging Beads In the mammalian brain, the corticotrophin-releasing factor (CRF) system comprises four CRF-related peptides (CRF and urocortin 1, 2, and 3...

Development of an adrenergic α2a receptor binding assay using the LEADseeker Multimodality Imaging System

Key words: α 2c receptor • GPCR • receptor binding assay • LEADseeker • SPA Imaging Beads The α 2 -adrenergic receptors are G protein-coupled receptors that play a key role in the control of numerous physiol...

The development of a serotonin 5-HT2C receptor-binding assay using the LEADseeker Multimodality Imaging System

Key words: serotonin • GPCR • receptor binding assay • LEADseeker • SPA Imaging Beads In mammals, serotonin (5-hydroxytryptamine, 5-HT) is a regulator of neural transmission which induces its biological effect by binding to ...

The development of a somatostatin sst4 receptor-binding assay using the LEADseeker Multimodality Imaging System

Key words: somatostatin • receptor binding assay • LEADseeker • SPA Imaging Beads Somatostatin (SS) is a neurotransmitter/hormone with a wide range of biological actions (1–3) and a reduction in cortical SS levels has been re...

Development of an NK2 neuropeptide receptor binding assay using LEADseeker Multimodality Imaging System

Key words: NK2 • GPCR • receptor binding assay • LEADseeker • SPA Imaging Beads Neurokinins, also known as tackykinins, are a family of small neuropeptides. Members of this family include peptides, substance P (SP), neurokin...

Use of BRET2 luminescence cell-based assays with LEADseeker Multimodality Imaging System

Key words: luminescence • BRET 2 • LEADseeker • DeepBlueC• cell-based assays Competitive pressure is forcing organizations to continually increase screening throughput. Yet accuracy and sensitivity remain vital concerns, par...

Use of the HitHunter EFC Chemiluminescent Detection Kits with LEADseeker Multimodality Imaging System

Key words: EFC chemiluminescence • HitHunter • LEADseeker Competitive pressure is forcing organizations to continually increase screening throughput. Yet accuracy and sensitivity remain vital concerns, particularly for common screens such...

Performance of fluorescent dyes with LEADseeker Multimodality Imaging System

Key words: fluorescence • LEADseeker • Cy • Alexa Fluor • TAMRA • Brij Flexible and scalable uHTS programs demand that organizations be able to select the most appropriate or cost-effective fluorescent reagents for t...

Development of a histamine H1 receptor binding assay using the LEADseeker Multimodality Imaging System

Key words: H 1 receptor • GPCR • receptor binding assay • LEADseeker • SPA Imaging Beads Histamine is a biogenic amine that plays important pathophysiological roles in central and peripheral tissues. Generally released from stimul...

The development of a calcitonin-gene related peptide (CGRP) receptor-binding assay using the LEADseeker Multimodality Imaging System

Key words: CGRP • receptor binding assay •LEADseeker • SPA Imaging Beads Calcitonin-gene related peptide (CGRP) is believed to have an important physiological role in the central nervous and cardiovascular systems. Indeed, using CG...

The development of a melanocortin MC5 receptor binding assay using the LEADseeker Multimodality Imaging System

Key words: Melanocortin • receptor binding assay • LEADseeker • SPA Imaging Beads Pro-melanocortins are present in high levels in the pituitary and are processed into three major peptide hormone fragments: adrenocorticotrophin (ACTH), th...

The development of a melanocortin MC4 receptor binding assay using the LEADseeker Multimodality Imaging System

Key words: Melanocortin • receptor binding assay • LEADseeker • SPA Imaging Beads Pro-melanocortins are present in high levels in the pituitary and are processed into three major peptide hormone fragments: adrenocorticotrophin (ACTH), th...

Performance of the AMARA HitHunter Chemiluminescence Kinase Assay with the LEADseeker Multimodality Imaging System

Key words: AMARA • kinase assay • LEADseeker • chemiluminescence It is predicted that at least 500 kinase and phosphatase enzymes exist, their activities having wide-ranging regulatory responses. Many kinases are part of a signaling cascade ...

The development of a CXCR2 chemokine receptorbinding assay using the LEADseeker Multimodality Imaging System

Key words: CXCR2 • GPCR • receptor binding assay • LEADseeker • SPA Imaging Beads Chemo-attractant cytokines (chemokines) are low molecular weight, pro-inflammatory cytokines with potent leukocyte activation and/or chemotactic activ...

Small Animal Imaging Market: Biospace Lab Wins Frost & Sullivan Accolade for Its Successful Product Line Strategy

...cal research in drug discovery and biology. The company has developed in this field a comprehensive portfolio of in vitro, in vivo and now in actio(R) multimodality small animal imaging solutions used by almost every major pharmaceutical company and many prestigious academic centers worldwide. Biospace Lab headq...

Varian Medical Systems Exhibits a New Version of RapidArc(TM) Radiotherapy Technology and Other Products for Fast, Precise Cancer Treatment

... Boston Waterfront Hotel, with presentations about: -- Early adopters' clinical experience with RapidArc(TM) radiotherapy technology -- The use of multimodality imaging to optimize treatment plans for difficult cases -- Using the ARIA(TM) oncology information system to achieve a paperless environment -- Pa...

Delivering Molecular Imaging Solutions Across Clinical Specialties: Siemens Showcases New Technologies at RSNA 2007

...s also versatile and it can be upgraded as a facility's workload grows. Preclinical Imaging and Radiopharmaceutical Preparation Siemens' preclinical multimodality imaging solutions offer a versatile and upgradeable platform as well as a comprehensive suite of analysis applications. Siemens' newest preclinical so...

Homogeneous, chemiluminescent kinase assay kits for assessing the functional activity of a broad range of serine-threonine and tyrosine kinases

...of luminescent substrate generates a signal that can be easily read on standard microplate readers and imaging platforms such as the LEADseeker™ multimodality Imaging System.

HitHunter Kinase Assay Kits utilize an ED-phosphorylated substrate conjugate that is capab...

Development of a sensitive enzyme fragment complementation assay for cyclic adenosine 3', 5' monophosphate and its validation for pharmacological screening at G protein-coupled receptors

...microplates and imaged using the LEADseeker™ multimodality Imaging System.

...ls Products used LEADseeker multimodality Imaging System 18-1140-71 ...ted overnight before measurement on the LEADseeker multimodality Imaging System.

Resul...

Utilization of Donkey Anti-Rabbit PS SPA Imaging Beads in the quantitative measurement of cAMP in cells

...etected by platforms such as the LEADseeker™ multimodality Imaging System. ...ls Products used LEADseeker multimodality Imaging System 18-1140-71 ... Beads was determined by imaging on the LEADseeker multimodality Imaging System for 5 min (2).

...