ALPCO Introduces a Mouse HMW and Total Adiponectin ELISA
SALEM, N.H., Aug. 7 /PRNewswire/ -- ALPCO Diagnostics has introduced a Mo u se HMW Adipone c tin EL I SA kit that facilitates the testing process for this biomarker. This ELISA is unique; it is a departure from other methods for determining mouse
HMW adiponectin and was first introd...
EnVivo Pharmaceuticals Announces Reversal of Cognitive Deficits in Alzheimer's Disease Transgenic Mouse Model With Gamma-Secretase Modulator
VIENNA, July 14 /PRNewswire/ -- EnVivo Pharmaceuticals today announced at the Alzheimer's Association 2009 International Conference on Alzheimer's Disease (ICAD) the reversal of behavioral deficits observed in an Alzheimer's disease transgenic animal model after chronic oral dosing of a propr...
febit First to Offer Newly Published Mouse Genome on a Chip for DNA/RNA Detection and Enrichment
febit Technology Enables the Conversion of New Sequence Data into Biochips for Gene Expression Profiling and Sequence Capture for Next-Generation Sequencing Within Days
LEXINGTON, Mass. and HEIDELBERG, Germany, June 29 /PRNewswire/ -- febit holding gmbh announced today the launch of the f...
ExonHit Launches Mouse Genome SpliceArray(TM) for use in Human Disease Modeling Studies
PARIS, November 28 /PRNewswire-FirstCall/ -- ExonHit Therapeutics S.A.
(Alternext: ALEHT), a drug and diagnostic discovery company, announces today
the availability of its new SpliceArray(TM) for use in studying mouse
of human disease. These SpliceArray(TM) products help our clients acceler...
A Novel Process for Gene Expression Profiling of Rat and Mouse Tissues from Formalin-Fixed Paraffin-Embedded Sections Using Microarrays
This application note describes a method for extracting and isolating total RNA from rodent tissues that have been fixed in formalin and embedded in paraffin, and the subsequent amplification of mRNA from these tissues for use in microarray experiments. We have used this...
Simultaneous Detection of 8 Cytokines in Mouse or Human Sera
Aiguo Zhang, Allora Aguilera, Chate Luu, Ivan Huang,
Diana Davis, Chloe Etienne, Yong Song, Reni Thomas,
Kris Simonyi, Jim Wong, Quan Nguyen
Bio-Rad Laboratories, Life Science Group, 2000 Alfred Nobel Drive,
Hercules, CA 94547
RNase Activity in Mouse Tissue: Classification, Hierarchy, and Methods for Control
Protecting RNA During Isolation
RNase activity varies dramatically across
different tissues. A comparison of total RNase activities for 8 different
tissues showed that total RNase activity spans a 181,000-fold range
from pancreas t...
Cenix-Designed siRNAs for 95% of Human and Mouse Genomes
siRNA designs now available
for >95% of all human and mouse
genes listed in RefSeq
Design algorithm developed by Cenix results in highly effective siRNAs
High quality custom siRNA synthes...
Amplification of Mouse cDNAs for Microarrays Using the Eppendorf
Katrine Verdun, Richard Rouse, and Gary Hardiman
BIOGEM, Division of Biology, University of California San Diego, La Jolla,
Simple, Sensitive Isotyping of Mouse Monoclonal Antibodies
Monoclonal antibody isotyping in only 5 minutes
Weiping Yang Matt C. Petre Darrel Holmes Peter L.
Stratagene Cloning Systems, Inc.
Stratagenes IsoDetect mouse
monoclonal antibody isotyping kit is a
simple, rapid and sensitive method for identifying mouse
RT-PCR Primer Sets for Human and Mouse Mismatch Repair Genes
Primer sets facilitate study of DNA mismatch repair
Stratagene Cloning Systems
Stratagene has designed RT-PCR primer sets from the cDNA
sequences of mismatch repair genes. These genes code for specialized proteins
that participate in correcting areas of ...
Embryonic stem cells, mouse
Protocol No. 4308 915.039 12/1999
Transposagen Creates a Rat Model of the Human Immune System
...ronment to reduce the likelihood of contracting a fatal infection. The SCID mouse
has been one of the most often used animal models in the history of drug di...splantation research," said Dr. Ostertag.
Rat models are superior to mouse
models for testing the pharmacodynamics and toxicity of potential therapeut...
Sangamo BioSciences Reports Second Quarter 2009 Financial Results
...c rats in which specific genes are deleted or knocked out. The technology opens the door for the production of knockout animals in species other than mouse
and broadens the possibilities for new animal models of human disease.
Sangamo awarded Grand Challenges Explorations Grant for Innovative Globa...
Time Clocks Technology Catches Up With Crooks
...y, NSW (PRWEB) July 24, 2009 -- Technology is putting an end to the cat and mouse
game of sneaking in late to work - the mouse
is caught at the door, in the back room, or on pay day! We rounded up a gro...
OMT announces a breakthrough in the development of a novel human antibody platform
...body technologies or licensing/fee for service arrangements. Currently, the mouse
is the only genetically engineered animal commercially available for the ge... and many targets are licensed already. The expense and limitations of the mouse
technology create an opportunity for OMT and its new monoclonal antibody pl...
Peregrine Pharmaceuticals Licenses Anti-VEGF Antibodies to Affitech
...ce in 2007 showed that r84 was as effective as Avastin(R) (bevacizumab) in inhibiting tumor growth in a number of models of human cancers, including a mouse
model of human breast cancer. r84 is distinctive because it selectively blocks VEGF from binding to VEGF receptor 2 (VEGFR2), while non-selective age...
Stem cells' 'suspended' state preserved by key step, scientists report
...could lead to treatments by directing the restored stem cells to produce healthy neurons to introduce into patients.
The new research, conducted on mouse
embryo cells, revealed that a gene known as Chd1 loosens the packaging that normally protects DNA in the cell nucleus. This step, known as chromatin r...
AEterna Zentaris: New Data Published on its Ghrelin Antagonist Compound, AEZS-123 (JMV2959), Supports its Use in Alcohol Addiction
...idence obtained with the administration of AEZS-123, and a ghrelin receptor mouse
knockout model, highlights the role of ghrelin to regulate the rewarding value of alcohol in a mouse
model of alcohol dependence. When ghrelin's actions are blocked, alcohol's ...
Lixte Biotechnology Holdings' Lead Compound, LB-1.2, Enhances the Effectiveness of Standard Cancer Chemotherapy in Animal Models
...d, LB-1.2, enhances the effectiveness of two standard chemotherapy drugs in mouse
models of human cancers. This research is being conducted under a Cooperati... from recovering from DNA-damage produced by standard anti-cancer drugs. In mouse
models, LB-1.2 plus Temozolomide caused complete regression without recurre...
Scientists identify gene vital to early embryonic cells forming a normal heart and skull
...yme that helps trigger a cascade of biochemical reactions in cells as they specify to form certain tissues.
Although the study was conducted using mouse
embryos, the findings are significant in efforts to understand congenital malformations of the heart and craniofacial region in people. Especially rel...
Assessment of safety and efficacy of human embryonic stem cell therapy
...dy was carried out in the NIH III immune deficient mouse
model. Long-term data (spanning the life of the a...as chosen for a GLP safety study using the NIH III mouse
model, an immune deficient animal model. Importan...ly, we also showed that vision can be rescued in a mouse
model of Stargardt's disease, which is a form of e...
Celator(R) Pharmaceuticals Presents Data on the Activity of CPX-351 Against Leukemia at the European Hematology Association Congress
...).(2) They reported that CPX-351 ablated leukemic cells but permitted the regrowth of normal bone marrow cells within 42 days of treatment in a Rag2-M mouse
xenograft model. These mice remained leukemia-free for up to 70 days (saline-treated controls all died by Day 42). In several additional experiments...
Clontech Laboratories, Inc. Releases the Xfect(TM) and Xfect(TM) Stem Transfection Reagents
...in the presence of serum. Xfect shows high efficiency over a broad range of cell types, while Xfect Stem meets the highly specialized requirements for mouse
embryonic stem cell transfections.
Carol Lou, General Manager of Clontech Laboratories, Inc., comments: "Clontech has a long history of leadershi...
ZyGEM Releases Application Note Showing its DNA Extraction Kits Rapidly Produce High Yields of Quality DNA
...er Commercial Kits--
-- Samples Prepared from mouse
Tails Using prepGEM(TM) Yielded Over 34 Times the ...racting DNA and determining precise genotypes from mouse
tail samples. Researchers performed extractions c...d DNA.
"This new application note focusing on mouse
genotyping demonstrates that our prep GEM(TM) Tis...
CEL-SCI's L.E.A.P.S. Technology Shows Potential to Treat Swine Influenza in Preclinical Studies
...n Presentation System) vaccine technology could potentially induce protection against illnesses such as swine influenza. In pre-clinical studies using mouse
models, several different L.E.A.P.S. conjugates focused on different diseases induced protection and disease improvement. In addition, it was recentl...
AMG Launches EVOS fl, an 'Evolutionary' Fluorescence Microscope Based on Innovative EVOS Platform
...s supported by an embedded microprocessor that gives the user full control of image acquisition and management without need for an external computer. mouse
control and a streamlined user interface provide tools for adjusting illumination levels, balancing fluorescence and transmitted light channels, cap...
Ascenta Therapeutics Announces Results of Preclinical Evaluation of AT-406 in Multiple Cancer Models
...ent in vitro in a number of cell lines, including breast cancer, lung cancer, pancreatic cancer, prostate cancer, and bladder cancer, and in several mouse
xenograft cancer models. AT-406 also showed synergistic or additive effects when used together with tyrosine kinase inhibitors or chemotherapy in vi...
AEterna Zentaris Presents Two Posters on its PI3K Inhibitor Compound, AEZS-126, at AACR Annual Meeting
...ofiling of the compound, as well as in vivo pharmacokinetic experiments and mouse
xenograft antitumor studies.
AEZS-126 was identified as a... ion-channels. During the course of in vivo pharmacokinetic experiments and mouse
xenograft antitumor studies, the oral bioavailability in mice was determine...
Keryx Biopharmaceuticals Presents Encouraging Preclinical Data at Annual Meeting of the American Association of Cancer Research
... phosphorylation, and decreases of cell survival. In vivo studies of perifosine treatment led to significant increases in neuroblastoma tumor bearing mouse
survival. In summary, Investigators conclude that the data indicates that as a single agent, perifosine targets activation of Akt in neuroblastoma ce...
Preclinical Data From Amgen's Oncology Pipeline to be Presented at AACR
...view: Two different neutralizing rat anti murine CSF-1R monoclonal
antibodies (mAb), M279 and AFS98 were evaluated for their effect on
corneal angiogenesis and corneal macrophage recruitment in vivo
Lead author: Liu H.
Abstract No. 1106 (Sunday, April 19, 2009, 1:00 pm...
AEterna Zentaris To Present Data on Anticancer Compounds AEZS-112 and AEZS-126 at AACR Annual Meeting
...ller and E. Guenther, the poster
focuses on ADMET and safety profiling of the compound, as well as in
vivo pharmacokinetic experiments and mouse
xenograft antitumor studies.
AEZS-126 (Poster #3706)
- Entitled, "In vitro profiling of the potent and selective PI3K
Amniotic Fluid May Provide New Source of Stem Cells for Future Therapies
...een, thymus, and lymph nodes) of the mice were dissected. Transplants using mouse
AFKL cells were found to be successful; newly formed white blood cells of a...topoietic organs examined after 10-13 weeks. The secondary transplants with mouse
AFKL cells were partially successful with some of the mice engrafting the d...
Oncolytics Biotech(R) Inc. Collaborators Present Reovirus Research at Replicating Oncolytic Virus Meeting
...tion entitled "Combination of Oncolytic Reovirus and Rapamycin in a B16.F10 mouse
Melanoma Model." In this study, the investigators examined the in vitro and in vivo oncolytic activity of reovirus against the mouse
melanoma cell line B16.F10 in combination with the mTOR inhibitor rapamycin...
Progress toward an Alzheimer's drug that saves brain cells
...rent shape and function according to the tissue in which the secretase is active. For their research on Alzheimer's disease, the researchers have used mouse
models. They have found that deactivating the variant, Aph1B γ-secretase, in Alzheimer mice leads to reduced formation of the plaques, without a...
InterMune to Present Abstracts on HCV Protease Inhibitor ITMN-191 and HCV Development Program at the EASL Meeting
...splay Unimpaired Activity Against an NS3 Sequence Variant Associated with Resistance to Linear Tetrapeptides and Macrocyclic Inhibitors .
Model with Long Term Expression of Hepatitis C Virus NS3/4A Protease for the Pharmacokinetic and Pharmacodynamic (PK-PD) Study of HCV Protease Inhibit...
GeneCopoeia Introduces Genome-Wide MicroRNA (miRNA) Functional Analysis Tools
...llections cover all known miRNAs for human (750), mouse
(450), and rat (270). These lentiviral vector base...' UTR) expression clones cover genome-wide human, mouse
and rat genes. These expression ready constructs a...largest number of full-sequence-verified human and mouse
full length protein coding ORF cDNA clones , whic...
Enobia Completes Target Enrollment in Clinical Trial for Infantile Hypophosphatasia
...cement therapy of tissue non-specific alkaline phosphatase (TNSALP) fused to a patented bone targeting peptide. Preclinical studies in the "knockout" mouse
model of severe hypophosphatasia showed that subcutaneous administration of ENB-0040 significantly improved survival, prevented the skeletal and denta...
Sigma-Aldrich Introduces MISSION(R) LentiPlex(TM) Pooled shRNA Libraries to Enable Rapid Whole Genome Screening in Primary Cells, Stem Cells or Tumor Cells
...iPlex Pooled shRNA Libraries were developed from the entire TRC-1 human and mouse
collections of more than 158,000 shRNA constructs targeting approximately 16,000 human genes and approximately 16,000 mouse
genes. Combining Sigma-Aldrich's high-throughput lentiviral production meth...
Anti-cancer gene discovered: Perspective for therapy
... Starting with the tiny fruit fly, and then moving into mouse
and human patients, researchers at VIB connected to the Center for Human Genetics (K.U. Leuven) showed that the same gene suppresses cancer in all thr...