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Metabolite in Biological Technology

XenoTech LLC Offers Drug Industry New Metabolite Profiling Services Following Acquisition of Waters Synapt HDMS System

Investing in Groundbreaking Mass Spectrometry Technology Allows Contract Research Organization to Offer Pharmaceutical Clients Comprehensive Pre-Clinical Study Data MILFORD, Mass., Feb. 16 /PRNewswire-FirstCall/ -- Waters Corporation (NYSE: WAT ) announced today that XenoTech (Lenexa, K...

Prometheus Strengthens Intellectual Property Portfolio with Newly Issued Patents for Thiopurine Metabolite Testing

SAN DIEGO, Oct. 30 /PRNewswire/ -- Prometheus Laboratories Inc., a specialty pharmaceutical and diagnostics company, announced that the U.S. Patent and Trademark Office (USPTO) has issued two separate patents covering the technology for PROMETHEUS(R) Thiopurine Metabolites, a diagnostic test t...

Codexis Licenses New Drug Metabolite Profiling and Lead Diversification Technology From the California Institute of Technology

Potential Earlier Identification of Toxicity, Efficacy for Pharmaceutical Developers REDWOOD CITY, Calif., Aug. 29 /PRNewswire/ -- Codexis, Inc., a private biotechnology company and leading developer of clean manufacturing processes, today announced it has licensed...

Determination of Acepromazine and its Major Metabolite in Equine Serum by LC-MS/MS using the Finnigan LCQ Deca XP Plus Ion Trap Mass Spectrometer

Chromatography and Mass Spectrometry Application Report Key Words Sensitivity Quantitation Finnigan LCQ Deca XP Plus Equine serum Acepromazine Gargi Choudhary, Thermo Electron Corporation, San Jose, CA USA Wayne Skinner and Scott Stanley, Universi...

Analysis of a Verapamil Microsomal Incubation using Metabolite ID and Mass FrontierTM

Chromatography and Mass Spectrometry Application Note Key Words Metabolism Study Structure Elucidation Metabolite ID Mass Frontier Mark R. Kagan, Thermo Electron Corporation Introduction The characterization of a drugs metabolites plays a ...

Simultaneously characterizing and quantifying chloramphenicol and its metabolite using LC/MS/MS

With the advent of liquid chromatography/ mass spectrometry and information dependent data acquisition function in mass spectrometry, it has become possible to characterise metabolites while to quantifying their parents during metabolic stability studies. This was once impossible to be an...

Supelco(R) and MIP Technologies Launch New SPE Product for the Selective Extraction of NSAIDs From Environmental Water

...uprofen, diclofenac and naproxen are non-steroidal anti-inflammatory drugs that have analgesic and antipyretic activities. Clofibric acid is an active metabolite of clofibrate, etofibrate and etofyllinclofibrate. These compounds are used as blood lipid regulators. Because of the pharmacological activity of the ...

DOR BioPharma Announces Publication of orBec(R) Clinical Pulmonary Data in Bone Marrow Transplantation

...ease. Blood 109: 4557 - 4563, 2007). "While these trials were not designed to look at pulmonary endpoints, these observations suggest that a metabolite of oral BDP may be having a beneficial anti-inflammatory effect in the lungs of hematopoietic cell transplant recipients," stated Jason W. Chien, MD, ...

Phase II Trial Demonstrates Elacytarabine May Increase Survival Threefold in Patients With Late-Stage Leukaemia

...xic activity of elacytarabine is thought to be mediated through increased cellular uptake, decreased deactivation and prolonged exposure to the active metabolite ara-C triphosphate (ara-CTP) within the cell. In the Phase II trial, Elacytarabine was given as a single agent to patients with late stage AML ...

Waters Introduces New SYNAPT G2 with Greater Power, Versatility and Speed Than Any Other High-End Mass Spectrometer

...SYNAPT G2 System provides researchers with intuitive operation, application flexibility, and a totally new level of performance for biopharmaceutical, metabolite identification, metabonomics, proteomics, biomarker studies, and food and environmental applications. Waters introduced the SYNAPT G2 System at the 57...

Ausio Pharmaceuticals to Present at Bio(R) 2009

...orgia. Ausio has developed AUS-131, a pharmaceutical formulation of the soy metabolite S-equol. AUS-131 is expected to provide soy health benefits by consistently...2010. About AUS-131 AUS-131 is pure, synthetic S-equol, a potent metabolite of the soy isoflavone, daidzein, which is produced in only a subset of indi...

Idenix Pharmaceuticals Reports Data From Three Hepatitis C Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver

...ic exposure to IDX184 and the resulting nucleoside metabolite (NM). IDX184 is fully active against HCV genotypes...acodynamic (PK/PD) relationship between nucleoside metabolite concentrations in serum and viral load reductions in this study. Trough serum nucleoside metabolite levels were low, ranging from 2-8 ng/mL, and there...

Solidus Bioscience Protect their Research and Improve Efficiency With Amphora's PatentSafe Solution

...ive. Solidus, with Research Labs in both New York and California, currently offers an in vitro toxicity screening service that determines compound and metabolite toxicity using a novel platform that supports arrays of miniaturized 3D cell cultures and metabolizing enzymes. Solidus has opted for Amphora's Patent...

Idenix Announces Data Presentations from Three HCV Discovery and Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver (EASL)

... ANTIVIRAL ACTIVITY OF THE LIVER-TARGETED NUCLEOTIDE HCV POLYMERASE INHIBITOR IDX184 CORRELATES WITH TROUGH SERUM LEVELS OF THE NUCLEOSIDE metabolite IN HCV-INFECTED CHIMPANZEES - Abstract #583; Oral presentation; Parallel session entitled: Hepatitis C Virus Drug Development II; Session date: Frid...

Corgenix to Exhibit AspirinWorks(R) Test at ACC.09

...he only FDA-cleared test that measures urinary 11dhTxB2 to accurately determine the effect of aspirin in apparently healthy individuals. 11dhTxB2 is a metabolite of thromboxane A2, the target of aspirin therapy. "The phenomenon of aspirin effect has been validated in numerous randomized, controlled prospe...

Waters Corporation Continues to Meet Today's Challenges for Improved Laboratory Operations with New Products at Pittcon 2009

...erations; and applications-specific UP LC/MS and UPLC/MS/MS system solutions for food safety, amino acid, intact protein, oligonucleotide, peptide, metabolite profiling, bioanalysis, impurity profiling, ADME screening, and proteomics analyses. UPLC for At-Line Process Analysis Designed with the same...

Romark Announces Presentation of New Data for Controlled Release Nitazoxanide in Chronic Hepatitis C

...er study. The 675 mg and 1,350 mg twice daily doses of controlled release nitazoxanide produced trough plasma concentrations of tizoxanide, the active metabolite of nitazoxanide, that were approximately 3x and 12x the trough concentrations observed in historical studies using a standard nitazoxanide 500 mg tabl...

First Patient Dosed in Phase 2 Clinical Trial of NKTR-102 in Ovarian Cancer

...th an extended half-life and sustained delivery of the active metabolite. The Phase 1 data also show the significantly longer half-life of the active metabolite of NKTR-102 (50 days) relative to its half-life with standard irinotecan (30 to 50 hours). About Nektar Nektar Therapeutics is a biopha...

Cyprotex Purchases Applied Biosystems Sciex QTRAP(R) 5500 LC-MS/MS

...cility and will enable us to offer a comprehensive bioanalytical method development and validation service as well as an enhanced and highly sensitive metabolite profiling and identification service. The instrument will increase the likelihood of detecting poorly sensitive molecules which are problematic in con...

Corgenix to Exhibit AspirinWorks(R) Test, Discuss New CHARISMA Trial Results at AHA 2008 Meeting

...he only FDA-cleared test that measures urinary 11dhTxB2 to accurately determine the effect of aspirin in apparently healthy individuals. 11dhTxB2 is a metabolite of thromboxane A2, the target of aspirin therapy. "The American Heart Association conference is an ideal forum in which to discuss the findings on t...

Significant Anti-Tumor Activity and Extended Half-Life of NKTR-102 (PEG-irinotecan) Highlighted in Phase 1 Data Presented at EORTC-NCI-AACR Symposium

... Active metabolite concentrations of NKTR-102 significantly more sust...008. The observed plasma half life of the active metabolite (SN38) of NKTR-102 was 50 days; this is significan...tecan dosing.(1) Increased SN38 levels, the active metabolite of irinotecan responsible for its anti-tumor activ...

Tethys Bioscience Announces Acquisition of Lipomics Technologies

... Addition of metabolite technology uniquely positions company as it expands its line...ncial terms were not disclosed. The acquisition brings together Lipomics' metabolite profiling technology with Tethys' proven expertise in the use of protein bi...

ESA Receives 2008 Frost & Sullivan North American Technology Innovation Award for Development of Integrated Metabolomics Systems

...e. Electrochemical detection in line with mass spectrometry streamlines the metabolite analysis, synthesis, and evaluation process. In order to determine the clin...olites are identified, scale-up can be done for clinical trials to evaluate metabolite toxicity in humans." Dr. Acworth continued, "We are honored to be recogni...

Marinus Pharmaceuticals Appoints John Krayacich as President and Chief Executive Officer

...s neurological, psychiatric and pain disorders. Its lead compound, ganaxolone, is a synthetic analog of the neurosteroid allopregnanolone (3a,5a-P), a metabolite of progesterone. It is currently being investigated in a Phase IIb clinical trial as a potential treatment of epilepsy in children (infantile spasms) ...

Instrumentation Laboratory Announces Contract for Multi-Parameter Testing Products with Broadlane

...ables and service, including IL's flagship products, the new GEM(R) Premier(TM) 4000 and the GEM Premier 3000 analyzers for blood gas, electrolyte and metabolite testing, new GEMweb(R) Plus information management system for the GEM analyzers, GEM PCL Plus, a portable coagulation analyzer and GEM OPL, a portable...

Fontus Pharmaceuticals Acquires Nephrology and Endocrinology Drug from Roche Laboratories Inc.

...roidism and pseudohypoparathyroidism. About ROCALTROL(R) (calcitriol) ROCALTROL, available as capsules and as an oral solution, is the most potent metabolite of vitamin D available and is active in regulating the absorption of calcium from the gastrointestinal tract and its utilization in the body. The calc...

Ardea Biosciences Presents Inflammation Program Data for Arthritis and Gout at 2008 Annual European Congress of Rheumatology

...s were conducted. Based on these studies, RDEA594 was identified as a major metabolite of RDEA806 in both humans and animals. RDEA594 exhibits a concentration-dep...t has potential for treating gout patients with hyperuricemia. RDEA594 is a metabolite of RDEA806, a non-nucleoside reverse transcriptase inhibitor (NNRTI) in dev...

Anadys Pharmaceuticals Reports First Quarter 2008 Financial Results and Highlights

...s, based on work done with the Moores Cancer Center at the University of California San Diego, reported the pro-apoptotic effect of the active metabolite of ANA773 on human chronic lymphocytic leukemia (CLL) cells ex vivo, and the enhancement of the apoptotic effect when added to either vinc...

FDA Approves PRISTIQ(TM) for the Treatment of Adult Patients with Major Depressive Disorder

...somnolence (sleepiness), decreased appetite, anxiety, and specific male sexual function disorders. About PRISTIQ PRISTIQ delivers the major active metabolite of EFFEXOR XR(R) (venlafaxine HCl) in its active state without going through the CYP2D6 metabolic pathway. This could be beneficial when PRISTIQ is co...

Anadys Pharmaceuticals Commences Phase I Clinical Trial of ANA773 in Cancer Patients

...g in October 2007 showed that activation of TLR7 by the biologically active metabolite of ANA773 initiates a cascade of immune stimulatory events that has the pot... 2007, data presented at the AACR meeting showed that ANA773 and its active metabolite stimulate secretion of interferon alpha and other cytokines as well as enha...

Codexis Launches Codex(TM) MicroCyp Platform to Produce Drug Metabolites and Novel Lead Compounds

... from the California Institute of Technology (see Codexis Licenses New Drug metabolite Profiling and Lead Diversification Technology from California Institute of ...ent and General Manager, Codexis Pharma Services. "Conventional methods for metabolite identification and production and lead diversification are difficult and ti...

HealthTrust Expands Contract With Instrumentation Laboratory for Critical Care Portfolio to Include Consorta

...ables and service, including IL's flagship products, the new GEM(R) Premier(TM) 4000 and the GEM Premier 3000 analyzers for blood gas, electrolyte and metabolite testing. Additionally, the GEM Premier 4000 includes integrated CO-Oximetry and GEMweb(R) Plus, unique information management software for complete co...

Bruker Announces Availability of New HUPO World Congress Proteomics Posters on Web Site

... based MAPKinase Inhibitors using Accurate MS(n) and Isotopic Pattern Data Poster M291 -- Analysis of the Intraspecies Variation of Secondary metabolite Production by Myxococcus xanthus using ESI-TOF-MS and PCA Poster M327 Bioinformatics -- Support Vector Classification of Proteomic Profile Sp...

Tandem Labs' New England Facility Doubles Discovery Support Capacity - Increasing Foothold in New England

...providing rapid turnaround non- GLP discovery PK/PD services in addition to metabolite identification and biomarker services. Combined with other advanced mass sp...TM) is a drug metabolism technology that increases the productivity of drug metabolite identification and quantification. MarkerScan(TM) is a biomarker discovery ...

Hyperion Therapeutics, Inc. Announces Senior Management Team and $15M Financing Event

...aration. The most common adverse reactions associated with BUPHENYL were amenorrhea dysfunction, decreased appetite, body odor (probably caused by its metabolite phenylacetate) and bad taste or taste aversion. Patients with urea cycle disorders should not take valproic acid, haloperidol, or steroids as these dr...

Scientists discover how cancer may take hold

...m different colors of the jellyfish green fluorescent protein (GFP). When a metabolite binds to the biosensor, it changes the shape of the sensors backbone, alter...n a specific wavelength of light activates one tag, it fluoresces. When the metabolite causes the tags to move close together, the other tag will also fluorescere...

DHEA Boosts Growth Rate of Human Neural Stem Cells

...europrotective, but the problem with DHEA in rats is that it is not a major metabolite in that animal so its effects may not be the same as those seen in humans,"...problem of whether DHEA itself is having this effect, or if there's another metabolite of the hormone involved, still exists." One of the intriguing aspects of...

Madison stem cell company gets $1M from state

...abolic profiling that studies chemical "fingerprints" that cellular processes leave behind. Such metabolic profiling concentrates on small-molecule or metabolite profiles, and can produce information about the physiology of a cell. Donley has said the company's sustainable market advantage is that it's an ea...

FERMENTATION BASICS

...The composition of the culture medium, the biomass concentration, and the metabolite concentration generally change constantly as a result of the metabolism o...mixing The transfer of energy, nutrients, substrate and metabolite within the bioreactor must be brought about by a suitable mixing device. ...

Inoculation, Growth & Harvesting in a New Easy-to-Use Disposable Cell Culture System

...90% of the tested cell lines will become immobilized in the disks within approximately 30 45 minutes. During the run, monitor the substrate and metabolite concentrations including glucose, glutamine, ammonia and lactate once a day. Media and glucose should be added as required. ...
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