Mac

Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier Software Package

Mark R. Kagan , Carrie Liu 1Thermo Finnigan, Piscataway, NJ; 2Thermo Finnigan, San Jose, CA; 3Eisai Research Institute, Andover, MA The data presented here can be a...

Purification of the Components of Human Macular Carotenoid-Binding Complex, Rev A

The macular region of the human retina is responsible for almost all color vision and most of the high resolution visual acuity. This part of the retina, known as the macula lutea, or yellow spot, accumulates approximately 200 ng of two closely-related compounds, lutein and zeaxanthin....

Third Wave receives FDA clearance of pharmacogenetic test

It is the first pharmacogenetic test to be approved by the FDA for use as a companion diagnostic to a specific drug therapy. The test is c...

Rapid PCR* Using Active Tube Temperature Control On Thermo's PCR Machines

Solutions Note The time taken to complete a standard PCRprotocol is becoming increasingly important forresearchers today. Whilst many manufacturers ofthermal cyclers focus on pushing the limits of ramprates, in this article we highlight how Thermo's approach of focussing on ach...

Rapid SNP Genotyping of the Pharmacogenomically Important Allele CYP2D6*4 Using Real-Time qPCR on the DNA Engine Opticon 2 System

MJ Research, Inc., South San Francisco, CA A two-color real-time quantitative PCR (qPCR) protocol was used on the MJ Research DNA Engine Opticon 2 system to genotype the CYP2D6*4 allele in 211patient samples. Two hydrolysis probes, one labe...

Development of a sensitive enzyme fragment complementation assay for cyclic adenosine 3', 5' monophosphate and its validation for pharmacological screening at G protein-coupled receptors

G protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors and are responsible for the transduction of a diverse range of extracellular signals. Up to 40% of clinically ma...

Laser Capture Microdissection (LCM) for the Analysis of Macrophage Gene Expression from Atherosclerotic Lesions

Macrophage foam cells are integral in the development of atherosclerotic lesions, however gene expression studies are complicated by the cellular heterogeneity of atherosclerotic plaque. This application note describes a protocol for LCM of cells identified immunohistochemi...

Practical Applications of HyperDSC in a Pharmaceutical Laboratory

PerkinElmer Life and Analytical Sciences 710 Bridgeport Avenue Shelton, CT 06484-4794 USA Analytical Sciences Department Physical Characterization Laboratory...

World Class Life Science and Pharmaceutical Companies Leverage DoveBid s Global Reach for Asset Management and Disposition

), the global leader in capital asset auction and valuation services, announced today it will be conducting its 50th global Life Sciences / BioPharma Exchange auction online, on August 15, 2006. The event...

Deltanoid Pharmaceuticals begins phase II osteoporosis study

The study is being conducted to determine whether 2MD can safely improve bone mineral density in postmenopausal women. Osteoporosis, a disease caused by the loss of nor...

Doing the pharmaceutical tango

The tango often seems like a battle of two people tryin...

Mac attack was unfair, says UW engineer

In that case, it took just 30 minutes for someone...

Voting machine source code must be available for review

Correction: the original story was based on an official summary that referred to the bill as introduced and did not take into account certain amendments. Under the law as enacted, the source code would be placed into escrow with the elections board. It would be analyzed in the case of a recount, but not open to the public. WTN very much regrets the error and any confusion it may have caused.</...

NimbleGen Systems CGS technique helps identify stomach bacteria

, have identified evolutionary changes in the human pathogen Helicobacter pyloria bacterium that infects the lining of the stomach and can cause complications such as peptic ulcers and gastric canceras it...

Machine like me

Computers aren't very good at tolerating unexpected difference. The boxes tend to get sulky and intractable when they encounter a spike in their power curve or an unanticipated condition in the data stream. They're a little like us that way. The difference, of course, is our ability to manage our own intractability, assuming we recognize it and choose to do somethin...

My 50 cents: Web sites and pinball machines

A pinball machine is a great metaphor for describing how a Web site works not the mechanical side of working that involves ASP, PHP and databases, but the reality of how a...

Want to squeeze U.S. pharmaceutical companies? Be careful what you ask for

The looming shortage of flu vaccine comes down to the fact that very few American drug companies are left in the bus...

Milwaukee Brewers to get X-ray machine

Eastman Kodak Company, through its division, will provide a <a href="http://w...

Small Tree releases fiber-optic gigabit Ethernet adapters for Mac OS X

EAU CLAIRE -- In the latest of a string of firsts for the Apple platform, The combination of with S...

Small Tree offers free trial of Mac OS X link aggregation for G4 and G5 servers

EAU CLAIRE, Wis. -- Link aggregation, an implementation of the <a target="blank" hr...

Charter and Berbee connect Pharmacy Cooperative

MADISON by adding a ninth fiber-based circuit, connecting <a href="https:...

Wisconsin Manufacturing and the Machinery for Change

Wisconsin got a much-needed boost from a recent , in which I discussed some of the economic reasons for a Wisconsin...

The Coming of Biotech Generic Pharmaceuticals

CHICAGO In a column last year, I commented on the growing generic pharmaceuticals business in the U.S. and around the world. Generic pharmaceuticals are not only big business but will continue to get even bigger. There are a couple reasons why: The increased concern in the U.S. about rising drug pr...

Knowledge Management: The Key to Success for Life Sciences and Pharmaceutical Companies

Your company has recently completed a merger with another new life science organization, and is on the way to achieve the integration of the information systems that supported the operations of both companies. However, the departments that are starting to get consolidated are facing new challenges they did not encounter within the separate, regionally based, organizations. The sharing of informat...

Pfizer-Pharmacia Fallout Gives Celltech A CEO

New York, NY - One certain consequence of the nearly $60 billion acquisition of Pharmacia by Pfizer: executive-suite cleaning. The first bigwig out the door is Dr. Gran Ando, who headed up Peapack, N.J.-based Pharmacia's research and development operations. Today, Celltech, one of Europe's biggest biotechnology companies, announced Ando as its new chief executive. "You will see that the...