Genes in Biological Technology

University of Lodz Invests in the Unique Cellaxess(R)HT System for Research on Multidrug Resistance Genes in Cancer

GOTHENBURG, Sweden, July 22 /PRNewswire/ -- Cellectricon, a leading provider of cell-based screening solutions for research and drug discovery, today announced its collaboration with University of Lodz, Poland. Under the agreement University of Lodz invests in Cellaxess(R)HT, the world's first...

Proteomics Study Reveals That Genes Involved in Invertebrate Longevity Have Surprising Parallels in Humans.

SALT LAKE CITY, March 13 /PRNewswire/ -- Prolexys Pharmaceuticals announced today the publication of the discovery of genes that are likely to have a role in the aging process of humans. The findings result from research on the human equivalents of proteins from simple animals which confer long l...

Mosquito genes linked to insecticide resistance may be new target in fight against malaria

Malaria remains one of the most serious diseases worldwide, claiming the lives of more than one million people per year in tropical and sub-tropical regions, the majority of whom are children under five years of age. Efforts to eliminate this mosquito-borne illness rely heavily on prevention meas...

RNAi Helps Illuminate the Inner Workings of the Cell Cycle: Synthetic RNAissance™ Genes Created by DNA2.0 Enable Key Research

DNA2.0 has designed RNAi-resistant genes that enabled a breakthrough in understanding the inner workings of the cell cycle. DNA2.0's RNAissance genes are simultaneously optimized for expression in the desired host and to escape inhibition by siRNA that is targeted to the natural gene. ...

The Michael J. Fox Foundation Awards $2 Million to Shed Light on Role of LRRK2 and Alpha-Synuclein Genes in Parkinson's Disease

NEW YORK, Jan. 15 /PRNewswire-USNewswire/ --- The Michael J. Fox Foundation for Parkinson's Research today announced approximately $2 million in total funding for seven research studies aiming to advance the ability of the Parkinson's research field, and drug makers, to therapeutically target ...

International team identifies 480 genes that control human cell division

PITTSBURGH A team of U.S., Israeli and German scientists used computational biology techniques to discover 480 genes that play a role in human cell division and to identify more than 100 of those genes that have an abnormal pattern of activation in cancer cells. Malignant cells have lost control...

Verenium Explores Bacterial Genes Inside Termite Guts to Understand How Wood is Broken Down and Converted to Energy

- Study findings published in November 22 issue of Nature - - Company partners with CalTech and DoE for first system-wide gene-analysis of microbial community focused on plant lignocellulose degradation - CAMBRIDGE, Mass., Nov. 21 /PRNewswire-FirstCall/ -- Verenium Corporation (Nasdaq: ...

Mathematical models reveal how organisms transcend the sum of their genes

MADISON Molecular and cellular biologists have made tremendous scientific advances by dissecting apart the functions of individual genes, proteins, and pathways. Researchers at the University of Wisconsin-Madison College of Engineering are looking to expand that understanding by putting the piece...

Massive reanalysis of genome data solves case of the lethal genes

WALNUT CREEK, CA It is better to be looked over than overlooked, Mae West supposedly said. These are words of wisdom for genome data-miners of today. Data that goes unnoticed, despite its widespread availability, can reveal extraordinary insights to the discerning eye. Such is the case of a syst...

Despite confinement, crop genes can spread fast to wild

MADISON - With the slim chance that farmers will stop planting crops containing genes from other organisms, researchers have started to develop strategies that trap these foreign genes, reducing the risk that they'll spread to wild relatives. But an investigation by scientists from the Universit...

Study shows that genes can protect kids against poverty

MADISON - For children growing up poor, money isn't the only solution to overcoming the challenges of poverty. According to a new study, the genes and warm support received from parents also can buffer these children against many of the cognitive and behavioral problems for which poverty puts th...

Predictive medicine: Genes indicate diseases before symptoms do

Madison, Wis. Since Hippocrates, born a few centuries before Christ, health care has focused on responding to symptoms of disease. Known as the Father of Medicine, Hippocrates was the first physician to observe and accurately describe disease symptoms. Today, doctors still follow the same b...

A Screen of shRNAs Targeting Tumor Suppressor Genes to Identify Factors Involved in Paclitaxel Sensitivity

Diana Ji, Stacy L. Deeds, and Edward J. Weinstein RNA interference methodologies have been utilized in small to large scale screening projects. The technology has allowed researchers to perform gene-silencing experiments in timeframes and target cells prev...

Detection of Variation in Highly Polymorphic Mhc Genes by Denaturing Gradient Gel Electrophoresis Using the DCode System

Kristi M. Miller, Tobi J. Ming and Ruth E. Withler, Pacific Biological Station, Department of Fisheries and Oceans, Nanaimo, B.C. V9R 5K6, Canada Introduction We describe a rapid and sensitive method for the detection of nucleotide s...

Your Data: Silencing Neural Cell Adhesion Genes with In Vitro Transcribed siRNAs

Ambion has developed a system for siRNA synthesis and purification based on in vitro transcription, the Silencer siRNA Construction Kit (patent pending). This kit produces transfection-ready siRNA ...

UW links with Israeli school to locate genes

Madison, Wis. - A collaborative project between the University of Wisconsin-Madison and the Technion-Israel Institute of Technology in Haifa has shown that thousands of sleeping computers can unravel the twisted code of genetic diseases. Superlink-Online , a program first developed at Tec...

Mirus provides low-cost way to modify genes

Madison, Wis. - Genetically engineered mice are very expensive for researchers, but one Madison-based company has developed a method for producing similarly modified animals at a much lower cost. Mirus Bio Corp. , a privately-held biopharmaceutical firm, has developed a way to bypass the conv...

Mutation detection for the K- rasand P16 genes

Mutations in the K-ras gene codon 12 region can lead to cancer, for example of the colon, pancreas, liver, spleen, stomach or lungs. The CDKN2A/P16 gene is a familial melanoma gene. Routine PCR and DNA sequencing methods ...

Stratagenes Human cDNA Microarrays: Perform Gene Expression Profiling and Discover New Genes

New GeneConnection discovery microarrays provide more than 4,000 unique human cDNA sequences Stratagene introduces the first in a series of human cDNA microarrays on glass slides. These GeneConnection discovery microarrays II which are based on the ...

RT-PCR Primer Sets for Human and Mouse Mismatch Repair Genes

Primer sets facilitate study of DNA mismatch repair Mark Dycaico Stratagene Cloning Systems Stratagene has designed RT-PCR primer sets from the cDNA sequences of mismatch repair genes. These genes code for specialized proteins that participate in correcting areas of ...

Webcast Alert: Transgenomic Inc. Announces Second Quarter 2009 Earnings Release Conference Call Webcast

...two laboratory services divisions utilize these technologies and expertise to provide a menu of mutation scanning tests for over 700 cancer-associated genes and more than 60 validated diagnostic tests to meet the needs of pharmaceutical and biotech companies, research and clinical laboratories, physicians ...

Genomic Health Announces Second Quarter 2009 Financial Results and Business Progress

...ple negative breast cancer and hormone receptor-positive disease, including genes for which targeted agents are currently being evaluated in clinical studies... cancer test covering methods for the algorithms used and methods utilizing genes beyond the current 21 gene set. Were granted a patent by the European...

Bacteria pack their own demise

...ulations from the editorial board. It's in the genes For years, Nathalie De Jonge, Remy Loris and the...ndy way of providing extra protection to important genes the toxin-antitoxin (T-A) system. These T-A genes are tucked in near the...

Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors

...echnology platform is expected to be further expanded with the use of other genes capable of promoting bone repair, in order to biologically enhance surgical...al fusion procedures in patients with degenerative disc disease. Exemplary genes include a chimeric variant of BMP-4 (chBMP4), which offers the potential fo...

First genetically engineered malaria vaccine to enter human trials

... the vaccine the research team had deleted two key genes in the Plasmodium falciparum parasite which cau... of malaria most deadly to humans. By removing the genes the malaria parasite is halted during its liver in...d produce similar results in humans. "Although two genes have been deleted the parasite is still alive and ...

Sangamo BioSciences Reports Second Quarter 2009 Financial Results

...nentech scientists demonstrated the successful knockout of two pre-selected genes in a Chinese hamster ovary (CHO) cell line using Sangamo's proprietary zinc...for the rapid and efficient production of transgenic rats in which specific genes are deleted or knocked out. The technology opens the door for the producti...

Nanotech particles affect brain development in mice

...osure to nanoparticles of titanium dioxide (TiO2) affects the expression of genes related to the central nervous system in developing mice. Researchers writi... of hundreds of genes. According to Takeda, "Diseases associated with these genes include those we normally consider to develop in childhood, such as autisti...

NeoGenomics Reports Second Quarter 2009 Results

...urope have demonstrated that a very specific FISH panel test containing the genes and IP covered by our agreement with Abbott can distinguish malignant melan... the next six months, we will be analyzing the best possible combination of genes to further maximize the sensitivity and specificity of this FISH test for t...

OMT announces a breakthrough in the development of a novel human antibody platform

... the cell's natural DNA-repair pathways and can result in site- specific changes in the DNA sequence. Up to now, ZFNs have been used to edit specific genes in fruit flies, worms (C. elegans), cultured cells and zebrafish embryos, but this is the first example of successful, permanent, heritable gene-editi...

Response Genetics Announces $4 Million Private Placement

...ed on the development and sale of molecular diagnostic tests for cancer. RGI's technologies enable extraction and analysis of genetic information from genes derived from tumor samples stored as formalin-fixed and paraffin-embedded specimens. In addition to diagnostic testing services, RGI generates revenue...

Sirnaomics Receives SBIR Grant from NIH/NCI for Its Multi-Targeted Lung Cancer siRNA Therapeutics

...tant biological phenomenon and as a versatile, powerful tool for biomedical research. RNAi plays a multifaceted role in molecular biology by silencing genes through chromatin remodeling, interfering with protein synthesis, and in its best-studied mode of action quashing gene expression by cleaving messenge...

Junying Yu, Leading Stem Cell Researcher, Joins Cellular Dynamics International

...ic breakthrough, iPS cells additionally enable the creation of stem cells from any individual. However in the original method, because the inserted genes are not an innate part of the cell's DNA and are integrated directly into the genome via a viral vector, concerns have arisen over the potential risks...

Axial Biotech Enters Partnership with the University of Utah to Utilize the Utah Population Database to Develop Personalized Diagnostic Tests for Spine Disorders

...e University of Utah has long been recognized for its leadership position in personalized medicine and genetic research. In fact, more disease-causing genes have been discovered in Utah than in any other place world-wide. The University is nationally recognized for it successful role in commercialization ...

New and Updated Online Tutorials for dbGaP, GAD, and DGV from OpenHelix

... resource is a database of genotypes and phenotypes with extensive variation data and clinical details GAD is an annotated resource connecting human genes and polymorphisms to diseases and traits, and DGV or Database of Genomic Variants, catalogs and displays structural variation in the human genome. T...

Novel gene found for dilated cardiomyopathy

... ANKRD1 gene. All four patients carrying the variants were male. This prevalence rate is consistent with prevalence data for most of the other known genes associated with DCM. This finding confirms previous gene discoveries by Dr. Towbin's group. It also "provides us with a better understanding of the ...

New method may accelerate drug discovery for difficult diseases like Parkinson's

...inson's disease from the Caldwell lab at the University of Alabama, they confirmed that the effective cyclic peptides have the same potency as natural genes that regulate Parkinson's related cellular processes, but intercept the disease's progress at a later point. This demonstrates that these cyclic pept...

First Catalog Cancer Biochip for Sequence Capture Now Available from febit

...ion Sequencing (NGS). The new catalog cancer biochip features 115 important genes which are reported to be associated with common types of cancer by the Well...ant brain cancer to obtain deep sequencing results of the 100 most relevant genes with high sequence coverage using the HybSelect technique. It is equally im...

Stem cells' 'suspended' state preserved by key step, scientists report

...cialized cells and tissue, such as neurons, muscle and bone. A number of genes are known to trigger chromatin remodeling, allowing small sections of DNA t...s report. The global condition sets the stage for turning on many different genes to make a broad range of specialized cells. "Embryonic stem cells are c...

CEL-SCI Corporation Releases Letter to Shareholders

...one-third (27 cases) have been fatal. As the swine flu pandemic rages on, there is a growing risk that H1N1 could find abundant opportunities to swap genes with the bird flu given the prevalence of pigs in Egypt - a common "breeding ground" for viruses that promotes resortment. A further-mutated swine fl...

Data on WaferGen's SmartChip(TM) System to be Presented at 3rd Annual Rediscovering Biomarkers Conference

...se (COPD), idiopathic pulmonary fibrosis (IPF), lung cancer and wound healing. WaferGen believes this research may lead to the discovery of specific genes responsible for causing these diseases and conditions. In turn, this critical genetic information may ultimately provide physicians with new tools fo...