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Fluorescence in Biological Technology

VisEn Launches New Cat-K FAST(TM) Fluorescence Molecular Imaging Agent

BEDFORD, Mass., July 7 /PRNewswire/ -- VisEn Medical Inc., a leader in fluorescence in vivo imaging from research through medicine, announced today the commercial launch of its new Cat-K FAST (TM) imaging agent for measuring and monitoring Cathepsin K activity associated with disease progr...

Oclaro(TM) Hits Milestone With Clarity(TM) Fluorescence Filters

SAN JOSE, Calif., June 17 /PRNewswire-FirstCall/ -- Oclaro, Inc. (Nasdaq: OCLR ) has announced the shipment of its 200,000th Fluorescence Filter for biomedical and analytical instrumentation markets. Oclaro filters are used by leading companies in a wide range of biomedical and analytical applic...

AMG Launches EVOS fl, an 'Evolutionary' Fluorescence Microscope Based on Innovative EVOS Platform

New microscope streamlines workflow while providing the highest quality imaging. Mill Creek, WA (PRWEB) April 27, 2009 -- Advanced Microscopy Group (a division of Westover Scientific, Inc.) announced today the launch of its newest microscope, the EVOS fl for fluores...

LI-COR Introduces Three IRDye(R) Near-Infrared Fluorescence Resonance Energy Transfer (NIR-FRET) Protease Substrates

LINCOLN, Neb., Nov. 12 /PRNewswire/ -- Protease substrates provide a sensitive method to detect protease activity, measure potency of inhibitors and screen compound collections for discovery of drug candidates. LI-COR Biosciences now offers three different IRDye NIR-FRET Protease Substrates: I...

VisEn Announces Commercial Launch of IntegriSenseTM Fluorescence Molecular Imaging Agent

- First Product Developed from the VisEn-Merck & Co., Inc. Biomarker Imaging Program - - Expands VisEn's Leading Fluorescence Molecular Imaging Agent Portfolio and Broadens Applications in Key Areas of Disease Research and Drug Development - BEDFORD, Mass., Aug. 19 /PRNewswire/ -- VisEn Me...

FLIPR Calcium 3 Assay Kit - An Optimal No-Wash Fluorescence Calcium Indicator Reagent for Non-Optimal Calcium Responses

By Brian Schlag and John Dunlop of Neuroscience Discovery Research, Wyeth Research, CN-8000, Princeton, NJ 08543. SUPERIOR PERFORMANCE HIGHER THROUGHPUT IMPROVED DATA QUALITY RESCUES SUB-OPTIMAL ASSAYS ...

LIVE/DEAD Viability/Cytotoxicity Assay for Animal Cells Using the SpectraMax Gemini XS Fluorescence Microplate Reader (MaxLine Application Note #43)

Anne T. Ferguson, Ph.D. Molecular Devices Corporation INTRODUCTION This application note describes the use of the SPECTRAmax GEMINI XS from Molecular Devices to study the performance of the LIVE/DEAD Viability/Cytoxicity Assay Kit for animal cells....

cAMP DataFile: Homogenous Cyclic AMP detection using High Efficiency Fluorescence Polarization

A Sensitive, Robust, Homogenous, and Rapid Assay Uses High Efficiency Fluorescence Polarization (HEFP) detection method Detects pmol amounts of cAMP Optimized for cell extract and enzyme preparations Requires no separation or wash steps Available in a kit and in bu...

TKXtra DataFile: Homogenous tyrosine kinase detection using High Efficiency Fluorescence Polarization

A Sensitive, Robust, Homogenous,and Rapid Assay Uses High Efficiency Fluorescence Polarization (HEFP) detection method Assays a broad range of tyrosine kinases Requires no separation or wash steps Available in a kit and in bulk packaging Introduction Sc...

Receptor Binding Assays using Fluorescence Polarization Detection: the [FP]2TM Characterized Tracers

A. Gagne, E. Robitaille, M. Harvey, J.-A. St. Pierre, D. Wenham and P. Banks Introduction High throughput screening is an indispensable tool for modern drug discovery 1-3 . The process is typically highly automated and can provide screening rates over 100,000 sample...

Immunoassay of Theophylline by fluorescence polarisation

Abstract Fluorescence immunoassay is applied to the detection of theophylline, a drug used for myocardial stimulation. Interference from other sample components is limited by use of polarization measurements, which discriminate between bound and unbound fluoro...

Minimizing Photobleaching of Blue Fluorescent Protein (BFP) using the Varian Cary Eclipse Fluorescence Spectrophotometer

Paul Gavin*, Mark Prescott*, Ph.D, Daren J. Fyfe#, Ph.D and Jeffrey J. Comerford#, Ph.D * Department of Biochemistry and Molecular Biology, Monash University, Clayton campus, Victoria 3800, Australia # Technical Assist...

Monitoring fluorescence resonance energy transfer (FRET) between GFP fusions in lysates of the yeast Saccharomyces cerevisiae using the Varian Cary Eclipse

Monitoring fluorescence resonance energy transfer (FRET) between GFP fusions in lysates of the yeast Saccharomyces cerevisiae using the Varian Cary Eclipse Paul Gavin # and Mark Prescott # , Ph.D Daren J. Fyfe, Ph.D* # Department o...

Identification of cells in S phase using the Cell Proliferation Fluorescence Kit and IN Cell Analyzer 1000

The cell cycle is of key importance to many areas of drug discovery. On the one hand this fundamental process provides the opportunity to discover new therapeutic targets for anti-cancer agents, and on the other hand drugs and targets in other therapeutic areas must be tested ...

Visualizing siRNA in Mammalian Cells: Fluorescence Analysis of the RNAi Effect

Mike Byrom, Vince Pallotta, David Brown*, and Lance Ford* Ambion, Inc. 2130 Woodward Street Austin, TX 78744-1832 * Corresponding authors dbrown@ambion.com , fluorescence resonance energy transfer (FRET) does not occur." ...

A breakthrough toward industrial production of fluorescent nanodiamonds

...ublished in Nanotechnology June10 2009 issue. fluorescence is a major tool in life and material sciences. In ...tions in cultured cells or in the body. Similarly, fluorescence is used in material sciences to detect electromagn... and possess long-term non-bleaching, non-blinking fluorescence in the red/NIR region. Based on these unique prope...

Exiqon Diagnostics Partners With MedTrust Online to Promote KRAS Mutation Analysis and Other Innovative Molecular Oncology Diagnostic Services to Oncologists

...reme Drug Resistance (EDR(R)) Assay, Exiqon Diagnostics offers an extensive test menu of prognostic and predictive molecular oncology biomarkers using fluorescence in situ hybridization (FISH), flow cytometry, polymerase chain reaction (PCR) and other cutting-edge technologies. For further information please vi...

ForteBio Launches New Assay Capabilities for High-Sensitivity Protein Quantitation and Fragment Screening on Its Octet(R) Platform

...ule can detect low nanogram per mL levels of analytes in quantitation mode. "For protein quantitation, life science researchers have traditionally run fluorescence and luminescence ELISA methods to achieve greater sensitivity in their assays. Now, using ForteBio's new modules, they can obtain highly precise resul...

A New Era in the Application of Lab-on-a-Chip to Rapid Point-of-Care Diagnosis

...sothermal conditions, alleviating the requirement for thermo-cycling. Combined with a simple optical method of detection that does not require complex fluorescence equipment, the system offers sensitivity comparable to Real-Time PCR. About HKLife: Hai Kang Life Corporation Limited, formerly known as Hon...

Accuri Cytometers Adds Automation to Its Revolutionary C6 Flow Cytometer(R) System With Commercial Launch of CSampler(TM)

...cludes the C6 Flow Cytometer, CFlow Plus Software and a Workstation PC. The C6 Flow Cytometer has forward and side-scatter detectors, as well as four fluorescence detectors equipped with user-replaceable optical filters. The operating software is designed to make data collection and analysis fast and hassle-fre...

VisEn Launches Next-Generation Fast ('Fluorescence Activatible Sensor Technology') Agent Platform for Expanded Performance in Imaging Disease Biomarkers In Vivo

...20 /PRNewswire/ -- VisEn Medical Inc., a leader in fluorescence in vivo imaging from research through medicine, ...T 2500 (TM) quantitative tomography system, tumor fluorescence due to in vivo activation of the agent was clear...rson noted, which underscored the ability of these fluorescence agents and FMT imaging to rapidly and non-invasive...

Fitting pieces for biosensors

...e SELEX method. One of these is known as FluMag SELEX. The 'Flu' stands for fluorescence and refers to the fact that a fluorescence molecule is added to the nucleic acids during the SELEX procedure to make t...

Researchers develop new way to see single RNA molecules inside living cells

...eral tiny holes in the cell membrane that allowed the probes to enter the cell's cytoplasm. The researchers tested the sensitivity of conventional fluorescence microscopy to image individual probes inside a cell. Previous studies showed that these techniques were able to image an accumulation of probes inside...

NeoGenomics Announces Fourth Quarter and Full Year 2008 Financial Results

...s in cancer genetics diagnostic testing, the fastest growing segment of the laboratory industry. The company's testing services include cytogenetics, fluorescence in-situ hybridization (FISH), flow cytometry, morphology studies, anatomic pathology and molecular genetic testing. Headquartered in Fort Myers, FL, ...

NeoGenomics Schedules its Q4 and Full Year 2008 Earnings Release for March 5, 2009

...s in cancer genetics diagnostic testing, the fastest growing segment of the laboratory industry. The company's testing services include cytogenetics, fluorescence in-situ hybridization (FISH), flow cytometry, morphology studies, anatomic pathology and molecular genetic testing. Headquartered in Fort Myers, FL, ...

Rice rolls out new nanocars

...lasmonics, took the wheel for a new series of experiments that built upon Tour's pioneering work. Link's primary achievement was using single-molecule fluorescence imaging to track the tiny vehicles, as opposed to the scanning tunneling microscopy (STM) used in earlier experiments. STM imaging can capture matter ...

Easy assembly of electronic biological chips

...f coatings. "The eventual idea would be to extend the method to more nanowire types, such as different DNA sequences or even proteins, and move from fluorescence to real-time electrical detection on the chip," says Keating. ...

ECBC's Environmental BioMonitoring Laboratory Focuses on the Future

...nosorbent assays, hand-held assays and gel electrophoresis. Identification of bacterial agents using cell culture coupled with traditional and fluorescence microscopy Analysis of samples for bacterial identification using a technology based on gas chromatographic analysis of cellular fatty acid me...

RainDance Technologies and Harvard University to Share in First Massachusetts Life Sciences Center Cooperative Research Grants

...es of Lexington, Mass., to develop and demonstrate the use of a new form of fluorescence activated cell sorter (FACS) used to collect biochemical information about ... allow his lab to work with RainDance Technologies to develop a new form of fluorescence assisted cell sorter (FACS). "This research is an important continuation o...

New technique allows simultaneous tracking of gene expression and movement

... a protein that absorbs blue light and emits green light. When a fly expressing GFP is illuminated by blue LEDs, filtered cameras can detect the green fluorescence that results and the fly's movement can be tracked at a rate of 60 frames per second. By linking the expression of GFP to the expression of other repo...

Nikon Instruments A1 Confocal Laser Microscope Series With NIS-Elements C Software Delivers Fully Integrated Comprehensive Confocal Imaging Capabilities

...iments requiring acquisition and photoactivation by concurrently scanning the specimen. This supports advanced research methods using photoactivation fluorescence proteins and facilitates high-speed, live-cell work with a huge array of new imaging strategies. A spectral imaging detector further enables the A1 a...

Nikon Instruments Introduces Exclusive VAAS Detector Imaging Method for Confocal Microscopy

...holes to collect emitted photons: a standard-sized one to enable confocality and one with a diameter three-times larger to capture more of the emitted fluorescence without increasing the out of focus background detection. VAAS is an effective method to reduce the out of focus haze signal without reducing the si...

Photo-catalytic, self cleaning coating for building exteriors

...elf-cleaning" coating using photocatalytic Titanium Dioxide (TiO2) has gained considerable industry attention. With assistance of little UV light from fluorescence source or sunlight, TiO2 offers two unique properties: (a) strong oxidation power, and (b) super-hydrophilicity. Strong oxidation power can be use...

Technical Note: E-PAGE(TM) 48- and 96-Well Gels on the Odyssey(R) Infrared Imaging System

...d Imaging System is uniquely equipped with two infrared channels for direct fluorescence detection on membranes with sensitivity that is equal to or better than che...lar imaging applications. LI-COR pioneered the development of near-infrared fluorescence detection systems for DNA sequencing and today provides systems for drug di...
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