Enzyme in Biological Technology

Structure of enzyme against chemical warfare agents determined

This release is available in German . The enzyme DFPase from the squid Loligo vulgaris , is able to rapidly and efficiently detoxify chemical warfare agents such as Sarin, which was used in the Tokyo subway attacks in 1995. A detailed understanding of the mechanism by which enzymes ca...

Structure of enzyme against chemical warfare agents determined

This release is available in German . The enzyme DFPase from the squid Loligo vulgaris , is able to rapidly and efficiently detoxify chemical warfare agents such as Sarin, which was used in the Tokyo subway attacks in 1995. A detailed understanding of the mechanism by which enzymes ca...

Structure of enzyme against chemical warfare agents determined

This release is available in German . The enzyme DFPase from the squid Loligo vulgaris , is able to rapidly and efficiently detoxify chemical warfare agents such as Sarin, which was used in the Tokyo subway attacks in 1995. A detailed understanding of the mechanism by which enzymes ca...

CBDM.T, The Market and Business Intelligence Company Reviews The Enzyme Market

According to CBDM.T®, The market and business intelligence company, the enzyme market is significant and estimated at €3.4 billion with an annual growth of about 6.5 to 10%. Enzymes are sold in many different industry segments. These segments are Detergents, Food, Feed, Technical, Phar...

Halozyme Therapeutics Presents Favorable New Safety and Pharmacokinetic Data on rHuPH20 Enzyme Produced Via New Manufacturing Process at European Federation for Pharmaceutical Sciences

MUNICH, Germany, March 10 /PRNewswire-FirstCall/ -- Halozyme Therapeutics, Inc. (Nasdaq: HALO ), a biopharmaceutical company developing and commercializing products based on the extracellular matrix, today announced new safety and pharmacokinetic data from a second generation manufacturing pr...

BioMarin and IGAN Biosciences to Collaborate on Development of an Enzyme Therapy to Treat IgA Nephropathy, a Rare and Life-Threatening Kidney Disease

NOVATO, Calif., Dec. 3 /PRNewswire-FirstCall/ -- BioMarin Pharmaceutical Inc. (Nasdaq and SWX: BMRN) and IGAN Biosciences announced today that they have initiated a program to develop an IgA protease for treating IgA nephropathy. IgA proteases have been shown to cleave IgA complexes, the depos...

Genencor Launches First Ever Commercial Enzyme Product for Cellulosic Ethanol

Accellerase(TM) 1000 is launched at the Cellulosic Ethanol Summit in Washington, DC ROCHESTER, N.Y., Oct. 15 /PRNewswire/ -- Genencor, a division of Danisco A/S, today announced a new product, Accellerase(TM) 1000, the first ever commercially available biomass enz...

Novozymes Launches Enzyme to Reduce Acrylamide in Food

DITTINGEN, Switzerland, August 31 /PRNewswire/ -- Researchers from Novozymes, the world leader in bio-innovations and bio-solutions have found a solution to reduce the level of acrylamide in food products such as cookies, crackers and snacks. Novozymes launches Acrylaway to reduce acrylamide ...

Lucigen Receives Funding, Breaks New Ground with Enzyme Research

Madison, Wis. - Sometimes the small things do count. Lucigen Corporation, which specializes in microbial enzyme cloning, has recently received $300,000 in initial investor funding. The Middleton, Wis.-based company plans to generate a total of $1 million through equity financing and a National Sci...

Development of a sensitive enzyme fragment complementation assay for cyclic adenosine 3', 5' monophosphate and its validation for pharmacological screening at G protein-coupled receptors

Key words: cAMP • GPCR • enzyme fragment complementation • LEADseeker • assay miniaturization G protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors and are responsible for the transduction of ...

Select the Optimal Enzyme for RT-PCR

A major factor to consider in reverse transcription polymerase chain reaction (RT-PCR) is the choice of the appropriate reverse transcriptase. Roche Applied Science has developed and optimized a wide variety of different ...

pfuturbo DNA Polymerase: A High-Performance, High-Fidelity Enzyme Ideal for PCR Cloning

Produce PCR amplicons that are easily cloned with high efficiency pfuturbo DNA Polymerase: A High-Performance, High-Fidelity Enzyme Ideal for PCR Cloning Jeff Braman Holly Hogrefe Stratagene A chloramphenicol resistance (CAM) gene generated from pfuturbo DNA poly...

The Best Enzyme for the Toughest PCR Challenges Improved with New Hot-Start Feature

Novel Herculase Hotstart DNA polymerase results in greater specificity and sensitivity Michael Borns Brad Scott Holly Hogrefe Stratagene Stratagenes Herculase DNA polym...

Improve Amplification Specificity with Hot Start PCR Enzyme

SureStart Taq DNA polymerase utilizes ultra-pure Taq2000 DNA polymerase SureStart Taq DNA polymerase features a modified version of Taq2000 DNA polymerase with hot start capability. Using SureStart Taq, hot start is in- corporated into PCR protocols previ...

Greater Amplification Specificity with New Hot Start PCR Enzyme

SureStart Taq DNA polymerase makes hot start simple and efficient Jonathan Eads Frances Bai Ronda Allen Holly Hogrefe ...

Amicus Therapeutics Announces Second Quarter 2009 Financial Results

...al will consist of a six-month double-blind, randomized, placebo-controlled treatment stage and will enroll approximately 60 subjects who are naive to enzyme replacement therapy (ERT) or who have not received ERT for at least six months prior to the start of treatment with Amigal. The Amigal treatment arm ...

Shire plc: Core Portfolio of Products Delivers 20% Sales Growth

... of Gaucher disease - On July 16, 2009 Shire announced that it had received Fast Track designation from the FDA for velaglucerase alfa, its enzyme replacement therapy in development for the treatment of Gaucher disease. On July 30 Shire began the rolling submission of a NDA for velagl...

Palatin Technologies, Inc. Receives U.S. Patent Allowance for Heart Failure Drug Candidate

...extended half-life, with reduced affinity for natriuretic peptide clearance receptors and increased resistance to neutral endopeptidase, an endogenous enzyme that degrades natriuretic peptides. The result is a drug candidate with improved pharmacokinetic and pharmacodynamic properties. About Heart ...

R-Tech Ueno Notifies R&D Items

...eneration. 2. Development code RTU-007 (eye diseases) The license is obtained from Astellas Pharma Inc. for the substance to inhibit the enzyme that increases in patients with diabetes mellitus. We intend to proceed with the development of this substance to be indicated for diabetic cataract, ...

BP and Verenium Announce Vercipia Biofuels to Advance the Commercialization of Cellulosic Ethanol

..., industrial, and animal health markets. The Company possesses integrated, end-to-end capabilities and cutting-edge technology in pre-treatment, novel enzyme development, fermentation and project development for next-generation biofuels. Through Vercipia, the Company is moving rapidly to commercialize cellu...

Growing Awareness and Increased Investments Lead to Growth of Biotechnology Applications in the Food & Beverage and Dietary Supplements Sector, Reveals Frost & Sullivan

...an Union, and Japan together account for more than 90 percent of the global enzyme market. Some of the countries in Asia such as China, South Korea, India, an...ozymes South Asia Pvt. Ltd., Dr J. Sambasiva Rao - Head Technical, Advanced enzyme Technologies Ltd.,Dr. K.K Tripathi - Biosafety Advisor, Dept of Biotechnolo...

Santaris Pharma - Interim Report for the Period 1 January to 30 June 2009

...ris Pharma and academic partners published an article titled: A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. BMC Med Genomics In June 2009 Santaris Pharma and academic partners published an article titled: ...

Politicians to Drive on Straw-Based Bioethanol at the Climate Change Conference

...zymes. Facts about Danisco/Genencor Genencor, a division of Danisco A/S, is a world leader in industrial biotechnology and a pioneer in enzyme innovation. Genencor improves process and product performance for a spectrum of industries, including biofuels. Find out more at www.danisc...

Evidence for a New Genetic Link to Therapeutic Efficacy for Alzheimer's Disease

...rther investigate pharmacogenomic responses of AC-1202 in AD, the effects of APOE4 carriage status and a polymorphism (IDE_7) in the insulin degrading enzyme gene (IDE) on ADAS-Cog scores were evaluated over the study course. In addition to degrading insulin, the Ide protein also degrades amyloid beta pepti...

DuPont and Arzeda Collaborate to Develop Improved Crops to Increase Productivity

... Custom enzyme Design Technology to Bring More Options to Global ...e and are currently inaccessible using traditional enzyme engineering approaches. Arzeda was founded by Davi...ommercialize and further develop its computational enzyme design technology. Arzeda's team includes the inve...

Shanghai ChemPartner and Agios Expand Integrated Drug Discovery Research Collaboration

...l therapeutics in the emerging field of cancer metabolism. ChemPartner will provide integrated services in the areas of protein science, HTS, in vitro enzyme assay, cell biology, in vivo pharmacology, etc., for Agios' innovative R&D program to discover novel clinical candidates for oncology indications....

Lexicon Initiates Phase 2 Clinical Trial of LX1032 in Patients With Carcinoid Syndrome

... About LX1032 LX1032 was discovered and developed at Lexicon to reduce serotonin production by inhibiting tryptophan hydroxylase (TPH), a key enzyme in the synthesis of serotonin. Excessive levels of serotonin have been implicated in symptoms associated with carcinoid syndrome. Serotonin's breakd...

Verenium Completes Amendment to 8% Senior Convertible Notes

...end-to-end capabilities and cutting-edge technology in pre-treatment, novel enzyme development, fermentation and project development for next-generation biofu...e production of low-cost, biomass-derived sugars. Verenium's Specialty enzyme business harnesses the power of enzymes to create a broad range of specialt...

Palkion Selects Novel Oral Development Candidate for the Treatment of Anemia

...ical development studies for its orally available anemia therapeutic candidate that modulates the Hypoxia-Inducible Factor Prolyl Hydroxylase (HIF-PH) enzyme system. In February 2008, Palkion was founded when a novel drug discovery and development firm, CrystalGenomics (KOSDAQ: CRYSTAL [A083790]) and a lead...

Helix BioPharma to Present L-DOS47 Analytical Method Development Findings at 2009 AAPS National Biotechnology Conference

...o function by leveraging a natural process in the body called the urea cycle, to produce an anti-cancer effect. It is based upon a naturally occurring enzyme called urease that essentially reverses the urea cycle by breaking down urea into metabolites that include ammonia and hydroxyl ions. By doing so at t...

Scientists identify gene vital to early embryonic cells forming a normal heart and skull

...This leads to anatomical and functional deficits so severe that it precludes viability of the developing fetus." SHP2 is a tyrosine phosphatase an enzyme that helps trigger a cascade of biochemical reactions in cells as they specify to form certain tissues. Although the study was conducted using mou...

Celsis Outlines the Top Five Advantages of Cryo-plateable Hepatocytes

... completed 50 percent faster using cryo-plateable hepatocytes. Improved Efficiency. Cryopreserved hepatocytes may be pre-characterized for enzyme activities, genotypes and for applications like induction or transport, representing another major advantage over fresh products. In fact, cryopreserv...

Kuvan Receives Priority Review Status From Health Canada

...R-BH4 (tetrahydrobiopterin), a naturally occurring enzyme cofactor that works in conjunction with phenylalan... developed world, is caused by a deficiency of the enzyme phenylalanine hydroxylase. PAH is required for the...nd in most protein-containing foods. If the active enzyme is not present in sufficient quantities, Phe accum...

Frost & Sullivan Recognizes Cisbio Bioassays for Technology Innovation

...a SNAP or CLIP tag, which is essentially a suicide enzyme with a capability of one successful reaction durin...is expressed on the cell surface. "Given that enzyme substrate reactions have the highest order of spec... only when the substrates come in contact with the enzyme active site," observes Dr. Basu. "Hence, non-speci...

Scripps Research Institute Highlights Groundbreaking Work of aTyr Pharma Scientific Co-Founder

...Pharma. Professor Yang's latest study (Chemistry & Biology, vol. 16, pp. 531-539) builds on her previous revolutionary research with an essential enzyme of protein synthesis, tyrosyl tRNA synthetase. Synthetases are fundamental components of protein synthesis machinery in all organisms, but human synt...

Researchers solve 'bloodcurdling' mystery

...sile forces by unfolding, and losing much of its complex three-dimensional organization. This unfolding event allows the cutting of the molecule by an enzyme known as ADAMTS13. "In the body, these cutting events decrease hemostatic potential and also enable blood clots to be trimmed in size. The system ...

VIA Pharmaceuticals' DGAT1 Inhibitors Featured in American Diabetes Association Poster Presentation

...on - Metabolism Title: Can DGAT Inhibition Improve Insulin Sensitivity? (Poster 1279-P) DGAT1 (diacylglycerol acyl transferase-1) is an enzyme that catalyzes triglyceride synthesis and fat storage. Triglycerides are the principal component of fat, which is the major repository for storage of ...

EUCODIS Bioscience Launches Beta-Lactamase for Antibiotics and Diagnostics Industries

...f EUCODIS Bioscience. "The EUCODIS Bioscience team has demonstrated its capacity to cover the whole value-chain of an integrated enzyme supplier, from enzyme development, to manufacturing, and to marketing. This success adds momentum to our efforts to bring to market further products that we are currently d...

Optimer Pharmaceuticals Announces Lower Recurrence Rates for Fidaxomicin Versus Vancocin(R) in Subgroup Analyses from Its Phase 3 Study for the Treatment of CDI

...timerpharma.com . About Fidaxomicin Fidaxomicin is the first in a new class of antibiotics called macrocyclics, which inhibit the bacterial enzyme RNA polymerase, resulting in the death of Clostridium difficile . The narrow spectrum profile of fidaxomicin may eradicate Clostridium difficile se...

MIT, BU engineer cellular circuits that count events

... the cell produces the first protein in the sequence, an RNA polymerase (an enzyme that controls transcription of another gene). During the second influx, the...ory, storing a series of "bits" of information. The process relies on an enzyme known as invertase, which chops out a specific section of double-stranded D...