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Measuring siRNA-mediated knockdown of IL-8 mRNA

By Genospectra, Inc., 6519 Dumbarton Circle, Fremont, CA 94555. A critical step in siRNA-mediated gene expression knockdown studies is the validation of expression inhibition. The QuantiGene Reagent System and the Molecular Devices LMax II microplate luminometer were used to measure IL-8 mRNA in PMA-induced HeLa cells, following siRNA t...

Housekeeping Genes: Universal Positive Controls in siRNA Knockdown Experiments

RNA interference is a powerful technique for geneknockdown experiments in academic research and animportant tool for target identification and target validationin therapeutic research. A growing number of different cell lines are us...

Reagents for Up and Down-Regulation of miRNA Activity in Mammalian Cells

More than 200 miRNAs have been cloned and sequenced from human and mouse samples. Each miRNA apparently regulates multiple genes, and miRNAs are thought to regulate as many as 10% of human genes [1]. Several reports predict mR...

Breaking down Wisconsin's angel capital numbers

The figures were outlined in a recent report titled Risk Capital in Wisconsin: A Progress Report for 2006, which was produced by NorthStar Economic...

Doyle wants sales tax applied to digital downloads

The proposed tax, put forth two years after a similar proposal died at the committee le...

Dunn to step down as Medical College dean

Dunn, 70, will become a distinguished professor in the M...

An upside down view of the future

. Lush, green, and blessed with majestic mountains, fertile valleys, sulfurous lava fields, and breathtaking water views. Oh, and a couple million sheep. After a day-and-a-half on airplanes (thank God I was able to fly business class), my weary, Northern hemispheric-orientated body touches down...

Start-ups "down under" not captivated by Web 2.0

I returned last week from a 15-day tour of some of Australia and New Zealands hottest IT start-ups. I specifically describe these as IT companies because unlike in the States, where the Web 2.0 movement has spawned hundreds of new companies, the Australasia marketplace hasnt been captivated by the same frenzy. Indeed, of the nearly 50 companies I met in a seven-stop...

Father of life patents downplays historic role

Chakrabarty, the first person to successfully patent life forms, visited Wisconsin this we...

Doctor using new media to break down barriers

Fred Kron probably has never been identified as a revolutionary, but he might be in the process of becoming one. Kron, a physician with ties to the entertainment industry, has starte...

Eau Claire business contest down to 7 applicants

From a total...

Merge execs step down following investigation

The stock market fallout that was predicted by company offi...

Summer marks countdown to DEMOfall

While the lunar calendar may not agree, Memorial Day marks the traditional start of summer. So this morning, millions of Americans have brushed off the three-day weekend to return to work, sure in the knowledge that school will soon adjourn for the year, vacations are around the corner, and the next three months will pose plenty of opportunity to consume one's weigh...

Merge president steps down in wake of shareholder suits

Bill Mortimore, who founded the company and served as its chief executive officer from 1987 to 2000, has been appointed...

Cracking down on identity theft

Identity thieves, armed...

Renaissance earnings down 46 percent

Renaissance is a provider of computerized assessment and progress...

Madison's downtown wireless network almost ready

A downtown wireless network called Mad City Broadband that will cover the area around the Capitol is almost ready to go live. Cellnet, a firm in Atlanta, Georgia, is building the system and will sell bandw...

Johnson Controls sales up, profits down

That was despite earnings growth bolstered by quarterly sales of $7.5 billion, up from $6.6 billion a year ago, partly from acquisitions of York International and Delphi's battery business....

Are guest worker programs causing backlash amid IT downsizing?

Last week, I heard two guests on CNBCs Kudlow Show discuss the American workforce and what was happening with various jobs. One gentleman was from the CATO Institute and the other was a Democratic representative (Pascrell) from New Jersey. The inference from the CATO Institute director that there is a shortage of skilled people in IT in the U.S. is very questionable. He is putting forth...

Marquette targets illegal downloading

The school is the first university working with the , a non-profit consortium of technologies companies inclu...

The future of work II: standard of working up, quality of work life down

Humans love to keep score. Nowadays there seems to be a scorecard or measurement index for just about everything from the cost of living to the cost of dying and everything in between. The problem with many of these measures is that they take a pure economic view of whatever is being measured. But conclusions about the economy or business can often be misleading whe...

Third Wave reports down quarter, which CEO calls temporary

Third Wave makes clinical molecular diagnostic products, including reagents for the study of infectious diseases an...

Midwest VC investment up in 2004, but number of deals down

We also took a look at how well the Midwest garnered its share of this investment as well as how the life science industry performed. Though I had hoped to give you a more detailed look at how the life science industry in the Midwest performed, that data is not yet out from the Pr...

Madison asks for wireless bids; airport, downtown would be first

The vendor would be able to charge user fees and would take on the cost of building the network, including fees to the city, county and state for the right to operate. The project would not be paid for with t...

Though VC investing is down, reloading on new funds is rising

This week, lets take a look at VC investments by compa...

Orion Energy turns the lights up and energy usage down

Plymouth, WI The new lights which offer 50 percent more light at half the energy usage are designed as a four-lamp fixt...

Academic ADL Co-Lab moving to downtown Madison

Academic ADL Co-Lab Web site The will make t...

Choice of next UW president comes down to matching skills with the challenge

MADISON Heres how a truthful employment ad for the job of University of Wisconsin President might have read: HELP WANTED Major Midwest university system seeks a chief executive officer who can multi-task and keep the following groups happy: Board of Regents, professors, academic staff, students and campus chancellors, most of whom can overrule or ignore you. State legislators also c...

5Nines Data Services: downtown Madisons new data center

MADISON If location is everything, then...

MyWeather-powered alerting system surpasses 165,000 downloads

MADISON - Powered by MyWeather t...

Sonic Foundry to Webcast Bridge Arch Floating Down Mississippi

MADISON, Wis.-- In a rare engineering feat, WisDOT will float the entire arch of the new Mississippi River Bridge in La Crosse, Wis., and connect i...

File Swapping: Download at your own Risk

In recent months, entertainment companies have hit universities and colleges across the country, including the University of Wisconsin-Madison, with complaints documenting alleged copyright infringement of both movies and music over their networks. Last February, Universal Studios sent several cease-and-desist notices to the Universirty of Wisconsin- Madison concerning 130 computers on c...