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Reprogramming human cells without inserting genes

WORCESTER, Mass. A research team comprised of faculty at Worcester Polytechnic Institute's (WPI) Life Sciences and Bioengineering Center (LSBC) and investigators at CellThera, a private company also located at the LSBC, has discovered a novel way to turn on stem cell genes in human fibroblasts (s...

Laboring without the labor bed: It's a good thing

(Toronto: July 6, 2009) A University of Toronto pilot study that re-conceptualized the hospital labour room by removing the standard, clinical bed and adding relaxation-promoting equipment had a 28 per cent drop in infusions of artificial oxcytocin, a powerful drug used to advance slow labours. ...

Reading the brain without poking it

SALT LAKE CITY, June 29, 2009 Experimental devices that read brain signals have helped paralyzed people use computers and may let amputees control bionic limbs. But existing devices use tiny electrodes that poke into the brain. Now, a University of Utah study shows that brain signals co...

Study finds DNA barcoding requires caution without closer examination

The goal of DNA barcoding is to find a simple, cheap, and rapid DNA assay that can be converted to a readily accessible technical skill that bypasses the need to rely on highly trained taxonomic specialists for identifications of the world's biota. This is driven by a desire to open taxonomic iden...

Molecular typesetting -- proofreading without a proofreader

Researchers at the Universities of Leeds and Bristol (UK) have developed a model of how errors are corrected whilst proteins are being built. Ensuring that proteins are built correctly is essential to the proper functioning of our bodies, but the 'quality assurance' mechanisms that take place d...

Researchers create freestanding nanoparticle films without fillers

Nanoparticle films are no longer a delicate matter: Vanderbilt physicists have found a way to make them strong enough so they don't disintegrate at the slightest touch. In the last 25 years, ever since scientists figured out how to create nanoparticles ultrafine particles with diameters less t...

Nanofarming technology harvest biofuel oils without harming algae

AMES, Iowa Algae is widely touted as the next best source for fueling the world's energy needs. But one of the greatest challenges in creating biofuels from algae is that when you extract the oil from the algae, it kills the organisms, dramatically raising production costs. Now researchers at ...

Montana State grad's work helps diagnose skin cancer without a biopsy

BOZEMAN -- A recent Montana State University master's graduate is working with doctors at Vanderbilt Medical Center in Tennessee to build a handheld laser microscope that could someday reduce the number of biopsies needed to diagnose skin cancer. Suspicious spots on the skin often prompt dermat...

New simulation shows consequences of a world without Earth's natural sunscreen

The year is 2065. Nearly two-thirds of Earth's ozone is gone -- not just over the poles, but everywhere. The infamous ozone hole over Antarctica, first discovered in the 1980s, is a year-round fixture, with a twin over the North Pole. The ultraviolet (UV) radiation falling on mid-latitude cities l...

Sudden cardiac death without recognizable cause

In about 10% of cases, sudden cardiac death (SCD) in young people is due to a cardiac gene defect. This was the conclusion drawn by Silke Kauferstein of the Department of Forensic Medicine of the Johann Wolfgang Goethe University, Frankfurt, and her coauthors in the current Deutsches rzteblatt In...

Crib-side studies help struggling newborns go home without feeding tubes

(COLUMBUS, Ohio) A new strategy developed in the Neonatal and Infant Feeding Disorders Program at Nationwide Children's Hospital is helping premature infants and other newborns with severe swallowing difficulties learn to feed on their own. According to a study appearing in the February issue of ...

Disabling enzyme allows mice to gorge without becoming obese, new study finds

Berkeley -- Researchers at the University of California, Berkeley, have identified a new enzyme that plays a far more important role than expected in controlling the breakdown of fat. In a new study to be published Jan. 11 in the journal Nature Medicine , researchers report that mice that have ha...

Fructose sets table for weight gain without warning

BETHESDA, Md. (Oct. 16, 2008) − Eating too much fructose can induce leptin resistance, a condition that can easily lead to becoming overweight when combined with a high-fat, high-calorie diet, according to a new study with rats. Although previous studies have shown that being leptin resis...

Older people who diet without exercising lose valuable muscle mass

BETHESDA, Md. (Sept. 17, 2008) - A group of sedentary and overweight older people placed on a four-month exercise program not only became more fit, but burned off more fat, compared to older sedentary people who were placed on a diet but did not exercise. The new study also showed that when old...

Mouse can do without man's most treasured genes

ANN ARBOR, Mich.---The mouse is a stalwart stand-in for humans in medical research, thanks to genomes that are 85 percent identical. But identical genes may behave differently in mouse and man, a study by University of Michigan evolutionary biologists Ben-Yang Liao and Jianzhi Zhang reveals. Th...

Herceptin and chemo improves response rates without major adverse effects in HER2 breast cancer

Berlin, Germany: Women with a particularly aggressive form of breast cancer seem to do better if they are treated with a combined anthracycline and taxane chemotherapy regimen before surgery, together with trastuzumab (Herceptin) before and after surgery, according to results from the largest mult...

Fire without smoke

Could combustion without flames be used to build industrial gas turbines for power generation that are much more efficient than current models and produce almost no polluting emissions? Researchers in the Middle East provide a possible answer in the current issue of the Inderscience publication, I...

Faster koa tree growth without adverse ecosystem effects

U.S. Forest Service scientists with the Institute of Pacific Islands Forestry have completed a study on ways to make high-value koa trees grow faster, while increasing biodiversity, carbon sequestration, scenic beauty and recreation opportunities in native Hawaian forests. Acacia koa is a native...

New decontamination system kills anthrax rapidly without lingering effects

In October 2001, letters containing anthrax spores were mailed to several news media offices and two U.S. senators, killing five people and infecting 17 others. Clearing the Senate office building of the spores with chlorine dioxide gas cost $27 million, according to the Government Accountability ...

Surgery without stitches

A thin polymer bio-film that seals surgical wounds could make sutures a relic of medical history. Measuring just 50 microns thick, the film is placed on a surgical wound and exposed to an infrared laser, which heats the film just enough to meld it and the tissue, thus perfectly sealing the wound...

Coral reefs will be permanently damaged without urgent action

Coral reefs could be damaged beyond repair, unless we change the way we manage the marine environment. New research by the Universities of Exeter and California Davis, published today (1 November 2007) in Nature, shows how damaged Caribbean reefs will continue to decline over the next 50 years. ...

The benefits of 80 million years without sex

Scientists have discovered how a microscopic organism has benefited from nearly 80 million years without sex. Bdelloid rotifers are asexual organisms, meaning that they reproduce without males. Without sex, these animals lack many of the ways in which sexual animals adapt over generations to su...

Neuronal conduction of excitation without action potentials based on ceramide production

Researchers from the Laboratoire de Physiologie Neurovg tative (CNRS-INRA-Universit Paul C zanne), the Laboratoire de Chimie Biologique Applique (INRA-Universit Paul Czanne) and from the D partement Lipoprotines et M diateurs Lipidiques (INSERM, Hopital Purpan Toulouse), and in particular Profes...

Researchers design pulsed mircrojet system to deliver protein drugs without pain or bruising

A team of UCSB researchers, in collaboration with colleagues from UC Berkeley and StrataGent Life Sciences, of Los Gatos, California, has designed a novel pulsed microjet system engineered to deliver protein drugs into the skin without the pain or bruising that deeper penetration injection systems...

Magnetic system could be key to surgery without scars

Physicians at UT Southwestern Medical Center and engineers at UT Arlington have collaborated to invent a groundbreaking system that could be key to delivering on the promise of surgery without scars. The new technique, which is still in the developmental stage, allows for magnetically maneuvering...

Biofuel cells without the bio cells

Proteins keep cells humming. Some are enzymes that taxi electrons to chemicals outside the cell, to discharge excess energy generated during metabolism. This maintains energy flow in the cell and, in turn, keeps the cell alive. The process has worked a little like that slogan for a hyper-electri...

Scientists stop autoimmune disease without shutting off immune system

Skin is our first line of defense against infection. But people with a rare, life-threatening autoimmune disease called pemphigus vulgaris lack that protection because their immune system attacks the proteins that hold skin cells together. They develop severe blisters and raw sores as the top layer...

Don't hold your breath: Carp can manage without oxygen for months

How long can you hold your breath? Scientists at the University of Oslo have recently discovered how the Crucian Carp, a close relative of the goldfish, is able to live for months without oxygen. The researchers hope that understanding how some animals cope with a lack of oxygen might give clues as...

For the first time: Longevity modulated without disrupting life-sustaining function

Within a hormone-triggered cascade of molecular signals that plays a crucial for a wide range of physiological functions, researchers for the very first time have identified a protein that functions specifically to extend lifespan and youthfulness -- without disrupting fertility, immunity or the or...

Bacteria that cause tooth decay able to survive without important biochemical pathway

Leave it to the bacteria that cause tooth decay to be able to live without something all cells were thought to require. Scientists have long believed a certain biochemical pathway involved in the folding and delivery of proteins to cell membranes is essential for survival. Now University of Flor...

Clocking in Pillow Time without the Pillow

If you snooze, you lose those uncomely grayish-brown crescents below your eyes. If you don't snooze, you lose a lot more. The body can't fight off infection, the muscles can't regenerate as quickly, the mind can't learn new words, and the eyes can't focus on the road. You also gain things: a bad mo...

Brain activity related to processing faces is similar in people with, without autism

New brain imaging research at the University of North Carolina at Chapel Hill indicates that when people with autism look at a face, activity in the brain area that responds is similar to that of people without autism. The finding is surprising, as it is widely known that autistic individuals ten...

Scientists develop nanotech-laser treatment that kills cancer cells without harming healthy tissue

Scientists at Stanford University have developed a new laser therapy that destroys cancer cells but leaves healthy ones unharmed. The new, non-invasive treatment is described in a study published in the Aug. 1 online edition of the Proceedings of the National Academy of Sciences (PNAS). "One of t...

MBL researchers probe how an ancient microbe thrives and evolves without sex

A January 2004 finding by biologists at the Josephine Bay Paul Center for Comparative Molecular Biology and Evolution added important evidence to the radical conclusion that a group of diminutive aquatic animals called bdelloid rotifers have evolved for tens of millions of years without sexual repr...

Stem cells bring fast direct improvement, without differentiation, in acute renal failure

Acute renal failure, or ARF, is as serious as it sounds. An estimated 40% of critical care hospital admissions experience ARF. Estimates of their death rate range from 50% to 80%, complicated by the fact that patients with ARF often simultaneously suffer failure of other major organ systems. The ...

Two chemicals boost immune cells' ability to fight HIV without gene therapy

A UCLA AIDS Institute study has discovered that two chemical compounds may help the immune systems of HIV-infected persons fight the disease without invasive gene therapy. Presented March 5 at the 2005 Palm Springs Symposium on HIV/AIDS, the new research demonstrates that the new chemicals activate...

First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes

Biologists at the University of Liverpool have discovered how the plagues of the Middle Ages have made around 10% of Europeans resistant to HIV. Scientists have known for some time that these individuals carry a genetic mutation (known as CCR5-delta32) that prevents the virus from entering the cell...

UCSD researchers maintain stem cells without contaminated animal feeder layers

The growth and maintenance of human embryonic stem cells in the absence of contaminated animal products has been demonstrated by University of California, San Diego (UCSD) School of Medicine researchers in the Whittier Institute, La Jolla, California. Published in the April 2005 issue of the jour...

EMBO pioneers pension plan for internationally mobile postdoctoral researchers

... of EMBO Fellows," said Harald Huhn, Managing Director of the Company Pension Scheme Division at MLP. "It allows them to make early pension provisions without having to make any concessions in terms of their mobility." Following completion of PhD studies, many young researchers often take up post-doctora...

AGU journal highlights -- Aug. 6, 2009

...nsider the effects of stratospheric ozone depletion, which most previous studies had not included. They compare coupled carbon-climate models with and without ozone depletion and find that including ozone depletion produced a significant reduction in Southern Ocean carbon uptake, in good agreement with obser...
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