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NIAID Initiates Trial of Experimental Avian Flu Vaccine

Fast-track recruitment has begun for a trial to investigate the safety of a vaccine against H5N1 avian influenza, the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), announced today. Sites in Rochester, NY, Baltimore and Los Angeles will enroll a total of 450 healthy adults. The clinical sites are part of the NIAID-sponsored V...

Drug resistant avian influenza viruses more common in Southeast Asia than North America

Analysis of a key protein in different subtypes of avian flu viruses shows that resistance to the antiviral drug amantadine in H5N1 occurs worldwide, but is especially prevalent in China, according to St. Jude Resistance to the antiviral drug amantadine is spreading more rapidly among avian influenza viruses of H5N1 subtype in Southeast Asia than in North America, according to the study d...

Bird samples from Mongolia confirmed as H5N1 avian flu

The United States Department of Agriculture (USDA) has positively identified the pathogenic form of avian flu--H5N1--in samples taken from birds last week in Mongolia by field veterinarians from the Wildlife Conservation Society (WCS). It is the first instance of this viral strain occurring in wild migratory birds with no apparent contact to domestic poultry or waterfowl. Present in Mong...

WCS says avian flu prevention should focus on farms, markets

Wildlife health experts from the Bronx Zoo-based Wildlife Conservation Society (WCS) warn that efforts to control the spread of avian flu across Asia and beyond must focus on better management practices on farms and in markets. WCS is currently working with Mongolian agencies on the ground in Mongolia's Kovsgol province, collecting samples from wild birds that have recently contracted the...

Less virulent strains of avian influenza can infect humans

In findings with implications for pandemic influenza, a new study reports for the first time that a less-virulent strain of avian influenza virus can spread from poultry to humans. The research appears in the October 1 issue of The Journal of Infectious Diseases, now available online. Crossing the species barrier is an important step in the development of a flu virus with pandemic potenti...

Volunteers sought for avian flu vaccine study

Vanderbilt University Medical Center is enrolling volunteers in a study to test a new vaccine that targets avian flu, the first such vaccine against the virus. The Vanderbilt trial, led by Kathryn Edwards, M.D., will test the new vaccine in nearly 100 individuals 65 years of age and over. It is the second phase of anational study led by the National Institute of Allergy and Infectious Diseases. <...

Swimming with dolphins can alleviate depression

Swimming with dolphins is an effective treatment for mild to moderate depression, say researchers in this week's BMJ. The study was carried out in Honduras and involved 30 patients diagnosed with mild or moderate depression. Hal...

Viagra's hidden help for wildlife

Chinese men spurn traditional virility medicines The finding supports a prediction made by Australian and Alaskan re...

HIV accessory protein disables host immunity via receptor-protein intermediary

Researchers at the University of Pennsylvania School of Medicine discovered that an HIV-1 accessory protein called Vpr destroys the host cell's ability to survive by binding to a host receptor. This, in turn, keeps an important enzyme from activating the cell's immune system. These findings refine an earlier understanding of Vpr HIV pathogenesis and imply new approaches to treating AIDS, inflamma...

H5N1 avian flu virus vaccine induces immune responses in healthy adults

Results from a clinical trial demonstrate that high doses of an experimental H5N1 avian influenza vaccine can induce immune responses in healthy adults. Approximately half of those volunteers who received an initial and a booster dose of the highest dosage of the vaccine tested in the trial developed levels of infection-fighting antibodies that current tests predict would neutralize the v...

Vaccine provides 100 percent protection against avian flu virus in animal study

Scientists have sequenced and compared the genomes of planktonic microbes living throughout the water column in the Pacific Ocean. The pioneering study yielded insight into the specialization of microbial communities at each depth--ranging from 40 to more than 13,000 feet. "By reading the information stored in the genomes of entire microbial communities, we can begin to measure the pulse o...

Medical experts: US unlikely to have enough vaccines to stop avian flu

A group of medical experts who attended a national avian flu conference last fall believe there is little chance the United States will be able to manufacture and stockpile enough vaccine or antiviral medication to stop a bird flu pandemic should the virus mutate into a form that can be spread easily from human to human, according to a survey led by researchers at Carnegie Mellon University. The...

Minor mutations in avian flu virus increase chances of human infection

The H5N1 avian influenza virus, commonly known as "bird flu," is a highly contagious and deadly disease in poultry. So far, its spread to humans has been limited, with 177 documented severe infections, and nearly 100 deaths in Indonesia, Vietnam, Thailand, Cambodia, China, Iraq, and Turkey as of March 14, 2006, according to the World Health Organization ( www.who.int</...

Avian influenza virus in mammals spreads beyond the site of infection to other organ systems

Researchers at Erasmus Medical Center have demonstrated systemic spread of avian influenza virus in cats infected by respiratory, digestive, and cat-to-cat contact. The paper by Rimmelzwaan et al., "Influenza A virus (H5N1) infection in cats causes systemic disease with potential novel routes of virus spread within and between hosts," appears in the January issue of The American Journal of Patho...

Avian flu transmission to humans may be higher than thought

A new study suggests that there is an association between direct contact with dead or sick poultry and flu-like illness in humans and that the transmission is probably more common than expected, according to a new study in the January 9 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. Anna Thorson, M.D., Ph.D., from the Karolinska Institutet, Stockholm, Sweden, an...

Avian flu modeled on supercomputer, explores vaccine and isolation options for thwarting a pandemic

Using supercomputers to respond to a potential national health emergency, scientists have developed a simulation model that makes stark predictions about the possible future course of an avian influenza pandemic, given today's environment of worldwide connectivity. The research, by a team of scientists from Los Alamos National Laboratory in New Mexico, the University of Washington and the Fred Hu...

Mayo Clinic researchers discover cancer cells may move via wave stimulation

Mayo Clinic researchers have uncovered a new cellular secret that may explain how certain cancers move and spread -- a feature of cancers that makes treatment especially difficult. If the mechanism that drives cancer movement -- also called metastasis -- can be understood well enough to manipulate it, new and better treatments can be developed for patients with metastatic cancers. Signi...

Viagra improves high altitude exercise performance up to 45% for some

Sildenafil (Viagra) significantly improved the cardiovascular and exercise performance measures of trained cyclists at high altitude, mostly because the drug helped some participants improve a lot -- up to 45% -- while others showed little change. Sildenafil provided no benefit at sea level. Ten cyclists who took sildenafil at altitude collectively lowered the time it took to cover six kil...

Sperm created in the laboratory from embryonic stem cells produce viable progeny

Scientists have demonstrated for the first time that embryonic stem (ES) cells cultured in the laboratory can produce sperm with the capacity to produce viable offspring. The research, published in the July issue of Developmental Cell, opens many exciting avenues for future studies, including investigation of mechanisms involved in sperm production and development of new treatment strategies for...

H9N2 avian flu vaccine paired with adjuvant provokes strong human immune response at low doses

When combined with an immune-boosting substance called an adjuvant, low doses of an experimental vaccine against a strain of avian influenza (H9N2) provoked a strong antibody response in human volunteers, report scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The clinical trial of 96 adults was conducted...

New neurons could act to alleviate epilepsy

The new neurons generated as a result of neural damage due to epilepsy show a reduced excitability that could alleviate the disorder, researchers have found. The researchers said their results suggest that therapies for epilepsy aimed at inducing neurogenesis could prove effective in alleviating the disorder. In an article in the December 21, 2006, issue of the journal Neuron, published by...

Study shows enzyme builds neurotransmitters via newly discovered pathway

The study, which was directed by Scripps Research Professor Benjamin Cravatt, Ph.D., is being published in the September 8 issue of The Journal of Biological Chemistry. The new study describes a pathway-different than the one previously suggested-for the biosynthesis of neurotransmitter lipids, N-acyl ethanolamines (NAEs), which include the endogenous cannabinoid ("endocannabinoid") ananda...

Pacific Rim researchers to collaborate on distributed bioinformatics analysis of avian flu

Researchers at the University of California, San Diego and the University of Hawaii will use bioinformatics, grid computing and networking infrastructure, as well as collaborative ties to Asian institutions to learn more about avian flu, in hopes of helping to head off a much-feared pandemic in the region of the world where the disease has already cost human lives. "We will use modern h...

Map predicting spread of avian flu

The 2003 epidemic of Highly Pathogenic Avian Influenza (HPAI) in the Netherlands is the only recent epidemic of HPAI in the developed world. Gert-Jan Boender and colleagues have examined the data from this outbreak and produced a model which can predict the probability of infection from one farm to another; the 'transmission kernel'. They also identify high-risk areas in the Netherlands and analy...

NIAID DNA vaccine for H5N1 avian influenza enters human trial

The first human trial of a DNA vaccine designed to prevent H5N1 avian influenza infection began on December 21, 2006, when the vaccine was administered to the first volunteer at the National Institutes of Health (NIH) Clinical Center in Bethesda, MD. Scientists from the Vaccine Research Center (VRC) at the National Institute of Allergy and Infectious Diseases (NIAID), one of the NIH Institutes, d...

UCI scientists reconstruct migration of avian flu virus

UC Irvine researchers have combined genetic and geographic data of the H5N1 avian flu virus to reconstruct its history over the past decade. They found that multiple strains of the virus originated in the Chinese province of Guangdong, and they identified many of the migration routes through which the strains spread regionally and internationally. By knowing where H5N1 strains develop and...

Genome sequencing reveals key to viable ethanol production

As the national push for alternative energy sources heats up, researchers at the University of Rochester have for the first time identified how genes responsible for biomass breakdown are turned on in a microorganism that produces valuable ethanol from materials like grass and cornstalks. Waste products such as grass clippings and wood chips—once thought too difficult to turn into ethanol—...

New host species for avian influenza identified

In a new study published online in the open-access journal PLoS Pathogens, Dr. Vincent J. Munster, of Erasmus Medical Center, Rotterdam, and colleagues identify new host species for avian influenza A virus (H5N1) and provide important information on the distinctions between the ecology and epidemiology of various global strains of the virus. An eight-year surveillance study, which included...

Avian influenza survivors' antibodies effective at neutralising H5N1 strain

Adults who have recovered from the potentially deadly H5N1 strain of avian influenza may hold the key to future treatments for the virus, according to an international team of researchers. In a study published today in the open access journal PLoS Medicine, the researchers have shown how specific antibodies taken from avian flu survivors in Vietnam can be reproduced in the laboratory and prove...