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Flexible neck in cell-receptor DC-SIGN targets more pathogens

CHAMPAIGN, Ill. Pathogen recognition is the foundation of the body's immune response and survival against infection. A small cell-receptor protein called DC-SIGN is part of the immune system, and recognizes certain pathogens, including those responsible for Ebola, Dengue fever and HIV. How the mo...

Demonstration Targets Terrorism

WASHINGTON, Feb. 23 /PRNewswire/ -- Military, homeland security, law enforcement and other first-responder personnel throughout the United States are being encouraged to attend the 2009 Force Protection Equipment Demonstration (FPED VII) in northern Virginia this May 19-21. Nearly 600 exhibit...

UC Davis researchers find molecule that targets brain tumors

(SACRAMENTO, Calif.) UC Davis Cancer Center researchers report today the discovery of a molecule that targets glioblastoma, a highly deadly form of cancer. The finding, which is published in the January 2009 issue of the European Journal of Nuclear Medicine and Molecular Imaging , provides hope ...

Modified gene targets cancer cells a thousand times more often than healthy cells

Researchers at the University of Rochester have designed a gene that produces a thousand times more protein in cancer cells than in healthy cells. The findings may help address the prime challenge in anti-cancer therapy: improving treatments' ability to specifically and effectively target cancer ...

UQ research targets West Nile virus and dengue fever

Research conducted at The University of Queensland could contribute to the development of a vaccine and cure for West Nile virus and Dengue fever. Led by Associate Professor Alexander Khromykh, a team of researchers from UQ's School of Molecular and Microbial Sciences identified a novel charac...

New genes present drug targets for managing cholesterol and glucose levels

ANN ARBOR, Mich.---Scientists have identified 12 new genes that are somewhat strange bedfellows: Some link gallstones and blood cholesterol levels, others link melatonin and sleep patterns to small increases in glucose levels and larger jumps in the risk of diabetes. While these associations a...

US Air Force grant targets medical evacuation procedures

University of Cincinnati (UC) researchers have received a grant in excess of $2 million from the U.S. Air Force School of Aerospace Medicine to determine the ideal time to fly that minimizes health complications to injured soldiers due to the rush to move them from the battlefield into a safe zone...

Viral 'magic bullet' targets cancer cells with help of new compound

This press release is available in French . Researchers at McGill University and the affiliated Lady Davis Research Institute of the Jewish General Hospital along with colleagues at the University of Ottawa and the Ottawa Health Research Institute (OHRI) report a significant breakthrough in...

Media invitation: 20th EORTC-NCI-ACR Symposium on Molecular Targets and Cancer Therapeutics

Journalists are invited to attend the 20th EORTCNCIAACR Symposium on "Molecular Targets and Cancer Therapeutics" in Geneva, Switzerland [Geneva Palexpo, Geneva] from Tuesday 21 October-Friday 24 October. Today (Monday 15 September) is the deadline for booking accommodation via the official loca...

Michael J. Fox Foundation awards $2.4M for validation of therapeutic targets for Parkinson's

The Michael J. Fox Foundation for Parkinson's Research today announced approximately $2.4 million in total funding to nine research teams under its Target Validation initiative. This annual MJFF program provides intellectual and financial resources to help push potential PD drug targets forward to...

U-M study: Herceptin targets breast cancer stem cells

ANN ARBOR, Mich. A gene that is overexpressed in 20 percent of breast cancers increases the number of cancer stem cells, the cells that fuel a tumor's growth and spread, according to a new study from the University of Michigan Comprehensive Cancer Center. The gene, HER2, causes cancer stem cel...

UT Southwestern researchers identify new targets for RNAs that regulate genes

DALLAS July 6, 2008 Tiny strands of genetic material called RNA a chemical cousin of DNA are emerging as major players in gene regulation, the process inside cells that drives all biology and that scientists seek to control in order to fight disease. The idea that RNA (ribonucleic acid) is...

Epigenetic research uncovers new targets for modification enzymes

Enzymes regulating genetic expression can be just as important as the genome itself, increasing evidence shows. The expanding field of epigenetics focuses on the multiple influences on DNA and surrounding molecules that determine whether genes are turned on or off during development and disease pr...

Promising new drug targets identified for Huntington's disease

Research funded by the Wellcome Trust has provided a number of promising new drug targets for Huntington's disease, a neurodegenerative disease. Scientists at the University of Cambridge have identified a number of candidate drugs to investigate further which encourage cells to "eat" the malformed...

A screening strategy using zebrafish targets genes that protect against hearing loss

A small striped fish is helping scientists understand what makes people susceptible to a common form of hearing loss, although, in this case, its not the fishs ears that are of interest. In a study published on February 29 in the open-access journal PLoS Genetics, researchers at the University of ...

Study of successful drug targets could hasten development of new medications

Guidance from an innovative computational approach could speed up the process and cut down the cost of new drug development, researchers from the University of Chicago Medical Center and Columbia University suggest in a study to be published in the February 2008 issue of Genome Research, available...

New drug targets may fight tuberculosis and other bacterial infections in novel way

NEW YORK (Dec. 27, 2007) -- Over the course of the 20th Century, doctors waged war against infectious bacterial illness with the best new weapon they had: antibiotics. But the emergence of dangerous, multi-drug resistant strains of tuberculosis and other killer infections means that in the 21s...

New X-ray technique targets terrorists and tumors

Scientists at The University of Manchester have developed a new x-ray technique that could be used to detect hidden explosives, drugs and human cancers more effectively. Professor Robert Cernik and colleagues from The School of Materials have built a prototype colour 3D X-ray system that allows...

UIC researchers find promising new targets for antibiotics

University of Illinois at Chicago researchers have identified new sites on the bacterial cell's protein-making machinery where antibiotics can be delivered to treat infections. "The primary challenge of antibiotic therapy has been fighting infections caused by the pathogens which became resista...

Central targets may hinder wider waste management objectives

Government priorities can drive local waste partnerships towards the achievement of central targets and efficiency savings rather than wider sustainable waste management objectives, a study funded by the Economic and Social Research Council shows. Reducing levels of waste and disposing of it in...

Nicotinic receptors may be important targets for treatment of multiple addictions

For years, scientists have known that some people are biologically more susceptible to drug addiction than others, but they have only been able to speculate why. In the August 15, 2007 issue of the Journal of Neuroscience, researchers at the University of Chicago report on a study that may help...

Got zinc? New zinc research suggests novel therapeutic targets

Everyone knows that vitamins "from A to zinc" are important for good health. Now, a new research study in the August 2009 print issue of the Journal of Leukocyte Biology ( http://www.jleukbio.org ) suggests that zinc may be pointing the way to new therapeutic targets for fighting infections. Spe...

A quicker, cheaper SARS virus detector -- one easily customizable for other targets

Members of a USC-led research team say they've made a big improvement in a new breed of electronic detectors for viruses and other biological materials one that may be a valuable addition to the battle against epidemics. It consists of a piece of synthetic antibody attached to a nanowire that'...

First comprehensive genomic study of common cold reveals new treatment targets

Cincinnati, OH (October 24, 2008) Today, scientists from Procter & Gamble (P&G), the University of Calgary and the University of Virginia announced results from the first study to examine the entire human genome's response to the most common cold virus, human rhinovirus. The research confirmed, ...

N.Y. research team discovers how antidepressants and cocaine interact with brain cell targets

NEW YORK (July 28, 2008) -- In a first, scientists from Weill Cornell Medical College and Columbia University Medical Center have described the specifics of how brain cells process antidepressant drugs, cocaine and amphetamines. These novel findings could prove useful in the development of more ta...

Genomic Analysis Uncovers New Targets for HIV Vaccine

DURHAM, N.C. – An international team of researchers has identified three gene variants in the DNA of 486 people infected with HIV that appear to have helped some of the patients fight off the virus and delay the onset of full-blown AIDS. The researchers expect the new findings to aid the search...

Biodiesel study targets cleaner air, cleaner engines

Cleaner engines, cleaner air and more uses for local farm products were the focus of a just-completed study of biodiesel as an alternative fuel source on selected Ontario farms. This province-wide initiative is the only one of its kind in Canada. It involved six farms to evaluate the effectiveness...

Synthetic peptide targets latent papilloma virus infections

While a newly marketed vaccine promises to drastically reduce human papilloma virus (HPV) infections, the major cause of cervical cancer, a new discovery by University of California, Berkeley, researchers could some day help the millions of people already infected and at constant risk of genital wa...

Protein discovery targets antibiotic-resistant bacteria

A new type of protein discovered by Queen’s University researchers may be useful in developing treatments for antibiotic-resistant bacteria, such as those that cause food poisoning and typhoid. By solving the structure and activity of the protein ?called YihE or RdoA ?a team of professors and st...

'Molecular assassin' targets disease gene

University of New South Wales (UNSW) researchers have announced they are developing a new class of experimental drug that has the potential to treat a diverse range of health problems, from inflammation and cancer through to eye and heart disease. The research is published in the July issue of Natu...

Compound in dairy products targets diabetes

Fatty acids commonly found in dairy products have successfully treated diabetes in mice, according to a researcher at Penn State. The compounds, known as conjugated linoleic acids (CLA), have also shown promising results in human trials, signaling a new way of potentially treating the disease witho...

Adult stem cell research at UB targets damaged hearts

A specialist in stem cell biology at the University at Buffalo has received a $1.98 million grant from National Institutes of Health to investigate the potential of bone marrow-derived adult stem cells to treat the serious heart malfunction known as hibernating myocardium. Hibernating myocardium ...

Study findings offer potential new targets for antibiotics

A new study of genetic changes in bacteria may ultimately help drug makers stay a step ahead of disease-causing bacteria that can become resistant to antibiotics. The secret lies in understanding the function of the ribosome, a tiny protein-making factory residing inside most cells. Many curre...

Vaccine targets tumors where they live

Vaccine strategies are being designed to battle cancer, but their use for metastatic melanoma is a challenge. Effective vaccines against established tumors require tumor-reactive T cells to traffic to the sites of the tumors and are locally activated there in order to kill cancer cells. A problem i...

Novel targets found for the development of drugs to complement, or replace, statins

Leading marine scientists for the first time have assessed dolphin and porpoise populations around the world which are severely threatened by entanglement in fishing gear and recommended nine urgent priorities for action in a report commissioned by the World Wildlife Fund. These nine projects highl...

Moffitt-USF head toward first human trials of anti-cancer drug that targets protein AKT

H. Lee Moffitt Cancer Center & Research Institute, working in partnership with the University of South Florida (USF), has discovered a new use for an old, previously discredited anti-cancer drug that could add another weapon in the arsenal against several cancers, including tumors of the breast...

NHGRI targets 12 more organisms for genome sequencing

The National Human Genome Research Institute (NHGRI), one of the National Institutes of Health (NIH), announced today that the Large-Scale Sequencing Research Network will begin sequencing 12 more strategically selected organisms, including the marmoset, a skate and several important insects, as pa...

'Smart drug' targets deadly brain cancer

A study led by Mayo Clinic researchers and conducted by the North Central Cancer Treatment Group (NCCTG) reports that a new "smart" drug treatment for an incurable form of recurrent brain cancer slowed tumor growth in more than one-third of the 65 adult patients who tried it. The same research team...

Study reveals candidate targets for anti-retroviral therapeutics

The increased frequency of drug resistance in isolates of the AIDS virus, HIV, makes identification of new antiviral targets an urgent necessity. Host genes required to support the replication of HIV are a potential source of such novel targets, but relatively few appropriate target genes have been...

A bacterial genome reveals new targets to combat infectious disease

More than a billion people are at risk for infection with filarial nematodes, parasites that cause elephantiasis, African river blindness, and other debilitating diseases in more than 150 million people worldwide. The nematodes themselves play host to bacteria that live within their cells, but in t...
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