Johns Hopkins scientists pull protein's tail to curtail cancer
When researchers look inside human cancer cells for the whereabouts of an important tumor-suppressor, they often catch the protein playing hooky, lolling around in cellular broth instead of muscling its way out to the cells' membranes and foiling cancer growth.
This phenomenon of delinquency ...
Venomous sea snakes play heads or tails with their predators
...our patterns to fool predators into thinking their tail
is a second head, complete with lethal venom.
...ellow-lipped Sea Krait has been found to twist its tail
so that the tip corresponds with the dorsal view o...rprised to see the "head" was facing him while the tail
probed the coral. Rasmussen's surprise grew when h...
Lead-based consumer paint remains a global public health threat
The UC team reports their findings in the journal Environmental Research online ahead of publication on Aug. 4, 2009. The report comes on the tail
of the U.S. Consumer Product Safety Commission's enforcement of heightened restrictions on lead in American consumer paints, which will take effect Au...
'Microfluidic palette' may paint clearer picture of biological processes
...hree in the prototype, but it could be moreallow various mixtures to flow into the chamber. Beneath the chamber, each access port connects to the long tail
of a Y-shaped channel etched into a second layer. These channels deliver test chemicals to the chamber. Fluid flow in and out of the short arms of eac...
Promising new treatment for Alzheimer's suggested based on Hebrew University research
...rew University, the researchers found that the mutation in the BChE-K gene damages the very end, or tail, of the resultant mutant enzyme protein. This tail
is the part of BChE which is important for protection from the Alzheimer's disease plaques. It does this by interacting with the Alzheimer's disease &...
Ozone, nitrogen change the way rising CO2 affects Earth's water
... ecosystems and how long it stays there. Plants draw in water from the atmosphere and soil, and they discharge it naturally through transpiration, the tail
end of photosynthesis when water vapor and oxygen are released into the air.
The amount of water that plants give up depends on how much carbon di...
The faster they come
...ckly and often, or that slower fish become more aggressive because they cannot manoeuvre quickly." The researchers also analysed whether damage to the tail
and fins may affect the social position of a given individual, and found that, indeed, aggressive behaviours tend to decline as fin damage sustained i...
Nematode courting caught on camera
...atory neurotransmitter acetylcholine in regulating tail
muscles to achieve an exploratory embrace.
The...ecessary contact. He presses the front side of his tail
against the hermaphrodite while he backs along and...the vulva. If not found along this first side, the tail
makes a sharp turn, curling round the end of the h...
Mate selection: How does she know he'll take care of the kids?
...rding to Natasha Kelly , a graduate student in ecology and evolutionary biology at Yale and lead author of the study.
The peacock's ornate fanned tail
or the primping and posturing of a guy in a bar are "advertisements" or mating displays that take substantial energy to maintain. When a male's ener...
TRAPping proteins that work together inside living cells
...ranslate DNA. One of the polymerase proteins has a tail
that is known to touch the DNA and some helper pro...polymerase starts translating. No one knew if this tail
-- also known as the C-terminus of the alpha subun...re protein called the beta subunit, suggesting the tail
of the alpha subunit makes contact with the beta s...
Boston University biomedical engineers teach bacteria to count
...t over and sticks it back in. Once the gene is backwards, it can no longer be transcribed but an extra snippet of DNA the researchers attached to its tail
acts as a bookmark, showing protein-making machinery where to resume work. Each successive flip-over counts another event, and the fluorescing protein...
The life histories of the earliest land animals
...ays Per Ahlberg.
Ichthyostega , which has robust limbs and only a small tail
fin, appears to be the more terrestrial of the two. Its forelimb becomes be...a weight-bearing position.
Acanthostega has feebler limbs and a large tail
fin, and seems to have been more aquatic. In this animal, there are no corr...
Risk of vibration-induced vascular injuries linked to vibration frequency differences
...nge of locale. A second control group stayed in their home cages, uninvolved in the activity.
After the last exposure, the scientists examined the tail
arteries for changes. Neither control group had changes, suggesting the changes seen were directly related to the effects of vibration. The rats tha...
Diet secrets of 'the Royals'
... collars and analyzed carbon and other isotopes in tail
hair to monitor the elephants' movements and diet ... for elephants to grab with their trunks, elephant tail
hair shows a ratio of carbon isotopes different f...often the scientists cut 1.8-foot-long samples of tail
hair. The hair grows about an inch per month, so a...
CSHL researchers explain process by which cells 'hide' potentially dangerous DNA segments
... chemical "marks" that are added to histones at specific locations on their tail
ends. These marks consist of methyl groups that get attached to the tail
of one of the histones, histone H3, at a specific spot the ninth residue, ...
First tri-continuous mesoporous Silica complex structure developed in Singapore
... a specially designed surfactant template, N,N-dimethyl-L-phenylalanine. This surfactant has a unique tunable head-group as well as a long hydrocarbon tail
variable levels of hydrophobic (water-repellent) qualities. By systematically changing the
synthesis conditions using this surfactant, IBN re...
Research yields potential target for cancer, wound healing and fibrosis
...f the protein inside the cell. The beta-1 integrin tail
is the portion found inside the cell. The beta-1 integrin tail
has two functions -- it connects integrins to the...n tail, that revealed the ability of this integrin tail
to provide a scaffold for signaling proteins that ...
Lab-on-a-chip homes in on how cancer cells break free
...l and biomolecular engineering and co-author of the Nature Methods paper. "The cell stretches way, way out across the chip and then, on command, the tail
snaps toward the body of the cell."
Cells survive this programmed-release process and can be tested again and again, the researchers said.
Cretaceous octopus with ink and suckers -- the world's least likely fossils?
... Even if you have never encountered one in the flesh, the eight arms, suckers, and sack-like body are almost as familiar a body-plan as the four legs, tail
and head of cats and dogs. Unlike our vertebrate cousins, however, octopuses don't have a well-developed skeleton, and while this famously allows them...
Female mammals follow their noses to the right mates
...ian mate choice.
"[I]t is possible that in some mammals, males produce olfactory signals that match the elaboration and complexity of the peacock's tail
or the sedge warbler's song ," Clutton-Brock and McAuliffe write.
Study offers clues to beating hearing loss
...n 7 only has one. What's more, for the first time we've found how this myosin can be switched on and switched off. When switched off, the tip of its tail
curls round and contacts the head, and switched on this contact is broken and the myosin stretches out. This knowledge should help inform any further ...
Tree lizards quick release escape system makes jumpers turn somersaults
... could see that the animals were tumbling backwards uncontrollably as their tail
stump flailed around. Filming other tailless anoles, three more backflipped...ls at take off to prevent themselves from spinning, or whether the trailing tail
passively stabilises the animal's departure. He is also keen to find out mo...
A new gene silencing platform -- silence is golden
... cellular splicing apparatus.
By combining both capabilities in the same molecule, the U1 Adaptor can inhibit the pre-mRNA maturation step of polyA tail
addition in a gene specific manner. Further, the domains of the oligonucleotide are independent so transcript binding and U1 snRNP binding can be inde...
Origin of claws seen in 390-million-year-old fossil
...sable appendages with spines projecting inward along their length. The trunk section is made up of 12 segments, each with small appendages, and a long tail
spine. Between the head and trunk, there is a pair of large triangular wing-like limbs that likely propelled the creature like a swimming penguin, ac...
Largest prehistoric snake on record discovered in Colombia
...rejonensis by its discoverers, the size of the snake's vertebrae suggest it weighed 1140 kg (2,500 pounds) and measured 13 metres (42.7 feet) nose to tail
tip. A report describing the find appears in this week's Nature .
Drs Jason Head and David Polly carried out much of the quantitative work behind ...
At 2,500 pounds and 43 feet, prehistoric snake is the largest on record
...is by its discoverers, the size of the snake's vertebrae suggest it weighed 1,140 kilograms (2,500 pounds) and measured 13 meters (42.7 feet) nose to tail
tip -- and that's a conservative estimate. A report describing the find appears in this week's Nature .
"At its greatest width, the snake would ha...
Viruses, start your engines!
...d where it is protected from damage, enabling the virus to survive and reproduce. After the DNA is inside the capsid, the motor falls off, and a virus tail
attaches to the capsid.
Until now, researchers did not know how T4, or any other virus, accomplished the DNA packaging. According to Rao, "Since th...
Biologists learn structure, mechanism of powerful 'molecular motor' in virus
...th of muscles.
The virus consists of a head and tail
portion. The DNA-packaging motor is located in the same place where the tail
eventually connects to the head. Most of the motor...fter the packaging step is completed, allowing the tail
to attach to the capsid. The DNA is a complete rec...
'Gray's Paradox' solved: Researchers discover secret of speedy dolphins
...selves with short, powerful thrusts of their tails.
The results show that dolphins produce on average about 200 pounds of force when flapping their tail
about 10 times more force than Gray originally hypothesized.
"It turns out that the answer to Gray's Paradox had nothing to do with the dolphins'...
'Fish technology' draws renewable energy from slow water currents
... each other's wake."
This generation of Bernitsas' machine looks nothing like a fish, though he says future versions will have the equivalent of a tail
and surface roughness a kin to scales. The working prototype in his lab is just one sleek cylinder attached to springs. The cylinder hangs horizontall...
How do bacteria swim? Brown physicists explain
...k" to them.
Caulobacter is a single-celled organism with a filament-like tail
called a flagellum. As it swims, its rounded cellular head rotates in one direction, while the tail
rotates in the opposite direction. This creates torque, which helps explain...
AGU journal highlights: Nov. 11, 2008
3. Comet-like tail
of ion flux streams from Mars
A comet tail
has two entities: a neutral tail
with debris along the orbit, and a plasma...
Acoustical Meeting, Nov. 10-14, 2008 in Miami, Florida
... that the reflected signal was weakest when the moth was pointed away from the transmitter - a "stealth" advantage that likely explains why moths turn tail
when they hear a bat's chirp.
Ultrasonic surveillance could later be used to listen to a bee hive or an ant colony without disturbing their natura...
'A dinosaur dance floor'
...Dense Collection of Dinosaur Footprints and a Few tail
Chan says the new study is the first sc...es State Park in Utah.
The dinosaur tracks and tail
marks near the Wave were preserved in the vast Nav...osaur tail-drag sites worldwide, Seiler says. Four tail
drags were within the 10 plots he surveyed, and th...
Study links nicotine with breast cancer growth and spread
...s, potentiates tumorigenesis in mammary cancer-prone or cancer cells," Chen said.
In vivo studies confirmed these findings. When injected into the tail
of a mouse the cancerous MCF7 cells migrated to the lungs.
From in vivo and in vitro studies, it indicates that nicotine is not a conventional car...
Fitness in a changing world
... and other fish-eating predators. The lateral plates develop first at the front of the fish, near the spines, and then are gradually added towards the tail
until the entire side of the stickleback is covered.
Freshwater stickleback almost always evolve the loss of lateral plates, and sometimes the spin...
MU scientists 'see' how HIV matures into an infection
...hers discovered that the 'tail,' or the flanking amino acid residues, of the HIV-1 protease precursor go through a temporarily formed tunnel where the tail
is cut off. At this point, the protease becomes active, the maturation process proceeds, and the virus becomes infective.
"The more we understand a...
Great white's mighty bite revealed
...onnes of bite force. Fossil evidence suggests that Big Tooth was an active predator of large whales that immobilised its huge prey by biting off their tail
and flippers before feeding at will.
A comparison of Tyrannosaurus rex with megalodon suggests that the great Tyrant Lizard was no match for the gi...
Cancer drug delivery research at Case Western Reserve University cuts time from days to hours
...mbered through the bloodstream.
A single 1/4-mL injection holds approximately 100 million Au NPs, each carrying approximately 100 drug molecules.
to Tumor in Two Minutes
In the laboratory of Baowei Fei, assistant professor of radiology and biomedical engineering at Case Western Reserve, these...
Study reveals air pollution is causing widespread and serious impacts to ecosystems
...ction. Currently, U.S. air quality standards are determined by direct impacts to human health, with regulations targeting emission levels what leaves tail
pipes and smoke stacks. They do not take into account where airborne pollution is actually deposited in the landscape or how this pollution compromise...