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New molecular pathway could reveal how cells stick together

Researchers at Rensselaer Polytechnic Institute have found a new pathway by which cells change their adhesive properties. With a $1.4 million grant from the National Institutes of Health, they plan to fill in the details behind how cells decide to stick to a surface, which could lead to a better un...

Tiny shock absorbers help bacteria stick around inside the body

Bacteria have hair-like protrusions with a sticky protein on the tip that lets them cling to surfaces. The coiled, bungee cord-like structure of the protrusions helps the bacteria hang on tightly, even under rough fluid flow inside the body, researchers report in the journal PLoS Biology. A grou...

Viral protein helps infected T cells stick to uninfected cells

New research shows that a protein made by a cancer virus causes infected immune cells to cling to other immune cells, enabling the virus to spread. The virus, the human T lymphotropic virus type 1 (HTLV-1), is transmitted mainly when infected cells known as T lymphocytes, or T cells, touch uninf...

Scientists find viruses can't stick to sea bugs in the dark

Blue-green algae, or cyanobacteria, in the seas are as vital to the survival of life on earth as the oxygen producing plants are on land. But marine bacteria are attacked by viruses, which can seriously affect their life-sustaining abilities but mow a researcher at the University of Warwick has dis...

NIH stimulus funding supports Emory biomedical scientists

...mory nursing professor Sandra Dunbar. Their project tests whether involving family members in the care of elderly heart failure patients can help them stick to their diets and medication plans. Emory undergraduate Garron Deshazer is working with Emory cardiologist John Oshinski to study how cardiac ima...

Knee injuries may start with strain on the brain, not the muscles

...rios, and train the brain to respond more rapidly, you can decrease the likelihood of a dangerous response," he said. It's analogous to how a seasoned stick shift driver versus a novice learner might both respond to a sudden stall. The inexperienced driver might make a slow or even incorrect decision. ...

New windows opened on cell-to-cell interactions

... said. "At the surface of every cell is a forest of molecules to induce interactions. These proteins need to rise from the forest. What allows them to stick up or lie down? We've really had a poor idea of what's going on. Knowing the genome and what proteins are there is crucially important, but that infor...

Reveal the enemy

...monella, the aptamers fit closely against the walls of the carbon nanotubes. If the biosensor is put into a salmonella-containing sample, the microbes stick to the aptamers like flies to flypaper. This influences the interaction between the aptamers and the nanotubes, which makes a change in the electrode ...

Building memories with actin

...hem so that heightened synapse sensitivity can persist. The researchers hypothesize that one pathway encodes memories, while the other makes sure they stick around. ...

Battle of the sexes benefits offspring, says research

...ns. Researchers therefore wanted to find out why, for some animals, parents stick together. The study, published in the Journal of Evolutionary Biology ,...rtially compensate for your lazy partner's failings, to make sure that they stick around." Professor Innes Cuthill, Professor of Behavioural Ecology at th...

Reading the brain without poking it

...g Utah Electrode Array Such technology already has been developed in experimental form using small arrays of penetrating electrodes that stick into the brain. The University of Utah pioneered development of the 100-electrode Utah Electrode Array used to read signals from the brain cells of pa...

TRAPping proteins that work together inside living cells

...he tag like two pieces in a puzzle. TRAP waves around, bumping into nearby proteins. The scientists control TRAP with a flash of light, causing it to stick to coworkers it bumps into. The researchers then identify the new "TRAPped" proteins in subsequent analyses. To demonstrate how well this method w...

Researchers create freestanding nanoparticle films without fillers

... mixed with molecules called chemical "cross-linkers" that act like glue to stick the nanoparticles together. "Adding this extra material can complicate ...oparticle film. According to the researchers, films made in this fashion stick together because the electrical field slams the nanoparticles into the film...

Genetic factors may predict depression in heart disease patients

... a significant association. vWF is a protein produced by the endothelium that is critical to the initial stages of blood clotting by helping platelets stick to damaged blood vessels. When elevated in concentration, VWF is a strong predictor of endothelial dysfunction and a risk factor for atherosclerosis. ...

New lead on malaria treatment

...ne of these compounds, fumarranol, because it interacts with human MetAP2 and is less toxic to mice. The team first tested whether fumarranol can stick to and interfere with PfMetAP2 by treating mouse cells containing PfMetAP2 with different amounts of fumarranol and fumagillin and comparing them to u...

100 reasons to change the way we think about genetics

...mical agent, for examplethat new pattern can be passed to future generations. The result, as in the case of the pregnant rats, can be dramatic and stick around for generations, despite the fact that underlying DNA remains unchanged. LAMARCK REVISITED New evidence for epigenetic inheritance has ...

UCSB scientists document fate of huge oil slicks from seeps at coal oil point

... much oil seeps up and floats on the sea surface. It's something we've long wondered. We know some of it will come ashore as tar balls, but it doesn't stick around. And then there are the massive slicks. You can see them, sometimes extending 20 miles from the seeps. But what is really the ultimate fate?" ...

Laughing hyenas, wailing levees, the sound of cheese and blaring bagpipes

...ments in gene therapy, which use microscopic bubbles chemically modified to stick to the cells that line blood vessels. This technique, ultrasound-mediate...g the behavior of these "targeted" bubbles in living tissue. The ability to stick these gene-laden microbubbles to the lining of blood vessels increased the ...

Children's Hospital Oakland is first pediatric hospital to use 'laboratory-on-a-card' technology

... cards at the supermarket or gas station, to read a child's blood sample. The procedure starts with a respiratory therapist who takes a tiny finger stick sample of patient blood at bedside and places it on the diagnostic card. The card is slipped into a handheld wireless card reader or "host mobile comp...

Caltech scientists show why anti-HIV antibodies are ineffective at blocking infection

...s at more or less the same time. In the case of HIV, antibodies that can block infection target the proteins that stud the surface of the virus, which stick out like spikes from the viral membrane. But an antibody can only bind to two spikes at the same time if those spikes fall within its span--the distan...

Plant gene mapping may lead to better biofuel production

... the paired genes (sequences of DNA) produce protein-encoding segments (RNAs) that are complementary to one another meaning the two RNA strands would stick to each other like highly specific Velcro. That would prevent the RNA from building its enzyme, so the expression of one gene in the pair appears to i...

Caltech scientists control complex nucleation processes using DNA origami seeds

...cking to each other and folding into shape--but the tiles and origami don't stick to each other yet," Winfree explains. "Then, at a lower temperature, the tiles start to stick to each other and to the origami. The critical concept here is that the DNA...

A London effort to develop point-of-care nanosensors for HIV diagnosis and monitoring

...vestigator Dr Rachel McKendry, Reader in Biomedical Nanoscience at the LCN, explains: "The nano-cantilever arrays are each coated with substances that stick to the HIV and other proteins, which are markers associated with disease progression. Accommodating these markers causes the highly sensitive sensors ...

A little java makes it easier to jive, researcher says

...hat tells you to withdraw. So if we could give people a little caffeine and reduce the amount of pain they're experiencing, maybe that would help them stick with that exercise. "Maybe then they'll push a little harder as well maybe get even better adaptations to the exercise." ...

Covering the bases: Quantum effect may hold promise for low-cost DNA sequencing, sensor applications

.... When this tip is fitted with a particular nucleotide and brought in contact with its complementary mateembedded in the substrate, the hydrogen bonds stick the bases together and they attach, like tiny magnets (see fig. 1). As Lindsay describes the method, " you have sensing chemicals attached to one elec...

Shellfish and inkjet printers may hold key to faster healing from surgeries

... Using the natural glue that marine mussels use to stick to rocks, and a variation on the inkjet printer, a team of researchers led by North Carolina State University has devised a new way of making medical ...

Synthesizing the most natural of all skin creams

...is how the mixture arranges itself. Lipid molecules are shaped something like lollipops, with a round end that prefers to be surrounded by water and a stick which prefers to make a raft with other lollipop sticks. VC contains several different lengths of lipids, which form different arrangements as the tem...

Microscope reveals how bacteria 'breathe' toxic metals

...in OmcA, which they suspected Shewanella would use to "breathe" the metal. Whenever the probe slid over an OmcA protein, the antibody coating would stick to the protein. By measuring the tiny increase in force needed to pull the two apart, the researchers could tell where on the bacteria surface the pro...

Scientists unlock the secrets of C. difficile's protective shell

... The detailed structure of a protective 'jacket' that surrounds cells of the Clostridium difficile superbug, and which helps the dangerous pathogen stick to human host cells and tissues, is revealed in part in the 1 March issue of Molecular Microbiology . Scientists hope that unravelling the secret...

Caltech and UCSD researchers shed light on how proteins find their shapes

...el and opposite charges attract," he explains. "And they had to consider the hydrophobic interactions--the way that oily parts of the proteins like to stick together but are repelled by the watery parts. When their models took account of these interactions, it fit the experimental data." "It was the fir...

Cell-building discovery could reduce need for some animal research

...ohydrate derived from seaweed with the consistency of Jell-O. Morgan and students in his lab developed the dish, creating a product where cells do not stick to the surface. Instead, the cells self-assemble naturally and form "microtissues." For the new research, Morgan, with students including Adam Rago...

New generation of orthopedic, dental and cardiovascular prostheses

...ted etching mixtures of acids and oxidants results in surfaces with a sponge-like pattern of nano (ultra small) pits. "We demonstrated that some cells stick better to these surfaces than they do to the traditional smooth ones," says Dr. Nanci. "This is already an improvement to the standard available bioma...

A crystal clear view of chalk formation

...stand the role of the oceans as carbon dioxide sinks. ( Science , December 19, 2008) Calcium carbonate is ubiquitous: everyone has probably held a stick of blackboard chalk in the hand at one time or another, or railed against the deposits it forms in washing machines. It is the main constituent of mar...

To climate-change worries, add 1 more: Extended mercury threat

...Wesleyan University who also studies mercury and the environment, agreed that Natali's results can be seen as both negative and positive. Mercury will stick around longer in a carbon-dioxide-enriched world, he said, but it also will remain bound to the soil for a longer period. "I agree with her conclus...

Team finds breast cancer gene linked to disease spread

...n" or MTDH, is located in a small region of human chromosome 8 and appears to be crucial to cancer's spread or metastasis because it helps tumor cells stick tightly to blood vessels in distant organs. The gene also makes tumors more resistant to the powerful chemotherapeutic agents normally used to wipe ou...

Potential therapy for congenital muscular dystrophy

... Reno, Nevada Current research suggests laminin, a protein that helps cells stick together, may lead to enhanced muscle repair in muscular dystrophy. The related report by Rooney et al, "Laminin-111 restores regenerative capacity i...

Peering inside the skull of a mouse to solve meningitis mystery

...ated to where the virus was, but when they got there, they couldn't do the right thing. At least they didn't do what we expected them to, which was to stick tightly to the infected cells." Intravital two-photon microscopy employs an oscillating infrared laser yielding high-resolution moving pictures. I...

Tiny MIT ecosystem may shed light on climate change

... CAMBRIDGE, Mass. MIT researchers have created a microbial ecosystem smaller than a stick of gum that sheds new light on the plankton-eat-plankton world at the bottom of the aquatic food chain. The work, reported in the January print iss...

GUMC researchers find gene function 'lost' in melanoma and glioblastoma

... protrudes outside the cell body is thought to be involved in helping cells stick to each other to form a tissue as well as in cell-to-cell communication. Th... technique uses a gene microarray that contains millions of probes that can stick to different regions of the human genome. The researchers purified DNA from...

New way of viewing cells could lead to easier routes for drug manufacture

...figuration. Weliky and colleagues took a closer look at the structure of the proteins that make up these inclusion bodies. Learning what makes them stick together might yield some clues as to how to separate them, he said, and that could make the manufacturing process more efficient. Instead of emplo...
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